Development Level

Tbio 9,704 | 11,445
Tdark 3,637 | 6,588
Tchem 1,371 | 1,598
Tclin 480 | 613

Collection

RFA-RM-18-021 231 | 328
Kinase: IDG Consortium (Target... 111 | 125
Ion Channel: IDG Consortium (T... 60 | 99
GPCR: IDG Consortium (Targets) 59 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 443 | 499
embryonic lethality prior to t... 269 | 278
abnormal behavior 268 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 206 | 220
decreased total body fat amoun... 188 | 207
enlarged heart 176 | 210
abnormal bone structure 165 | 187
decreased vertical activity 163 | 208
increased lean body mass 157 | 172
decreased body weight 145 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 137 | 151
hyperactivity 132 | 148
decreased lean body mass 123 | 135
increased total body fat amoun... 119 | 134
hypoactivity 114 | 132
decreased bone mineral density 111 | 126
decreased circulating glucose ... 109 | 126
increased circulating alkaline... 106 | 122
decreased grip strength 103 | 116
embryonic growth retardation 101 | 106
abnormal seminal vesicle morph... 99 | 114
increased startle reflex 98 | 112
male infertility 98 | 123
increased bone mineral content 97 | 108
decreased body length 91 | 101
increased mean corpuscular vol... 90 | 92
short tibia 89 | 97
increased or absent threshold ... 87 | 101
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 85 | 96
cataract 82 | 92
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 75 | 83
abnormal lens morphology 73 | 81
decreased circulating serum al... 73 | 82
decreased prepulse inhibition 72 | 82
decreased circulating triglyce... 71 | 79
decreased mean corpuscular vol... 70 | 79
improved glucose tolerance 70 | 79
increased bone mineral density 70 | 72
decreased startle reflex 68 | 75
decreased leukocyte cell numbe... 67 | 73
impaired glucose tolerance 66 | 75
increased circulating HDL chol... 66 | 80
increased fasted circulating g... 65 | 76
abnormal retina morphology 64 | 71
decreased circulating HDL chol... 63 | 68
decreased circulating insulin ... 63 | 76
abnormal eye morphology 61 | 68
abnormal gait 61 | 69
abnormal sleep behavior 60 | 70
small superior vagus ganglion 60 | 74
decreased fasted circulating g... 59 | 65
increased circulating sodium l... 59 | 71
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
decreased hemoglobin content 58 | 68
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
increased monocyte cell number 57 | 63
edema 55 | 59
increased circulating choleste... 55 | 66
increased heart weight 53 | 62
decreased caudal vertebrae num... 51 | 53
small testis 50 | 58
thrombocytopenia 50 | 56
female infertility 49 | 60
decreased circulating total pr... 48 | 49
abnormal spleen morphology 47 | 55
abnormal skin morphology 45 | 50
decreased mean corpuscular hem... 45 | 50
increased hematocrit 44 | 46
abnormal neural tube closure 43 | 46
decreased blood urea nitrogen ... 43 | 51
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 43 | 46
decreased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
hydrometra 41 | 53
decreased neutrophil cell numb... 40 | 42
increased blood urea nitrogen ... 40 | 48
increased leukocyte cell numbe... 40 | 47
increased hemoglobin content 39 | 45
abnormal testis morphology 37 | 43
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
enlarged spleen 37 | 41
increased circulating triglyce... 37 | 42
increased mean platelet volume 37 | 45
tremors 36 | 39
increased circulating chloride... 35 | 41
increased erythrocyte cell num... 35 | 39
abnormal bone mineralization 34 | 38
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased grip strength 34 | 41
pallor 33 | 34

Disease

Carcinoma 9,316 | 11,493
ovarian cancer 7,975 | 8,520
osteosarcoma 7,251 | 7,950
medulloblastoma, large-cell 5,607 | 6,241
psoriasis 5,410 | 6,694
glioblastoma 5,298 | 5,792
atypical teratoid / rhabdoid tumor 4,647 | 5,112
lung cancer 4,375 | 4,740
ependymoma 4,195 | 4,679
group 3 medulloblastoma 3,733 | 4,104
adult high grade glioma 3,360 | 3,801
Breast cancer 3,279 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,091 | 3,291
malignant mesothelioma 3,027 | 3,232
invasive ductal carcinoma 2,829 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,818 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,781 | 2,955
primitive neuroectodermal tumor 2,771 | 3,035
Astrocytoma, Pilocytic 2,737 | 3,081
non-small cell lung cancer 2,669 | 2,890
oligodendroglioma 2,563 | 2,850
lung carcinoma 2,549 | 2,843
lung adenocarcinoma 2,462 | 2,716
astrocytic glioma 2,352 | 2,597
pancreatic cancer 2,210 | 2,398
Kidney cancer 2,205 | 2,613
subependymal giant cell astrocytoma 2,124 | 2,287
Cancer 2,118 | 2,499
interstitial cystitis 2,103 | 2,312
tuberculosis 1,873 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,836 | 1,962
Pick disease 1,771 | 1,894
pituitary cancer 1,762 | 1,972
group 4 medulloblastoma 1,718 | 1,855
ulcerative colitis 1,671 | 1,819
ductal carcinoma in situ 1,666 | 1,745
breast carcinoma 1,540 | 1,638
cystic fibrosis 1,537 | 1,696
adrenocortical carcinoma 1,363 | 1,428
colon cancer 1,355 | 1,478
Multiple myeloma 1,299 | 1,332
diabetes mellitus 1,288 | 1,728
Autosomal recessive predisposition 1,227 | 1,442
juvenile dermatomyositis 1,157 | 1,187
acute quadriplegic myopathy 1,134 | 1,158
astrocytoma 1,088 | 1,146
primary pancreatic ductal adenocarcinoma 1,070 | 1,109
Rheumatoid arthritis 1,055 | 1,191
pediatric high grade glioma 994 | 1,064
spina bifida 990 | 1,074
cutaneous lupus erythematosus 967 | 1,057
Schizophrenia 940 | 1,160
dermatomyositis 920 | 966
nasopharyngeal carcinoma 916 | 1,058
Intellectual disability 906 | 1,016
active Crohn's disease 829 | 922
Atopic dermatitis 824 | 952
non primary Sjogren syndrome sicca 787 | 891
acute myeloid leukemia 764 | 783
Waldenstrons macroglobulinemia 756 | 765
gastric carcinoma 756 | 807
Liver Cirrhosis, Experimental 709 | 769
primary Sjogren syndrome 705 | 735
Epilepsy 686 | 792
active ulcerative colitis 664 | 764
esophageal adenocarcinoma 656 | 737
medulloblastoma 654 | 720
progressive supranuclear palsy 641 | 676
aldosterone-producing adenoma 637 | 665
Alzheimer's disease 584 | 658
Duchenne muscular dystrophy 580 | 601
Dull intelligence 576 | 645
Low intelligence 576 | 645
Mental Retardation 576 | 645
Mental deficiency 576 | 645
Poor school performance 576 | 645
Cognitive delay 560 | 608
Global developmental delay 560 | 608
Mental and motor retardation 560 | 608
Obesity 554 | 678
pancreatic carcinoma 542 | 562
Bipolar Disorder 534 | 666
hepatocellular carcinoma 530 | 547
fibroadenoma 528 | 559
Melanoma 526 | 711
Muscle hypotonia 525 | 571
Seizures 522 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 503 | 510
Liver cancer 479 | 604
Endometriosis 476 | 540
Short stature 474 | 531
Down syndrome 460 | 499
gastric cancer 445 | 459
mucosa-associated lymphoid tissue lymphoma 440 | 484
chronic rhinosinusitis 439 | 512
Multiple Sclerosis 437 | 540
Prostatic Neoplasms 435 | 495
sonic hedgehog group medulloblastoma 431 | 467
posterior fossa group A ependymoma 424 | 468
Amyotrophic lateral sclerosis 422 | 451

Tissue

Cardiovascular System 15,192 | 15,192
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Blood and immune system 16,909 | 16,909
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393

Target Family

Non-IDG 8,844 | 12,091
Enzyme 3,536 | 4,145
Transcription Factor 1,096 | 1,400
Kinase 581 | 634
Transporter 356 | 473
GPCR 243 | 408
Epigenetic 229 | 242
Ion Channel 221 | 344
Nuclear Receptor 41 | 48
TF/Epigenetic 34 | 38
oGPCR 11 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93