Development Level

Tbio 424 | 10,625
Tdark 151 | 7,003
Tchem 80 | 1,890
Tclin 19 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 28 | 633
abnormal behavior 21 | 226
decreased total body fat amoun... 14 | 186
decreased body weight 13 | 174
decreased lean body mass 13 | 195
increased or absent threshold ... 12 | 128
abnormal retina morphology 9 | 100
hyperactivity 9 | 108
decreased bone mineral content 8 | 157
decreased circulating serum al... 8 | 79
decreased circulating triglyce... 8 | 83
increased lean body mass 8 | 107
decreased body length 7 | 108
embryonic lethality prior to o... 7 | 148
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
abnormal coat/hair pigmentatio... 6 | 54
decreased erythrocyte cell num... 6 | 43
embryonic lethality prior to t... 6 | 187
increased bone mineral content 6 | 92
increased sacral vertebrae num... 6 | 62
preweaning lethality, incomple... 6 | 260
abnormal embryo size 5 | 112
abnormal tail morphology 5 | 17
decreased circulating fructosa... 5 | 31
decreased circulating total pr... 5 | 41
decreased grip strength 5 | 123
decreased hematocrit 5 | 25
decreased leukocyte cell numbe... 5 | 54
abnormal bone mineralization 4 | 55
abnormal retinal pigmentation 4 | 61
abnormal testis morphology 4 | 30
decreased NK T cell number 4 | 28
decreased bone mineral density 4 | 126
decreased caudal vertebrae num... 4 | 49
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased hemoglobin content 4 | 53
decreased mean corpuscular vol... 4 | 50
decreased neutrophil cell numb... 4 | 37
decreased prepulse inhibition 4 | 52
enlarged lymph nodes 4 | 27
hypoactivity 4 | 89
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased circulating choleste... 4 | 53
increased hemoglobin content 4 | 45
increased total body fat amoun... 4 | 57
tremors 4 | 34
abnormal cornea morphology 3 | 24
abnormal cranium morphology 3 | 32
abnormal retinal vasculature m... 3 | 15
abnormal sleep behavior 3 | 63
decreased circulating HDL chol... 3 | 77
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating aspartat... 3 | 27
decreased circulating insulin ... 3 | 75
decreased eosinophil cell numb... 3 | 41
decreased mean corpuscular hem... 3 | 34
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating creatini... 3 | 29
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular hem... 3 | 93
increased mean corpuscular hem... 3 | 25
small testis 3 | 37
thrombocytosis 3 | 23
vertebral fusion 3 | 23
abnormal coping response 2 | 12
abnormal gait 2 | 51
abnormal kidney morphology 2 | 30
abnormal lens morphology 2 | 73
abnormal retinal blood vessel ... 2 | 18
abnormal rib morphology 2 | 28
abnormal spleen morphology 2 | 36
abnormal vertebrae morphology 2 | 14
corneal opacity 2 | 25
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased basophil cell number 2 | 11
decreased cervical vertebrae n... 2 | 12
decreased circulating calcium ... 2 | 33
decreased circulating glycerol... 2 | 19
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
female infertility 2 | 34
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating glucose ... 2 | 16
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased rib number 2 | 41
limb grasping 2 | 35
persistence of hyaloid vascula... 2 | 22

Disease

progressive supranuclear palsy 674 | 674
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 669 | 18,473
Female tissues 669 | 18,647
Liver and Pancreas 669 | 18,136
Nervous System 669 | 18,561
Blood and immune system 668 | 17,995
Cardiovascular System 668 | 17,958
Endocrine System 667 | 18,512
Male tissues 667 | 17,969
Urinary Tract 667 | 18,444
Respiratory system 664 | 17,484
Skin and soft tissues 664 | 18,115

Target Family

Non-IDG 403 | 11,971
Enzyme 149 | 4,146
Kinase 35 | 634
Transcription Factor 34 | 1,400
Transporter 20 | 473
Epigenetic 14 | 242
Ion Channel 14 | 341
GPCR 2 | 406
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Myelin basic protein MBP Tbio Non-IDG -3.69577 5257.0 715
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282
Striatin STRN Tbio Non-IDG -1.63637 51.0 118
LanC-like protein 1 LANCL1 Tbio Non-IDG -1.03436 11.5 49