Development Level

Tbio 197 | 11,651
Tdark 47 | 6,593
Tchem 34 | 1,388
Tclin 20 | 612

Collection

RFA-RM-18-021 6 | 328
GPCR: IDG Consortium (Targets) 3 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal behavior 298 | 298
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 201 | 11,493
ovarian cancer 156 | 8,520
osteosarcoma 142 | 7,950
medulloblastoma, large-cell 139 | 6,241
glioblastoma 127 | 5,792
atypical teratoid / rhabdoid tumor 123 | 5,112
psoriasis 121 | 6,694
ependymoma 111 | 4,679
group 3 medulloblastoma 96 | 4,104
adult high grade glioma 92 | 3,801
oligodendroglioma 85 | 2,850
primitive neuroectodermal tumor 85 | 3,035
lung cancer 78 | 4,740
astrocytic glioma 72 | 2,597
Astrocytoma, Pilocytic 68 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 66 | 3,291
Breast cancer 65 | 3,578
malignant mesothelioma 64 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,955
invasive ductal carcinoma 58 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,989
subependymal giant cell astrocytoma 52 | 2,287
Pick disease 51 | 1,894
pituitary cancer 51 | 1,972
Kidney cancer 50 | 2,613
lung carcinoma 48 | 2,843
non-small cell lung cancer 47 | 2,890
Cancer 44 | 2,499
lung adenocarcinoma 42 | 2,716
pancreatic cancer 40 | 2,398
tuberculosis 40 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
breast carcinoma 36 | 1,638
cystic fibrosis 36 | 1,696
interstitial cystitis 33 | 2,312
Autosomal recessive predisposition 32 | 1,442
ulcerative colitis 32 | 1,819
adrenocortical carcinoma 31 | 1,428
group 4 medulloblastoma 31 | 1,855
Intellectual disability 29 | 1,016
Schizophrenia 29 | 1,160
colon cancer 28 | 1,478
ductal carcinoma in situ 28 | 1,745
juvenile dermatomyositis 28 | 1,187
progressive supranuclear palsy 24 | 676
primary pancreatic ductal adenocarcinoma 23 | 1,109
spina bifida 23 | 1,074
Epilepsy 22 | 792
Rheumatoid arthritis 22 | 1,191
dermatomyositis 21 | 966
pediatric high grade glioma 21 | 1,064
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
cutaneous lupus erythematosus 20 | 1,057
medulloblastoma 20 | 720
Bipolar Disorder 19 | 666
acute quadriplegic myopathy 19 | 1,158
aldosterone-producing adenoma 18 | 665
Atopic dermatitis 17 | 952
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
diabetes mellitus 17 | 1,728
Muscle hypotonia 16 | 571
astrocytoma 16 | 1,146
Alzheimer's disease 15 | 658
Depressive disorder 15 | 409
Liver Cirrhosis, Experimental 15 | 769
acute myeloid leukemia 15 | 783
Multiple myeloma 14 | 1,332
Neurodegenerative disease 14 | 414
Nystagmus 14 | 317
Obesity 14 | 678
fibroadenoma 14 | 559
Duchenne muscular dystrophy 13 | 601
Parkinson's disease 13 | 392
Seizures 13 | 596
gastric carcinoma 13 | 807
Autistic Disorder 12 | 364
Melanoma 12 | 711
Multiple Sclerosis 12 | 540
Prostatic Neoplasms 12 | 495
Acquired metabolic disease 11 | 336
Down syndrome 11 | 499
Failure to gain weight 11 | 365
Mental Depression 11 | 333
Pediatric failure to thrive 11 | 365
Skin cancer 11 | 469
tuberculosis and treatment for 6 months 11 | 409
Amyotrophic lateral sclerosis 10 | 451
Attention deficit hyperactivity disorder 10 | 278
Endometriosis 10 | 540
active Crohn's disease 10 | 922
active ulcerative colitis 10 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
non primary Sjogren syndrome sicca 10 | 891
primary Sjogren syndrome 10 | 735

Tissue

Endocrine System 294 | 18,159
Digestive Tract 292 | 17,369
Female tissues 287 | 17,400
Skin and soft tissues 287 | 17,230
Liver and Pancreas 285 | 16,750
Blood and immune system 283 | 16,909
Nervous System 283 | 16,725
Male tissues 282 | 17,142
Respiratory system 279 | 16,393
Urinary Tract 279 | 16,678
Cardiovascular System 268 | 15,192

Target Family

Non-IDG 157 | 12,091
Enzyme 72 | 4,145
Epigenetic 14 | 242
Transcription Factor 13 | 1,400
Kinase 12 | 634
Ion Channel 10 | 344
GPCR 9 | 408
Transporter 8 | 473
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase FTSJ1 Tbio Enzyme -1.64419 45.9 108
Protein phosphatase 1 regulatory subunit 26 PPP1R26 Tdark Enzyme -0.60309 4.64 9
Parathymosin PTMS Tbio Non-IDG -1.95003 86.3 141
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Protein phosphatase 1 regulatory subunit 29 ELFN2 Tdark Enzyme 0.06 0.68 51
Spindlin-1 SPIN1 Tbio Non-IDG -2.02987 109.3 128
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.05580 115.6 135