Development Level

Tbio 1,234 | 11,445
Tchem 254 | 1,598
Tdark 225 | 6,588
Tclin 106 | 613

Collection

RFA-RM-18-021 28 | 328
Kinase: IDG Consortium (Target... 13 | 125
GPCR: IDG Consortium (Targets) 8 | 126
Ion Channel: IDG Consortium (T... 7 | 99
GPCR: IDG Consortium (Complete... 6 | 25
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 76 | 979
preweaning lethality, incomple... 66 | 499
abnormal behavior 32 | 298
enlarged heart 32 | 210
embryonic lethality prior to t... 27 | 278
decreased total body fat amoun... 24 | 207
abnormal embryo size 23 | 220
abnormal heart morphology 22 | 162
decreased vertical activity 21 | 208
embryonic lethality prior to o... 20 | 239
abnormal bone structure 19 | 187
decreased body weight 17 | 161
increased lean body mass 17 | 172
abnormal seminal vesicle morph... 16 | 114
decreased bone mineral density 15 | 126
increased mean corpuscular hem... 15 | 96
short tibia 15 | 97
abnormal coat-hair pigmentatio... 14 | 64
decreased bone mineral content 14 | 151
decreased lymphocyte cell numb... 14 | 83
increased bone mineral content 14 | 108
cataract 13 | 92
decreased circulating triglyce... 13 | 79
increased circulating alkaline... 13 | 122
decreased circulating glucose ... 12 | 126
decreased erythrocyte cell num... 12 | 62
decreased lean body mass 12 | 135
hypoactivity 12 | 132
increased monocyte cell number 12 | 63
increased or absent threshold ... 12 | 101
increased startle reflex 12 | 112
abnormal retina morphology 11 | 71
decreased circulating choleste... 11 | 93
male infertility 11 | 123
abnormal eye morphology 10 | 68
abnormal lens morphology 10 | 81
abnormal sleep behavior 10 | 70
decreased circulating insulin ... 10 | 76
decreased fasted circulating g... 10 | 65
decreased grip strength 10 | 116
decreased hematocrit 10 | 46
decreased prepulse inhibition 10 | 82
embryonic growth retardation 10 | 106
impaired glucose tolerance 10 | 75
increased mean corpuscular vol... 10 | 92
increased total body fat amoun... 10 | 134
decreased hemoglobin content 9 | 68
decreased leukocyte cell numbe... 9 | 73
increased bone mineral density 9 | 72
increased neutrophil cell numb... 9 | 46
small superior vagus ganglion 9 | 74
small testis 9 | 58
abnormal epididymis morphology 8 | 42
abnormal kidney morphology 8 | 65
abnormal testis morphology 8 | 43
decreased mean corpuscular vol... 8 | 79
decreased startle reflex 8 | 75
edema 8 | 59
female infertility 8 | 60
hyperactivity 8 | 148
increased circulating calcium ... 8 | 34
increased erythrocyte cell num... 8 | 39
increased fasted circulating g... 8 | 76
increased hematocrit 8 | 46
prenatal lethality prior to he... 8 | 87
abnormal skin morphology 7 | 50
decreased blood urea nitrogen ... 7 | 51
decreased circulating HDL chol... 7 | 68
enlarged epididymis 7 | 31
increased circulating HDL chol... 7 | 80
increased circulating sodium l... 7 | 71
increased circulating triglyce... 7 | 42
increased grip strength 7 | 41
tremors 7 | 39
abnormal tooth morphology 6 | 24
absent vibrissae 6 | 12
anophthalmia 6 | 33
corneal opacity 6 | 32
decreased body length 6 | 101
decreased circulating calcium ... 6 | 36
decreased circulating creatini... 6 | 39
decreased circulating serum al... 6 | 82
decreased mean corpuscular hem... 6 | 31
decreased neutrophil cell numb... 6 | 42
enlarged spleen 6 | 41
improved glucose tolerance 6 | 79
increased heart weight 6 | 62
increased leukocyte cell numbe... 6 | 47
abnormal behavioral response t... 5 | 66
abnormal craniofacial morpholo... 5 | 33
cardiovascular system phenotyp... 5 | 36
decreased circulating alanine ... 5 | 47
decreased circulating free fat... 5 | 31
decreased circulating iron lev... 5 | 32
decreased circulating total pr... 5 | 49
decreased mean corpuscular hem... 5 | 50
decreased red blood cell distr... 5 | 41
increased circulating choleste... 5 | 66
increased circulating iron lev... 5 | 30
thrombocytopenia 5 | 56

Disease

ulcerative colitis 1,819 | 1,819
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 1,783 | 17,369
Skin and soft tissues 1,779 | 17,230
Endocrine System 1,777 | 18,159
Female tissues 1,773 | 17,400
Liver and Pancreas 1,767 | 16,750
Blood and immune system 1,763 | 16,909
Urinary Tract 1,763 | 16,678
Male tissues 1,758 | 17,142
Respiratory system 1,745 | 16,393
Nervous System 1,725 | 16,725
Cardiovascular System 1,671 | 15,192

Target Family

Non-IDG 1,052 | 12,091
Enzyme 422 | 4,145
Transcription Factor 101 | 1,400
Kinase 90 | 634
Transporter 48 | 473
GPCR 44 | 408
Ion Channel 30 | 344
Epigenetic 13 | 242
Nuclear Receptor 13 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Ribonucleoprotein PTB-binding 2 RAVER2 Tdark Non-IDG -0.31876 3.20 38
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214