Development Level

Tbio 219 | 10,625
Tdark 44 | 7,003
Tchem 38 | 1,890
Tclin 17 | 602

Collection

GPCR: IDG Consortium (Complete/Control) 1 | 24
GPCR: IDG Consortium (Targets) 1 | 128
Ion Channel: IDG Consortium (Targets) 1 | 102
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 633
decreased total body fat amoun... 6 | 186
decreased body length 5 | 108
decreased grip strength 5 | 123
decreased lean body mass 5 | 195
hypoactivity 5 | 89
increased mean corpuscular vol... 5 | 91
abnormal behavior 4 | 226
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
increased fasted circulating g... 4 | 68
preweaning lethality, incomple... 4 | 260
short tibia 4 | 82
abnormal retina morphology 3 | 100
decreased mean corpuscular hem... 3 | 19
embryonic lethality prior to t... 3 | 187
increased bone mineral content 3 | 92
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased lean body mass 3 | 107
increased vertical activity 3 | 18
abnormal coat-hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal femur morphology 2 | 14
abnormal head morphology 2 | 10
abnormal humerus morphology 2 | 11
abnormal skin morphology 2 | 23
abnormal tibia morphology 2 | 14
corneal opacity 2 | 25
decreased NK T cell number 2 | 28
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased vertical activity 2 | 22
dilated heart left ventricle 2 | 10
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased CD4-positive, CD25-p... 2 | 18
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased circulating triglyce... 2 | 24
increased grip strength 2 | 83
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
abnormal brain morphology 1 | 6
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal lymph node morphology 1 | 3
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
absent teeth 1 | 4
cataract 1 | 26
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased red blood cell distr... 1 | 11
hydroencephaly 1 | 6
impaired righting response 1 | 19
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased circulating alanine ... 1 | 11
increased circulating creatini... 1 | 29
increased circulating glycerol... 1 | 11
increased effector memory T-he... 1 | 5
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased lactate dehydrogenas... 1 | 3
increased memory-marker gamma-... 1 | 2
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

urothelial carcinoma 318 | 318
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 316 | 17,968
Digestive Tract 315 | 18,472
Female tissues 315 | 18,646
Liver and Pancreas 315 | 18,135
Endocrine System 314 | 18,511
Nervous System 314 | 18,560
Urinary Tract 314 | 18,443
Blood and immune system 313 | 17,994
Cardiovascular System 313 | 17,957
Skin and soft tissues 312 | 18,114
Respiratory system 310 | 17,483

Target Family

Non-IDG 191 | 11,969
Enzyme 75 | 4,146
Transcription Factor 21 | 1,400
Kinase 13 | 634
Transporter 6 | 473
GPCR 5 | 408
Nuclear Receptor 4 | 48
Ion Channel 3 | 341

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806
Guanylate-binding protein 4 GBP4 Tbio Non-IDG -1.67376 45.5 102
Aquaporin-1 AQP1 Tbio Non-IDG -3.06090 1040.5 321
Protein FAM181B FAM181B Tdark Non-IDG 0.30 0.63 19
Junctophilin-1 JPH1 Tbio Non-IDG -1.75131 52.9 77
Chloride intracellular channel protein 6 CLIC6 Tbio Ion Channel -1.03083 11.5 146
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.78255 613.4 202
Collagen alpha-1(VIII) chain COL8A1 Tbio Non-IDG -1.25305 16.3 98