Development Level

Tbio 10,939 | 11,651
Tdark 4,391 | 6,593
Tchem 1,332 | 1,388
Tclin 568 | 612

Collection

RFA-RM-18-021 287 | 328
Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 87 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 963 | 979
preweaning lethality, incomple... 486 | 499
abnormal behavior 287 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 216 | 220
decreased total body fat amoun... 200 | 207
enlarged heart 199 | 210
decreased vertical activity 189 | 208
abnormal bone structure 177 | 187
increased lean body mass 165 | 172
decreased body weight 157 | 161
abnormal heart morphology 154 | 162
hyperactivity 143 | 148
decreased bone mineral content 142 | 151
decreased lean body mass 129 | 135
increased total body fat amoun... 127 | 134
hypoactivity 126 | 132
decreased circulating glucose ... 123 | 126
decreased bone mineral density 120 | 126
increased circulating alkaline... 115 | 122
male infertility 113 | 123
decreased grip strength 109 | 116
abnormal seminal vesicle morph... 107 | 114
increased startle reflex 107 | 112
embryonic growth retardation 104 | 106
increased bone mineral content 102 | 108
increased or absent threshold ... 97 | 101
decreased body length 96 | 101
short tibia 96 | 97
increased mean corpuscular vol... 91 | 92
increased mean corpuscular hem... 90 | 96
decreased circulating choleste... 89 | 93
cataract 88 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
decreased circulating triglyce... 79 | 79
decreased circulating serum al... 78 | 82
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 76 | 79
improved glucose tolerance 74 | 79
decreased leukocyte cell numbe... 73 | 73
increased circulating HDL chol... 73 | 80
increased fasted circulating g... 73 | 76
decreased circulating insulin ... 72 | 76
decreased startle reflex 72 | 75
small superior vagus ganglion 71 | 74
increased bone mineral density 70 | 72
increased circulating sodium l... 70 | 71
impaired glucose tolerance 69 | 75
abnormal gait 68 | 69
abnormal retina morphology 68 | 71
abnormal sleep behavior 68 | 70
abnormal eye morphology 67 | 68
decreased circulating HDL chol... 66 | 68
decreased hemoglobin content 64 | 68
abnormal behavioral response t... 63 | 66
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 63 | 65
increased circulating choleste... 63 | 66
increased monocyte cell number 63 | 63
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 59 | 62
increased heart weight 59 | 62
edema 57 | 59
small testis 56 | 58
decreased caudal vertebrae num... 53 | 53
female infertility 53 | 60
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
hydrometra 51 | 53
abnormal skin morphology 49 | 50
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased leukocyte cell numbe... 45 | 47
increased neutrophil cell numb... 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
increased circulating chloride... 40 | 41
decreased red blood cell distr... 39 | 41
limb grasping 39 | 41
abnormal epididymis morphology 38 | 42
increased erythrocyte cell num... 38 | 39
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
tremors 37 | 39
prolonged QT interval 36 | 38

Disease

Carcinoma 10,434 | 11,493
ovarian cancer 8,293 | 8,520
osteosarcoma 7,666 | 7,950
psoriasis 6,212 | 6,694
medulloblastoma, large-cell 6,020 | 6,241
glioblastoma 5,652 | 5,792
atypical teratoid / rhabdoid tumor 4,982 | 5,112
lung cancer 4,581 | 4,740
ependymoma 4,558 | 4,679
group 3 medulloblastoma 4,005 | 4,104
adult high grade glioma 3,670 | 3,801
Breast cancer 3,498 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,239 | 3,291
malignant mesothelioma 3,168 | 3,232
Astrocytoma, Pilocytic 2,997 | 3,081
primitive neuroectodermal tumor 2,970 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,948 | 2,989
invasive ductal carcinoma 2,921 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,914 | 2,955
non-small cell lung cancer 2,842 | 2,890
oligodendroglioma 2,773 | 2,850
lung carcinoma 2,759 | 2,843
lung adenocarcinoma 2,658 | 2,716
astrocytic glioma 2,530 | 2,597
Kidney cancer 2,452 | 2,613
pancreatic cancer 2,351 | 2,398
Cancer 2,316 | 2,499
interstitial cystitis 2,258 | 2,312
subependymal giant cell astrocytoma 2,233 | 2,287
tuberculosis 1,942 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,919 | 1,962
pituitary cancer 1,915 | 1,972
Pick disease 1,862 | 1,894
group 4 medulloblastoma 1,809 | 1,855
ulcerative colitis 1,779 | 1,819
ductal carcinoma in situ 1,729 | 1,745
cystic fibrosis 1,667 | 1,696
breast carcinoma 1,618 | 1,638
colon cancer 1,446 | 1,478
diabetes mellitus 1,443 | 1,728
adrenocortical carcinoma 1,410 | 1,428
Autosomal recessive predisposition 1,372 | 1,442
Multiple myeloma 1,311 | 1,332
juvenile dermatomyositis 1,173 | 1,187
acute quadriplegic myopathy 1,151 | 1,158
astrocytoma 1,121 | 1,146
Rheumatoid arthritis 1,114 | 1,191
primary pancreatic ductal adenocarcinoma 1,097 | 1,109
Schizophrenia 1,084 | 1,160
spina bifida 1,060 | 1,074
nasopharyngeal carcinoma 1,041 | 1,058
pediatric high grade glioma 1,039 | 1,064
cutaneous lupus erythematosus 1,038 | 1,057
Intellectual disability 984 | 1,016
dermatomyositis 924 | 966
Atopic dermatitis 917 | 952
active Crohn's disease 901 | 922
non primary Sjogren syndrome sicca 852 | 891
gastric carcinoma 789 | 807
acute myeloid leukemia 778 | 783
Waldenstrons macroglobulinemia 761 | 765
Epilepsy 760 | 792
Liver Cirrhosis, Experimental 747 | 769
active ulcerative colitis 743 | 764
esophageal adenocarcinoma 729 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 700 | 720
progressive supranuclear palsy 661 | 676
aldosterone-producing adenoma 659 | 665
Obesity 639 | 678
Melanoma 635 | 711
Alzheimer's disease 630 | 658
Dull intelligence 628 | 645
Low intelligence 628 | 645
Mental Retardation 628 | 645
Mental deficiency 628 | 645
Poor school performance 628 | 645
Bipolar Disorder 615 | 666
Duchenne muscular dystrophy 591 | 601
Cognitive delay 590 | 608
Global developmental delay 590 | 608
Mental and motor retardation 590 | 608
Seizures 574 | 596
Muscle hypotonia 560 | 571
Liver cancer 556 | 604
fibroadenoma 555 | 559
pancreatic carcinoma 555 | 562
hepatocellular carcinoma 541 | 547
Endometriosis 527 | 540
Short stature 506 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 506 | 510
chronic rhinosinusitis 500 | 512
Down syndrome 483 | 499
Multiple Sclerosis 481 | 540
Prostatic Neoplasms 477 | 495
mucosa-associated lymphoid tissue lymphoma 468 | 484
posterior fossa group A ependymoma 460 | 468
sonic hedgehog group medulloblastoma 456 | 467
gastric cancer 454 | 459
Amyotrophic lateral sclerosis 443 | 451

Tissue

Skin and soft tissues 17,230 | 17,230
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 10,064 | 12,091
Enzyme 3,890 | 4,145
Transcription Factor 1,275 | 1,400
Kinase 615 | 634
Transporter 427 | 473
GPCR 321 | 408
Ion Channel 300 | 344
Epigenetic 233 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 35 | 38
oGPCR 22 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115