Development Level

Tbio 1,386 | 11,651
Tdark 310 | 6,593
Tchem 210 | 1,388
Tclin 104 | 612

Collection

RFA-RM-18-021 22 | 328
Kinase: IDG Consortium (Target... 10 | 125
GPCR: IDG Consortium (Targets) 9 | 126
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 3 | 25
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 91 | 979
preweaning lethality, incomple... 55 | 499
abnormal behavior 40 | 298
embryonic lethality prior to t... 33 | 278
embryonic lethality prior to o... 27 | 239
enlarged heart 26 | 210
abnormal embryo size 24 | 220
decreased vertical activity 24 | 208
abnormal heart morphology 23 | 162
decreased total body fat amoun... 19 | 207
increased lean body mass 19 | 172
abnormal seminal vesicle morph... 18 | 114
decreased bone mineral content 18 | 151
increased total body fat amoun... 18 | 134
decreased lean body mass 17 | 135
decreased circulating glucose ... 16 | 126
hyperactivity 16 | 148
decreased body weight 15 | 161
decreased bone mineral density 15 | 126
increased circulating alkaline... 15 | 122
hypoactivity 14 | 132
prenatal lethality prior to he... 14 | 87
abnormal bone structure 13 | 187
decreased grip strength 13 | 116
increased bone mineral content 13 | 108
increased bone mineral density 13 | 72
increased mean corpuscular vol... 13 | 92
cataract 12 | 92
decreased lymphocyte cell numb... 12 | 83
embryonic growth retardation 12 | 106
abnormal gait 11 | 69
decreased hemoglobin content 11 | 68
decreased mean corpuscular vol... 11 | 79
increased circulating HDL chol... 11 | 80
increased circulating sodium l... 11 | 71
thrombocytopenia 11 | 56
abnormal retina morphology 10 | 71
decreased circulating insulin ... 10 | 76
decreased circulating triglyce... 10 | 79
increased circulating calcium ... 10 | 34
increased mean corpuscular hem... 10 | 96
increased monocyte cell number 10 | 63
short tibia 10 | 97
abnormal kidney morphology 9 | 65
abnormal lens morphology 9 | 81
decreased circulating HDL chol... 9 | 68
decreased circulating choleste... 9 | 93
decreased circulating serum al... 9 | 82
decreased prepulse inhibition 9 | 82
improved glucose tolerance 9 | 79
increased neutrophil cell numb... 9 | 46
tremors 9 | 39
decreased threshold for audito... 8 | 26
increased blood urea nitrogen ... 8 | 48
increased circulating potassiu... 8 | 29
increased fasted circulating g... 8 | 76
increased or absent threshold ... 8 | 101
increased startle reflex 8 | 112
male infertility 8 | 123
abnormal behavioral response t... 7 | 66
abnormal bone mineralization 7 | 38
abnormal coat-hair pigmentatio... 7 | 64
decreased body length 7 | 101
decreased circulating amylase ... 7 | 28
decreased circulating potassiu... 7 | 20
decreased fasted circulating g... 7 | 65
decreased heart weight 7 | 27
decreased mean corpuscular hem... 7 | 50
decreased neutrophil cell numb... 7 | 42
increased hematocrit 7 | 46
small testis 7 | 58
abnormal coat appearance 6 | 31
abnormal epididymis morphology 6 | 42
abnormal lung morphology 6 | 26
abnormal neural tube closure 6 | 46
abnormal skin morphology 6 | 50
abnormal sleep behavior 6 | 70
decreased caudal vertebrae num... 6 | 53
decreased circulating alanine ... 6 | 47
decreased circulating alkaline... 6 | 46
decreased circulating calcium ... 6 | 36
decreased circulating free fat... 6 | 31
decreased eosinophil cell numb... 6 | 24
decreased erythrocyte cell num... 6 | 62
decreased hematocrit 6 | 46
decreased leukocyte cell numbe... 6 | 73
decreased mean corpuscular hem... 6 | 31
decreased startle reflex 6 | 75
enlarged spleen 6 | 41
female infertility 6 | 60
increased circulating choleste... 6 | 66
increased erythrocyte cell num... 6 | 39
increased mean corpuscular hem... 6 | 36
small superior vagus ganglion 6 | 74
abnormal eye morphology 5 | 68
abnormal vibrissa morphology 5 | 25
decreased circulating aspartat... 5 | 34
decreased circulating creatini... 5 | 39
decreased circulating total pr... 5 | 49
increased prepulse inhibition 5 | 32

Disease

tuberculosis 2,010 | 2,010
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Blood and immune system 1,952 | 16,909
Digestive Tract 1,951 | 17,369
Endocrine System 1,950 | 18,159
Female tissues 1,947 | 17,400
Liver and Pancreas 1,946 | 16,750
Urinary Tract 1,944 | 16,678
Skin and soft tissues 1,942 | 17,230
Respiratory system 1,941 | 16,393
Male tissues 1,939 | 17,142
Nervous System 1,912 | 16,725
Cardiovascular System 1,873 | 15,192

Target Family

Non-IDG 1,147 | 12,091
Enzyme 491 | 4,145
Transcription Factor 129 | 1,400
Kinase 85 | 634
Transporter 66 | 473
GPCR 46 | 408
Epigenetic 18 | 242
Ion Channel 18 | 344
Nuclear Receptor 7 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444