Development Level

Tbio 10,303 | 10,625
Tdark 5,387 | 7,003
Tchem 1,859 | 1,890
Tclin 587 | 602

Collection

Eligible Kinase Proteins 131 | 134
Eligible non-olfactory GPCR Proteins 114 | 145
Eligible Ion Channel Proteins 112 | 117

IMPC Term

preweaning lethality, complete... 632 | 633
preweaning lethality, incomple... 259 | 260
abnormal behavior 223 | 226
decreased lean body mass 193 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 185 | 186
decreased body weight 173 | 174
decreased bone mineral content 156 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 129 | 131
increased or absent threshold ... 127 | 128
decreased bone mineral density 124 | 126
decreased grip strength 121 | 123
decreased circulating glucose ... 120 | 121
increased circulating alkaline... 118 | 119
abnormal embryo size 112 | 112
enlarged heart 109 | 111
decreased body length 108 | 108
increased lean body mass 106 | 107
hyperactivity 104 | 108
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 92 | 93
increased bone mineral content 91 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 88 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 82 | 83
short tibia 82 | 82
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 72 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 67 | 68
prenatal lethality prior to he... 63 | 64
decreased lumbar vertebrae num... 62 | 62
increased circulating HDL chol... 62 | 63
increased sacral vertebrae num... 62 | 62
abnormal sleep behavior 61 | 63
abnormal retinal pigmentation 60 | 61
male infertility 60 | 62
decreased rib number 59 | 59
increased exploration in new e... 56 | 56
increased total body fat amoun... 56 | 57
improved glucose tolerance 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
abnormal bone mineralization 53 | 55
increased bone mineral density 52 | 52
increased circulating choleste... 52 | 53
abnormal heart morphology 51 | 51
decreased circulating alanine ... 51 | 53
decreased hemoglobin content 51 | 53
decreased prepulse inhibition 51 | 52
impaired glucose tolerance 51 | 52
abnormal behavioral response t... 50 | 52
abnormal gait 50 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 46 | 47
increased hemoglobin content 45 | 45
thrombocytopenia 45 | 46
decreased heart weight 44 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
decreased circulating alkaline... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
decreased neutrophil cell numb... 36 | 37
increased hematocrit 36 | 36
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
increased heart weight 35 | 37
limb grasping 34 | 35
decreased circulating calcium ... 33 | 33
decreased mean corpuscular hem... 33 | 34
tremors 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
female infertility 32 | 34
increased circulating calcium ... 32 | 32
decreased blood urea nitrogen ... 31 | 31
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
abnormal testis morphology 30 | 30
decreased T cell number 30 | 31

Disease

ovarian cancer 8,368 | 8,492
osteosarcoma 7,776 | 7,933
psoriasis 6,411 | 6,685
medulloblastoma, large-cell 6,136 | 6,234
glioblastoma 5,513 | 5,572
lung cancer 4,426 | 4,473
atypical teratoid / rhabdoid tumor 4,321 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,261 | 3,289
malignant mesothelioma 3,131 | 3,163
Breast cancer 3,070 | 3,099
pilocytic astrocytoma 3,055 | 3,086
primitive neuroectodermal tumor 3,008 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,964 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,937 | 2,956
invasive ductal carcinoma 2,925 | 2,950
oligodendroglioma 2,827 | 2,849
lung carcinoma 2,804 | 2,844
non-small cell lung cancer 2,778 | 2,798
pediatric high grade glioma 2,683 | 2,712
lung adenocarcinoma 2,680 | 2,714
ependymoma 2,492 | 2,514
pancreatic cancer 2,287 | 2,300
interstitial cystitis 2,277 | 2,299
subependymal giant cell astrocytoma 2,257 | 2,287
group 3 medulloblastoma 2,226 | 2,254
astrocytic glioma 2,219 | 2,241
Cancer 2,207 | 2,346
adult high grade glioma 2,106 | 2,148
Carcinoma 2,099 | 2,147
ulcerative colitis 2,068 | 2,087
pituitary cancer 1,948 | 1,972
Pick disease 1,883 | 1,893
group 4 medulloblastoma 1,853 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,785 | 1,795
ductal carcinoma in situ 1,731 | 1,745
cystic fibrosis 1,653 | 1,670
breast carcinoma 1,601 | 1,614
tuberculosis 1,545 | 1,563
medulloblastoma 1,506 | 1,524
posterior fossa group B ependymoma 1,505 | 1,530
posterior fossa group A ependymoma 1,493 | 1,511
astrocytoma 1,483 | 1,493
diabetes mellitus 1,479 | 1,663
sonic hedgehog group medulloblastoma 1,468 | 1,482
colon cancer 1,461 | 1,475
adrenocortical carcinoma 1,416 | 1,427
Multiple myeloma 1,324 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,183 | 1,189
acute quadriplegic myopathy 1,153 | 1,157
Rheumatoid Arthritis 1,113 | 1,171
atypical teratoid/rhabdoid tumor 1,078 | 1,095
spina bifida 1,056 | 1,064
nasopharyngeal carcinoma 1,047 | 1,056
cutaneous lupus erythematosus 1,044 | 1,056
dermatomyositis 932 | 967
Atopic dermatitis 926 | 944
active Crohn's disease 908 | 918
gastric carcinoma 824 | 832
non primary Sjogren syndrome sicca 819 | 840
primary Sjogren syndrome 781 | 789
acute myeloid leukemia 779 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 734 | 737
tuberculosis and treatment for 6 months 682 | 686
progressive supranuclear palsy 669 | 674
aldosterone-producing adenoma 662 | 664
Alzheimer's disease 634 | 644
Obesity 602 | 616
Duchenne muscular dystrophy 596 | 602
Intellectual disability 567 | 573
pancreatic carcinoma 564 | 567
fibroadenoma 554 | 557
hepatocellular carcinoma 545 | 550
Down syndrome 538 | 548
Endometriosis 531 | 535
chronic rhinosinusitis 507 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 499
Schizophrenia 486 | 503
mucosa-associated lymphoid tissue lymphoma 472 | 480
active ulcerative colitis 467 | 477
Prostatic Neoplasms 465 | 471
Multiple Sclerosis 459 | 498
IGA Glomerulonephritis 452 | 454
gastric cancer 431 | 436
Amyotrophic Lateral Sclerosis 430 | 432
non-small cell lung carcinoma 407 | 413
Mammary Neoplasms 406 | 410
inflammatory breast cancer 394 | 404
Neurodegenerative disease 379 | 383
Kidney disease 369 | 397
Parkinson's disease 358 | 364
sarcoidosis 352 | 368
glioblastoma multiforme 344 | 347
Epilepsy 338 | 346
Asthma 337 | 349
Polycystic Ovary Syndrome 330 | 335
nephrosclerosis 328 | 329
tuberculosis and treatment for 3 months 324 | 327
urothelial carcinoma 315 | 318

Tissue

Liver and Pancreas 18,136 | 18,136
Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 10,571 | 11,969
Enzyme 3,992 | 4,146
Transcription Factor 1,348 | 1,400
Kinase 627 | 634
Transporter 460 | 473
GPCR 358 | 408
Ion Channel 332 | 341
Epigenetic 240 | 242
oGPCR 124 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101