Development Level

Tbio 10,238 | 10,625
Tdark 5,287 | 7,003
Tchem 1,846 | 1,890
Tclin 587 | 602

Collection

Eligible Kinase Proteins 131 | 134
Eligible non-olfactory GPCR Proteins 115 | 143
Eligible Ion Channel Proteins 107 | 117

IMPC Term

preweaning lethality, complete... 630 | 633
preweaning lethality, incomple... 258 | 260
abnormal behavior 223 | 226
decreased lean body mass 193 | 195
decreased total body fat amoun... 186 | 186
embryonic lethality prior to t... 186 | 187
decreased body weight 171 | 174
decreased bone mineral content 156 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 129 | 131
increased or absent threshold ... 126 | 128
decreased bone mineral density 123 | 126
decreased circulating glucose ... 121 | 121
decreased grip strength 118 | 123
increased circulating alkaline... 118 | 119
abnormal embryo size 110 | 112
decreased body length 108 | 108
enlarged heart 108 | 111
hyperactivity 106 | 108
increased lean body mass 105 | 107
abnormal retina morphology 98 | 100
increased bone mineral content 92 | 92
increased mean corpuscular hem... 92 | 93
increased mean corpuscular vol... 91 | 91
hypoactivity 88 | 89
decreased circulating choleste... 84 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 82 | 83
short tibia 81 | 82
decreased circulating serum al... 78 | 79
decreased circulating HDL chol... 76 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 72 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 67 | 68
abnormal sleep behavior 62 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
prenatal lethality prior to he... 62 | 64
abnormal retinal pigmentation 60 | 61
increased circulating HDL chol... 60 | 63
decreased rib number 59 | 59
increased exploration in new e... 56 | 56
improved glucose tolerance 55 | 56
increased total body fat amoun... 55 | 57
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
abnormal behavioral response t... 52 | 52
abnormal bone mineralization 52 | 55
decreased circulating alanine ... 52 | 53
decreased hemoglobin content 51 | 53
impaired glucose tolerance 51 | 52
increased bone mineral density 51 | 52
increased circulating choleste... 51 | 53
abnormal gait 50 | 51
abnormal heart morphology 50 | 51
decreased mean corpuscular vol... 50 | 50
decreased prepulse inhibition 50 | 52
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
abnormal seminal vesicle morph... 45 | 47
thrombocytopenia 45 | 46
increased hemoglobin content 44 | 45
decreased heart weight 43 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating alkaline... 38 | 41
increased startle reflex 38 | 38
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 37 | 37
abnormal neural tube closure 36 | 37
decreased neutrophil cell numb... 36 | 37
increased heart weight 36 | 37
increased hematocrit 36 | 36
increased leukocyte cell numbe... 36 | 37
small testis 36 | 37
abnormal spleen morphology 34 | 36
cardiovascular system phenotyp... 34 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
limb grasping 34 | 35
tremors 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
decreased circulating chloride... 32 | 32
decreased T cell number 31 | 31
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased blood urea nitrogen ... 30 | 31
decreased threshold for audito... 30 | 32

Disease

ovarian cancer 8,343 | 8,484
osteosarcoma 7,750 | 7,933
psoriasis 6,368 | 6,685
medulloblastoma, large-cell 6,118 | 6,234
glioblastoma 5,502 | 5,572
lung cancer 4,412 | 4,466
atypical teratoid / rhabdoid tumor 4,312 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,248 | 3,289
malignant mesothelioma 3,123 | 3,162
Breast cancer 3,058 | 3,094
pilocytic astrocytoma 3,049 | 3,086
primitive neuroectodermal tumor 3,001 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,951 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,923 | 2,956
invasive ductal carcinoma 2,918 | 2,950
oligodendroglioma 2,820 | 2,849
lung carcinoma 2,787 | 2,844
non-small cell lung cancer 2,768 | 2,798
pediatric high grade glioma 2,682 | 2,712
lung adenocarcinoma 2,666 | 2,713
ependymoma 2,487 | 2,514
pancreatic cancer 2,275 | 2,300
interstitial cystitis 2,269 | 2,299
subependymal giant cell astrocytoma 2,256 | 2,287
group 3 medulloblastoma 2,221 | 2,254
astrocytic glioma 2,213 | 2,241
Cancer 2,190 | 2,346
Carcinoma 2,098 | 2,147
adult high grade glioma 2,096 | 2,148
ulcerative colitis 2,058 | 2,087
pituitary cancer 1,946 | 1,972
Pick disease 1,879 | 1,893
group 4 medulloblastoma 1,849 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,778 | 1,795
ductal carcinoma in situ 1,728 | 1,745
cystic fibrosis 1,642 | 1,665
breast carcinoma 1,594 | 1,614
tuberculosis 1,534 | 1,557
posterior fossa group B ependymoma 1,508 | 1,530
medulloblastoma 1,505 | 1,524
posterior fossa group A ependymoma 1,491 | 1,511
astrocytoma 1,480 | 1,493
sonic hedgehog group medulloblastoma 1,467 | 1,482
colon cancer 1,453 | 1,475
diabetes mellitus 1,450 | 1,663
adrenocortical carcinoma 1,414 | 1,427
Multiple myeloma 1,323 | 1,327
primary pancreatic ductal adenocarcinoma 1,269 | 1,271
juvenile dermatomyositis 1,181 | 1,189
acute quadriplegic myopathy 1,152 | 1,157
Rheumatoid Arthritis 1,103 | 1,160
atypical teratoid/rhabdoid tumor 1,080 | 1,095
spina bifida 1,056 | 1,064
nasopharyngeal carcinoma 1,041 | 1,056
cutaneous lupus erythematosus 1,039 | 1,056
dermatomyositis 928 | 933
Atopic dermatitis 919 | 944
active Crohn's disease 899 | 918
gastric carcinoma 821 | 832
non primary Sjogren syndrome sicca 815 | 840
primary Sjogren syndrome 777 | 789
acute myeloid leukemia 771 | 780
Waldenstrons macroglobulinemia 763 | 765
esophageal adenocarcinoma 731 | 737
tuberculosis and treatment for 6 months 680 | 686
progressive supranuclear palsy 668 | 674
aldosterone-producing adenoma 661 | 664
Alzheimer's disease 629 | 644
Obesity 597 | 616
Duchenne muscular dystrophy 595 | 602
Intellectual disability 564 | 573
pancreatic carcinoma 562 | 567
fibroadenoma 552 | 557
Down syndrome 538 | 548
Endometriosis 526 | 535
hepatocellular carcinoma 526 | 532
chronic rhinosinusitis 506 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 499
Schizophrenia 482 | 501
mucosa-associated lymphoid tissue lymphoma 470 | 480
active ulcerative colitis 468 | 477
Prostatic Neoplasms 464 | 471
Multiple Sclerosis 456 | 498
IGA Glomerulonephritis 449 | 454
Amyotrophic Lateral Sclerosis 429 | 431
gastric cancer 423 | 430
Mammary Neoplasms 404 | 410
non-small cell lung carcinoma 402 | 413
inflammatory breast cancer 393 | 404
Neurodegenerative disease 380 | 383
Kidney disease 366 | 396
Parkinson's disease 359 | 364
sarcoidosis 349 | 358
glioblastoma multiforme 343 | 347
Epilepsy 335 | 346
Asthma 330 | 349
Polycystic Ovary Syndrome 326 | 332
nephrosclerosis 325 | 329
tuberculosis and treatment for 3 months 324 | 327
urothelial carcinoma 313 | 318

Tissue

Cardiovascular System 17,958 | 17,958
Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 10,466 | 11,971
Enzyme 3,963 | 4,146
Transcription Factor 1,340 | 1,400
Kinase 625 | 634
Transporter 455 | 473
GPCR 357 | 406
Ion Channel 328 | 341
Epigenetic 237 | 242
oGPCR 103 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102