Development Level

Tbio 145 | 10,625
Tdark 39 | 7,003
Tchem 29 | 1,890
Tclin 13 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

abnormal behavior 226 | 226
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 120 | 8,484
osteosarcoma 114 | 7,933
medulloblastoma, large-cell 109 | 6,234
psoriasis 104 | 6,685
glioblastoma 91 | 5,572
atypical teratoid / rhabdoid tumor 84 | 4,369
oligodendroglioma 71 | 2,849
primitive neuroectodermal tumor 62 | 3,031
lung cancer 56 | 4,466
pilocytic astrocytoma 54 | 3,086
ependymoma 52 | 2,514
malignant mesothelioma 49 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,289
subependymal giant cell astrocytoma 46 | 2,287
lung carcinoma 45 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,956
invasive ductal carcinoma 44 | 2,950
Pick disease 42 | 1,893
pituitary cancer 42 | 1,972
astrocytic glioma 41 | 2,241
pediatric high grade glioma 41 | 2,712
adult high grade glioma 40 | 2,148
Breast cancer 39 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
group 3 medulloblastoma 35 | 2,254
non-small cell lung cancer 35 | 2,798
pancreatic cancer 32 | 2,300
Cancer 31 | 2,346
cystic fibrosis 31 | 1,665
group 4 medulloblastoma 31 | 1,875
medulloblastoma 31 | 1,524
astrocytoma 29 | 1,493
lung adenocarcinoma 29 | 2,713
Carcinoma 28 | 2,147
breast carcinoma 28 | 1,614
interstitial cystitis 26 | 2,299
tuberculosis 25 | 1,557
ulcerative colitis 25 | 2,087
juvenile dermatomyositis 24 | 1,189
adrenocortical carcinoma 23 | 1,427
colon cancer 23 | 1,475
posterior fossa group A ependymoma 23 | 1,511
sonic hedgehog group medulloblastoma 23 | 1,482
ductal carcinoma in situ 22 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
primary pancreatic ductal adenocarcinoma 21 | 1,271
progressive supranuclear palsy 21 | 674
atypical teratoid/rhabdoid tumor 20 | 1,095
spina bifida 18 | 1,064
Intellectual disability 17 | 573
diabetes mellitus 17 | 1,663
posterior fossa group B ependymoma 16 | 1,530
Alzheimer's disease 15 | 644
acute quadriplegic myopathy 15 | 1,157
cutaneous lupus erythematosus 15 | 1,056
tuberculosis and treatment for 6 months 15 | 686
Atopic dermatitis 14 | 944
Rheumatoid Arthritis 14 | 1,160
dermatomyositis 14 | 933
Schizophrenia 13 | 501
gastric carcinoma 13 | 832
Neurodegenerative disease 12 | 383
Down syndrome 11 | 548
acute myeloid leukemia 11 | 780
esophageal adenocarcinoma 11 | 737
Duchenne muscular dystrophy 10 | 602
Multiple myeloma 10 | 1,327
Parkinson's disease 10 | 364
Peripheral Neuropathy 10 | 303
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
Autistic Disorder 9 | 320
Endometriosis 9 | 535
Multiple Sclerosis 9 | 498
aldosterone-producing adenoma 9 | 664
Epilepsy 8 | 346
Obesity 8 | 616
Prostatic Neoplasms 8 | 471
Waldenstrons macroglobulinemia 8 | 765
nasopharyngeal carcinoma 8 | 1,056
non primary Sjogren syndrome sicca 8 | 840
primary Sjogren syndrome 8 | 789
Amyotrophic Lateral Sclerosis 7 | 431
Bipolar Disorder 7 | 266
active Crohn's disease 7 | 918
active ulcerative colitis 7 | 477
interstitial lung disease 7 | 291
Hypertensive disease 6 | 193
IGA Glomerulonephritis 6 | 454
fibroadenoma 6 | 557
glioblastoma multiforme 6 | 347
mucosa-associated lymphoid tissue lymphoma 6 | 480
non diabetic and post-ischemic heart failure 6 | 200
Atrial Fibrillation 5 | 110
Cocaine-Related Disorders 5 | 88
Liver carcinoma 5 | 217
Polycystic Ovary Syndrome 5 | 332
chronic rhinosinusitis 5 | 512
inflammatory breast cancer 5 | 404
nephrosclerosis 5 | 329
tuberculosis and treatment for 3 months 5 | 327

Tissue

Digestive Tract 225 | 18,473
Endocrine System 225 | 18,512
Nervous System 225 | 18,561
Male tissues 224 | 17,969
Blood and immune system 223 | 17,995
Cardiovascular System 223 | 17,958
Female tissues 223 | 18,647
Liver and Pancreas 223 | 18,136
Skin and soft tissues 222 | 18,115
Urinary Tract 222 | 18,444
Respiratory system 220 | 17,484

Target Family

Non-IDG 118 | 11,971
Enzyme 60 | 4,146
Epigenetic 11 | 242
Transcription Factor 10 | 1,400
Kinase 9 | 634
Ion Channel 6 | 341
Transporter 6 | 473
GPCR 4 | 406
Nuclear Receptor 2 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Cytochrome b561 CYB561 Tbio Non-IDG -1.41910 20.4 45
Inactive ribonuclease-like protein 10 RNASE10 Tdark Enzyme -0.65321 4.33 16
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.31313 210.4 193
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
NF-kappa-B inhibitor delta NFKBID Tbio Non-IDG -1.14443 17.8 77
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87
Leptin receptor LEPR Tclin Non-IDG -2.98449 751.7 530
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3 Tclin Transporter -2.09703 131.9 103
Neurensin-1 NRSN1 Tdark Non-IDG -1.70429 52.8 50