Development Level

Tbio 24 | 11,445
Tdark 6 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

abnormal coat appearance 31 | 31
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 19 | 11,493
osteosarcoma 18 | 7,950
medulloblastoma, large-cell 15 | 6,241
psoriasis 15 | 6,694
atypical teratoid / rhabdoid tumor 13 | 5,112
ovarian cancer 13 | 8,520
glioblastoma 11 | 5,792
group 3 medulloblastoma 11 | 4,104
non-small cell lung cancer 10 | 2,890
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung cancer 8 | 4,740
primitive neuroectodermal tumor 8 | 3,035
Breast cancer 7 | 3,578
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic cancer 7 | 2,398
Astrocytoma, Pilocytic 6 | 3,081
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
spina bifida 6 | 1,074
tuberculosis 6 | 2,010
Pick disease 5 | 1,894
lung adenocarcinoma 5 | 2,716
malignant mesothelioma 5 | 3,232
Kidney cancer 4 | 2,613
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Atopic dermatitis 3 | 952
Bipolar Disorder 3 | 666
Down syndrome 3 | 499
Liver cancer 3 | 604
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
primary pancreatic ductal adenocarcinoma 3 | 1,109
Becker muscular dystrophy 2 | 191
Cancer 2 | 2,499
Liver Cirrhosis, Experimental 2 | 769
Male infertility 2 | 206
Rheumatoid arthritis 2 | 1,191
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
mucosa-associated lymphoid tissue lymphoma 2 | 484
non primary Sjogren syndrome sicca 2 | 891
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 676
sarcoidosis 2 | 370
Adenoid Cystic Carcinoma 1 | 99
Adrenoleukodystrophy 1 | 29
Alcoholic Intoxication, Chronic 1 | 289
Anemia 1 | 365
Arrhythmogenic right ventricular cardiomyopathy 1 | 30
Autism spectrum disorder 1 | 101
Autistic Disorder 1 | 364
Carcinoma, Adenoid Cystic 1 | 99
Cardiomyopathy 1 | 116
Cardiomyopathy, Dilated 1 | 83
Chemical and Drug Induced Liver Injury 1 | 195
Congestive heart failure 1 | 113
Dementia 1 | 175
Dilated cardiomyopathy 1 | 56
Endometrial cancer 1 | 311
Facioscapulohumeral muscular dystrophy 1 | 26
Hyperhomocysteinemia 1 | 37
Hyperinsulinism 1 | 133
Infertility 1 | 188
Liver disease 1 | 237
Liver neoplasms 1 | 130
Lung Neoplasms 1 | 232
Mediastinitis 1 | 7
Mucopolysaccharidosis 1 | 26
Neurodevelopmental Disorders 1 | 70
Pancytopenia 1 | 45
Skin cancer 1 | 469
Sudden Cardiac Death 1 | 29
Syndromic X-linked intellectual disability Najm type 1 | 3
active ulcerative colitis 1 | 764
facioscapulohumeral dystrophy 1 | 288
fascioscapulohumeral muscular dystrophy 1 | 100
interleukin-7 receptor alpha deficiency 1 | 18
pulmonary arterial hypertension 1 | 75
tuberculosis and treatment for 3 months 1 | 179

Tissue

Female tissues 31 | 17,400
Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Non-IDG 15 | 12,091
Enzyme 9 | 4,145
Transporter 4 | 473
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Choline transporter-like protein 1 SLC44A1 Tbio Transporter -1.60796 43.9 212
Magnesium-dependent phosphatase 1 MDP1 Tdark Enzyme -0.52288 4.23 35
Protein dopey-2 DOPEY2 Tbio Non-IDG -0.68663 6.12 17
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
Neuralized-like protein 2 NEURL2 Tdark Non-IDG -0.41285 3.16 58
Keratin-associated protein 17-1 KRTAP17-1 Tdark Non-IDG 0.00000 0
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67762 525.7 663
ATP-dependent RNA helicase DDX55 DDX55 Tdark Enzyme 0.48 0.33 109
Placenta-specific gene 8 protein PLAC8 Tbio Non-IDG -1.79564 62.5 24