Development Level

Tbio 10,415 | 10,625
Tdark 5,673 | 7,003
Tchem 1,876 | 1,890
Tclin 597 | 602

Collection

Eligible Kinase Proteins 132 | 134
Eligible non-olfactory GPCR Proteins 130 | 143
Eligible Ion Channel Proteins 114 | 117

IMPC Term

preweaning lethality, complete... 632 | 633
preweaning lethality, incomple... 258 | 260
abnormal behavior 225 | 226
decreased lean body mass 194 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 185 | 186
decreased body weight 173 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 130 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 125 | 126
decreased grip strength 122 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 118 | 119
abnormal embryo size 111 | 112
enlarged heart 110 | 111
decreased body length 108 | 108
hyperactivity 107 | 108
increased lean body mass 106 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 92 | 93
increased bone mineral content 91 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 82 | 83
short tibia 82 | 82
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 74 | 75
abnormal lens morphology 72 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
increased circulating HDL chol... 63 | 63
abnormal sleep behavior 62 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
prenatal lethality prior to he... 62 | 64
male infertility 61 | 62
abnormal retinal pigmentation 60 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
increased exploration in new e... 56 | 56
improved glucose tolerance 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
abnormal bone mineralization 53 | 55
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased hemoglobin content 52 | 53
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
decreased mean corpuscular vol... 50 | 50
decreased fasted circulating g... 49 | 49
decreased caudal vertebrae num... 48 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
increased hemoglobin content 45 | 45
thrombocytopenia 45 | 46
decreased heart weight 44 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating alkaline... 39 | 41
decreased circulating free fat... 39 | 39
increased startle reflex 38 | 38
abnormal eye morphology 37 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased heart weight 36 | 37
increased hematocrit 36 | 36
increased leukocyte cell numbe... 36 | 37
cardiovascular system phenotyp... 35 | 35
limb grasping 34 | 35
decreased circulating calcium ... 33 | 33
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
tremors 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
increased circulating calcium ... 32 | 32
decreased blood urea nitrogen ... 31 | 31
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
decreased threshold for audito... 31 | 32
increased circulating potassiu... 31 | 31
abnormal epididymis morphology 30 | 31

Disease

ovarian cancer 8,391 | 8,484
osteosarcoma 7,805 | 7,933
psoriasis 6,489 | 6,685
medulloblastoma, large-cell 6,165 | 6,234
glioblastoma 5,525 | 5,572
lung cancer 4,431 | 4,466
atypical teratoid / rhabdoid tumor 4,333 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,256 | 3,289
malignant mesothelioma 3,138 | 3,162
Breast cancer 3,066 | 3,094
pilocytic astrocytoma 3,061 | 3,086
primitive neuroectodermal tumor 3,012 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,960 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,931 | 2,956
invasive ductal carcinoma 2,927 | 2,950
oligodendroglioma 2,832 | 2,849
lung carcinoma 2,806 | 2,844
non-small cell lung cancer 2,780 | 2,798
pediatric high grade glioma 2,692 | 2,712
lung adenocarcinoma 2,681 | 2,713
ependymoma 2,498 | 2,514
pancreatic cancer 2,285 | 2,300
interstitial cystitis 2,275 | 2,299
subependymal giant cell astrocytoma 2,267 | 2,287
group 3 medulloblastoma 2,233 | 2,254
Cancer 2,230 | 2,346
astrocytic glioma 2,224 | 2,241
Carcinoma 2,121 | 2,147
adult high grade glioma 2,117 | 2,148
ulcerative colitis 2,068 | 2,087
pituitary cancer 1,956 | 1,972
Pick disease 1,884 | 1,893
group 4 medulloblastoma 1,856 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,783 | 1,795
ductal carcinoma in situ 1,733 | 1,745
cystic fibrosis 1,649 | 1,665
breast carcinoma 1,601 | 1,614
tuberculosis 1,542 | 1,557
diabetes mellitus 1,534 | 1,663
posterior fossa group B ependymoma 1,515 | 1,530
medulloblastoma 1,510 | 1,524
posterior fossa group A ependymoma 1,498 | 1,511
astrocytoma 1,485 | 1,493
sonic hedgehog group medulloblastoma 1,475 | 1,482
colon cancer 1,462 | 1,475
adrenocortical carcinoma 1,417 | 1,427
Multiple myeloma 1,323 | 1,327
primary pancreatic ductal adenocarcinoma 1,270 | 1,271
juvenile dermatomyositis 1,183 | 1,189
acute quadriplegic myopathy 1,153 | 1,157
Rheumatoid Arthritis 1,112 | 1,160
atypical teratoid/rhabdoid tumor 1,085 | 1,095
spina bifida 1,058 | 1,064
cutaneous lupus erythematosus 1,047 | 1,056
nasopharyngeal carcinoma 1,047 | 1,056
Atopic dermatitis 931 | 944
dermatomyositis 928 | 933
active Crohn's disease 906 | 918
gastric carcinoma 824 | 832
non primary Sjogren syndrome sicca 819 | 840
primary Sjogren syndrome 781 | 789
acute myeloid leukemia 775 | 780
Waldenstrons macroglobulinemia 764 | 765
esophageal adenocarcinoma 733 | 737
tuberculosis and treatment for 6 months 682 | 686
progressive supranuclear palsy 669 | 674
aldosterone-producing adenoma 662 | 664
Alzheimer's disease 635 | 644
Obesity 610 | 616
Duchenne muscular dystrophy 596 | 602
Intellectual disability 570 | 573
pancreatic carcinoma 564 | 567
fibroadenoma 554 | 557
Down syndrome 542 | 548
Endometriosis 530 | 535
hepatocellular carcinoma 526 | 532
chronic rhinosinusitis 508 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 499
Schizophrenia 493 | 501
mucosa-associated lymphoid tissue lymphoma 472 | 480
active ulcerative colitis 467 | 477
Multiple Sclerosis 466 | 498
Prostatic Neoplasms 466 | 471
IGA Glomerulonephritis 451 | 454
Amyotrophic Lateral Sclerosis 429 | 431
gastric cancer 423 | 430
Mammary Neoplasms 409 | 410
non-small cell lung carcinoma 406 | 413
inflammatory breast cancer 395 | 404
Neurodegenerative disease 380 | 383
Kidney disease 372 | 396
Parkinson's disease 362 | 364
sarcoidosis 352 | 358
glioblastoma multiforme 344 | 347
Asthma 343 | 349
Epilepsy 343 | 346
Polycystic Ovary Syndrome 327 | 332
nephrosclerosis 327 | 329
tuberculosis and treatment for 3 months 324 | 327
Autistic Disorder 317 | 320

Tissue

Nervous System 18,561 | 18,561
Female tissues 18,647 | 18,647
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 10,783 | 11,971
Enzyme 4,019 | 4,146
Transcription Factor 1,383 | 1,400
Kinase 627 | 634
Transporter 462 | 473
GPCR 388 | 406
Ion Channel 337 | 341
Epigenetic 241 | 242
oGPCR 235 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 38 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102