Development Level

Tbio 1,326 | 10,625
Tchem 346 | 1,890
Tdark 304 | 7,003
Tclin 111 | 602

Collection

Eligible Kinase Proteins 14 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 61 | 633
preweaning lethality, incomple... 41 | 260
decreased total body fat amoun... 28 | 186
decreased lean body mass 26 | 195
abnormal behavior 25 | 226
embryonic lethality prior to t... 22 | 187
decreased body weight 20 | 174
decreased bone mineral content 20 | 157
abnormal retina morphology 18 | 100
decreased bone mineral density 17 | 126
enlarged heart 17 | 111
increased mean corpuscular hem... 17 | 93
decreased body length 16 | 108
increased grip strength 16 | 83
abnormal embryo size 15 | 112
increased circulating alkaline... 15 | 119
increased or absent threshold ... 15 | 128
abnormal coat/hair pigmentatio... 14 | 54
abnormal lens morphology 14 | 73
decreased circulating glucose ... 14 | 121
increased mean corpuscular vol... 14 | 91
abnormal bone structure 13 | 131
increased bone mineral content 13 | 92
decreased circulating insulin ... 12 | 75
decreased grip strength 12 | 123
increased lean body mass 12 | 107
short tibia 12 | 82
decreased circulating HDL chol... 11 | 77
embryonic lethality prior to o... 11 | 148
hyperactivity 11 | 108
increased circulating HDL chol... 11 | 63
decreased circulating choleste... 10 | 85
decreased circulating triglyce... 10 | 83
decreased lumbar vertebrae num... 10 | 62
decreased prepulse inhibition 10 | 52
hypoactivity 10 | 89
increased fasted circulating g... 10 | 68
abnormal retinal pigmentation 9 | 61
abnormal seminal vesicle morph... 9 | 47
decreased mean corpuscular vol... 9 | 50
impaired glucose tolerance 9 | 52
increased circulating calcium ... 9 | 32
increased circulating sodium l... 9 | 71
increased exploration in new e... 9 | 56
abnormal heart morphology 8 | 51
abnormal sleep behavior 8 | 63
decreased threshold for audito... 8 | 32
increased bone mineral density 8 | 52
increased circulating choleste... 8 | 53
increased hemoglobin content 8 | 45
increased sacral vertebrae num... 8 | 62
prenatal lethality prior to he... 8 | 64
small testis 8 | 37
abnormal epididymis morphology 7 | 31
decreased CD4-positive, CD25-p... 7 | 24
decreased blood urea nitrogen ... 7 | 31
decreased circulating creatini... 7 | 31
decreased leukocyte cell numbe... 7 | 54
decreased mean corpuscular hem... 7 | 19
decreased rib number 7 | 59
enlarged epididymis 7 | 27
increased blood urea nitrogen ... 7 | 44
thrombocytopenia 7 | 46
tremors 7 | 34
abnormal tooth morphology 6 | 24
corneal opacity 6 | 25
decreased B cell number 6 | 30
decreased NK T cell number 6 | 28
decreased circulating alanine ... 6 | 53
decreased circulating serum al... 6 | 79
decreased effector memory CD8-... 6 | 24
decreased erythrocyte cell num... 6 | 43
decreased heart weight 6 | 44
decreased mature B cell number 6 | 25
decreased startle reflex 6 | 48
female infertility 6 | 34
increased circulating serum al... 6 | 25
increased hematocrit 6 | 36
increased rib number 6 | 41
increased total body fat amoun... 6 | 57
abnormal behavioral response t... 5 | 52
abnormal cornea morphology 5 | 24
abnormal eye morphology 5 | 38
abnormal neural tube closure 5 | 37
abnormal testis morphology 5 | 30
anophthalmia 5 | 20
cardiovascular system phenotyp... 5 | 35
decreased circulating free fat... 5 | 39
decreased circulating glycerol... 5 | 19
decreased circulating iron lev... 5 | 25
decreased fasted circulating g... 5 | 49
decreased hemoglobin content 5 | 53
decreased mean corpuscular hem... 5 | 34
decreased neutrophil cell numb... 5 | 37
increased circulating chloride... 5 | 43
increased circulating iron lev... 5 | 25
increased circulating potassiu... 5 | 31
increased mean corpuscular hem... 5 | 25
increased startle reflex 5 | 38
male infertility 5 | 62

Disease

ulcerative colitis 2,087 | 2,087
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 2,071 | 18,473
Female tissues 2,068 | 18,647
Liver and Pancreas 2,068 | 18,136
Nervous System 2,068 | 18,561
Endocrine System 2,066 | 18,512
Urinary Tract 2,066 | 18,444
Blood and immune system 2,064 | 17,995
Cardiovascular System 2,058 | 17,958
Male tissues 2,058 | 17,969
Respiratory system 2,053 | 17,484
Skin and soft tissues 2,053 | 18,115

Target Family

Non-IDG 1,180 | 11,971
Enzyme 514 | 4,146
Transcription Factor 113 | 1,400
Kinase 99 | 634
Transporter 66 | 473
GPCR 48 | 406
Ion Channel 33 | 341
Epigenetic 14 | 242
Nuclear Receptor 13 | 48
TF/Epigenetic 6 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788