Development Level

Tbio 272 | 11,178
Tdark 90 | 6,569
Tchem 29 | 1,885
Tclin 8 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 15 | 499
abnormal behavior 11 | 298
embryonic lethality prior to t... 10 | 278
decreased body weight 9 | 161
increased total body fat amoun... 9 | 134
abnormal embryo size 8 | 220
decreased total body fat amoun... 7 | 207
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 135
decreased leukocyte cell numbe... 6 | 73
hyperactivity 6 | 148
increased lean body mass 6 | 172
abnormal bone structure 5 | 187
decreased body length 5 | 101
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
decreased vertical activity 5 | 208
embryonic lethality prior to o... 5 | 239
increased bone mineral density 5 | 72
abnormal sleep behavior 4 | 70
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
decreased circulating insulin ... 4 | 76
decreased hematocrit 4 | 46
embryonic growth retardation 4 | 106
enlarged heart 4 | 210
increased bone mineral content 4 | 108
increased mean corpuscular hem... 4 | 96
increased or absent threshold ... 4 | 101
short tibia 4 | 97
abnormal cornea morphology 3 | 31
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
abnormal skin morphology 3 | 50
abnormal startle reflex 3 | 15
corneal opacity 3 | 32
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating sodium l... 3 | 22
decreased circulating total pr... 3 | 49
decreased fasted circulating g... 3 | 65
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
male infertility 3 | 123
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal coat- hair morphology 2 | 19
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal femur morphology 2 | 14
abnormal locomotor activation 2 | 16
abnormal pelvic girdle bone mo... 2 | 12
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal vocalization 2 | 21
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating chloride... 2 | 30
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
enlarged epididymis 2 | 31
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased blood uric acid leve... 2 | 5
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased thermal nociceptive ... 2 | 9
microphthalmia 2 | 26
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged ST segment 2 | 36
thrombocytosis 2 | 27
trunk curl 2 | 16
vertebral fusion 2 | 23
abnormal body wall morphology 1 | 9
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased circulating phosphat... 1 | 26

Disease

tuberculosis and treatment for 6 months 399 | 399
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Blood and immune system 398 | 16,909
Cardiovascular System 398 | 15,192
Digestive Tract 398 | 17,369
Endocrine System 398 | 18,159
Female tissues 398 | 17,400
Liver and Pancreas 398 | 16,750
Male tissues 398 | 17,142
Respiratory system 398 | 16,393
Skin and soft tissues 398 | 17,230
Urinary Tract 398 | 16,678
Nervous System 397 | 16,725

Target Family

Non-IDG 236 | 12,091
Enzyme 90 | 4,145
Transcription Factor 38 | 1,400
Kinase 18 | 634
Epigenetic 12 | 242
Transporter 3 | 473
GPCR 1 | 408
Ion Channel 1 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 470 ZNF470 Tdark Transcription Factor -1.12959 14.5 10
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
Interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2 Tbio Kinase -1.96184 89.9 894
Centrosomal protein of 104 kDa CEP104 Tbio Non-IDG -1.23064 17.5 69
Krueppel-like factor 3 KLF3 Tbio Transcription Factor -1.51393 35.3 140
Eukaryotic translation initiation factor 5 EIF5 Tbio Non-IDG -1.93055 83.2 159
Bax inhibitor 1 TMBIM6 Tbio Non-IDG -2.47515 305.3 151
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
E3 ubiquitin-protein ligase UBR4 UBR4 Tbio Enzyme -1.10111 13.3 76
Leucine-rich repeat-containing protein 41 LRRC41 Tdark Non-IDG -0.39406 2.80 103