Development Level

Tbio 10,666 | 11,651
Tdark 4,143 | 6,593
Tchem 1,306 | 1,388
Tclin 563 | 612

Collection

RFA-RM-18-021 262 | 328
Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 70 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 960 | 979
preweaning lethality, incomple... 476 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 201 | 207
enlarged heart 200 | 210
decreased vertical activity 186 | 208
abnormal bone structure 171 | 187
increased lean body mass 166 | 172
abnormal heart morphology 158 | 162
decreased body weight 153 | 161
decreased bone mineral content 142 | 151
hyperactivity 133 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 126 | 134
decreased circulating glucose ... 120 | 126
decreased bone mineral density 117 | 126
hypoactivity 117 | 132
increased circulating alkaline... 112 | 122
decreased grip strength 108 | 116
male infertility 108 | 123
abnormal seminal vesicle morph... 104 | 114
increased startle reflex 104 | 112
embryonic growth retardation 102 | 106
increased bone mineral content 101 | 108
decreased body length 95 | 101
short tibia 95 | 97
increased or absent threshold ... 93 | 101
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
cataract 86 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased circulating serum al... 78 | 82
decreased circulating triglyce... 77 | 79
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased mean corpuscular vol... 74 | 79
decreased circulating insulin ... 72 | 76
improved glucose tolerance 72 | 79
increased circulating HDL chol... 72 | 80
increased fasted circulating g... 71 | 76
decreased leukocyte cell numbe... 70 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
small superior vagus ganglion 68 | 74
abnormal retina morphology 67 | 71
impaired glucose tolerance 67 | 75
abnormal eye morphology 66 | 68
abnormal gait 65 | 69
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
abnormal coat-hair pigmentatio... 62 | 64
abnormal kidney morphology 62 | 65
decreased fasted circulating g... 62 | 65
decreased hemoglobin content 62 | 68
increased circulating sodium l... 62 | 71
increased circulating choleste... 61 | 66
increased monocyte cell number 60 | 63
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
edema 57 | 59
increased heart weight 56 | 62
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 53 | 56
female infertility 50 | 60
abnormal skin morphology 49 | 50
decreased circulating total pr... 49 | 49
hydrometra 49 | 53
decreased blood urea nitrogen ... 48 | 51
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 45 | 46
decreased circulating alanine ... 44 | 47
increased leukocyte cell numbe... 43 | 47
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
enlarged spleen 41 | 41
increased circulating triglyce... 40 | 42
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
increased circulating creatini... 37 | 38
tremors 37 | 39
cardiovascular system phenotyp... 36 | 36
increased circulating chloride... 36 | 41
increased grip strength 36 | 41
prolonged QT interval 36 | 38

Disease

Carcinoma 10,186 | 11,493
ovarian cancer 8,238 | 8,520
osteosarcoma 7,581 | 7,950
psoriasis 5,984 | 6,694
medulloblastoma, large-cell 5,927 | 6,241
glioblastoma 5,577 | 5,792
atypical teratoid / rhabdoid tumor 4,892 | 5,112
lung cancer 4,559 | 4,740
ependymoma 4,478 | 4,679
group 3 medulloblastoma 3,942 | 4,104
adult high grade glioma 3,599 | 3,801
Breast cancer 3,453 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,233 | 3,291
malignant mesothelioma 3,153 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,938 | 2,989
Astrocytoma, Pilocytic 2,935 | 3,081
primitive neuroectodermal tumor 2,917 | 3,035
invasive ductal carcinoma 2,911 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,906 | 2,955
non-small cell lung cancer 2,837 | 2,890
lung carcinoma 2,736 | 2,843
oligodendroglioma 2,726 | 2,850
lung adenocarcinoma 2,640 | 2,716
astrocytic glioma 2,489 | 2,597
Kidney cancer 2,400 | 2,613
pancreatic cancer 2,338 | 2,398
Cancer 2,281 | 2,499
interstitial cystitis 2,262 | 2,312
subependymal giant cell astrocytoma 2,198 | 2,287
tuberculosis 1,944 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,936 | 1,962
pituitary cancer 1,887 | 1,972
Pick disease 1,846 | 1,894
group 4 medulloblastoma 1,791 | 1,855
ulcerative colitis 1,763 | 1,819
ductal carcinoma in situ 1,720 | 1,745
cystic fibrosis 1,648 | 1,696
breast carcinoma 1,605 | 1,638
colon cancer 1,440 | 1,478
adrenocortical carcinoma 1,406 | 1,428
diabetes mellitus 1,394 | 1,728
Autosomal recessive predisposition 1,359 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,168 | 1,187
acute quadriplegic myopathy 1,140 | 1,158
astrocytoma 1,116 | 1,146
Rheumatoid arthritis 1,114 | 1,191
primary pancreatic ductal adenocarcinoma 1,095 | 1,109
Schizophrenia 1,060 | 1,160
spina bifida 1,051 | 1,074
pediatric high grade glioma 1,035 | 1,064
cutaneous lupus erythematosus 1,029 | 1,057
nasopharyngeal carcinoma 1,026 | 1,058
Intellectual disability 962 | 1,016
dermatomyositis 924 | 966
active Crohn's disease 898 | 922
Atopic dermatitis 888 | 952
non primary Sjogren syndrome sicca 843 | 891
gastric carcinoma 789 | 807
acute myeloid leukemia 776 | 783
Waldenstrons macroglobulinemia 759 | 765
Liver Cirrhosis, Experimental 753 | 769
Epilepsy 742 | 792
active ulcerative colitis 737 | 764
esophageal adenocarcinoma 724 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 689 | 720
progressive supranuclear palsy 657 | 676
aldosterone-producing adenoma 655 | 665
Melanoma 622 | 711
Obesity 621 | 678
Alzheimer's disease 619 | 658
Dull intelligence 613 | 645
Low intelligence 613 | 645
Mental Retardation 613 | 645
Mental deficiency 613 | 645
Poor school performance 613 | 645
Bipolar Disorder 602 | 666
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Duchenne muscular dystrophy 581 | 601
Seizures 559 | 596
pancreatic carcinoma 553 | 562
fibroadenoma 552 | 559
Muscle hypotonia 546 | 571
hepatocellular carcinoma 541 | 547
Liver cancer 536 | 604
Endometriosis 520 | 540
Short stature 505 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
chronic rhinosinusitis 489 | 512
Down syndrome 478 | 499
Prostatic Neoplasms 473 | 495
Multiple Sclerosis 472 | 540
mucosa-associated lymphoid tissue lymphoma 464 | 484
posterior fossa group A ependymoma 459 | 468
gastric cancer 453 | 459
sonic hedgehog group medulloblastoma 446 | 467
Amyotrophic lateral sclerosis 437 | 451

Tissue

Urinary Tract 16,678 | 16,678
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,699 | 12,091
Enzyme 3,821 | 4,145
Transcription Factor 1,215 | 1,400
Kinase 603 | 634
Transporter 432 | 473
GPCR 291 | 408
Ion Channel 280 | 344
Epigenetic 232 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 25 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50