Development Level

Tbio 938 | 10,625
Tdark 327 | 7,003
Tchem 167 | 1,890
Tclin 50 | 602

Collection

Ion Channel: IDG Consortium (Targets) 8 | 102
Kinase: IDG Consortium (Targets) 8 | 125
GPCR: IDG Consortium (Targets) 5 | 127
GPCR: IDG Consortium (Complete/Control) 2 | 26
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 56 | 633
preweaning lethality, incomple... 25 | 260
abnormal behavior 23 | 226
decreased lean body mass 21 | 195
decreased total body fat amoun... 20 | 186
decreased bone mineral content 19 | 157
decreased body weight 18 | 174
embryonic lethality prior to t... 16 | 187
decreased bone mineral density 15 | 126
abnormal bone structure 14 | 131
decreased grip strength 13 | 123
hyperactivity 13 | 108
decreased body length 12 | 108
hypoactivity 12 | 89
abnormal retina morphology 11 | 100
embryonic lethality prior to o... 11 | 148
decreased circulating choleste... 10 | 85
decreased circulating triglyce... 10 | 83
increased circulating alkaline... 10 | 119
increased or absent threshold ... 10 | 128
abnormal coat-hair pigmentatio... 9 | 54
decreased circulating HDL chol... 9 | 77
decreased circulating glucose ... 9 | 121
enlarged heart 9 | 111
increased lean body mass 9 | 107
increased mean corpuscular vol... 9 | 91
short tibia 9 | 82
decreased mean corpuscular vol... 8 | 50
decreased prepulse inhibition 8 | 52
increased mean corpuscular hem... 8 | 93
abnormal retinal pigmentation 7 | 61
decreased circulating insulin ... 7 | 75
decreased circulating serum al... 7 | 79
decreased rib number 7 | 59
increased blood urea nitrogen ... 7 | 44
increased bone mineral content 7 | 92
abnormal lens morphology 6 | 73
abnormal locomotor activation 6 | 26
abnormal sleep behavior 6 | 63
decreased circulating alanine ... 6 | 53
decreased hemoglobin content 6 | 53
improved glucose tolerance 6 | 56
increased body weight 6 | 42
increased fasted circulating g... 6 | 68
tremors 6 | 34
abnormal behavioral response t... 5 | 52
abnormal bone mineralization 5 | 55
abnormal embryo size 5 | 112
absent pinna reflex 5 | 21
decreased circulating LDL chol... 5 | 37
decreased mean corpuscular hem... 5 | 34
decreased startle reflex 5 | 48
increased bone mineral density 5 | 52
increased circulating sodium l... 5 | 71
increased grip strength 5 | 83
increased sacral vertebrae num... 5 | 62
increased startle reflex 5 | 38
persistence of hyaloid vascula... 5 | 22
abnormal QRS complex 4 | 25
abnormal digit morphology 4 | 13
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal startle reflex 4 | 14
abnormal thoracic vertebrae mo... 4 | 16
cardiovascular system phenotyp... 4 | 35
corneal opacity 4 | 25
decreased circulating calcium ... 4 | 33
decreased circulating potassiu... 4 | 17
decreased eosinophil cell numb... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased fasted circulating g... 4 | 49
decreased lumbar vertebrae num... 4 | 62
increased CD4-positive, CD25-p... 4 | 18
increased circulating chloride... 4 | 43
increased circulating choleste... 4 | 53
increased rib number 4 | 41
increased total body fat amoun... 4 | 57
increased vertical activity 4 | 18
male infertility 4 | 62
prenatal lethality prior to he... 4 | 64
shortened ST segment 4 | 9
thrombocytopenia 4 | 46
abnormal embryo turning 3 | 15
abnormal neural tube closure 3 | 37
abnormal tooth morphology 3 | 24
convulsive seizures 3 | 11
decreased NK T cell number 3 | 28
decreased caudal vertebrae num... 3 | 49
decreased circulating chloride... 3 | 32
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating total pr... 3 | 41
decreased heart weight 3 | 44
decreased vertical activity 3 | 22
impaired glucose tolerance 3 | 52
increased circulating HDL chol... 3 | 63
increased exploration in new e... 3 | 56
increased hematocrit 3 | 36
small testis 3 | 37
straub tail 3 | 26

Disease

sonic hedgehog group medulloblastoma 1,482 | 1,482
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,475 | 18,560
Female tissues 1,471 | 18,646
Digestive Tract 1,470 | 18,472
Endocrine System 1,470 | 18,511
Liver and Pancreas 1,468 | 18,135
Cardiovascular System 1,467 | 17,957
Male tissues 1,466 | 17,968
Urinary Tract 1,465 | 18,443
Blood and immune system 1,460 | 17,994
Respiratory system 1,457 | 17,483
Skin and soft tissues 1,457 | 18,114

Target Family

Non-IDG 880 | 11,969
Enzyme 292 | 4,146
Transcription Factor 122 | 1,400
Kinase 53 | 634
Transporter 44 | 473
Ion Channel 31 | 341
Epigenetic 25 | 242
GPCR 25 | 408
Nuclear Receptor 5 | 48
TF/Epigenetic 3 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
N-cym protein MYCNOS Tdark Non-IDG 0.00000 0
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Alternative prion protein PRNP Tbio Non-IDG -3.44085 5471.9 0
Neurexin-3-beta NRXN3 Tbio Non-IDG -1.29937 33.0 142