Development Level

Tbio 10,566 | 11,445
Tdark 4,279 | 6,588
Tchem 1,513 | 1,598
Tclin 551 | 613

Collection

RFA-RM-18-021 270 | 328
Kinase: IDG Consortium (Target... 113 | 125
GPCR: IDG Consortium (Targets) 85 | 126
Ion Channel: IDG Consortium (T... 83 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 959 | 979
preweaning lethality, incomple... 476 | 499
abnormal behavior 283 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 214 | 220
enlarged heart 198 | 210
decreased total body fat amoun... 196 | 207
decreased vertical activity 180 | 208
abnormal bone structure 174 | 187
increased lean body mass 161 | 172
abnormal heart morphology 156 | 162
decreased body weight 154 | 161
decreased bone mineral content 142 | 151
hyperactivity 141 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 124 | 134
hypoactivity 123 | 132
decreased bone mineral density 119 | 126
decreased circulating glucose ... 119 | 126
increased circulating alkaline... 115 | 122
male infertility 111 | 123
decreased grip strength 108 | 116
abnormal seminal vesicle morph... 105 | 114
increased startle reflex 105 | 112
embryonic growth retardation 103 | 106
increased bone mineral content 102 | 108
increased or absent threshold ... 97 | 101
decreased body length 96 | 101
short tibia 94 | 97
increased mean corpuscular hem... 91 | 96
increased mean corpuscular vol... 90 | 92
cataract 89 | 92
decreased circulating choleste... 89 | 93
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 81 | 83
decreased circulating serum al... 79 | 82
abnormal lens morphology 77 | 81
decreased circulating triglyce... 75 | 79
decreased prepulse inhibition 75 | 82
increased circulating HDL chol... 74 | 80
decreased mean corpuscular vol... 72 | 79
increased fasted circulating g... 72 | 76
decreased leukocyte cell numbe... 71 | 73
improved glucose tolerance 71 | 79
increased bone mineral density 71 | 72
small superior vagus ganglion 71 | 74
decreased startle reflex 70 | 75
decreased circulating insulin ... 69 | 76
abnormal eye morphology 68 | 68
increased circulating sodium l... 68 | 71
abnormal retina morphology 67 | 71
decreased circulating HDL chol... 66 | 68
impaired glucose tolerance 66 | 75
abnormal gait 65 | 69
abnormal sleep behavior 64 | 70
increased circulating choleste... 64 | 66
abnormal coat-hair pigmentatio... 62 | 64
decreased fasted circulating g... 62 | 65
abnormal behavioral response t... 61 | 66
decreased erythrocyte cell num... 61 | 62
decreased hemoglobin content 61 | 68
increased monocyte cell number 61 | 63
abnormal kidney morphology 59 | 65
increased heart weight 58 | 62
edema 57 | 59
small testis 55 | 58
female infertility 54 | 60
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 53 | 53
abnormal spleen morphology 52 | 55
hydrometra 50 | 53
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal skin morphology 47 | 50
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
increased leukocyte cell numbe... 46 | 47
decreased circulating alanine ... 45 | 47
increased neutrophil cell numb... 45 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 43 | 46
increased hematocrit 43 | 46
increased mean platelet volume 43 | 45
decreased neutrophil cell numb... 42 | 42
abnormal testis morphology 41 | 43
decreased red blood cell distr... 40 | 41
enlarged spleen 40 | 41
increased circulating triglyce... 40 | 42
increased hemoglobin content 40 | 45
increased circulating chloride... 39 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
abnormal cranium morphology 36 | 36
decreased circulating creatini... 36 | 39
increased grip strength 36 | 41
tremors 36 | 39
abnormal epididymis morphology 35 | 42

Disease

Carcinoma 10,221 | 11,493
ovarian cancer 8,237 | 8,520
osteosarcoma 7,618 | 7,950
psoriasis 6,031 | 6,694
medulloblastoma, large-cell 5,931 | 6,241
glioblastoma 5,562 | 5,792
atypical teratoid / rhabdoid tumor 4,895 | 5,112
lung cancer 4,559 | 4,740
ependymoma 4,462 | 4,679
group 3 medulloblastoma 3,945 | 4,104
adult high grade glioma 3,580 | 3,801
Breast cancer 3,465 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,224 | 3,291
malignant mesothelioma 3,154 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,930 | 2,989
Astrocytoma, Pilocytic 2,928 | 3,081
invasive ductal carcinoma 2,912 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,899 | 2,955
primitive neuroectodermal tumor 2,898 | 3,035
non-small cell lung cancer 2,843 | 2,890
lung carcinoma 2,727 | 2,843
oligodendroglioma 2,722 | 2,850
lung adenocarcinoma 2,637 | 2,716
astrocytic glioma 2,477 | 2,597
Kidney cancer 2,387 | 2,613
pancreatic cancer 2,331 | 2,398
Cancer 2,294 | 2,499
interstitial cystitis 2,242 | 2,312
subependymal giant cell astrocytoma 2,197 | 2,287
tuberculosis 1,952 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,904 | 1,962
pituitary cancer 1,892 | 1,972
Pick disease 1,833 | 1,894
group 4 medulloblastoma 1,788 | 1,855
ulcerative colitis 1,763 | 1,819
ductal carcinoma in situ 1,723 | 1,745
cystic fibrosis 1,660 | 1,696
breast carcinoma 1,607 | 1,638
colon cancer 1,437 | 1,478
diabetes mellitus 1,426 | 1,728
adrenocortical carcinoma 1,398 | 1,428
Autosomal recessive predisposition 1,354 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,167 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
astrocytoma 1,118 | 1,146
Rheumatoid arthritis 1,106 | 1,191
primary pancreatic ductal adenocarcinoma 1,093 | 1,109
Schizophrenia 1,057 | 1,160
spina bifida 1,046 | 1,074
pediatric high grade glioma 1,035 | 1,064
cutaneous lupus erythematosus 1,034 | 1,057
nasopharyngeal carcinoma 1,029 | 1,058
Intellectual disability 970 | 1,016
dermatomyositis 921 | 966
Atopic dermatitis 902 | 952
active Crohn's disease 894 | 922
non primary Sjogren syndrome sicca 847 | 891
gastric carcinoma 784 | 807
acute myeloid leukemia 781 | 783
Waldenstrons macroglobulinemia 761 | 765
Epilepsy 750 | 792
Liver Cirrhosis, Experimental 747 | 769
active ulcerative colitis 730 | 764
esophageal adenocarcinoma 729 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 682 | 720
progressive supranuclear palsy 659 | 676
aldosterone-producing adenoma 647 | 665
Obesity 619 | 678
Alzheimer's disease 617 | 658
Dull intelligence 617 | 645
Low intelligence 617 | 645
Mental Retardation 617 | 645
Mental deficiency 617 | 645
Poor school performance 617 | 645
Melanoma 607 | 711
Bipolar Disorder 603 | 666
Cognitive delay 587 | 608
Global developmental delay 587 | 608
Mental and motor retardation 587 | 608
Duchenne muscular dystrophy 586 | 601
Seizures 564 | 596
pancreatic carcinoma 557 | 562
Muscle hypotonia 555 | 571
fibroadenoma 552 | 559
hepatocellular carcinoma 540 | 547
Liver cancer 529 | 604
Endometriosis 521 | 540
Short stature 505 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
chronic rhinosinusitis 491 | 512
Multiple Sclerosis 478 | 540
Down syndrome 475 | 499
Prostatic Neoplasms 472 | 495
mucosa-associated lymphoid tissue lymphoma 472 | 484
gastric cancer 454 | 459
posterior fossa group A ependymoma 453 | 468
sonic hedgehog group medulloblastoma 446 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Blood and immune system 16,909 | 16,909
Endocrine System 18,159 | 18,159
Female tissues 17,400 | 17,400
Digestive Tract 17,369 | 17,369
Skin and soft tissues 17,230 | 17,230
Male tissues 17,142 | 17,142
Liver and Pancreas 16,750 | 16,750
Nervous System 16,725 | 16,725
Urinary Tract 16,678 | 16,678
Respiratory system 16,393 | 16,393
Cardiovascular System 15,192 | 15,192

Target Family

Non-IDG 9,879 | 12,091
Enzyme 3,835 | 4,145
Transcription Factor 1,231 | 1,400
Kinase 607 | 634
Transporter 413 | 473
GPCR 306 | 408
Ion Channel 283 | 344
Epigenetic 233 | 242
Nuclear Receptor 47 | 48
oGPCR 39 | 421
TF/Epigenetic 36 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39