Development Level

Tbio 10,402 | 10,625
Tdark 5,600 | 7,003
Tchem 1,874 | 1,890
Tclin 596 | 602

Collection

Kinase: IDG Consortium (Targets) 123 | 125
GPCR: IDG Consortium (Targets) 117 | 128
Ion Channel: IDG Consortium (Targets) 101 | 102
Kinase: IDG Consortium (Complete/Control) 37 | 37
GPCR: IDG Consortium (Complete/Control) 23 | 24

IMPC Phenotype

preweaning lethality, complete... 631 | 633
preweaning lethality, incomple... 257 | 260
abnormal behavior 225 | 226
decreased lean body mass 194 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 184 | 186
decreased body weight 173 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 130 | 131
increased or absent threshold ... 127 | 128
decreased bone mineral density 125 | 126
decreased grip strength 122 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 118 | 119
abnormal embryo size 110 | 112
enlarged heart 110 | 111
decreased body length 108 | 108
hyperactivity 107 | 108
increased lean body mass 105 | 107
abnormal retina morphology 100 | 100
increased bone mineral content 91 | 92
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 82 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 74 | 75
abnormal lens morphology 72 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 67 | 68
increased circulating HDL chol... 63 | 63
abnormal sleep behavior 62 | 63
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 61 | 62
male infertility 61 | 62
abnormal retinal pigmentation 60 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 55 | 56
abnormal coat-hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
abnormal bone mineralization 53 | 55
increased circulating choleste... 53 | 53
decreased hemoglobin content 52 | 53
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal behavioral response t... 51 | 52
abnormal heart morphology 51 | 51
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
abnormal gait 50 | 51
decreased mean corpuscular vol... 50 | 50
decreased fasted circulating g... 49 | 49
decreased caudal vertebrae num... 48 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 46 | 47
increased hemoglobin content 45 | 45
thrombocytopenia 45 | 46
decreased heart weight 44 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating total pr... 40 | 41
decreased circulating alkaline... 39 | 41
decreased circulating free fat... 39 | 39
increased startle reflex 38 | 38
abnormal eye morphology 37 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
small testis 37 | 37
increased heart weight 36 | 37
increased hematocrit 36 | 36
increased leukocyte cell numbe... 36 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 34 | 35
decreased circulating calcium ... 33 | 33
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
tremors 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
increased circulating calcium ... 32 | 32
decreased blood urea nitrogen ... 31 | 31
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
abnormal epididymis morphology 30 | 31
decreased T cell number 30 | 31

Disease

ovarian cancer 8,396 | 8,491
osteosarcoma 7,794 | 7,933
psoriasis 6,494 | 6,685
medulloblastoma, large-cell 6,160 | 6,234
glioblastoma 5,517 | 5,572
lung cancer 4,434 | 4,473
atypical teratoid / rhabdoid tumor 4,329 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,258 | 3,289
malignant mesothelioma 3,133 | 3,163
Breast cancer 3,073 | 3,098
pilocytic astrocytoma 3,059 | 3,086
primitive neuroectodermal tumor 3,008 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,962 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,932 | 2,956
invasive ductal carcinoma 2,926 | 2,950
oligodendroglioma 2,829 | 2,849
lung carcinoma 2,808 | 2,844
non-small cell lung cancer 2,777 | 2,798
pediatric high grade glioma 2,687 | 2,712
lung adenocarcinoma 2,686 | 2,714
ependymoma 2,496 | 2,514
pancreatic cancer 2,287 | 2,300
interstitial cystitis 2,276 | 2,299
subependymal giant cell astrocytoma 2,262 | 2,287
Cancer 2,227 | 2,346
group 3 medulloblastoma 2,227 | 2,254
astrocytic glioma 2,219 | 2,241
Carcinoma 2,122 | 2,147
adult high grade glioma 2,119 | 2,148
ulcerative colitis 2,071 | 2,087
pituitary cancer 1,953 | 1,972
Pick disease 1,885 | 1,893
group 4 medulloblastoma 1,858 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,783 | 1,795
ductal carcinoma in situ 1,732 | 1,745
cystic fibrosis 1,656 | 1,670
breast carcinoma 1,601 | 1,614
tuberculosis 1,547 | 1,563
diabetes mellitus 1,515 | 1,663
posterior fossa group B ependymoma 1,514 | 1,530
medulloblastoma 1,507 | 1,524
posterior fossa group A ependymoma 1,493 | 1,511
astrocytoma 1,485 | 1,493
sonic hedgehog group medulloblastoma 1,470 | 1,482
colon cancer 1,462 | 1,475
adrenocortical carcinoma 1,417 | 1,427
Multiple myeloma 1,322 | 1,327
primary pancreatic ductal adenocarcinoma 1,270 | 1,271
juvenile dermatomyositis 1,183 | 1,189
acute quadriplegic myopathy 1,152 | 1,157
Rheumatoid Arthritis 1,118 | 1,170
atypical teratoid/rhabdoid tumor 1,084 | 1,095
spina bifida 1,056 | 1,064
nasopharyngeal carcinoma 1,048 | 1,056
cutaneous lupus erythematosus 1,046 | 1,056
Atopic dermatitis 936 | 944
dermatomyositis 929 | 966
active Crohn's disease 910 | 918
gastric carcinoma 824 | 832
non primary Sjogren syndrome sicca 823 | 840
acute myeloid leukemia 781 | 785
primary Sjogren syndrome 780 | 788
Waldenstrons macroglobulinemia 763 | 764
esophageal adenocarcinoma 734 | 737
tuberculosis and treatment for 6 months 681 | 686
progressive supranuclear palsy 669 | 674
aldosterone-producing adenoma 662 | 664
Alzheimer's disease 633 | 644
Obesity 610 | 616
Duchenne muscular dystrophy 596 | 602
Intellectual disability 570 | 573
pancreatic carcinoma 564 | 567
fibroadenoma 553 | 557
hepatocellular carcinoma 545 | 550
Down syndrome 540 | 548
Endometriosis 531 | 535
chronic rhinosinusitis 507 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 499
Schizophrenia 493 | 503
mucosa-associated lymphoid tissue lymphoma 474 | 480
active ulcerative colitis 470 | 477
Prostatic Neoplasms 468 | 471
Multiple Sclerosis 464 | 498
IGA Glomerulonephritis 452 | 454
Amyotrophic Lateral Sclerosis 430 | 432
gastric cancer 429 | 436
non-small cell lung carcinoma 408 | 413
Mammary Neoplasms 407 | 410
inflammatory breast cancer 395 | 404
Neurodegenerative disease 380 | 383
Kidney disease 372 | 397
Parkinson's disease 360 | 364
sarcoidosis 354 | 368
glioblastoma multiforme 344 | 347
Asthma 343 | 349
Epilepsy 341 | 346
Polycystic Ovary Syndrome 330 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 324 | 327
urothelial carcinoma 315 | 318

Tissue

Digestive Tract 18,472 | 18,472
Female tissues 18,646 | 18,646
Nervous System 18,560 | 18,560
Endocrine System 18,511 | 18,511
Urinary Tract 18,443 | 18,443
Liver and Pancreas 18,135 | 18,135
Skin and soft tissues 18,114 | 18,114
Blood and immune system 17,994 | 17,994
Male tissues 17,968 | 17,968
Cardiovascular System 17,957 | 17,957
Respiratory system 17,483 | 17,483

Target Family

Non-IDG 10,739 | 11,969
Enzyme 4,011 | 4,146
Transcription Factor 1,379 | 1,400
Kinase 627 | 634
Transporter 461 | 473
GPCR 381 | 408
Ion Channel 336 | 341
Epigenetic 240 | 242
oGPCR 213 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Interleukin-9 IL9 Tbio Non-IDG -2.46520 301.6 339
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74