Development Level

Tbio 10,840 | 11,651
Tdark 4,421 | 6,593
Tchem 1,314 | 1,388
Tclin 567 | 612

Collection

Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 86 | 99
GPCR: IDG Consortium (Targets) 84 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 961 | 979
preweaning lethality, incomple... 482 | 499
abnormal behavior 282 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 201 | 207
enlarged heart 201 | 210
decreased vertical activity 193 | 208
abnormal bone structure 175 | 187
increased lean body mass 165 | 172
abnormal heart morphology 157 | 162
decreased body weight 154 | 161
decreased bone mineral content 143 | 151
hyperactivity 140 | 148
decreased lean body mass 129 | 135
increased total body fat amoun... 126 | 134
hypoactivity 122 | 132
decreased circulating glucose ... 121 | 126
decreased bone mineral density 119 | 126
increased circulating alkaline... 116 | 122
male infertility 114 | 123
decreased grip strength 108 | 116
abnormal seminal vesicle morph... 107 | 114
increased bone mineral content 105 | 108
increased startle reflex 105 | 112
embryonic growth retardation 102 | 106
increased or absent threshold ... 98 | 101
decreased body length 95 | 101
short tibia 94 | 97
increased mean corpuscular hem... 92 | 96
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 90 | 93
cataract 88 | 92
prenatal lethality prior to he... 86 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 82 | 83
decreased circulating triglyce... 78 | 79
decreased prepulse inhibition 78 | 82
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 77 | 79
decreased circulating insulin ... 74 | 76
increased fasted circulating g... 74 | 76
improved glucose tolerance 73 | 79
increased circulating HDL chol... 73 | 80
decreased leukocyte cell numbe... 72 | 73
decreased startle reflex 72 | 75
small superior vagus ganglion 72 | 74
impaired glucose tolerance 70 | 75
increased bone mineral density 70 | 72
abnormal eye morphology 68 | 68
abnormal sleep behavior 68 | 70
abnormal retina morphology 67 | 71
increased circulating sodium l... 66 | 71
abnormal gait 65 | 69
decreased circulating HDL chol... 65 | 68
increased circulating choleste... 64 | 66
abnormal behavioral response t... 63 | 66
decreased hemoglobin content 63 | 68
abnormal coat-hair pigmentatio... 62 | 64
abnormal kidney morphology 62 | 65
increased monocyte cell number 62 | 63
decreased fasted circulating g... 61 | 65
decreased erythrocyte cell num... 60 | 62
increased heart weight 59 | 62
edema 58 | 59
female infertility 56 | 60
small testis 55 | 58
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
hydrometra 51 | 53
decreased blood urea nitrogen ... 50 | 51
abnormal skin morphology 49 | 50
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 48 | 50
abnormal neural tube closure 46 | 46
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased neutrophil cell numb... 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased hemoglobin content 42 | 45
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
increased circulating triglyce... 41 | 42
decreased neutrophil cell numb... 39 | 42
abnormal epididymis morphology 38 | 42
decreased circulating LDL chol... 38 | 38
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
increased circulating creatini... 37 | 38
tremors 37 | 39
increased grip strength 36 | 41

Disease

Carcinoma 10,395 | 11,493
ovarian cancer 8,273 | 8,520
osteosarcoma 7,617 | 7,950
psoriasis 6,118 | 6,694
medulloblastoma, large-cell 5,999 | 6,241
glioblastoma 5,640 | 5,792
atypical teratoid / rhabdoid tumor 4,962 | 5,112
lung cancer 4,584 | 4,740
ependymoma 4,544 | 4,679
group 3 medulloblastoma 3,987 | 4,104
adult high grade glioma 3,656 | 3,801
Breast cancer 3,492 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,221 | 3,291
malignant mesothelioma 3,166 | 3,232
Astrocytoma, Pilocytic 2,984 | 3,081
primitive neuroectodermal tumor 2,951 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,934 | 2,989
invasive ductal carcinoma 2,917 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,900 | 2,955
non-small cell lung cancer 2,840 | 2,890
oligodendroglioma 2,765 | 2,850
lung carcinoma 2,759 | 2,843
lung adenocarcinoma 2,646 | 2,716
astrocytic glioma 2,523 | 2,597
Kidney cancer 2,448 | 2,613
pancreatic cancer 2,333 | 2,398
Cancer 2,310 | 2,499
interstitial cystitis 2,260 | 2,312
subependymal giant cell astrocytoma 2,220 | 2,287
tuberculosis 1,939 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,962
pituitary cancer 1,911 | 1,972
Pick disease 1,857 | 1,894
group 4 medulloblastoma 1,808 | 1,855
ulcerative colitis 1,758 | 1,819
ductal carcinoma in situ 1,724 | 1,745
cystic fibrosis 1,646 | 1,696
breast carcinoma 1,610 | 1,638
colon cancer 1,439 | 1,478
diabetes mellitus 1,417 | 1,728
adrenocortical carcinoma 1,412 | 1,428
Autosomal recessive predisposition 1,366 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,170 | 1,187
acute quadriplegic myopathy 1,150 | 1,158
astrocytoma 1,120 | 1,146
Rheumatoid arthritis 1,109 | 1,191
primary pancreatic ductal adenocarcinoma 1,096 | 1,109
Schizophrenia 1,062 | 1,160
spina bifida 1,052 | 1,074
pediatric high grade glioma 1,043 | 1,064
cutaneous lupus erythematosus 1,035 | 1,057
nasopharyngeal carcinoma 1,027 | 1,058
Intellectual disability 983 | 1,016
dermatomyositis 924 | 966
active Crohn's disease 901 | 922
Atopic dermatitis 885 | 952
non primary Sjogren syndrome sicca 851 | 891
gastric carcinoma 787 | 807
acute myeloid leukemia 777 | 783
Waldenstrons macroglobulinemia 759 | 765
Epilepsy 754 | 792
Liver Cirrhosis, Experimental 745 | 769
active ulcerative colitis 740 | 764
primary Sjogren syndrome 721 | 735
esophageal adenocarcinoma 717 | 737
medulloblastoma 701 | 720
progressive supranuclear palsy 661 | 676
aldosterone-producing adenoma 658 | 665
Melanoma 639 | 711
Obesity 625 | 678
Dull intelligence 623 | 645
Low intelligence 623 | 645
Mental Retardation 623 | 645
Mental deficiency 623 | 645
Poor school performance 623 | 645
Alzheimer's disease 619 | 658
Bipolar Disorder 610 | 666
Duchenne muscular dystrophy 590 | 601
Cognitive delay 585 | 608
Global developmental delay 585 | 608
Mental and motor retardation 585 | 608
Seizures 573 | 596
Liver cancer 555 | 604
Muscle hypotonia 555 | 571
fibroadenoma 555 | 559
pancreatic carcinoma 555 | 562
hepatocellular carcinoma 537 | 547
Endometriosis 528 | 540
Short stature 508 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 505 | 510
chronic rhinosinusitis 504 | 512
Down syndrome 484 | 499
Prostatic Neoplasms 482 | 495
Multiple Sclerosis 478 | 540
mucosa-associated lymphoid tissue lymphoma 458 | 484
posterior fossa group A ependymoma 458 | 468
sonic hedgehog group medulloblastoma 452 | 467
gastric cancer 451 | 459
Amyotrophic lateral sclerosis 439 | 451

Tissue

Male tissues 17,142 | 17,142
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 10,019 | 12,091
Enzyme 3,860 | 4,145
Transcription Factor 1,255 | 1,400
Kinase 614 | 634
Transporter 430 | 473
GPCR 311 | 408
Ion Channel 295 | 344
Epigenetic 234 | 242
Nuclear Receptor 46 | 48
oGPCR 41 | 421
TF/Epigenetic 37 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50