Development Level

Tbio 10,230 | 11,178
Tdark 4,129 | 6,569
Tchem 1,756 | 1,885
Tclin 563 | 612

Collection

Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 70 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 960 | 979
preweaning lethality, incomple... 476 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 201 | 207
enlarged heart 200 | 210
decreased vertical activity 186 | 208
abnormal bone structure 171 | 187
increased lean body mass 166 | 172
abnormal heart morphology 158 | 162
decreased body weight 153 | 161
decreased bone mineral content 142 | 151
hyperactivity 133 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 126 | 134
decreased circulating glucose ... 120 | 126
decreased bone mineral density 117 | 126
hypoactivity 117 | 132
increased circulating alkaline... 112 | 122
decreased grip strength 108 | 116
male infertility 108 | 123
abnormal seminal vesicle morph... 104 | 114
increased startle reflex 104 | 112
embryonic growth retardation 102 | 106
increased bone mineral content 101 | 108
decreased body length 95 | 101
short tibia 95 | 97
increased or absent threshold ... 93 | 101
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
cataract 86 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased circulating serum al... 78 | 82
decreased circulating triglyce... 77 | 79
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased mean corpuscular vol... 74 | 79
decreased circulating insulin ... 72 | 76
improved glucose tolerance 72 | 79
increased circulating HDL chol... 72 | 80
increased fasted circulating g... 71 | 76
decreased leukocyte cell numbe... 70 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
small superior vagus ganglion 68 | 74
abnormal retina morphology 67 | 71
impaired glucose tolerance 67 | 75
abnormal eye morphology 66 | 68
abnormal gait 65 | 69
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
abnormal coat-hair pigmentatio... 62 | 64
abnormal kidney morphology 62 | 65
decreased fasted circulating g... 62 | 65
decreased hemoglobin content 62 | 68
increased circulating sodium l... 62 | 71
increased circulating choleste... 61 | 66
increased monocyte cell number 60 | 63
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
edema 57 | 59
increased heart weight 56 | 62
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 53 | 56
female infertility 50 | 60
abnormal skin morphology 49 | 50
decreased circulating total pr... 49 | 49
hydrometra 49 | 53
decreased blood urea nitrogen ... 48 | 51
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 45 | 46
decreased circulating alanine ... 44 | 47
increased leukocyte cell numbe... 43 | 47
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
enlarged spleen 41 | 41
increased circulating triglyce... 40 | 42
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
increased circulating creatini... 37 | 38
tremors 37 | 39
cardiovascular system phenotyp... 36 | 36
increased circulating chloride... 36 | 41
increased grip strength 36 | 41
prolonged QT interval 36 | 38

Disease

Carcinoma 9,925 | 11,192
ovarian cancer 8,023 | 8,297
osteosarcoma 7,404 | 7,766
psoriasis 5,824 | 6,514
medulloblastoma, large-cell 5,782 | 6,086
glioblastoma 5,428 | 5,635
atypical teratoid / rhabdoid tumor 4,757 | 4,971
lung cancer 4,434 | 4,607
ependymoma 4,366 | 4,559
group 3 medulloblastoma 3,848 | 4,002
adult high grade glioma 3,505 | 3,701
Breast cancer 3,352 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,149 | 3,204
malignant mesothelioma 3,057 | 3,135
Astrocytoma, Pilocytic 2,865 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,854 | 2,902
primitive neuroectodermal tumor 2,843 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 2,827 | 2,872
invasive ductal carcinoma 2,827 | 2,867
non-small cell lung cancer 2,748 | 2,799
lung carcinoma 2,648 | 2,755
oligodendroglioma 2,648 | 2,768
lung adenocarcinoma 2,553 | 2,627
astrocytic glioma 2,425 | 2,530
Kidney cancer 2,344 | 2,548
pancreatic cancer 2,265 | 2,322
interstitial cystitis 2,187 | 2,237
Cancer 2,179 | 2,388
subependymal giant cell astrocytoma 2,147 | 2,230
tuberculosis 1,897 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,887 | 1,911
pituitary cancer 1,831 | 1,915
Pick disease 1,810 | 1,856
group 4 medulloblastoma 1,746 | 1,806
ulcerative colitis 1,711 | 1,765
ductal carcinoma in situ 1,662 | 1,686
cystic fibrosis 1,587 | 1,629
breast carcinoma 1,556 | 1,589
colon cancer 1,395 | 1,428
adrenocortical carcinoma 1,365 | 1,385
diabetes mellitus 1,350 | 1,683
Autosomal recessive predisposition 1,329 | 1,407
Multiple myeloma 1,273 | 1,296
juvenile dermatomyositis 1,128 | 1,147
acute quadriplegic myopathy 1,115 | 1,133
astrocytoma 1,085 | 1,113
Rheumatoid arthritis 1,080 | 1,156
primary pancreatic ductal adenocarcinoma 1,057 | 1,071
Schizophrenia 1,041 | 1,136
spina bifida 1,031 | 1,053
pediatric high grade glioma 1,007 | 1,035
nasopharyngeal carcinoma 994 | 1,024
cutaneous lupus erythematosus 990 | 1,016
Intellectual disability 948 | 998
dermatomyositis 899 | 941
active Crohn's disease 860 | 882
Atopic dermatitis 852 | 915
non primary Sjogren syndrome sicca 817 | 861
gastric carcinoma 764 | 781
acute myeloid leukemia 753 | 760
Waldenstrons macroglobulinemia 737 | 742
Epilepsy 729 | 775
Liver Cirrhosis, Experimental 717 | 733
active ulcerative colitis 712 | 736
primary Sjogren syndrome 696 | 710
esophageal adenocarcinoma 684 | 696
medulloblastoma 672 | 702
progressive supranuclear palsy 639 | 656
aldosterone-producing adenoma 637 | 646
Dull intelligence 605 | 634
Low intelligence 605 | 634
Melanoma 605 | 689
Mental Retardation 605 | 634
Mental deficiency 605 | 634
Poor school performance 605 | 634
Alzheimer's disease 601 | 640
Obesity 601 | 655
Bipolar Disorder 584 | 646
Cognitive delay 574 | 596
Global developmental delay 574 | 596
Mental and motor retardation 574 | 596
Duchenne muscular dystrophy 567 | 587
Seizures 551 | 584
pancreatic carcinoma 546 | 555
Muscle hypotonia 540 | 562
fibroadenoma 531 | 538
hepatocellular carcinoma 530 | 536
Liver cancer 523 | 589
Endometriosis 502 | 521
Short stature 492 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 492
chronic rhinosinusitis 483 | 505
Down syndrome 460 | 480
Multiple Sclerosis 460 | 527
mucosa-associated lymphoid tissue lymphoma 454 | 473
Prostatic Neoplasms 451 | 472
posterior fossa group A ependymoma 447 | 456
gastric cancer 439 | 445
sonic hedgehog group medulloblastoma 438 | 459
Amyotrophic lateral sclerosis 423 | 437

Tissue

Urinary Tract 16,678 | 16,678
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,699 | 12,091
Enzyme 3,821 | 4,145
Transcription Factor 1,215 | 1,400
Kinase 603 | 634
Transporter 432 | 473
GPCR 291 | 408
Ion Channel 280 | 344
Epigenetic 232 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 25 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93