Development Level

Tbio 10,255 | 10,625
Tdark 5,298 | 7,003
Tchem 1,832 | 1,890
Tclin 583 | 602

Collection

Kinase: IDG Consortium (Targets) 123 | 125
GPCR: IDG Consortium (Targets) 98 | 127
Ion Channel: IDG Consortium (Targets) 95 | 102
Kinase: IDG Consortium (Complete/Control) 37 | 37
GPCR: IDG Consortium (Complete/Control) 24 | 26

IMPC Phenotype

preweaning lethality, complete... 631 | 633
preweaning lethality, incomple... 256 | 260
abnormal behavior 224 | 226
decreased lean body mass 193 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 171 | 174
decreased bone mineral content 156 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 128 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 122 | 126
decreased circulating glucose ... 120 | 121
decreased grip strength 120 | 123
increased circulating alkaline... 117 | 119
abnormal embryo size 111 | 112
enlarged heart 109 | 111
decreased body length 108 | 108
hyperactivity 105 | 108
increased lean body mass 104 | 107
abnormal retina morphology 99 | 100
increased bone mineral content 91 | 92
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 91 | 91
hypoactivity 88 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
short tibia 82 | 82
increased grip strength 81 | 83
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 76 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 66 | 68
prenatal lethality prior to he... 63 | 64
increased circulating HDL chol... 62 | 63
abnormal sleep behavior 61 | 63
abnormal retinal pigmentation 60 | 61
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
male infertility 59 | 62
decreased rib number 58 | 59
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
increased total body fat amoun... 56 | 57
decreased leukocyte cell numbe... 54 | 54
abnormal bone mineralization 53 | 55
abnormal coat-hair pigmentatio... 53 | 54
increased circulating choleste... 53 | 53
decreased hemoglobin content 51 | 53
increased bone mineral density 51 | 52
abnormal behavioral response t... 50 | 52
abnormal gait 50 | 51
abnormal heart morphology 50 | 51
decreased circulating alanine ... 50 | 53
decreased mean corpuscular vol... 50 | 50
decreased prepulse inhibition 50 | 52
impaired glucose tolerance 50 | 52
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
abnormal seminal vesicle morph... 46 | 47
increased hemoglobin content 45 | 45
thrombocytopenia 45 | 46
decreased heart weight 43 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating alkaline... 40 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
decreased neutrophil cell numb... 37 | 37
small testis 37 | 37
abnormal neural tube closure 36 | 37
abnormal spleen morphology 36 | 36
decreased circulating LDL chol... 36 | 37
increased heart weight 36 | 37
increased hematocrit 36 | 36
increased leukocyte cell numbe... 36 | 37
cardiovascular system phenotyp... 35 | 35
decreased mean corpuscular hem... 33 | 34
limb grasping 33 | 35
tremors 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
female infertility 32 | 34
increased circulating calcium ... 32 | 32
decreased blood urea nitrogen ... 31 | 31
decreased circulating chloride... 31 | 32
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
abnormal kidney morphology 30 | 30
decreased T cell number 30 | 31

Disease

ovarian cancer 8,347 | 8,491
osteosarcoma 7,758 | 7,933
psoriasis 6,346 | 6,685
medulloblastoma, large-cell 6,113 | 6,234
glioblastoma 5,498 | 5,572
lung cancer 4,429 | 4,473
atypical teratoid / rhabdoid tumor 4,303 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,254 | 3,289
malignant mesothelioma 3,126 | 3,163
Breast cancer 3,062 | 3,098
pilocytic astrocytoma 3,042 | 3,086
primitive neuroectodermal tumor 3,001 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,957 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,930 | 2,956
invasive ductal carcinoma 2,920 | 2,950
oligodendroglioma 2,817 | 2,849
lung carcinoma 2,794 | 2,844
non-small cell lung cancer 2,776 | 2,798
lung adenocarcinoma 2,680 | 2,714
pediatric high grade glioma 2,676 | 2,712
ependymoma 2,489 | 2,514
pancreatic cancer 2,280 | 2,300
interstitial cystitis 2,273 | 2,299
subependymal giant cell astrocytoma 2,258 | 2,287
group 3 medulloblastoma 2,222 | 2,254
astrocytic glioma 2,211 | 2,241
Cancer 2,202 | 2,346
Carcinoma 2,097 | 2,147
adult high grade glioma 2,096 | 2,148
ulcerative colitis 2,058 | 2,087
pituitary cancer 1,945 | 1,972
Pick disease 1,879 | 1,893
group 4 medulloblastoma 1,852 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,780 | 1,795
ductal carcinoma in situ 1,728 | 1,745
cystic fibrosis 1,648 | 1,670
breast carcinoma 1,600 | 1,614
tuberculosis 1,539 | 1,563
posterior fossa group B ependymoma 1,505 | 1,530
medulloblastoma 1,500 | 1,524
posterior fossa group A ependymoma 1,492 | 1,511
astrocytoma 1,481 | 1,493
sonic hedgehog group medulloblastoma 1,466 | 1,482
colon cancer 1,460 | 1,475
diabetes mellitus 1,431 | 1,663
adrenocortical carcinoma 1,416 | 1,427
Multiple myeloma 1,322 | 1,327
primary pancreatic ductal adenocarcinoma 1,269 | 1,271
juvenile dermatomyositis 1,183 | 1,189
acute quadriplegic myopathy 1,154 | 1,157
Rheumatoid Arthritis 1,111 | 1,170
atypical teratoid/rhabdoid tumor 1,082 | 1,095
spina bifida 1,053 | 1,064
nasopharyngeal carcinoma 1,046 | 1,056
cutaneous lupus erythematosus 1,044 | 1,056
dermatomyositis 929 | 966
Atopic dermatitis 912 | 944
active Crohn's disease 903 | 918
gastric carcinoma 820 | 832
non primary Sjogren syndrome sicca 817 | 840
acute myeloid leukemia 781 | 785
primary Sjogren syndrome 778 | 788
Waldenstrons macroglobulinemia 763 | 764
esophageal adenocarcinoma 730 | 737
tuberculosis and treatment for 6 months 683 | 686
progressive supranuclear palsy 667 | 674
aldosterone-producing adenoma 659 | 664
Alzheimer's disease 627 | 644
Duchenne muscular dystrophy 597 | 602
Obesity 593 | 616
Intellectual disability 567 | 573
pancreatic carcinoma 564 | 567
fibroadenoma 554 | 557
hepatocellular carcinoma 542 | 550
Down syndrome 537 | 548
Endometriosis 531 | 535
chronic rhinosinusitis 506 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Schizophrenia 482 | 503
mucosa-associated lymphoid tissue lymphoma 470 | 480
Prostatic Neoplasms 469 | 471
active ulcerative colitis 466 | 477
IGA Glomerulonephritis 452 | 454
Multiple Sclerosis 451 | 498
gastric cancer 430 | 436
Amyotrophic Lateral Sclerosis 428 | 432
non-small cell lung carcinoma 406 | 413
Mammary Neoplasms 404 | 410
inflammatory breast cancer 394 | 404
Neurodegenerative disease 379 | 383
Kidney disease 364 | 397
Parkinson's disease 354 | 364
sarcoidosis 351 | 368
glioblastoma multiforme 343 | 347
Epilepsy 339 | 346
Asthma 331 | 349
Polycystic Ovary Syndrome 326 | 334
tuberculosis and treatment for 3 months 324 | 327
nephrosclerosis 322 | 329
urothelial carcinoma 316 | 318

Tissue

Male tissues 17,968 | 17,968
Female tissues 18,646 | 18,646
Nervous System 18,560 | 18,560
Endocrine System 18,511 | 18,511
Digestive Tract 18,472 | 18,472
Urinary Tract 18,443 | 18,443
Liver and Pancreas 18,135 | 18,135
Skin and soft tissues 18,114 | 18,114
Blood and immune system 17,994 | 17,994
Cardiovascular System 17,957 | 17,957
Respiratory system 17,483 | 17,483

Target Family

Non-IDG 10,502 | 11,969
Enzyme 3,962 | 4,146
Transcription Factor 1,353 | 1,400
Kinase 626 | 634
Transporter 453 | 473
GPCR 343 | 408
Ion Channel 322 | 341
Epigenetic 242 | 242
oGPCR 83 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
F-box/LRR-repeat protein 21 FBXL21 Tdark Non-IDG 0.00000 0
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74