Development Level

Tbio 10,492 | 11,178
Tdark 4,377 | 6,569
Tchem 1,793 | 1,885
Tclin 568 | 612

Collection

Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 87 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 963 | 979
preweaning lethality, incomple... 486 | 499
abnormal behavior 287 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 216 | 220
decreased total body fat amoun... 200 | 207
enlarged heart 199 | 210
decreased vertical activity 189 | 208
abnormal bone structure 177 | 187
increased lean body mass 165 | 172
decreased body weight 157 | 161
abnormal heart morphology 154 | 162
hyperactivity 143 | 148
decreased bone mineral content 142 | 151
decreased lean body mass 129 | 135
increased total body fat amoun... 127 | 134
hypoactivity 126 | 132
decreased circulating glucose ... 123 | 126
decreased bone mineral density 120 | 126
increased circulating alkaline... 115 | 122
male infertility 113 | 123
decreased grip strength 109 | 116
abnormal seminal vesicle morph... 107 | 114
increased startle reflex 107 | 112
embryonic growth retardation 104 | 106
increased bone mineral content 102 | 108
increased or absent threshold ... 97 | 101
decreased body length 96 | 101
short tibia 96 | 97
increased mean corpuscular vol... 91 | 92
increased mean corpuscular hem... 90 | 96
decreased circulating choleste... 89 | 93
cataract 88 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
decreased circulating triglyce... 79 | 79
decreased circulating serum al... 78 | 82
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 76 | 79
improved glucose tolerance 74 | 79
decreased leukocyte cell numbe... 73 | 73
increased circulating HDL chol... 73 | 80
increased fasted circulating g... 73 | 76
decreased circulating insulin ... 72 | 76
decreased startle reflex 72 | 75
small superior vagus ganglion 71 | 74
increased bone mineral density 70 | 72
increased circulating sodium l... 70 | 71
impaired glucose tolerance 69 | 75
abnormal gait 68 | 69
abnormal retina morphology 68 | 71
abnormal sleep behavior 68 | 70
abnormal eye morphology 67 | 68
decreased circulating HDL chol... 66 | 68
decreased hemoglobin content 64 | 68
abnormal behavioral response t... 63 | 66
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 63 | 65
increased circulating choleste... 63 | 66
increased monocyte cell number 63 | 63
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 59 | 62
increased heart weight 59 | 62
edema 57 | 59
small testis 56 | 58
decreased caudal vertebrae num... 53 | 53
female infertility 53 | 60
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
hydrometra 51 | 53
abnormal skin morphology 49 | 50
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased leukocyte cell numbe... 45 | 47
increased neutrophil cell numb... 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
increased circulating chloride... 40 | 41
decreased red blood cell distr... 39 | 41
limb grasping 39 | 41
abnormal epididymis morphology 38 | 42
increased erythrocyte cell num... 38 | 39
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
tremors 37 | 39
prolonged QT interval 36 | 38

Disease

Carcinoma 10,168 | 11,192
ovarian cancer 8,073 | 8,297
osteosarcoma 7,487 | 7,766
psoriasis 6,046 | 6,514
medulloblastoma, large-cell 5,870 | 6,086
glioblastoma 5,500 | 5,635
atypical teratoid / rhabdoid tumor 4,844 | 4,971
lung cancer 4,454 | 4,607
ependymoma 4,443 | 4,559
group 3 medulloblastoma 3,906 | 4,002
adult high grade glioma 3,573 | 3,701
Breast cancer 3,396 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,153 | 3,204
malignant mesothelioma 3,073 | 3,135
Astrocytoma, Pilocytic 2,924 | 3,006
primitive neuroectodermal tumor 2,895 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,863 | 2,902
invasive ductal carcinoma 2,838 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,833 | 2,872
non-small cell lung cancer 2,753 | 2,799
oligodendroglioma 2,694 | 2,768
lung carcinoma 2,673 | 2,755
lung adenocarcinoma 2,571 | 2,627
astrocytic glioma 2,465 | 2,530
Kidney cancer 2,397 | 2,548
pancreatic cancer 2,275 | 2,322
Cancer 2,208 | 2,388
interstitial cystitis 2,184 | 2,237
subependymal giant cell astrocytoma 2,179 | 2,230
tuberculosis 1,896 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,870 | 1,911
pituitary cancer 1,859 | 1,915
Pick disease 1,825 | 1,856
group 4 medulloblastoma 1,761 | 1,806
ulcerative colitis 1,725 | 1,765
ductal carcinoma in situ 1,670 | 1,686
cystic fibrosis 1,601 | 1,629
breast carcinoma 1,569 | 1,589
colon cancer 1,401 | 1,428
diabetes mellitus 1,398 | 1,683
adrenocortical carcinoma 1,368 | 1,385
Autosomal recessive predisposition 1,341 | 1,407
Multiple myeloma 1,275 | 1,296
juvenile dermatomyositis 1,133 | 1,147
acute quadriplegic myopathy 1,126 | 1,133
astrocytoma 1,090 | 1,113
Rheumatoid arthritis 1,080 | 1,156
Schizophrenia 1,063 | 1,136
primary pancreatic ductal adenocarcinoma 1,059 | 1,071
spina bifida 1,039 | 1,053
pediatric high grade glioma 1,011 | 1,035
nasopharyngeal carcinoma 1,007 | 1,024
cutaneous lupus erythematosus 999 | 1,016
Intellectual disability 967 | 998
dermatomyositis 899 | 941
Atopic dermatitis 881 | 915
active Crohn's disease 863 | 882
non primary Sjogren syndrome sicca 824 | 861
gastric carcinoma 763 | 781
acute myeloid leukemia 755 | 760
Epilepsy 745 | 775
Waldenstrons macroglobulinemia 738 | 742
active ulcerative colitis 717 | 736
Liver Cirrhosis, Experimental 712 | 733
primary Sjogren syndrome 696 | 710
esophageal adenocarcinoma 688 | 696
medulloblastoma 683 | 702
progressive supranuclear palsy 643 | 656
aldosterone-producing adenoma 641 | 646
Melanoma 619 | 689
Obesity 618 | 655
Dull intelligence 617 | 634
Low intelligence 617 | 634
Mental Retardation 617 | 634
Mental deficiency 617 | 634
Poor school performance 617 | 634
Alzheimer's disease 613 | 640
Bipolar Disorder 597 | 646
Cognitive delay 580 | 596
Global developmental delay 580 | 596
Mental and motor retardation 580 | 596
Duchenne muscular dystrophy 577 | 587
Seizures 564 | 584
Muscle hypotonia 552 | 562
pancreatic carcinoma 548 | 555
Liver cancer 544 | 589
fibroadenoma 534 | 538
hepatocellular carcinoma 530 | 536
Endometriosis 508 | 521
chronic rhinosinusitis 494 | 505
Short stature 492 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 492
Multiple Sclerosis 469 | 527
Down syndrome 465 | 480
mucosa-associated lymphoid tissue lymphoma 457 | 473
Prostatic Neoplasms 455 | 472
posterior fossa group A ependymoma 448 | 456
sonic hedgehog group medulloblastoma 448 | 459
gastric cancer 440 | 445
Amyotrophic lateral sclerosis 429 | 437

Tissue

Skin and soft tissues 17,230 | 17,230
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 10,064 | 12,091
Enzyme 3,890 | 4,145
Transcription Factor 1,275 | 1,400
Kinase 615 | 634
Transporter 427 | 473
GPCR 321 | 408
Ion Channel 300 | 344
Epigenetic 233 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 35 | 38
oGPCR 22 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93