Development Level

Tbio 10,388 | 10,625
Tdark 5,656 | 7,003
Tchem 1,873 | 1,890
Tclin 595 | 602

Collection

Eligible Kinase Proteins 132 | 134
Eligible non-olfactory GPCR Proteins 126 | 145
Eligible Ion Channel Proteins 113 | 117

IMPC Term

preweaning lethality, complete... 631 | 633
preweaning lethality, incomple... 258 | 260
abnormal behavior 225 | 226
decreased lean body mass 193 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 185 | 186
decreased body weight 171 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 129 | 131
increased or absent threshold ... 126 | 128
decreased bone mineral density 124 | 126
decreased circulating glucose ... 121 | 121
decreased grip strength 120 | 123
increased circulating alkaline... 117 | 119
abnormal embryo size 112 | 112
enlarged heart 110 | 111
decreased body length 107 | 108
hyperactivity 107 | 108
increased lean body mass 105 | 107
abnormal retina morphology 99 | 100
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
hypoactivity 89 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 82 | 83
short tibia 81 | 82
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 76 | 77
abnormal lens morphology 73 | 73
decreased circulating insulin ... 73 | 75
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 63 | 64
abnormal sleep behavior 62 | 63
increased circulating HDL chol... 62 | 63
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 61 | 62
male infertility 61 | 62
abnormal retinal pigmentation 60 | 61
decreased rib number 59 | 59
increased exploration in new e... 56 | 56
increased total body fat amoun... 56 | 57
improved glucose tolerance 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 53 | 54
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
abnormal bone mineralization 52 | 55
decreased hemoglobin content 52 | 53
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
impaired glucose tolerance 51 | 52
increased bone mineral density 51 | 52
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 46 | 47
decreased heart weight 44 | 44
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
decreased circulating alkaline... 38 | 41
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased leukocyte cell numbe... 37 | 37
increased heart weight 36 | 37
increased hematocrit 36 | 36
small testis 36 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 34 | 35
decreased circulating calcium ... 33 | 33
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
tremors 32 | 34
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
decreased threshold for audito... 31 | 32
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
abnormal epididymis morphology 30 | 31
decreased T cell number 30 | 31

Disease

ovarian cancer 8,384 | 8,492
osteosarcoma 7,787 | 7,933
psoriasis 6,459 | 6,685
medulloblastoma, large-cell 6,145 | 6,234
glioblastoma 5,505 | 5,572
lung cancer 4,428 | 4,473
atypical teratoid / rhabdoid tumor 4,317 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,249 | 3,289
malignant mesothelioma 3,130 | 3,163
Breast cancer 3,065 | 3,099
pilocytic astrocytoma 3,051 | 3,086
primitive neuroectodermal tumor 2,998 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,952 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,927 | 2,956
invasive ductal carcinoma 2,921 | 2,950
oligodendroglioma 2,824 | 2,849
lung carcinoma 2,799 | 2,844
non-small cell lung cancer 2,775 | 2,798
pediatric high grade glioma 2,682 | 2,712
lung adenocarcinoma 2,677 | 2,714
ependymoma 2,487 | 2,514
pancreatic cancer 2,282 | 2,300
interstitial cystitis 2,273 | 2,299
subependymal giant cell astrocytoma 2,256 | 2,287
group 3 medulloblastoma 2,224 | 2,254
Cancer 2,223 | 2,346
astrocytic glioma 2,218 | 2,241
Carcinoma 2,114 | 2,147
adult high grade glioma 2,111 | 2,148
ulcerative colitis 2,066 | 2,087
pituitary cancer 1,952 | 1,972
Pick disease 1,880 | 1,893
group 4 medulloblastoma 1,851 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,783 | 1,795
ductal carcinoma in situ 1,729 | 1,745
cystic fibrosis 1,653 | 1,670
breast carcinoma 1,597 | 1,614
tuberculosis 1,542 | 1,563
diabetes mellitus 1,518 | 1,663
posterior fossa group B ependymoma 1,511 | 1,530
medulloblastoma 1,506 | 1,524
posterior fossa group A ependymoma 1,493 | 1,511
astrocytoma 1,479 | 1,493
sonic hedgehog group medulloblastoma 1,470 | 1,482
colon cancer 1,456 | 1,475
adrenocortical carcinoma 1,415 | 1,427
Multiple myeloma 1,325 | 1,328
primary pancreatic ductal adenocarcinoma 1,269 | 1,271
juvenile dermatomyositis 1,183 | 1,189
acute quadriplegic myopathy 1,152 | 1,157
Rheumatoid Arthritis 1,116 | 1,171
atypical teratoid/rhabdoid tumor 1,081 | 1,095
spina bifida 1,056 | 1,064
nasopharyngeal carcinoma 1,044 | 1,056
cutaneous lupus erythematosus 1,043 | 1,056
dermatomyositis 931 | 967
Atopic dermatitis 915 | 944
active Crohn's disease 906 | 918
gastric carcinoma 823 | 832
non primary Sjogren syndrome sicca 821 | 840
acute myeloid leukemia 780 | 785
primary Sjogren syndrome 779 | 789
Waldenstrons macroglobulinemia 764 | 765
esophageal adenocarcinoma 732 | 737
tuberculosis and treatment for 6 months 681 | 686
progressive supranuclear palsy 667 | 674
aldosterone-producing adenoma 660 | 664
Alzheimer's disease 634 | 644
Obesity 610 | 616
Duchenne muscular dystrophy 596 | 602
Intellectual disability 565 | 573
pancreatic carcinoma 563 | 567
fibroadenoma 552 | 557
hepatocellular carcinoma 545 | 550
Down syndrome 539 | 548
Endometriosis 528 | 535
chronic rhinosinusitis 507 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 499
Schizophrenia 491 | 503
mucosa-associated lymphoid tissue lymphoma 471 | 480
active ulcerative colitis 468 | 477
Prostatic Neoplasms 466 | 471
Multiple Sclerosis 463 | 498
IGA Glomerulonephritis 451 | 454
Amyotrophic Lateral Sclerosis 430 | 432
gastric cancer 429 | 436
Mammary Neoplasms 407 | 410
non-small cell lung carcinoma 405 | 413
inflammatory breast cancer 395 | 404
Neurodegenerative disease 379 | 383
Kidney disease 371 | 397
Parkinson's disease 361 | 364
sarcoidosis 353 | 368
glioblastoma multiforme 344 | 347
Asthma 341 | 349
Epilepsy 341 | 346
Polycystic Ovary Syndrome 328 | 335
nephrosclerosis 327 | 329
tuberculosis and treatment for 3 months 324 | 327
Autistic Disorder 316 | 320

Tissue

Endocrine System 18,512 | 18,512
Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 10,762 | 11,969
Enzyme 3,994 | 4,146
Transcription Factor 1,382 | 1,400
Kinase 628 | 634
Transporter 463 | 473
GPCR 382 | 408
Ion Channel 335 | 341
Epigenetic 241 | 242
oGPCR 240 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101