Development Level

Tbio 4,454 | 11,651
Tdark 1,308 | 6,593
Tchem 652 | 1,388
Tclin 280 | 612

Collection

RFA-RM-18-021 110 | 328
Kinase: IDG Consortium (Target... 42 | 125
GPCR: IDG Consortium (Targets) 35 | 126
Ion Channel: IDG Consortium (T... 35 | 99
Kinase: IDG Consortium (Comple... 13 | 37
GPCR: IDG Consortium (Complete... 11 | 25

IMPC Phenotype

preweaning lethality, complete... 342 | 979
preweaning lethality, incomple... 187 | 499
abnormal behavior 121 | 298
decreased total body fat amoun... 103 | 207
embryonic lethality prior to t... 92 | 278
enlarged heart 90 | 210
decreased vertical activity 86 | 208
abnormal bone structure 77 | 187
embryonic lethality prior to o... 76 | 239
increased lean body mass 73 | 172
abnormal embryo size 70 | 220
abnormal heart morphology 70 | 162
decreased body weight 66 | 161
hypoactivity 61 | 132
increased circulating alkaline... 61 | 122
decreased bone mineral content 59 | 151
decreased circulating glucose ... 58 | 126
hyperactivity 57 | 148
decreased bone mineral density 56 | 126
decreased grip strength 56 | 116
increased total body fat amoun... 53 | 134
increased bone mineral content 49 | 108
increased startle reflex 49 | 112
male infertility 47 | 123
decreased body length 45 | 101
decreased lean body mass 43 | 135
increased mean corpuscular vol... 43 | 92
decreased circulating choleste... 42 | 93
increased or absent threshold ... 41 | 101
abnormal seminal vesicle morph... 40 | 114
embryonic growth retardation 39 | 106
abnormal gait 38 | 69
decreased circulating insulin ... 36 | 76
decreased lymphocyte cell numb... 36 | 83
decreased mean corpuscular vol... 36 | 79
short tibia 36 | 97
decreased circulating triglyce... 35 | 79
decreased prepulse inhibition 35 | 82
impaired glucose tolerance 35 | 75
cataract 33 | 92
increased mean corpuscular hem... 33 | 96
abnormal sleep behavior 32 | 70
decreased circulating serum al... 32 | 82
decreased circulating HDL chol... 31 | 68
decreased leukocyte cell numbe... 31 | 73
decreased startle reflex 31 | 75
increased circulating choleste... 30 | 66
improved glucose tolerance 29 | 79
thrombocytopenia 29 | 56
abnormal lens morphology 28 | 81
increased circulating HDL chol... 28 | 80
increased circulating sodium l... 28 | 71
increased monocyte cell number 28 | 63
abnormal behavioral response t... 27 | 66
decreased circulating total pr... 27 | 49
increased bone mineral density 27 | 72
prenatal lethality prior to he... 27 | 87
small superior vagus ganglion 27 | 74
decreased fasted circulating g... 26 | 65
abnormal spleen morphology 25 | 55
abnormal eye morphology 24 | 68
decreased erythrocyte cell num... 24 | 62
decreased hemoglobin content 24 | 68
increased heart weight 24 | 62
abnormal kidney morphology 23 | 65
abnormal skin morphology 23 | 50
decreased mean corpuscular hem... 23 | 50
increased circulating triglyce... 23 | 42
small testis 23 | 58
abnormal epididymis morphology 22 | 42
abnormal retina morphology 22 | 71
decreased blood urea nitrogen ... 22 | 51
increased fasted circulating g... 22 | 76
increased leukocyte cell numbe... 22 | 47
decreased caudal vertebrae num... 21 | 53
decreased circulating alkaline... 21 | 46
edema 21 | 59
increased circulating calcium ... 21 | 34
increased neutrophil cell numb... 21 | 46
abnormal coat-hair pigmentatio... 20 | 64
decreased hematocrit 20 | 46
female infertility 20 | 60
increased circulating chloride... 20 | 41
increased hematocrit 20 | 46
tremors 20 | 39
decreased circulating alanine ... 19 | 47
decreased circulating calcium ... 19 | 36
decreased circulating iron lev... 19 | 32
decreased neutrophil cell numb... 19 | 42
hydrometra 19 | 53
increased blood urea nitrogen ... 19 | 48
increased erythrocyte cell num... 19 | 39
limb grasping 19 | 41
prolonged QT interval 19 | 38
increased grip strength 18 | 41
increased hemoglobin content 17 | 45
increased red blood cell distr... 17 | 34
abnormal bone mineralization 16 | 38
enlarged epididymis 16 | 31
enlarged spleen 16 | 41

Disease

psoriasis 6,694 | 6,694
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 6,341 | 18,159
Female tissues 6,258 | 17,400
Digestive Tract 6,243 | 17,369
Skin and soft tissues 6,212 | 17,230
Male tissues 6,118 | 17,142
Blood and immune system 6,031 | 16,909
Liver and Pancreas 6,001 | 16,750
Urinary Tract 5,984 | 16,678
Nervous System 5,953 | 16,725
Respiratory system 5,866 | 16,393
Cardiovascular System 5,410 | 15,192

Target Family

Non-IDG 3,935 | 12,091
Enzyme 1,435 | 4,145
Transcription Factor 456 | 1,400
Kinase 263 | 634
Transporter 169 | 473
GPCR 164 | 408
Ion Channel 130 | 344
Epigenetic 81 | 242
Nuclear Receptor 30 | 48
TF/Epigenetic 18 | 38
oGPCR 13 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143