Development Level

Tbio 42 | 11,445
Tdark 14 | 6,588
Tclin 6 | 613
Tchem 4 | 1,598

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

abnormal behavioral response t... 66 | 66
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 44 | 11,493
ovarian cancer 33 | 8,520
medulloblastoma, large-cell 31 | 6,241
osteosarcoma 31 | 7,950
psoriasis 27 | 6,694
glioblastoma 24 | 5,792
group 3 medulloblastoma 24 | 4,104
atypical teratoid / rhabdoid tumor 21 | 5,112
adult high grade glioma 18 | 3,801
ependymoma 17 | 4,679
lung cancer 17 | 4,740
malignant mesothelioma 16 | 3,232
Breast cancer 15 | 3,578
lung carcinoma 14 | 2,843
Kidney cancer 13 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Astrocytoma, Pilocytic 12 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
non-small cell lung cancer 12 | 2,890
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
astrocytic glioma 11 | 2,597
lung adenocarcinoma 11 | 2,716
pituitary cancer 11 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
subependymal giant cell astrocytoma 10 | 2,287
ductal carcinoma in situ 9 | 1,745
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
pancreatic cancer 8 | 2,398
Atopic dermatitis 7 | 952
breast carcinoma 7 | 1,638
colon cancer 7 | 1,478
tuberculosis 7 | 2,010
adrenocortical carcinoma 6 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Autosomal recessive predisposition 5 | 1,442
Cancer 5 | 2,499
Endometriosis 5 | 540
Pick disease 5 | 1,894
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Asthma 4 | 385
Autistic Disorder 4 | 364
Bipolar Disorder 4 | 666
Duchenne muscular dystrophy 4 | 601
Heart disease 4 | 306
Intellectual disability 4 | 1,016
Melanoma 4 | 711
Obesity 4 | 678
Parkinson's disease 4 | 392
Schizophrenia 4 | 1,160
active ulcerative colitis 4 | 764
atypical teratoid/rhabdoid tumor 4 | 357
chronic rhinosinusitis 4 | 512
juvenile dermatomyositis 4 | 1,187
medulloblastoma 4 | 720
posterior fossa group A ependymoma 4 | 468
Attention deficit hyperactivity disorder 3 | 278
Cocaine-Related Disorders 3 | 92
Colorectal Neoplasms 3 | 243
Depressive disorder 3 | 409
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Glaucoma 3 | 239
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Neurodegenerative disease 3 | 414
Nystagmus 3 | 317
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Short stature 3 | 531
active Crohn's disease 3 | 922
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
Alzheimer's disease 2 | 658
Autism spectrum disorder 2 | 101
Broad flat nasal bridge 2 | 236
Delayed bone age 2 | 136
Down syndrome 2 | 499
Hypereosinophilic syndrome 2 | 71
Mental Depression 2 | 333
Migraine 2 | 83
Nasal bridge wide 2 | 236
Unipolar Depression 2 | 250
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
limb girdle muscular dystrophy 2A 2 | 213
nephrosclerosis 2 | 333
non diabetic and post-ischemic heart failure 2 | 200
progressive supranuclear palsy 2 | 676
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 65 | 18,159
Digestive Tract 63 | 17,369
Male tissues 63 | 17,142
Skin and soft tissues 63 | 17,230
Respiratory system 62 | 16,393
Blood and immune system 61 | 16,909
Female tissues 61 | 17,400
Liver and Pancreas 61 | 16,750
Nervous System 61 | 16,725
Urinary Tract 59 | 16,678
Cardiovascular System 57 | 15,192

Target Family

Non-IDG 34 | 12,091
Enzyme 13 | 4,145
Transcription Factor 5 | 1,400
Kinase 4 | 634
GPCR 3 | 408
Epigenetic 2 | 242
Ion Channel 2 | 344
Transporter 2 | 473
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
Iron-sulfur cluster assembly 1 homolog, mitochondrial ISCA1 Tbio Non-IDG -1.68100 45.7 44
Tubulin polymerization-promoting protein TPPP Tbio Non-IDG -1.95532 92.5 179
Prolyl endopeptidase PREP Tchem Enzyme -2.49875 314.7 157
Carbohydrate deacetylase YDJC Tdark Enzyme -0.35310 2.02 59
Transmembrane protein 151B TMEM151B Tdark Non-IDG 0.00000 64