Development Level

Tbio 4,094 | 10,625
Tdark 1,450 | 7,003
Tchem 869 | 1,890
Tclin 272 | 602

Collection

Eligible Kinase Proteins 47 | 134
Eligible Ion Channel Proteins 43 | 117
Eligible non-olfactory GPCR Proteins 40 | 143

IMPC Term

preweaning lethality, complete... 221 | 633
abnormal behavior 104 | 226
decreased total body fat amoun... 91 | 186
preweaning lethality, incomple... 90 | 260
decreased lean body mass 82 | 195
decreased body weight 71 | 174
decreased bone mineral content 71 | 157
increased circulating alkaline... 62 | 119
decreased bone mineral density 59 | 126
decreased grip strength 58 | 123
abnormal bone structure 56 | 131
embryonic lethality prior to t... 56 | 187
decreased circulating glucose ... 55 | 121
decreased body length 51 | 108
increased or absent threshold ... 51 | 128
increased lean body mass 49 | 107
enlarged heart 48 | 111
hyperactivity 45 | 108
hypoactivity 45 | 89
increased mean corpuscular vol... 44 | 91
embryonic lethality prior to o... 43 | 148
increased bone mineral content 41 | 92
short tibia 41 | 82
decreased circulating choleste... 40 | 85
increased mean corpuscular hem... 40 | 93
decreased circulating triglyce... 39 | 83
abnormal embryo size 38 | 112
decreased circulating insulin ... 38 | 75
abnormal retina morphology 36 | 100
decreased circulating HDL chol... 34 | 77
decreased circulating serum al... 33 | 79
increased grip strength 33 | 83
decreased mean corpuscular vol... 30 | 50
abnormal lens morphology 29 | 73
abnormal sleep behavior 29 | 63
decreased lumbar vertebrae num... 28 | 62
male infertility 28 | 62
improved glucose tolerance 27 | 56
decreased fasted circulating g... 26 | 49
increased circulating sodium l... 26 | 71
decreased startle reflex 25 | 48
increased sacral vertebrae num... 25 | 62
abnormal gait 24 | 51
decreased circulating total pr... 24 | 41
decreased prepulse inhibition 24 | 52
abnormal behavioral response t... 23 | 52
decreased hemoglobin content 23 | 53
decreased leukocyte cell numbe... 23 | 54
impaired glucose tolerance 23 | 52
increased circulating choleste... 23 | 53
decreased caudal vertebrae num... 22 | 49
decreased circulating alkaline... 22 | 41
decreased heart weight 22 | 44
increased circulating HDL chol... 22 | 63
thrombocytopenia 22 | 46
abnormal heart morphology 21 | 51
abnormal retinal pigmentation 21 | 61
decreased circulating alanine ... 21 | 53
decreased erythrocyte cell num... 21 | 43
decreased rib number 21 | 59
increased hemoglobin content 21 | 45
abnormal bone mineralization 20 | 55
abnormal seminal vesicle morph... 20 | 47
increased body weight 20 | 42
increased hematocrit 20 | 36
increased total body fat amoun... 20 | 57
prenatal lethality prior to he... 20 | 64
increased circulating calcium ... 19 | 32
increased circulating chloride... 19 | 43
increased exploration in new e... 19 | 56
increased rib number 19 | 41
abnormal coat/hair pigmentatio... 18 | 54
increased bone mineral density 18 | 52
increased fasted circulating g... 18 | 68
increased leukocyte cell numbe... 18 | 37
tremors 18 | 34
abnormal spleen morphology 17 | 36
decreased T cell number 17 | 31
decreased circulating iron lev... 17 | 25
decreased mean corpuscular hem... 17 | 34
increased blood urea nitrogen ... 17 | 44
limb grasping 17 | 35
decreased CD8-positive, alpha-... 16 | 26
decreased NK T cell number 16 | 28
decreased circulating calcium ... 16 | 33
decreased threshold for audito... 16 | 32
small testis 16 | 37
abnormal cranium morphology 15 | 32
abnormal epididymis morphology 15 | 31
decreased circulating free fat... 15 | 39
increased circulating iron lev... 15 | 25
abnormal eye morphology 14 | 38
abnormal neural tube closure 14 | 37
decreased circulating LDL chol... 14 | 37
enlarged epididymis 14 | 27
increased erythrocyte cell num... 14 | 26
increased startle reflex 14 | 38
abnormal skin morphology 13 | 23
decreased eosinophil cell numb... 13 | 41
increased circulating total pr... 13 | 20

Disease

psoriasis 6,685 | 6,685
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 6,494 | 18,473
Nervous System 6,489 | 18,561
Female tissues 6,483 | 18,647
Urinary Tract 6,465 | 18,444
Endocrine System 6,459 | 18,512
Skin and soft tissues 6,421 | 18,115
Liver and Pancreas 6,411 | 18,136
Cardiovascular System 6,368 | 17,958
Blood and immune system 6,364 | 17,995
Male tissues 6,346 | 17,969
Respiratory system 6,265 | 17,484

Target Family

Non-IDG 3,928 | 11,971
Enzyme 1,433 | 4,146
Transcription Factor 457 | 1,400
Kinase 263 | 634
Transporter 169 | 473
GPCR 164 | 406
Ion Channel 129 | 341
Epigenetic 81 | 242
Nuclear Receptor 30 | 48
TF/Epigenetic 18 | 38
oGPCR 13 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193