Development Level

Tbio 730 | 10,625
Tdark 215 | 7,003
Tchem 97 | 1,890
Tclin 22 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 38 | 633
preweaning lethality, incomple... 27 | 260
decreased lean body mass 24 | 195
decreased total body fat amoun... 21 | 186
abnormal behavior 18 | 226
decreased body weight 18 | 174
embryonic lethality prior to t... 18 | 187
increased or absent threshold ... 17 | 128
decreased bone mineral density 16 | 126
enlarged heart 15 | 111
abnormal bone structure 14 | 131
increased lean body mass 12 | 107
abnormal embryo size 11 | 112
abnormal retina morphology 11 | 100
abnormal bone mineralization 10 | 55
decreased bone mineral content 10 | 157
decreased circulating HDL chol... 10 | 77
decreased circulating choleste... 10 | 85
decreased circulating glucose ... 10 | 121
decreased circulating triglyce... 10 | 83
hyperactivity 10 | 108
increased bone mineral content 10 | 92
increased circulating alkaline... 10 | 119
decreased circulating alkaline... 9 | 41
embryonic lethality prior to o... 9 | 148
decreased circulating insulin ... 8 | 75
decreased grip strength 8 | 123
decreased hemoglobin content 8 | 53
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular vol... 8 | 50
decreased prepulse inhibition 8 | 52
increased grip strength 8 | 83
abnormal retinal pigmentation 7 | 61
decreased T cell number 7 | 31
decreased body length 7 | 108
decreased circulating serum al... 7 | 79
decreased erythrocyte cell num... 7 | 43
decreased leukocyte cell numbe... 7 | 54
decreased startle reflex 7 | 48
increased bone mineral density 7 | 52
increased heart weight 7 | 37
increased mean corpuscular vol... 7 | 91
increased sacral vertebrae num... 7 | 62
abnormal eye morphology 6 | 38
abnormal neural tube closure 6 | 37
decreased B cell number 6 | 30
decreased circulating free fat... 6 | 39
decreased circulating total pr... 6 | 41
decreased heart weight 6 | 44
increased circulating calcium ... 6 | 32
increased rib number 6 | 41
limb grasping 6 | 35
prenatal lethality prior to he... 6 | 64
abnormal coat/hair pigmentatio... 5 | 54
abnormal sleep behavior 5 | 63
corneal opacity 5 | 25
decreased Ly6C low monocyte nu... 5 | 23
decreased circulating fructosa... 5 | 31
decreased mean corpuscular hem... 5 | 34
decreased rib number 5 | 59
hypoactivity 5 | 89
improved glucose tolerance 5 | 56
increased blood urea nitrogen ... 5 | 44
increased body weight 5 | 42
increased circulating HDL chol... 5 | 63
increased circulating choleste... 5 | 53
increased circulating iron lev... 5 | 25
increased fasted circulating g... 5 | 68
increased mean corpuscular hem... 5 | 93
short tibia 5 | 82
abnormal behavioral response t... 4 | 52
abnormal coat appearance 4 | 25
abnormal epididymis morphology 4 | 31
abnormal hindbrain development 4 | 24
abnormal midbrain development 4 | 22
abnormal seminal vesicle morph... 4 | 47
abnormal spleen morphology 4 | 36
absent pinna reflex 4 | 21
absent startle reflex 4 | 15
decreased CD8-positive, alpha-... 4 | 26
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating amylase ... 4 | 24
decreased circulating creatini... 4 | 31
decreased eosinophil cell numb... 4 | 41
decreased fasted circulating g... 4 | 49
decreased monocyte cell number 4 | 28
decreased neutrophil cell numb... 4 | 37
decreased spleen weight 4 | 13
enlarged epididymis 4 | 27
enlarged spleen 4 | 26
impaired glucose tolerance 4 | 52
increased NK cell number 4 | 19
increased circulating triglyce... 4 | 24
increased gamma-delta T cell n... 4 | 16
narrow eye opening 4 | 15
thrombocytopenia 4 | 46
tremors 4 | 34
decreased NK T cell number 3 | 28
increased circulating sodium l... 3 | 71

Disease

spina bifida 1,064 | 1,064
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,058 | 18,647
Nervous System 1,058 | 18,561
Urinary Tract 1,057 | 18,444
Cardiovascular System 1,056 | 17,958
Digestive Tract 1,056 | 18,473
Endocrine System 1,056 | 18,512
Liver and Pancreas 1,056 | 18,136
Blood and immune system 1,053 | 17,995
Male tissues 1,053 | 17,969
Skin and soft tissues 1,047 | 18,115
Respiratory system 1,043 | 17,484

Target Family

Non-IDG 640 | 11,971
Enzyme 217 | 4,146
Transcription Factor 90 | 1,400
Kinase 51 | 634
Transporter 20 | 473
Epigenetic 19 | 242
GPCR 11 | 406
Ion Channel 9 | 341
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Transmembrane gamma-carboxyglutamic acid protein 4 PRRG4 Tdark Non-IDG -0.29670 2.24 21
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Monocarboxylate transporter 9 SLC16A9 Tbio Transporter -0.78270 6.92 47
Striatin STRN Tbio Non-IDG -1.63637 51.0 118
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320