Development Level

Tbio 1,580 | 11,651
Tdark 401 | 6,593
Tchem 220 | 1,388
Tclin 86 | 612

Collection

RFA-RM-18-021 27 | 328
Ion Channel: IDG Consortium (T... 12 | 99
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 8 | 37
GPCR: IDG Consortium (Targets) 5 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 99 | 979
preweaning lethality, incomple... 73 | 499
abnormal behavior 52 | 298
decreased total body fat amoun... 41 | 207
increased lean body mass 38 | 172
abnormal bone structure 34 | 187
enlarged heart 33 | 210
hyperactivity 30 | 148
increased circulating alkaline... 28 | 122
decreased bone mineral content 27 | 151
increased total body fat amoun... 26 | 134
decreased body weight 25 | 161
hypoactivity 25 | 132
decreased vertical activity 24 | 208
embryonic lethality prior to t... 24 | 278
abnormal embryo size 23 | 220
decreased grip strength 23 | 116
increased bone mineral content 22 | 108
abnormal heart morphology 21 | 162
decreased bone mineral density 21 | 126
decreased lean body mass 20 | 135
decreased circulating choleste... 17 | 93
decreased circulating serum al... 17 | 82
cataract 16 | 92
embryonic lethality prior to o... 16 | 239
impaired glucose tolerance 16 | 75
abnormal lens morphology 15 | 81
decreased circulating glucose ... 14 | 126
decreased circulating triglyce... 14 | 79
decreased mean corpuscular vol... 14 | 79
decreased startle reflex 14 | 75
increased mean corpuscular hem... 14 | 96
decreased circulating HDL chol... 13 | 68
decreased circulating insulin ... 13 | 76
decreased lymphocyte cell numb... 13 | 83
increased startle reflex 13 | 112
short tibia 13 | 97
abnormal seminal vesicle morph... 12 | 114
decreased hemoglobin content 12 | 68
increased circulating sodium l... 12 | 71
increased mean corpuscular vol... 12 | 92
male infertility 12 | 123
abnormal kidney morphology 11 | 65
abnormal sleep behavior 11 | 70
decreased body length 11 | 101
decreased fasted circulating g... 11 | 65
improved glucose tolerance 11 | 79
increased circulating chloride... 11 | 41
increased circulating choleste... 11 | 66
increased heart weight 11 | 62
increased or absent threshold ... 11 | 101
abnormal behavioral response t... 10 | 66
abnormal bone mineralization 10 | 38
abnormal coat-hair pigmentatio... 10 | 64
abnormal eye morphology 10 | 68
abnormal retina morphology 10 | 71
abnormal spleen morphology 10 | 55
decreased erythrocyte cell num... 10 | 62
decreased prepulse inhibition 10 | 82
enlarged spleen 10 | 41
increased bone mineral density 10 | 72
increased circulating HDL chol... 10 | 80
increased circulating calcium ... 10 | 34
increased erythrocyte cell num... 10 | 39
small testis 10 | 58
decreased blood urea nitrogen ... 9 | 51
decreased caudal vertebrae num... 9 | 53
decreased circulating alkaline... 9 | 46
decreased leukocyte cell numbe... 9 | 73
increased blood urea nitrogen ... 9 | 48
increased circulating triglyce... 9 | 42
increased monocyte cell number 9 | 63
small superior vagus ganglion 9 | 74
abnormal gait 8 | 69
abnormal testis morphology 8 | 43
decreased circulating LDL chol... 8 | 38
decreased circulating amylase ... 8 | 28
decreased circulating total pr... 8 | 49
decreased mean corpuscular hem... 8 | 50
increased body length 8 | 32
increased circulating creatini... 8 | 38
increased mean corpuscular hem... 8 | 36
abnormal epididymis morphology 7 | 42
abnormal skin morphology 7 | 50
decreased hematocrit 7 | 46
decreased neutrophil cell numb... 7 | 42
edema 7 | 59
enlarged epididymis 7 | 31
increased circulating potassiu... 7 | 29
increased hematocrit 7 | 46
thrombocytopenia 7 | 56
cardiovascular system phenotyp... 6 | 36
decreased circulating alanine ... 6 | 47
decreased red blood cell distr... 6 | 41
increased leukocyte cell numbe... 6 | 47
increased mean platelet volume 6 | 45
increased red blood cell distr... 6 | 34
limb grasping 6 | 41
prenatal lethality prior to he... 6 | 87
trunk curl 6 | 16

Disease

subependymal giant cell astrocytoma 2,287 | 2,287
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,257 | 18,159
Nervous System 2,254 | 16,725
Digestive Tract 2,239 | 17,369
Female tissues 2,236 | 17,400
Skin and soft tissues 2,233 | 17,230
Male tissues 2,220 | 17,142
Liver and Pancreas 2,207 | 16,750
Urinary Tract 2,198 | 16,678
Blood and immune system 2,197 | 16,909
Respiratory system 2,182 | 16,393
Cardiovascular System 2,124 | 15,192

Target Family

Non-IDG 1,328 | 12,091
Enzyme 538 | 4,145
Transcription Factor 129 | 1,400
Kinase 91 | 634
Ion Channel 66 | 344
Transporter 60 | 473
GPCR 32 | 408
Epigenetic 27 | 242
TF/Epigenetic 9 | 38
Nuclear Receptor 7 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Contactin-associated protein-like 4 CNTNAP4 Tbio Non-IDG -0.73408 0.00000 148
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242