Development Level

Tbio 10,782 | 11,178
Tdark 4,938 | 6,569
Tchem 1,839 | 1,885
Tclin 600 | 612

Collection

Kinase: IDG Consortium (Target... 123 | 125
GPCR: IDG Consortium (Targets) 97 | 126
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 971 | 979
preweaning lethality, incomple... 496 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 277 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 218 | 220
enlarged heart 206 | 210
decreased total body fat amoun... 203 | 207
decreased vertical activity 196 | 208
abnormal bone structure 181 | 187
increased lean body mass 168 | 172
abnormal heart morphology 159 | 162
decreased body weight 159 | 161
decreased bone mineral content 150 | 151
hyperactivity 146 | 148
decreased lean body mass 132 | 135
hypoactivity 129 | 132
increased total body fat amoun... 129 | 134
decreased circulating glucose ... 126 | 126
decreased bone mineral density 124 | 126
increased circulating alkaline... 120 | 122
male infertility 120 | 123
decreased grip strength 113 | 116
abnormal seminal vesicle morph... 112 | 114
increased startle reflex 107 | 112
increased bone mineral content 106 | 108
embryonic growth retardation 105 | 106
decreased body length 100 | 101
increased or absent threshold ... 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 93 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 89 | 92
prenatal lethality prior to he... 87 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
decreased circulating triglyce... 79 | 79
abnormal lens morphology 78 | 81
improved glucose tolerance 78 | 79
decreased mean corpuscular vol... 77 | 79
increased circulating HDL chol... 76 | 80
decreased startle reflex 74 | 75
increased fasted circulating g... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
decreased circulating insulin ... 71 | 76
increased bone mineral density 71 | 72
increased circulating sodium l... 70 | 71
small superior vagus ganglion 70 | 74
abnormal sleep behavior 69 | 70
abnormal gait 68 | 69
abnormal retina morphology 68 | 71
abnormal eye morphology 67 | 68
decreased hemoglobin content 67 | 68
decreased circulating HDL chol... 66 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 64 | 65
increased monocyte cell number 63 | 63
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 61 | 62
increased heart weight 59 | 62
edema 58 | 59
female infertility 57 | 60
small testis 57 | 58
abnormal spleen morphology 55 | 55
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 53 | 53
hydrometra 51 | 53
abnormal skin morphology 50 | 50
decreased blood urea nitrogen ... 50 | 51
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 49 | 50
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 45 | 46
decreased hematocrit 45 | 46
increased hemoglobin content 44 | 45
increased mean platelet volume 44 | 45
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
abnormal testis morphology 41 | 43
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
increased circulating chloride... 40 | 41
limb grasping 40 | 41
increased erythrocyte cell num... 39 | 39
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
tremors 37 | 39

Disease

Carcinoma 10,637 | 11,192
ovarian cancer 8,155 | 8,297
osteosarcoma 7,563 | 7,766
psoriasis 6,170 | 6,514
medulloblastoma, large-cell 5,974 | 6,086
glioblastoma 5,568 | 5,635
atypical teratoid / rhabdoid tumor 4,911 | 4,971
lung cancer 4,517 | 4,607
ependymoma 4,512 | 4,559
group 3 medulloblastoma 3,953 | 4,002
adult high grade glioma 3,642 | 3,701
Breast cancer 3,423 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,158 | 3,204
malignant mesothelioma 3,094 | 3,135
Astrocytoma, Pilocytic 2,975 | 3,006
primitive neuroectodermal tumor 2,927 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,865 | 2,902
invasive ductal carcinoma 2,842 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,838 | 2,872
non-small cell lung cancer 2,765 | 2,799
oligodendroglioma 2,735 | 2,768
lung carcinoma 2,710 | 2,755
lung adenocarcinoma 2,581 | 2,627
astrocytic glioma 2,501 | 2,530
Kidney cancer 2,490 | 2,548
pancreatic cancer 2,287 | 2,322
Cancer 2,237 | 2,388
subependymal giant cell astrocytoma 2,203 | 2,230
interstitial cystitis 2,187 | 2,237
tuberculosis 1,903 | 1,963
pituitary cancer 1,890 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,884 | 1,911
Pick disease 1,839 | 1,856
group 4 medulloblastoma 1,784 | 1,806
ulcerative colitis 1,724 | 1,765
ductal carcinoma in situ 1,672 | 1,686
cystic fibrosis 1,606 | 1,629
breast carcinoma 1,568 | 1,589
diabetes mellitus 1,462 | 1,683
colon cancer 1,403 | 1,428
Autosomal recessive predisposition 1,381 | 1,407
adrenocortical carcinoma 1,375 | 1,385
Multiple myeloma 1,276 | 1,296
juvenile dermatomyositis 1,136 | 1,147
acute quadriplegic myopathy 1,125 | 1,133
astrocytoma 1,100 | 1,113
Schizophrenia 1,096 | 1,136
Rheumatoid arthritis 1,086 | 1,156
primary pancreatic ductal adenocarcinoma 1,065 | 1,071
spina bifida 1,039 | 1,053
pediatric high grade glioma 1,023 | 1,035
nasopharyngeal carcinoma 1,010 | 1,024
cutaneous lupus erythematosus 1,000 | 1,016
Intellectual disability 986 | 998
dermatomyositis 899 | 941
Atopic dermatitis 873 | 915
active Crohn's disease 865 | 882
non primary Sjogren syndrome sicca 843 | 861
gastric carcinoma 768 | 781
Epilepsy 766 | 775
acute myeloid leukemia 758 | 760
Waldenstrons macroglobulinemia 739 | 742
Liver Cirrhosis, Experimental 723 | 733
active ulcerative colitis 719 | 736
primary Sjogren syndrome 696 | 710
medulloblastoma 688 | 702
esophageal adenocarcinoma 684 | 696
Melanoma 662 | 689
progressive supranuclear palsy 647 | 656
aldosterone-producing adenoma 644 | 646
Obesity 636 | 655
Dull intelligence 629 | 634
Low intelligence 629 | 634
Mental Retardation 629 | 634
Mental deficiency 629 | 634
Poor school performance 629 | 634
Bipolar Disorder 626 | 646
Alzheimer's disease 621 | 640
Cognitive delay 591 | 596
Global developmental delay 591 | 596
Mental and motor retardation 591 | 596
Seizures 581 | 584
Duchenne muscular dystrophy 578 | 587
Liver cancer 572 | 589
Muscle hypotonia 558 | 562
pancreatic carcinoma 548 | 555
fibroadenoma 535 | 538
hepatocellular carcinoma 531 | 536
Endometriosis 518 | 521
Short stature 503 | 514
chronic rhinosinusitis 501 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 492
Multiple Sclerosis 483 | 527
Down syndrome 470 | 480
Prostatic Neoplasms 462 | 472
mucosa-associated lymphoid tissue lymphoma 457 | 473
sonic hedgehog group medulloblastoma 453 | 459
posterior fossa group A ependymoma 451 | 456
Skin cancer 439 | 451
gastric cancer 439 | 445

Tissue

Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 10,630 | 12,091
Enzyme 3,969 | 4,145
Transcription Factor 1,355 | 1,400
Kinase 628 | 634
Transporter 452 | 473
GPCR 358 | 408
Ion Channel 333 | 344
Epigenetic 241 | 242
oGPCR 109 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116