Development Level

Tbio 10,064 | 10,625
Tdark 5,019 | 7,003
Tchem 1,824 | 1,890
Tclin 577 | 602

Collection

Eligible Kinase Proteins 129 | 134
Eligible Ion Channel Proteins 106 | 117
Eligible non-olfactory GPCR Proteins 104 | 143

IMPC Term

preweaning lethality, complete... 626 | 633
preweaning lethality, incomple... 252 | 260
abnormal behavior 220 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 169 | 174
decreased bone mineral content 154 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 127 | 131
increased or absent threshold ... 124 | 128
decreased bone mineral density 122 | 126
decreased circulating glucose ... 119 | 121
increased circulating alkaline... 116 | 119
decreased grip strength 115 | 123
abnormal embryo size 109 | 112
enlarged heart 108 | 111
decreased body length 107 | 108
hyperactivity 102 | 108
increased lean body mass 102 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
hypoactivity 86 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 81 | 83
short tibia 81 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 75 | 77
decreased circulating insulin ... 72 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 66 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
abnormal retinal pigmentation 60 | 61
decreased lumbar vertebrae num... 60 | 62
increased circulating HDL chol... 60 | 63
increased sacral vertebrae num... 60 | 62
decreased rib number 59 | 59
male infertility 59 | 62
improved glucose tolerance 56 | 56
increased exploration in new e... 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
increased total body fat amoun... 54 | 57
decreased leukocyte cell numbe... 53 | 54
abnormal bone mineralization 52 | 55
increased circulating choleste... 52 | 53
decreased circulating alanine ... 51 | 53
decreased hemoglobin content 51 | 53
increased bone mineral density 51 | 52
decreased prepulse inhibition 50 | 52
abnormal behavioral response t... 49 | 52
abnormal heart morphology 49 | 51
decreased mean corpuscular vol... 49 | 50
abnormal gait 48 | 51
decreased fasted circulating g... 48 | 49
impaired glucose tolerance 48 | 52
decreased caudal vertebrae num... 47 | 49
decreased startle reflex 47 | 48
abnormal seminal vesicle morph... 44 | 47
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
decreased heart weight 43 | 44
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 38 | 39
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 37 | 37
decreased circulating alkaline... 37 | 41
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
decreased neutrophil cell numb... 36 | 37
increased heart weight 36 | 37
small testis 36 | 37
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
limb grasping 34 | 35
abnormal spleen morphology 33 | 36
cardiovascular system phenotyp... 33 | 35
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
tremors 32 | 34
decreased circulating creatini... 31 | 31
female infertility 31 | 34
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
decreased circulating fructosa... 30 | 31
abnormal testis morphology 29 | 30

Disease

ovarian cancer 8,279 | 8,484
osteosarcoma 7,696 | 7,933
psoriasis 6,265 | 6,685
medulloblastoma, large-cell 6,044 | 6,234
glioblastoma 5,463 | 5,572
lung cancer 4,392 | 4,466
atypical teratoid / rhabdoid tumor 4,278 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,242 | 3,289
malignant mesothelioma 3,097 | 3,162
Breast cancer 3,043 | 3,094
pilocytic astrocytoma 3,022 | 3,086
primitive neuroectodermal tumor 2,979 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,940 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,916 | 2,956
invasive ductal carcinoma 2,913 | 2,950
oligodendroglioma 2,793 | 2,849
lung carcinoma 2,786 | 2,844
non-small cell lung cancer 2,766 | 2,798
lung adenocarcinoma 2,670 | 2,713
pediatric high grade glioma 2,662 | 2,712
ependymoma 2,471 | 2,514
pancreatic cancer 2,273 | 2,300
interstitial cystitis 2,260 | 2,299
subependymal giant cell astrocytoma 2,245 | 2,287
group 3 medulloblastoma 2,203 | 2,254
astrocytic glioma 2,195 | 2,241
Cancer 2,172 | 2,346
adult high grade glioma 2,070 | 2,148
Carcinoma 2,055 | 2,147
ulcerative colitis 2,053 | 2,087
pituitary cancer 1,929 | 1,972
Pick disease 1,870 | 1,893
group 4 medulloblastoma 1,832 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,774 | 1,795
ductal carcinoma in situ 1,727 | 1,745
cystic fibrosis 1,636 | 1,665
breast carcinoma 1,592 | 1,614
tuberculosis 1,535 | 1,557
posterior fossa group B ependymoma 1,500 | 1,530
medulloblastoma 1,491 | 1,524
posterior fossa group A ependymoma 1,484 | 1,511
astrocytoma 1,471 | 1,493
sonic hedgehog group medulloblastoma 1,457 | 1,482
colon cancer 1,446 | 1,475
adrenocortical carcinoma 1,412 | 1,427
diabetes mellitus 1,409 | 1,663
Multiple myeloma 1,320 | 1,327
primary pancreatic ductal adenocarcinoma 1,267 | 1,271
juvenile dermatomyositis 1,178 | 1,189
acute quadriplegic myopathy 1,147 | 1,157
Rheumatoid Arthritis 1,098 | 1,160
atypical teratoid/rhabdoid tumor 1,072 | 1,095
nasopharyngeal carcinoma 1,043 | 1,056
spina bifida 1,043 | 1,064
cutaneous lupus erythematosus 1,038 | 1,056
dermatomyositis 928 | 933
active Crohn's disease 897 | 918
Atopic dermatitis 894 | 944
gastric carcinoma 820 | 832
non primary Sjogren syndrome sicca 807 | 840
primary Sjogren syndrome 777 | 789
acute myeloid leukemia 769 | 780
Waldenstrons macroglobulinemia 763 | 765
esophageal adenocarcinoma 729 | 737
tuberculosis and treatment for 6 months 679 | 686
progressive supranuclear palsy 664 | 674
aldosterone-producing adenoma 657 | 664
Alzheimer's disease 624 | 644
Duchenne muscular dystrophy 594 | 602
Obesity 586 | 616
pancreatic carcinoma 563 | 567
Intellectual disability 561 | 573
fibroadenoma 552 | 557
Down syndrome 531 | 548
Endometriosis 526 | 535
hepatocellular carcinoma 523 | 532
chronic rhinosinusitis 505 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 499
Schizophrenia 474 | 501
mucosa-associated lymphoid tissue lymphoma 471 | 480
active ulcerative colitis 465 | 477
Prostatic Neoplasms 464 | 471
Multiple Sclerosis 453 | 498
IGA Glomerulonephritis 450 | 454
Amyotrophic Lateral Sclerosis 426 | 431
gastric cancer 422 | 430
non-small cell lung carcinoma 407 | 413
Mammary Neoplasms 399 | 410
inflammatory breast cancer 390 | 404
Neurodegenerative disease 377 | 383
Kidney disease 358 | 396
Parkinson's disease 352 | 364
sarcoidosis 351 | 358
glioblastoma multiforme 342 | 347
Asthma 332 | 349
Epilepsy 326 | 346
tuberculosis and treatment for 3 months 324 | 327
Polycystic Ovary Syndrome 321 | 332
nephrosclerosis 321 | 329
hereditary spastic paraplegia 313 | 313

Tissue

Respiratory system 17,484 | 17,484
Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958

Target Family

Non-IDG 10,191 | 11,971
Enzyme 3,912 | 4,146
Transcription Factor 1,285 | 1,400
Kinase 620 | 634
Transporter 444 | 473
GPCR 337 | 406
Ion Channel 320 | 341
Epigenetic 234 | 242
oGPCR 59 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27