Development Level

Tbio 235 | 11,445
Tdark 36 | 6,588
Tchem 30 | 1,598
Tclin 17 | 613

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
enlarged heart 7 | 210
preweaning lethality, incomple... 7 | 499
decreased bone mineral density 6 | 126
decreased total body fat amoun... 6 | 207
hypoactivity 6 | 132
increased heart weight 6 | 62
increased lean body mass 6 | 172
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
increased mean corpuscular vol... 5 | 92
abnormal eye morphology 4 | 68
abnormal heart morphology 4 | 162
abnormal skin morphology 4 | 50
decreased body length 4 | 101
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased grip strength 4 | 116
decreased lean body mass 4 | 135
decreased vertical activity 4 | 208
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
increased fasted circulating g... 4 | 76
increased total body fat amoun... 4 | 134
abnormal embryo size 3 | 220
decreased circulating choleste... 3 | 93
decreased mean corpuscular hem... 3 | 31
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating total pr... 3 | 28
increased vertical activity 3 | 24
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
abnormal femur morphology 2 | 14
abnormal head morphology 2 | 10
abnormal humerus morphology 2 | 11
abnormal seminal vesicle morph... 2 | 114
abnormal tibia morphology 2 | 14
abnormal tooth morphology 2 | 24
corneal opacity 2 | 32
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased red blood cell distr... 2 | 41
dilated heart left ventricle 2 | 11
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased startle reflex 2 | 112
limb grasping 2 | 41
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased food intake 1 | 13
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased body weight 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
scaly skin 1 | 4

Disease

urothelial carcinoma 318 | 318
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Female tissues 313 | 17,400
Urinary Tract 313 | 16,678
Endocrine System 312 | 18,159
Digestive Tract 311 | 17,369
Male tissues 311 | 17,142
Skin and soft tissues 311 | 17,230
Blood and immune system 308 | 16,909
Respiratory system 307 | 16,393
Liver and Pancreas 306 | 16,750
Nervous System 300 | 16,725
Cardiovascular System 285 | 15,192

Target Family

Non-IDG 191 | 12,091
Enzyme 75 | 4,145
Transcription Factor 21 | 1,400
Kinase 13 | 634
Transporter 6 | 473
GPCR 5 | 408
Nuclear Receptor 4 | 48
Ion Channel 3 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
Transmembrane protein 246 TMEM246 Tdark Non-IDG 0.00000 17
Protocadherin-18 PCDH18 Tbio Non-IDG -0.69395 5.31 87
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Transmembrane protease serine 11E TMPRSS11E Tbio Enzyme -0.90309 9.71 126
Peptidyl-prolyl cis-trans isomerase FKBP7 FKBP7 Tbio Enzyme -1.41965 24.7 112
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
SID1 transmembrane family member 1 SIDT1 Tbio Non-IDG -1.59973 38.5 125
Neuropeptide-like protein C4orf48 C4orf48 Tdark Non-IDG 0.00000 1.00 3