Development Level

Tbio 10,236 | 11,178
Tdark 4,189 | 6,569
Tchem 1,768 | 1,885
Tclin 557 | 612

Collection

Kinase: IDG Consortium (Target... 119 | 125
Ion Channel: IDG Consortium (T... 79 | 99
GPCR: IDG Consortium (Targets) 75 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 954 | 979
preweaning lethality, incomple... 479 | 499
abnormal behavior 285 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 199 | 207
enlarged heart 196 | 210
decreased vertical activity 186 | 208
abnormal bone structure 173 | 187
increased lean body mass 164 | 172
decreased body weight 154 | 161
abnormal heart morphology 151 | 162
decreased bone mineral content 142 | 151
hyperactivity 142 | 148
decreased lean body mass 128 | 135
increased total body fat amoun... 127 | 134
hypoactivity 123 | 132
decreased bone mineral density 121 | 126
decreased circulating glucose ... 120 | 126
increased circulating alkaline... 113 | 122
male infertility 106 | 123
increased startle reflex 105 | 112
abnormal seminal vesicle morph... 104 | 114
decreased grip strength 104 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 100 | 108
decreased body length 97 | 101
increased or absent threshold ... 97 | 101
short tibia 95 | 97
increased mean corpuscular hem... 91 | 96
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 90 | 93
cataract 89 | 92
prenatal lethality prior to he... 83 | 87
decreased circulating serum al... 80 | 82
decreased lymphocyte cell numb... 80 | 83
decreased prepulse inhibition 79 | 82
abnormal lens morphology 78 | 81
decreased circulating triglyce... 76 | 79
decreased mean corpuscular vol... 76 | 79
improved glucose tolerance 76 | 79
increased circulating HDL chol... 73 | 80
decreased startle reflex 72 | 75
decreased leukocyte cell numbe... 71 | 73
increased fasted circulating g... 71 | 76
increased bone mineral density 70 | 72
impaired glucose tolerance 69 | 75
decreased circulating insulin ... 68 | 76
increased circulating sodium l... 68 | 71
abnormal eye morphology 67 | 68
small superior vagus ganglion 67 | 74
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
abnormal gait 65 | 69
abnormal sleep behavior 65 | 70
decreased hemoglobin content 63 | 68
decreased fasted circulating g... 62 | 65
abnormal behavioral response t... 61 | 66
abnormal coat-hair pigmentatio... 61 | 64
increased circulating choleste... 61 | 66
increased monocyte cell number 61 | 63
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
edema 56 | 59
increased heart weight 56 | 62
small testis 55 | 58
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
female infertility 51 | 60
abnormal skin morphology 49 | 50
hydrometra 49 | 53
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
increased leukocyte cell numbe... 46 | 47
decreased circulating alanine ... 45 | 47
increased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
decreased circulating alkaline... 43 | 46
decreased hematocrit 43 | 46
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
increased circulating triglyce... 41 | 42
abnormal testis morphology 40 | 43
decreased red blood cell distr... 40 | 41
increased circulating chloride... 40 | 41
increased hemoglobin content 40 | 45
increased mean platelet volume 40 | 45
limb grasping 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
prolonged QT interval 37 | 38
tremors 37 | 39
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 9,936 | 11,192
ovarian cancer 8,016 | 8,297
osteosarcoma 7,422 | 7,766
psoriasis 5,843 | 6,514
medulloblastoma, large-cell 5,786 | 6,086
glioblastoma 5,439 | 5,635
atypical teratoid / rhabdoid tumor 4,777 | 4,971
lung cancer 4,427 | 4,607
ependymoma 4,372 | 4,559
group 3 medulloblastoma 3,852 | 4,002
adult high grade glioma 3,506 | 3,701
Breast cancer 3,346 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,153 | 3,204
malignant mesothelioma 3,051 | 3,135
Astrocytoma, Pilocytic 2,873 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,860 | 2,902
primitive neuroectodermal tumor 2,850 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 2,835 | 2,872
invasive ductal carcinoma 2,829 | 2,867
non-small cell lung cancer 2,731 | 2,799
oligodendroglioma 2,654 | 2,768
lung carcinoma 2,651 | 2,755
lung adenocarcinoma 2,546 | 2,627
astrocytic glioma 2,428 | 2,530
Kidney cancer 2,344 | 2,548
pancreatic cancer 2,271 | 2,322
Cancer 2,182 | 2,388
interstitial cystitis 2,168 | 2,237
subependymal giant cell astrocytoma 2,155 | 2,230
tuberculosis 1,900 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,891 | 1,911
pituitary cancer 1,838 | 1,915
Pick disease 1,813 | 1,856
group 4 medulloblastoma 1,750 | 1,806
ulcerative colitis 1,713 | 1,765
ductal carcinoma in situ 1,664 | 1,686
cystic fibrosis 1,578 | 1,629
breast carcinoma 1,557 | 1,589
colon cancer 1,395 | 1,428
adrenocortical carcinoma 1,365 | 1,385
diabetes mellitus 1,365 | 1,683
Autosomal recessive predisposition 1,330 | 1,407
Multiple myeloma 1,274 | 1,296
juvenile dermatomyositis 1,129 | 1,147
acute quadriplegic myopathy 1,112 | 1,133
astrocytoma 1,087 | 1,113
Rheumatoid arthritis 1,067 | 1,156
primary pancreatic ductal adenocarcinoma 1,062 | 1,071
Schizophrenia 1,030 | 1,136
spina bifida 1,029 | 1,053
pediatric high grade glioma 1,011 | 1,035
cutaneous lupus erythematosus 985 | 1,016
nasopharyngeal carcinoma 979 | 1,024
Intellectual disability 953 | 998
dermatomyositis 899 | 941
active Crohn's disease 857 | 882
Atopic dermatitis 852 | 915
non primary Sjogren syndrome sicca 817 | 861
gastric carcinoma 763 | 781
acute myeloid leukemia 756 | 760
Epilepsy 738 | 775
Waldenstrons macroglobulinemia 738 | 742
Liver Cirrhosis, Experimental 723 | 733
active ulcerative colitis 710 | 736
primary Sjogren syndrome 696 | 710
esophageal adenocarcinoma 682 | 696
medulloblastoma 673 | 702
progressive supranuclear palsy 643 | 656
aldosterone-producing adenoma 638 | 646
Alzheimer's disease 608 | 640
Dull intelligence 606 | 634
Low intelligence 606 | 634
Mental Retardation 606 | 634
Mental deficiency 606 | 634
Poor school performance 606 | 634
Obesity 604 | 655
Melanoma 599 | 689
Bipolar Disorder 583 | 646
Cognitive delay 578 | 596
Global developmental delay 578 | 596
Mental and motor retardation 578 | 596
Duchenne muscular dystrophy 571 | 587
Seizures 565 | 584
pancreatic carcinoma 547 | 555
Muscle hypotonia 546 | 562
fibroadenoma 531 | 538
hepatocellular carcinoma 530 | 536
Liver cancer 523 | 589
Endometriosis 505 | 521
Short stature 488 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 484 | 492
chronic rhinosinusitis 484 | 505
Down syndrome 464 | 480
Multiple Sclerosis 459 | 527
Prostatic Neoplasms 456 | 472
mucosa-associated lymphoid tissue lymphoma 454 | 473
posterior fossa group A ependymoma 441 | 456
sonic hedgehog group medulloblastoma 439 | 459
gastric cancer 438 | 445
Amyotrophic lateral sclerosis 425 | 437

Tissue

Liver and Pancreas 16,750 | 16,750
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,767 | 12,091
Enzyme 3,840 | 4,145
Transcription Factor 1,207 | 1,400
Kinase 606 | 634
Transporter 423 | 473
GPCR 295 | 408
Ion Channel 279 | 344
Epigenetic 235 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 18 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101