Development Level

Tbio 10,263 | 10,625
Tdark 5,409 | 7,003
Tchem 1,854 | 1,890
Tclin 589 | 602

Collection

Eligible Kinase Proteins 129 | 134
Eligible non-olfactory GPCR Proteins 120 | 143
Eligible Ion Channel Proteins 109 | 117

IMPC Term

preweaning lethality, complete... 625 | 633
preweaning lethality, incomple... 256 | 260
abnormal behavior 222 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 171 | 174
decreased bone mineral content 154 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 126 | 131
increased or absent threshold ... 126 | 128
decreased bone mineral density 123 | 126
decreased circulating glucose ... 121 | 121
decreased grip strength 119 | 123
increased circulating alkaline... 117 | 119
abnormal embryo size 110 | 112
enlarged heart 109 | 111
decreased body length 107 | 108
hyperactivity 104 | 108
increased lean body mass 104 | 107
abnormal retina morphology 99 | 100
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
hypoactivity 88 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 81 | 83
short tibia 81 | 82
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 76 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 72 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 66 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
decreased lumbar vertebrae num... 61 | 62
increased circulating HDL chol... 61 | 63
increased sacral vertebrae num... 61 | 62
abnormal retinal pigmentation 60 | 61
male infertility 60 | 62
decreased rib number 58 | 59
improved glucose tolerance 55 | 56
increased exploration in new e... 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
increased total body fat amoun... 54 | 57
decreased leukocyte cell numbe... 53 | 54
decreased hemoglobin content 52 | 53
increased circulating choleste... 52 | 53
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
increased bone mineral density 51 | 52
abnormal behavioral response t... 50 | 52
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
abnormal heart morphology 50 | 51
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
decreased fasted circulating g... 48 | 49
decreased startle reflex 48 | 48
decreased caudal vertebrae num... 47 | 49
abnormal seminal vesicle morph... 44 | 47
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
decreased heart weight 43 | 44
increased blood urea nitrogen ... 43 | 44
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
increased circulating chloride... 42 | 43
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating alkaline... 38 | 41
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 37 | 37
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
decreased neutrophil cell numb... 36 | 37
increased hematocrit 36 | 36
increased leukocyte cell numbe... 36 | 37
small testis 36 | 37
cardiovascular system phenotyp... 35 | 35
abnormal spleen morphology 34 | 36
limb grasping 34 | 35
decreased mean corpuscular hem... 33 | 34
increased heart weight 33 | 37
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
decreased circulating chloride... 32 | 32
female infertility 32 | 34
tremors 32 | 34
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased B cell number 30 | 30
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31

Disease

ovarian cancer 8,322 | 8,484
osteosarcoma 7,729 | 7,933
psoriasis 6,421 | 6,685
medulloblastoma, large-cell 6,103 | 6,234
glioblastoma 5,470 | 5,572
lung cancer 4,389 | 4,466
atypical teratoid / rhabdoid tumor 4,293 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,233 | 3,289
malignant mesothelioma 3,107 | 3,162
Breast cancer 3,036 | 3,094
pilocytic astrocytoma 3,033 | 3,086
primitive neuroectodermal tumor 2,983 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,933 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,906 | 2,956
invasive ductal carcinoma 2,905 | 2,950
oligodendroglioma 2,807 | 2,849
lung carcinoma 2,783 | 2,844
non-small cell lung cancer 2,757 | 2,798
pediatric high grade glioma 2,668 | 2,712
lung adenocarcinoma 2,659 | 2,713
ependymoma 2,478 | 2,514
pancreatic cancer 2,264 | 2,300
interstitial cystitis 2,259 | 2,299
subependymal giant cell astrocytoma 2,242 | 2,287
group 3 medulloblastoma 2,213 | 2,254
astrocytic glioma 2,208 | 2,241
Cancer 2,192 | 2,346
adult high grade glioma 2,095 | 2,148
Carcinoma 2,082 | 2,147
ulcerative colitis 2,053 | 2,087
pituitary cancer 1,934 | 1,972
Pick disease 1,869 | 1,893
group 4 medulloblastoma 1,836 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,771 | 1,795
ductal carcinoma in situ 1,720 | 1,745
cystic fibrosis 1,643 | 1,665
breast carcinoma 1,589 | 1,614
tuberculosis 1,526 | 1,557
medulloblastoma 1,503 | 1,524
posterior fossa group B ependymoma 1,503 | 1,530
diabetes mellitus 1,489 | 1,663
posterior fossa group A ependymoma 1,484 | 1,511
astrocytoma 1,462 | 1,493
sonic hedgehog group medulloblastoma 1,457 | 1,482
colon cancer 1,443 | 1,475
adrenocortical carcinoma 1,411 | 1,427
Multiple myeloma 1,316 | 1,327
primary pancreatic ductal adenocarcinoma 1,263 | 1,271
juvenile dermatomyositis 1,170 | 1,189
acute quadriplegic myopathy 1,145 | 1,157
Rheumatoid Arthritis 1,097 | 1,160
atypical teratoid/rhabdoid tumor 1,077 | 1,095
spina bifida 1,047 | 1,064
nasopharyngeal carcinoma 1,040 | 1,056
cutaneous lupus erythematosus 1,039 | 1,056
Atopic dermatitis 931 | 944
dermatomyositis 919 | 933
active Crohn's disease 896 | 918
gastric carcinoma 820 | 832
non primary Sjogren syndrome sicca 816 | 840
primary Sjogren syndrome 773 | 789
acute myeloid leukemia 769 | 780
Waldenstrons macroglobulinemia 757 | 765
esophageal adenocarcinoma 729 | 737
tuberculosis and treatment for 6 months 676 | 686
progressive supranuclear palsy 664 | 674
aldosterone-producing adenoma 658 | 664
Alzheimer's disease 626 | 644
Obesity 598 | 616
Duchenne muscular dystrophy 587 | 602
Intellectual disability 563 | 573
pancreatic carcinoma 559 | 567
fibroadenoma 550 | 557
Down syndrome 536 | 548
Endometriosis 527 | 535
hepatocellular carcinoma 525 | 532
chronic rhinosinusitis 506 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 499
Schizophrenia 477 | 501
mucosa-associated lymphoid tissue lymphoma 469 | 480
active ulcerative colitis 464 | 477
Prostatic Neoplasms 463 | 471
Multiple Sclerosis 457 | 498
IGA Glomerulonephritis 445 | 454
Amyotrophic Lateral Sclerosis 426 | 431
gastric cancer 419 | 430
Mammary Neoplasms 406 | 410
non-small cell lung carcinoma 399 | 413
inflammatory breast cancer 391 | 404
Neurodegenerative disease 377 | 383
Kidney disease 364 | 396
Parkinson's disease 358 | 364
sarcoidosis 347 | 358
glioblastoma multiforme 344 | 347
Epilepsy 337 | 346
Asthma 336 | 349
tuberculosis and treatment for 3 months 324 | 327
Polycystic Ovary Syndrome 323 | 332
nephrosclerosis 323 | 329
hereditary spastic paraplegia 313 | 313

Tissue

Skin and soft tissues 18,115 | 18,115
Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 10,514 | 11,971
Enzyme 3,961 | 4,146
Transcription Factor 1,360 | 1,400
Kinase 617 | 634
Transporter 460 | 473
GPCR 373 | 406
Ion Channel 329 | 341
Epigenetic 234 | 242
oGPCR 183 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102