Development Level

Tbio 127 | 11,651
Tchem 28 | 1,388
Tdark 24 | 6,593
Tclin 8 | 612

Collection

RFA-RM-18-021 5 | 328
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

abnormal bone structure 187 | 187
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 138 | 11,493
ovarian cancer 103 | 8,520
osteosarcoma 91 | 7,950
glioblastoma 85 | 5,792
medulloblastoma, large-cell 79 | 6,241
psoriasis 77 | 6,694
atypical teratoid / rhabdoid tumor 74 | 5,112
ependymoma 58 | 4,679
lung cancer 55 | 4,740
adult high grade glioma 52 | 3,801
group 3 medulloblastoma 49 | 4,104
Breast cancer 46 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
Astrocytoma, Pilocytic 44 | 3,081
primitive neuroectodermal tumor 44 | 3,035
astrocytic glioma 41 | 2,597
Cancer 39 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
malignant mesothelioma 37 | 3,232
invasive ductal carcinoma 36 | 2,951
oligodendroglioma 35 | 2,850
Kidney cancer 34 | 2,613
subependymal giant cell astrocytoma 34 | 2,287
Pick disease 32 | 1,894
pancreatic cancer 31 | 2,398
non-small cell lung cancer 26 | 2,890
breast carcinoma 25 | 1,638
ductal carcinoma in situ 25 | 1,745
pituitary cancer 25 | 1,972
lung carcinoma 24 | 2,843
group 4 medulloblastoma 23 | 1,855
lung adenocarcinoma 23 | 2,716
Rheumatoid arthritis 21 | 1,191
interstitial cystitis 21 | 2,312
Obesity 19 | 678
ulcerative colitis 19 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Autosomal recessive predisposition 17 | 1,442
Schizophrenia 17 | 1,160
colon cancer 17 | 1,478
spina bifida 17 | 1,074
cutaneous lupus erythematosus 16 | 1,057
cystic fibrosis 16 | 1,696
juvenile dermatomyositis 16 | 1,187
primary pancreatic ductal adenocarcinoma 16 | 1,109
astrocytoma 15 | 1,146
pediatric high grade glioma 15 | 1,064
Intellectual disability 14 | 1,016
adrenocortical carcinoma 14 | 1,428
diabetes mellitus 13 | 1,728
tuberculosis 13 | 2,010
Epilepsy 12 | 792
medulloblastoma 12 | 720
Bipolar Disorder 11 | 666
Liver cancer 11 | 604
esophageal adenocarcinoma 11 | 737
Alzheimer's disease 10 | 658
Atopic dermatitis 10 | 952
acute quadriplegic myopathy 10 | 1,158
progressive supranuclear palsy 10 | 676
Adenoma 9 | 167
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Multiple myeloma 9 | 1,332
Poor school performance 9 | 645
dermatomyositis 9 | 966
non primary Sjogren syndrome sicca 9 | 891
Hyperphosphatemia 8 | 32
Neurodegenerative disease 8 | 414
Parkinson's disease 8 | 392
Seizures 8 | 596
acute myeloid leukemia 8 | 783
nasopharyngeal carcinoma 8 | 1,058
primary Sjogren syndrome 8 | 735
Amyotrophic lateral sclerosis 7 | 451
Depressive disorder 7 | 409
Down syndrome 7 | 499
Duchenne muscular dystrophy 7 | 601
Melanoma 7 | 711
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
active ulcerative colitis 7 | 764
fibroadenoma 7 | 559
gastric carcinoma 7 | 807
substance-related disorder 7 | 162
Cognitive delay 6 | 608
Cushing's syndrome 6 | 48
Endometrial cancer 6 | 311
Global developmental delay 6 | 608
Hypothyroidism 6 | 122
Mental and motor retardation 6 | 608
Multiple Sclerosis 6 | 540
Pituitary adenoma 6 | 38
Polycystic ovary syndrome 6 | 360
Prostatic Neoplasms 6 | 495
active Crohn's disease 6 | 922
pancreatic carcinoma 6 | 562

Tissue

Endocrine System 181 | 18,159
Digestive Tract 178 | 17,369
Female tissues 178 | 17,400
Skin and soft tissues 177 | 17,230
Male tissues 175 | 17,142
Nervous System 175 | 16,725
Blood and immune system 174 | 16,909
Liver and Pancreas 173 | 16,750
Urinary Tract 171 | 16,678
Respiratory system 170 | 16,393
Cardiovascular System 165 | 15,192

Target Family

Non-IDG 84 | 12,091
Enzyme 53 | 4,145
Transcription Factor 13 | 1,400
Kinase 12 | 634
Transporter 7 | 473
Epigenetic 6 | 242
GPCR 4 | 408
Ion Channel 3 | 344
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Ankyrin repeat domain-containing protein 10 ANKRD10 Tdark Non-IDG 0.00000 33
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 29
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248