Development Level

Tbio 433 | 10,625
Tdark 172 | 7,003
Tchem 61 | 1,890
Tclin 20 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 4 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 31 | 633
abnormal behavior 15 | 226
preweaning lethality, incomple... 13 | 260
decreased lean body mass 12 | 195
embryonic lethality prior to t... 10 | 187
decreased body weight 9 | 174
abnormal bone structure 8 | 131
decreased bone mineral density 7 | 126
decreased leukocyte cell numbe... 7 | 54
decreased total body fat amoun... 7 | 186
increased mean corpuscular hem... 7 | 93
abnormal bone mineralization 6 | 55
abnormal lens morphology 6 | 73
decreased body length 6 | 108
decreased caudal vertebrae num... 6 | 49
decreased circulating HDL chol... 6 | 77
decreased circulating triglyce... 6 | 83
embryonic lethality prior to o... 6 | 148
abnormal retina morphology 5 | 100
decreased Ly6C low monocyte nu... 5 | 23
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating total pr... 5 | 41
decreased erythrocyte cell num... 5 | 43
hyperactivity 5 | 108
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased mean corpuscular vol... 5 | 91
male infertility 5 | 62
abnormal cornea morphology 4 | 24
abnormal embryo size 4 | 112
corneal opacity 4 | 25
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased prepulse inhibition 4 | 52
decreased rib number 4 | 59
hypoactivity 4 | 89
prenatal lethality prior to he... 4 | 64
thrombocytopenia 4 | 46
tremors 4 | 34
abnormal coping response 3 | 12
abnormal cranium morphology 3 | 32
abnormal sleep behavior 3 | 63
abnormal vocalization 3 | 21
decreased circulating LDL chol... 3 | 37
decreased circulating chloride... 3 | 32
decreased circulating creatini... 3 | 31
decreased circulating serum al... 3 | 79
decreased circulating sodium l... 3 | 18
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased neutrophil cell numb... 3 | 37
enlarged heart 3 | 111
increased B cell number 3 | 23
increased NK cell number 3 | 19
increased bone mineral density 3 | 52
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 25
increased or absent threshold ... 3 | 128
increased sacral vertebrae num... 3 | 62
short tibia 3 | 82
trunk curl 3 | 15
abnormal coat/hair pigmentatio... 2 | 54
abnormal eye morphology 2 | 38
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal snout morphology 2 | 18
abnormal startle reflex 2 | 14
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
absent pinna reflex 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased basophil cell number 2 | 11
decreased effector memory CD8-... 2 | 24
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased startle reflex 2 | 48
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
increased blood urea nitrogen ... 2 | 44
increased blood uric acid leve... 2 | 5
increased body length 2 | 20
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating iron lev... 2 | 25
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased lactate dehydrogenas... 2 | 3
increased prepulse inhibition 2 | 21
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
persistence of hyaloid vascula... 2 | 22
thrombocytosis 2 | 23
vertebral fusion 2 | 23

Disease

tuberculosis and treatment for 6 months 686 | 686
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 683 | 17,969
Blood and immune system 682 | 17,995
Female tissues 682 | 18,647
Liver and Pancreas 682 | 18,136
Nervous System 682 | 18,561
Digestive Tract 681 | 18,473
Endocrine System 681 | 18,512
Cardiovascular System 680 | 17,958
Urinary Tract 680 | 18,444
Respiratory system 679 | 17,484
Skin and soft tissues 676 | 18,115

Target Family

Non-IDG 393 | 11,971
Enzyme 159 | 4,146
Transcription Factor 59 | 1,400
Kinase 29 | 634
Epigenetic 16 | 242
Transporter 13 | 473
Ion Channel 8 | 341
GPCR 7 | 406
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Apoptosis inhibitor 5 API5 Tbio Non-IDG -1.32754 23.5 171
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157
Indoleamine 2,3-dioxygenase 2 IDO2 Tchem Enzyme -1.88853 82.2 208
Pre-mRNA-splicing factor 38A PRPF38A Tdark Non-IDG -0.69167 4.80 72
A-kinase anchor protein 8 AKAP8 Tbio Enzyme -1.32097 22.6 240
Protein Niban FAM129A Tbio Non-IDG -1.03213 12.4 149