Development Level

Tbio 191 | 11,178
Tdark 46 | 6,569
Tchem 41 | 1,885
Tclin 20 | 612

Collection

GPCR: IDG Consortium (Targets) 3 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal behavior 298 | 298
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 196 | 11,192
ovarian cancer 151 | 8,297
osteosarcoma 137 | 7,766
medulloblastoma, large-cell 135 | 6,086
glioblastoma 122 | 5,635
psoriasis 120 | 6,514
atypical teratoid / rhabdoid tumor 119 | 4,971
ependymoma 108 | 4,559
group 3 medulloblastoma 92 | 4,002
adult high grade glioma 88 | 3,701
primitive neuroectodermal tumor 84 | 2,957
oligodendroglioma 82 | 2,768
lung cancer 78 | 4,607
astrocytic glioma 69 | 2,530
Astrocytoma, Pilocytic 66 | 3,006
Breast cancer 65 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 64 | 3,204
malignant mesothelioma 63 | 3,135
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,872
invasive ductal carcinoma 55 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,902
subependymal giant cell astrocytoma 51 | 2,230
pituitary cancer 50 | 1,915
Kidney cancer 49 | 2,548
Pick disease 48 | 1,856
lung carcinoma 46 | 2,755
non-small cell lung cancer 46 | 2,799
Cancer 43 | 2,388
lung adenocarcinoma 40 | 2,627
tuberculosis 40 | 1,963
pancreatic cancer 39 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,911
breast carcinoma 36 | 1,589
cystic fibrosis 35 | 1,629
Autosomal recessive predisposition 31 | 1,407
ulcerative colitis 31 | 1,765
group 4 medulloblastoma 30 | 1,806
interstitial cystitis 30 | 2,237
Intellectual disability 29 | 998
adrenocortical carcinoma 29 | 1,385
Schizophrenia 28 | 1,136
colon cancer 28 | 1,428
ductal carcinoma in situ 27 | 1,686
juvenile dermatomyositis 26 | 1,147
progressive supranuclear palsy 23 | 656
Epilepsy 22 | 775
primary pancreatic ductal adenocarcinoma 22 | 1,071
spina bifida 22 | 1,053
Rheumatoid arthritis 21 | 1,156
dermatomyositis 21 | 941
pediatric high grade glioma 21 | 1,035
Cognitive delay 20 | 596
Global developmental delay 20 | 596
Mental and motor retardation 20 | 596
cutaneous lupus erythematosus 20 | 1,016
medulloblastoma 20 | 702
Bipolar Disorder 18 | 646
acute quadriplegic myopathy 18 | 1,133
aldosterone-producing adenoma 18 | 646
Dull intelligence 17 | 634
Low intelligence 17 | 634
Mental Retardation 17 | 634
Mental deficiency 17 | 634
Poor school performance 17 | 634
diabetes mellitus 17 | 1,683
Atopic dermatitis 16 | 915
Muscle hypotonia 16 | 562
astrocytoma 16 | 1,113
Depressive disorder 15 | 401
Liver Cirrhosis, Experimental 15 | 733
Alzheimer's disease 14 | 640
Multiple myeloma 14 | 1,296
Neurodegenerative disease 14 | 402
Nystagmus 14 | 309
Obesity 14 | 655
fibroadenoma 14 | 538
Duchenne muscular dystrophy 13 | 587
Parkinson's disease 13 | 378
Seizures 13 | 584
acute myeloid leukemia 13 | 760
gastric carcinoma 13 | 781
Autistic Disorder 12 | 358
Melanoma 12 | 689
Multiple Sclerosis 12 | 527
Prostatic Neoplasms 12 | 472
Acquired metabolic disease 11 | 329
Down syndrome 11 | 480
Failure to gain weight 11 | 359
Mental Depression 11 | 325
Pediatric failure to thrive 11 | 359
Skin cancer 11 | 451
tuberculosis and treatment for 6 months 11 | 399
Attention deficit hyperactivity disorder 10 | 272
Breast Neoplasms 10 | 423
Endometriosis 10 | 521
active ulcerative colitis 10 | 736
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 492
non primary Sjogren syndrome sicca 10 | 861
primary Sjogren syndrome 10 | 710
Optic Atrophy 9 | 239

Tissue

Endocrine System 294 | 18,159
Digestive Tract 292 | 17,369
Female tissues 287 | 17,400
Skin and soft tissues 287 | 17,230
Liver and Pancreas 285 | 16,750
Blood and immune system 283 | 16,909
Nervous System 283 | 16,725
Male tissues 282 | 17,142
Respiratory system 279 | 16,393
Urinary Tract 279 | 16,678
Cardiovascular System 268 | 15,192

Target Family

Non-IDG 157 | 12,091
Enzyme 72 | 4,145
Epigenetic 14 | 242
Transcription Factor 13 | 1,400
Kinase 12 | 634
Ion Channel 10 | 344
GPCR 9 | 408
Transporter 8 | 473
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase N1 PKN1 Tchem Kinase -2.03368 117.6 153
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242
AP2-associated protein kinase 1 AAK1 Tchem Kinase -1.28486 18.8 271
Protein ELFN1 ELFN1 Tdark Non-IDG -0.79239 5.92 49
Leucine-rich repeat LGI family member 4 LGI4 Tbio Non-IDG -0.95884 8.52 114
Adhesion G protein-coupled receptor B2 ADGRB2 Tbio GPCR -1.30715 21.2 175
SH3 domain-binding protein 5 SH3BP5 Tbio Non-IDG -2.76639 566.7 116
Mesoderm induction early response protein 1 MIER1 Tbio Non-IDG -2.21641 165.6 93
Interferon-induced protein 44 IFI44 Tbio Non-IDG -1.13472 12.1 99
Glucose-dependent insulinotropic receptor GPR119 Tchem GPCR -2.06190 120.0 180