Development Level

Tbio 10,471 | 11,651
Tdark 4,104 | 6,593
Tchem 1,282 | 1,388
Tclin 536 | 612

Collection

RFA-RM-18-021 259 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 71 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 952 | 979
preweaning lethality, incomple... 474 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 195 | 210
decreased vertical activity 179 | 208
abnormal bone structure 170 | 187
increased lean body mass 159 | 172
abnormal heart morphology 152 | 162
decreased body weight 152 | 161
decreased bone mineral content 139 | 151
hyperactivity 134 | 148
decreased lean body mass 128 | 135
increased total body fat amoun... 125 | 134
hypoactivity 119 | 132
decreased bone mineral density 118 | 126
decreased circulating glucose ... 117 | 126
increased circulating alkaline... 113 | 122
male infertility 108 | 123
decreased grip strength 107 | 116
abnormal seminal vesicle morph... 104 | 114
embryonic growth retardation 104 | 106
increased startle reflex 104 | 112
increased bone mineral content 102 | 108
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 88 | 96
cataract 87 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 80 | 83
decreased circulating serum al... 78 | 82
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 75 | 79
decreased startle reflex 71 | 75
increased bone mineral density 71 | 72
decreased mean corpuscular vol... 70 | 79
improved glucose tolerance 70 | 79
decreased leukocyte cell numbe... 69 | 73
impaired glucose tolerance 69 | 75
increased circulating HDL chol... 69 | 80
increased fasted circulating g... 69 | 76
small superior vagus ganglion 69 | 74
decreased circulating insulin ... 68 | 76
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
increased circulating sodium l... 63 | 71
abnormal behavioral response t... 62 | 66
abnormal coat-hair pigmentatio... 62 | 64
abnormal gait 61 | 69
decreased fasted circulating g... 61 | 65
increased monocyte cell number 60 | 63
abnormal kidney morphology 59 | 65
decreased erythrocyte cell num... 59 | 62
increased circulating choleste... 59 | 66
decreased hemoglobin content 58 | 68
edema 57 | 59
increased heart weight 56 | 62
small testis 53 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
female infertility 50 | 60
abnormal skin morphology 48 | 50
hydrometra 48 | 53
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 45 | 50
increased neutrophil cell numb... 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
increased leukocyte cell numbe... 42 | 47
decreased hematocrit 41 | 46
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
decreased circulating LDL chol... 38 | 38
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
abnormal bone mineralization 37 | 38
increased erythrocyte cell num... 37 | 39
increased grip strength 36 | 41
limb grasping 36 | 41
tremors 36 | 39
abnormal epididymis morphology 35 | 42
decreased circulating creatini... 35 | 39
increased circulating chloride... 35 | 41

Disease

Carcinoma 9,965 | 11,493
ovarian cancer 8,196 | 8,520
osteosarcoma 7,539 | 7,950
psoriasis 5,866 | 6,694
medulloblastoma, large-cell 5,850 | 6,241
glioblastoma 5,520 | 5,792
atypical teratoid / rhabdoid tumor 4,848 | 5,112
lung cancer 4,530 | 4,740
ependymoma 4,435 | 4,679
group 3 medulloblastoma 3,897 | 4,104
adult high grade glioma 3,539 | 3,801
Breast cancer 3,436 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,206 | 3,291
malignant mesothelioma 3,138 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,916 | 2,989
invasive ductal carcinoma 2,902 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,891 | 2,955
Astrocytoma, Pilocytic 2,890 | 3,081
primitive neuroectodermal tumor 2,886 | 3,035
non-small cell lung cancer 2,824 | 2,890
lung carcinoma 2,749 | 2,843
oligodendroglioma 2,690 | 2,850
lung adenocarcinoma 2,653 | 2,716
astrocytic glioma 2,456 | 2,597
Kidney cancer 2,356 | 2,613
pancreatic cancer 2,316 | 2,398
Cancer 2,262 | 2,499
interstitial cystitis 2,234 | 2,312
subependymal giant cell astrocytoma 2,182 | 2,287
tuberculosis 1,941 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,887 | 1,962
pituitary cancer 1,871 | 1,972
Pick disease 1,831 | 1,894
group 4 medulloblastoma 1,777 | 1,855
ulcerative colitis 1,745 | 1,819
ductal carcinoma in situ 1,715 | 1,745
cystic fibrosis 1,627 | 1,696
breast carcinoma 1,600 | 1,638
colon cancer 1,421 | 1,478
adrenocortical carcinoma 1,399 | 1,428
diabetes mellitus 1,364 | 1,728
Autosomal recessive predisposition 1,312 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,162 | 1,187
acute quadriplegic myopathy 1,130 | 1,158
astrocytoma 1,109 | 1,146
Rheumatoid arthritis 1,093 | 1,191
primary pancreatic ductal adenocarcinoma 1,089 | 1,109
spina bifida 1,032 | 1,074
pediatric high grade glioma 1,031 | 1,064
nasopharyngeal carcinoma 1,026 | 1,058
Schizophrenia 1,019 | 1,160
cutaneous lupus erythematosus 1,019 | 1,057
Intellectual disability 947 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 883 | 922
Atopic dermatitis 873 | 952
non primary Sjogren syndrome sicca 832 | 891
acute myeloid leukemia 779 | 783
gastric carcinoma 779 | 807
Waldenstrons macroglobulinemia 761 | 765
Liver Cirrhosis, Experimental 733 | 769
Epilepsy 724 | 792
active ulcerative colitis 724 | 764
primary Sjogren syndrome 719 | 735
esophageal adenocarcinoma 708 | 737
medulloblastoma 681 | 720
aldosterone-producing adenoma 651 | 665
progressive supranuclear palsy 651 | 676
Alzheimer's disease 612 | 658
Obesity 606 | 678
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Melanoma 594 | 711
Bipolar Disorder 582 | 666
Cognitive delay 578 | 608
Duchenne muscular dystrophy 578 | 601
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Seizures 555 | 596
pancreatic carcinoma 554 | 562
fibroadenoma 548 | 559
Muscle hypotonia 542 | 571
hepatocellular carcinoma 537 | 547
Liver cancer 534 | 604
Endometriosis 522 | 540
chronic rhinosinusitis 500 | 512
Short stature 498 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Down syndrome 473 | 499
Prostatic Neoplasms 468 | 495
mucosa-associated lymphoid tissue lymphoma 464 | 484
Multiple Sclerosis 459 | 540
gastric cancer 453 | 459
posterior fossa group A ependymoma 450 | 468
sonic hedgehog group medulloblastoma 444 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Respiratory system 16,393 | 16,393
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,599 | 12,091
Enzyme 3,746 | 4,145
Transcription Factor 1,178 | 1,400
Kinase 599 | 634
Transporter 396 | 473
GPCR 284 | 408
Ion Channel 264 | 344
Epigenetic 232 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 34 | 38
oGPCR 15 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50