Development Level

Tbio 10,491 | 11,445
Tdark 4,197 | 6,588
Tchem 1,504 | 1,598
Tclin 558 | 613

Collection

RFA-RM-18-021 267 | 328
Kinase: IDG Consortium (Target... 119 | 125
Ion Channel: IDG Consortium (T... 79 | 99
GPCR: IDG Consortium (Targets) 75 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 954 | 979
preweaning lethality, incomple... 479 | 499
abnormal behavior 285 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 199 | 207
enlarged heart 196 | 210
decreased vertical activity 186 | 208
abnormal bone structure 173 | 187
increased lean body mass 164 | 172
decreased body weight 154 | 161
abnormal heart morphology 151 | 162
decreased bone mineral content 142 | 151
hyperactivity 142 | 148
decreased lean body mass 128 | 135
increased total body fat amoun... 127 | 134
hypoactivity 123 | 132
decreased bone mineral density 121 | 126
decreased circulating glucose ... 120 | 126
increased circulating alkaline... 113 | 122
male infertility 106 | 123
increased startle reflex 105 | 112
abnormal seminal vesicle morph... 104 | 114
decreased grip strength 104 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 100 | 108
decreased body length 97 | 101
increased or absent threshold ... 97 | 101
short tibia 95 | 97
increased mean corpuscular hem... 91 | 96
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 90 | 93
cataract 89 | 92
prenatal lethality prior to he... 83 | 87
decreased circulating serum al... 80 | 82
decreased lymphocyte cell numb... 80 | 83
decreased prepulse inhibition 79 | 82
abnormal lens morphology 78 | 81
decreased circulating triglyce... 76 | 79
decreased mean corpuscular vol... 76 | 79
improved glucose tolerance 76 | 79
increased circulating HDL chol... 73 | 80
decreased startle reflex 72 | 75
decreased leukocyte cell numbe... 71 | 73
increased fasted circulating g... 71 | 76
increased bone mineral density 70 | 72
impaired glucose tolerance 69 | 75
decreased circulating insulin ... 68 | 76
increased circulating sodium l... 68 | 71
abnormal eye morphology 67 | 68
small superior vagus ganglion 67 | 74
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
abnormal gait 65 | 69
abnormal sleep behavior 65 | 70
decreased hemoglobin content 63 | 68
decreased fasted circulating g... 62 | 65
abnormal behavioral response t... 61 | 66
abnormal coat-hair pigmentatio... 61 | 64
increased circulating choleste... 61 | 66
increased monocyte cell number 61 | 63
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
edema 56 | 59
increased heart weight 56 | 62
small testis 55 | 58
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
female infertility 51 | 60
abnormal skin morphology 49 | 50
hydrometra 49 | 53
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
increased leukocyte cell numbe... 46 | 47
decreased circulating alanine ... 45 | 47
increased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
decreased circulating alkaline... 43 | 46
decreased hematocrit 43 | 46
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
increased circulating triglyce... 41 | 42
abnormal testis morphology 40 | 43
decreased red blood cell distr... 40 | 41
increased circulating chloride... 40 | 41
increased hemoglobin content 40 | 45
increased mean platelet volume 40 | 45
limb grasping 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
prolonged QT interval 37 | 38
tremors 37 | 39
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 10,190 | 11,493
ovarian cancer 8,230 | 8,520
osteosarcoma 7,598 | 7,950
psoriasis 6,001 | 6,694
medulloblastoma, large-cell 5,931 | 6,241
glioblastoma 5,585 | 5,792
atypical teratoid / rhabdoid tumor 4,911 | 5,112
lung cancer 4,553 | 4,740
ependymoma 4,483 | 4,679
group 3 medulloblastoma 3,946 | 4,104
adult high grade glioma 3,598 | 3,801
Breast cancer 3,445 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,239 | 3,291
malignant mesothelioma 3,146 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,944 | 2,989
Astrocytoma, Pilocytic 2,943 | 3,081
primitive neuroectodermal tumor 2,923 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,916 | 2,955
invasive ductal carcinoma 2,911 | 2,951
non-small cell lung cancer 2,816 | 2,890
lung carcinoma 2,736 | 2,843
oligodendroglioma 2,729 | 2,850
lung adenocarcinoma 2,631 | 2,716
astrocytic glioma 2,489 | 2,597
Kidney cancer 2,399 | 2,613
pancreatic cancer 2,344 | 2,398
Cancer 2,285 | 2,499
interstitial cystitis 2,240 | 2,312
subependymal giant cell astrocytoma 2,207 | 2,287
tuberculosis 1,946 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,941 | 1,962
pituitary cancer 1,895 | 1,972
Pick disease 1,848 | 1,894
group 4 medulloblastoma 1,795 | 1,855
ulcerative colitis 1,767 | 1,819
ductal carcinoma in situ 1,722 | 1,745
cystic fibrosis 1,641 | 1,696
breast carcinoma 1,605 | 1,638
colon cancer 1,441 | 1,478
diabetes mellitus 1,408 | 1,728
adrenocortical carcinoma 1,406 | 1,428
Autosomal recessive predisposition 1,361 | 1,442
Multiple myeloma 1,310 | 1,332
juvenile dermatomyositis 1,168 | 1,187
acute quadriplegic myopathy 1,137 | 1,158
astrocytoma 1,118 | 1,146
Rheumatoid arthritis 1,101 | 1,191
primary pancreatic ductal adenocarcinoma 1,100 | 1,109
Schizophrenia 1,050 | 1,160
spina bifida 1,046 | 1,074
pediatric high grade glioma 1,038 | 1,064
cutaneous lupus erythematosus 1,023 | 1,057
nasopharyngeal carcinoma 1,011 | 1,058
Intellectual disability 968 | 1,016
dermatomyositis 924 | 966
active Crohn's disease 894 | 922
Atopic dermatitis 886 | 952
non primary Sjogren syndrome sicca 845 | 891
gastric carcinoma 789 | 807
acute myeloid leukemia 779 | 783
Waldenstrons macroglobulinemia 761 | 765
Liver Cirrhosis, Experimental 758 | 769
Epilepsy 752 | 792
active ulcerative colitis 736 | 764
primary Sjogren syndrome 721 | 735
esophageal adenocarcinoma 720 | 737
medulloblastoma 690 | 720
progressive supranuclear palsy 661 | 676
aldosterone-producing adenoma 656 | 665
Alzheimer's disease 625 | 658
Obesity 625 | 678
Melanoma 616 | 711
Dull intelligence 615 | 645
Low intelligence 615 | 645
Mental Retardation 615 | 645
Mental deficiency 615 | 645
Poor school performance 615 | 645
Bipolar Disorder 602 | 666
Cognitive delay 586 | 608
Global developmental delay 586 | 608
Mental and motor retardation 586 | 608
Duchenne muscular dystrophy 585 | 601
Seizures 574 | 596
pancreatic carcinoma 554 | 562
Muscle hypotonia 553 | 571
fibroadenoma 552 | 559
hepatocellular carcinoma 541 | 547
Liver cancer 534 | 604
Endometriosis 523 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 502 | 510
Short stature 500 | 531
chronic rhinosinusitis 490 | 512
Down syndrome 482 | 499
Prostatic Neoplasms 476 | 495
Multiple Sclerosis 471 | 540
mucosa-associated lymphoid tissue lymphoma 465 | 484
posterior fossa group A ependymoma 453 | 468
gastric cancer 452 | 459
sonic hedgehog group medulloblastoma 447 | 467
Amyotrophic lateral sclerosis 439 | 451

Tissue

Liver and Pancreas 16,750 | 16,750
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,767 | 12,091
Enzyme 3,840 | 4,145
Transcription Factor 1,207 | 1,400
Kinase 606 | 634
Transporter 423 | 473
GPCR 295 | 408
Ion Channel 279 | 344
Epigenetic 235 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 18 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39