Development Level

Tbio 11,042 | 11,445
Tdark 4,951 | 6,588
Tchem 1,565 | 1,598
Tclin 601 | 613

Collection

RFA-RM-18-021 305 | 328
Kinase: IDG Consortium (Target... 123 | 125
GPCR: IDG Consortium (Targets) 97 | 126
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 971 | 979
preweaning lethality, incomple... 496 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 277 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 218 | 220
enlarged heart 206 | 210
decreased total body fat amoun... 203 | 207
decreased vertical activity 196 | 208
abnormal bone structure 181 | 187
increased lean body mass 168 | 172
abnormal heart morphology 159 | 162
decreased body weight 159 | 161
decreased bone mineral content 150 | 151
hyperactivity 146 | 148
decreased lean body mass 132 | 135
hypoactivity 129 | 132
increased total body fat amoun... 129 | 134
decreased circulating glucose ... 126 | 126
decreased bone mineral density 124 | 126
increased circulating alkaline... 120 | 122
male infertility 120 | 123
decreased grip strength 113 | 116
abnormal seminal vesicle morph... 112 | 114
increased startle reflex 107 | 112
increased bone mineral content 106 | 108
embryonic growth retardation 105 | 106
decreased body length 100 | 101
increased or absent threshold ... 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 93 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 89 | 92
prenatal lethality prior to he... 87 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
decreased circulating triglyce... 79 | 79
abnormal lens morphology 78 | 81
improved glucose tolerance 78 | 79
decreased mean corpuscular vol... 77 | 79
increased circulating HDL chol... 76 | 80
decreased startle reflex 74 | 75
increased fasted circulating g... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
decreased circulating insulin ... 71 | 76
increased bone mineral density 71 | 72
increased circulating sodium l... 70 | 71
small superior vagus ganglion 70 | 74
abnormal sleep behavior 69 | 70
abnormal gait 68 | 69
abnormal retina morphology 68 | 71
abnormal eye morphology 67 | 68
decreased hemoglobin content 67 | 68
decreased circulating HDL chol... 66 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 64 | 65
increased monocyte cell number 63 | 63
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 61 | 62
increased heart weight 59 | 62
edema 58 | 59
female infertility 57 | 60
small testis 57 | 58
abnormal spleen morphology 55 | 55
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 53 | 53
hydrometra 51 | 53
abnormal skin morphology 50 | 50
decreased blood urea nitrogen ... 50 | 51
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 49 | 50
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 45 | 46
decreased hematocrit 45 | 46
increased hemoglobin content 44 | 45
increased mean platelet volume 44 | 45
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
abnormal testis morphology 41 | 43
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
increased circulating chloride... 40 | 41
limb grasping 40 | 41
increased erythrocyte cell num... 39 | 39
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
tremors 37 | 39

Disease

Carcinoma 10,923 | 11,493
ovarian cancer 8,376 | 8,520
osteosarcoma 7,744 | 7,950
psoriasis 6,341 | 6,694
medulloblastoma, large-cell 6,127 | 6,241
glioblastoma 5,723 | 5,792
atypical teratoid / rhabdoid tumor 5,051 | 5,112
lung cancer 4,646 | 4,740
ependymoma 4,629 | 4,679
group 3 medulloblastoma 4,053 | 4,104
adult high grade glioma 3,739 | 3,801
Breast cancer 3,529 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,243 | 3,291
malignant mesothelioma 3,190 | 3,232
Astrocytoma, Pilocytic 3,049 | 3,081
primitive neuroectodermal tumor 3,004 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,949 | 2,989
invasive ductal carcinoma 2,926 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,918 | 2,955
non-small cell lung cancer 2,856 | 2,890
oligodendroglioma 2,816 | 2,850
lung carcinoma 2,798 | 2,843
lung adenocarcinoma 2,669 | 2,716
astrocytic glioma 2,568 | 2,597
Kidney cancer 2,553 | 2,613
pancreatic cancer 2,362 | 2,398
Cancer 2,345 | 2,499
interstitial cystitis 2,262 | 2,312
subependymal giant cell astrocytoma 2,257 | 2,287
tuberculosis 1,950 | 2,010
pituitary cancer 1,947 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,934 | 1,962
Pick disease 1,876 | 1,894
group 4 medulloblastoma 1,832 | 1,855
ulcerative colitis 1,777 | 1,819
ductal carcinoma in situ 1,731 | 1,745
cystic fibrosis 1,671 | 1,696
breast carcinoma 1,617 | 1,638
diabetes mellitus 1,507 | 1,728
colon cancer 1,450 | 1,478
adrenocortical carcinoma 1,417 | 1,428
Autosomal recessive predisposition 1,416 | 1,442
Multiple myeloma 1,312 | 1,332
juvenile dermatomyositis 1,176 | 1,187
acute quadriplegic myopathy 1,150 | 1,158
astrocytoma 1,131 | 1,146
Rheumatoid arthritis 1,121 | 1,191
Schizophrenia 1,119 | 1,160
primary pancreatic ductal adenocarcinoma 1,103 | 1,109
spina bifida 1,060 | 1,074
pediatric high grade glioma 1,052 | 1,064
nasopharyngeal carcinoma 1,043 | 1,058
cutaneous lupus erythematosus 1,040 | 1,057
Intellectual disability 1,004 | 1,016
dermatomyositis 924 | 966
Atopic dermatitis 908 | 952
active Crohn's disease 904 | 922
non primary Sjogren syndrome sicca 872 | 891
gastric carcinoma 793 | 807
Epilepsy 783 | 792
acute myeloid leukemia 781 | 783
Waldenstrons macroglobulinemia 762 | 765
Liver Cirrhosis, Experimental 758 | 769
active ulcerative colitis 745 | 764
esophageal adenocarcinoma 725 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 706 | 720
Melanoma 682 | 711
progressive supranuclear palsy 665 | 676
aldosterone-producing adenoma 662 | 665
Obesity 658 | 678
Bipolar Disorder 645 | 666
Dull intelligence 640 | 645
Low intelligence 640 | 645
Mental Retardation 640 | 645
Mental deficiency 640 | 645
Poor school performance 640 | 645
Alzheimer's disease 639 | 658
Cognitive delay 603 | 608
Global developmental delay 603 | 608
Mental and motor retardation 603 | 608
Seizures 593 | 596
Duchenne muscular dystrophy 592 | 601
Liver cancer 586 | 604
Muscle hypotonia 567 | 571
fibroadenoma 556 | 559
pancreatic carcinoma 555 | 562
hepatocellular carcinoma 542 | 547
Endometriosis 537 | 540
Short stature 520 | 531
chronic rhinosinusitis 508 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 506 | 510
Multiple Sclerosis 495 | 540
Down syndrome 488 | 499
Prostatic Neoplasms 485 | 495
mucosa-associated lymphoid tissue lymphoma 467 | 484
posterior fossa group A ependymoma 463 | 468
sonic hedgehog group medulloblastoma 461 | 467
Skin cancer 455 | 469
gastric cancer 453 | 459

Tissue

Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 10,630 | 12,091
Enzyme 3,969 | 4,145
Transcription Factor 1,355 | 1,400
Kinase 628 | 634
Transporter 452 | 473
GPCR 358 | 408
Ion Channel 333 | 344
Epigenetic 241 | 242
oGPCR 109 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93