Development Level

Tbio 1,462 | 10,625
Tdark 450 | 7,003
Tchem 290 | 1,890
Tclin 85 | 602

Collection

Eligible Ion Channel Proteins 15 | 117
Eligible Kinase Proteins 12 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 60 | 633
abnormal behavior 46 | 226
decreased total body fat amoun... 38 | 186
preweaning lethality, incomple... 36 | 260
decreased lean body mass 35 | 195
abnormal bone structure 30 | 131
decreased body weight 28 | 174
decreased bone mineral content 27 | 157
increased circulating alkaline... 26 | 119
decreased bone mineral density 25 | 126
hyperactivity 25 | 108
decreased circulating choleste... 22 | 85
decreased grip strength 22 | 123
increased lean body mass 21 | 107
increased bone mineral content 20 | 92
decreased circulating triglyce... 19 | 83
increased or absent threshold ... 19 | 128
decreased body length 18 | 108
decreased circulating HDL chol... 18 | 77
decreased circulating serum al... 18 | 79
abnormal lens morphology 17 | 73
embryonic lethality prior to t... 17 | 187
hypoactivity 17 | 89
abnormal retina morphology 15 | 100
decreased circulating glucose ... 14 | 121
decreased circulating insulin ... 14 | 75
enlarged heart 14 | 111
abnormal bone mineralization 13 | 55
abnormal sleep behavior 13 | 63
increased blood urea nitrogen ... 13 | 44
increased mean corpuscular hem... 13 | 93
short tibia 13 | 82
impaired glucose tolerance 12 | 52
increased body weight 11 | 42
increased circulating chloride... 11 | 43
increased circulating sodium l... 11 | 71
increased total body fat amoun... 11 | 57
decreased circulating alanine ... 10 | 53
decreased hemoglobin content 10 | 53
increased bone mineral density 10 | 52
increased circulating choleste... 10 | 53
abnormal coat/hair pigmentatio... 9 | 54
abnormal embryo size 9 | 112
abnormal retinal pigmentation 9 | 61
abnormal spleen morphology 9 | 36
decreased fasted circulating g... 9 | 49
decreased mean corpuscular vol... 9 | 50
embryonic lethality prior to o... 9 | 148
enlarged spleen 9 | 26
increased circulating calcium ... 9 | 32
increased mean corpuscular vol... 9 | 91
decreased circulating LDL chol... 8 | 37
decreased startle reflex 8 | 48
increased erythrocyte cell num... 8 | 26
increased sacral vertebrae num... 8 | 62
abnormal locomotor activation 7 | 26
cataract 7 | 26
decreased blood urea nitrogen ... 7 | 31
decreased circulating alkaline... 7 | 41
decreased circulating amylase ... 7 | 24
decreased circulating glycerol... 7 | 19
decreased lumbar vertebrae num... 7 | 62
decreased rib number 7 | 59
increased circulating HDL chol... 7 | 63
increased grip strength 7 | 83
increased heart weight 7 | 37
male infertility 7 | 62
thrombocytopenia 7 | 46
abnormal gait 6 | 51
cardiovascular system phenotyp... 6 | 35
decreased CD4-positive, CD25-p... 6 | 24
decreased caudal vertebrae num... 6 | 49
decreased circulating aspartat... 6 | 27
decreased circulating free fat... 6 | 39
decreased circulating total pr... 6 | 41
decreased leukocyte cell numbe... 6 | 54
decreased neutrophil cell numb... 6 | 37
impaired righting response 6 | 19
improved glucose tolerance 6 | 56
increased circulating LDL chol... 6 | 15
increased circulating potassiu... 6 | 31
increased effector memory CD4-... 6 | 15
increased startle reflex 6 | 38
limb grasping 6 | 35
straub tail 6 | 26
abnormal behavioral response t... 5 | 52
abnormal epididymis morphology 5 | 31
decreased NK T cell number 5 | 28
decreased circulating fructosa... 5 | 31
decreased heart weight 5 | 44
decreased prepulse inhibition 5 | 52
enlarged epididymis 5 | 27
increased body length 5 | 20
increased circulating free fat... 5 | 17
increased circulating iron lev... 5 | 25
increased fasted circulating g... 5 | 68
increased hematocrit 5 | 36
persistence of hyaloid vascula... 5 | 22
small testis 5 | 37
tremors 5 | 34

Disease

subependymal giant cell astrocytoma 2,287 | 2,287
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,267 | 18,561
Digestive Tract 2,262 | 18,473
Female tissues 2,259 | 18,647
Blood and immune system 2,258 | 17,995
Male tissues 2,258 | 17,969
Liver and Pancreas 2,257 | 18,136
Urinary Tract 2,257 | 18,444
Cardiovascular System 2,256 | 17,958
Endocrine System 2,256 | 18,512
Respiratory system 2,245 | 17,484
Skin and soft tissues 2,242 | 18,115

Target Family

Non-IDG 1,331 | 11,971
Enzyme 537 | 4,146
Transcription Factor 129 | 1,400
Kinase 89 | 634
Ion Channel 66 | 341
Transporter 60 | 473
GPCR 32 | 406
Epigenetic 27 | 242
TF/Epigenetic 9 | 38
Nuclear Receptor 7 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161