Development Level

Tbio 971 | 10,625
Tdark 260 | 7,003
Tchem 236 | 1,890
Tclin 90 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 54 | 633
preweaning lethality, incomple... 29 | 260
abnormal behavior 25 | 226
decreased lean body mass 18 | 195
embryonic lethality prior to t... 18 | 187
decreased bone mineral content 17 | 157
decreased total body fat amoun... 17 | 186
embryonic lethality prior to o... 14 | 148
increased circulating alkaline... 13 | 119
abnormal embryo size 12 | 112
decreased circulating glucose ... 12 | 121
enlarged heart 12 | 111
abnormal retina morphology 11 | 100
increased circulating sodium l... 11 | 71
increased lean body mass 11 | 107
increased mean corpuscular vol... 11 | 91
hypoactivity 10 | 89
increased or absent threshold ... 10 | 128
prenatal lethality prior to he... 10 | 64
short tibia 10 | 82
abnormal bone structure 9 | 131
decreased body weight 9 | 174
decreased grip strength 9 | 123
increased bone mineral content 9 | 92
thrombocytopenia 9 | 46
decreased bone mineral density 8 | 126
decreased neutrophil cell numb... 8 | 37
hyperactivity 8 | 108
increased circulating calcium ... 8 | 32
abnormal retinal pigmentation 7 | 61
decreased body length 7 | 108
decreased circulating calcium ... 7 | 33
decreased circulating serum al... 7 | 79
decreased hemoglobin content 7 | 53
decreased mean corpuscular vol... 7 | 50
increased circulating HDL chol... 7 | 63
increased circulating serum al... 7 | 25
increased mean corpuscular hem... 7 | 93
increased sacral vertebrae num... 7 | 62
increased total body fat amoun... 7 | 57
abnormal sleep behavior 6 | 63
decreased NK T cell number 6 | 28
decreased circulating HDL chol... 6 | 77
decreased circulating potassiu... 6 | 17
decreased circulating triglyce... 6 | 83
increased T cell number 6 | 15
increased bone mineral density 6 | 52
increased circulating choleste... 6 | 53
increased circulating iron lev... 6 | 25
increased circulating potassiu... 6 | 31
increased rib number 6 | 41
abnormal bone mineralization 5 | 55
abnormal epididymis morphology 5 | 31
abnormal gait 5 | 51
abnormal heart morphology 5 | 51
abnormal lens morphology 5 | 73
abnormal neural tube closure 5 | 37
decreased eosinophil cell numb... 5 | 41
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular hem... 5 | 34
decreased rib number 5 | 59
enlarged epididymis 5 | 27
increased exploration in new e... 5 | 56
increased gamma-delta T cell n... 5 | 16
increased hematocrit 5 | 36
increased hemoglobin content 5 | 45
increased mean corpuscular hem... 5 | 25
tremors 5 | 34
abnormal coat appearance 4 | 25
abnormal coat/hair pigmentatio... 4 | 54
abnormal seminal vesicle morph... 4 | 47
cardiovascular system phenotyp... 4 | 35
decreased CD8-positive, alpha-... 4 | 26
decreased NK cell number 4 | 16
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased circulating glycerol... 4 | 19
decreased circulating insulin ... 4 | 75
decreased effector memory CD8-... 4 | 24
decreased prepulse inhibition 4 | 52
embryonic growth retardation 4 | 28
enlarged lymph nodes 4 | 27
enlarged spleen 4 | 26
improved glucose tolerance 4 | 56
increased CD4-positive, alpha ... 4 | 15
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased circulating chloride... 4 | 43
increased circulating total pr... 4 | 20
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased grip strength 4 | 83
increased heart rate 4 | 17
increased leukocyte cell numbe... 4 | 37
increased mature B cell number 4 | 12
increased respiratory quotient 4 | 12
straub tail 4 | 26

Disease

tuberculosis 1,557 | 1,557
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 1,542 | 17,995
Nervous System 1,542 | 18,561
Digestive Tract 1,541 | 18,473
Female tissues 1,541 | 18,647
Urinary Tract 1,540 | 18,444
Liver and Pancreas 1,539 | 18,136
Endocrine System 1,536 | 18,512
Respiratory system 1,535 | 17,484
Cardiovascular System 1,534 | 17,958
Male tissues 1,533 | 17,969
Skin and soft tissues 1,526 | 18,115

Target Family

Non-IDG 879 | 11,971
Enzyme 395 | 4,146
Transcription Factor 97 | 1,400
Kinase 63 | 634
Transporter 54 | 473
GPCR 33 | 406
Epigenetic 17 | 242
Ion Channel 10 | 341
Nuclear Receptor 7 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Transmembrane gamma-carboxyglutamic acid protein 4 PRRG4 Tdark Non-IDG -0.29670 2.24 21
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373