Development Level

Tbio 2,040 | 11,651
Tdark 594 | 6,593
Tchem 266 | 1,388
Tclin 135 | 612

Collection

RFA-RM-18-021 57 | 328
Kinase: IDG Consortium (Target... 24 | 125
Ion Channel: IDG Consortium (T... 22 | 99
GPCR: IDG Consortium (Targets) 12 | 126
Kinase: IDG Consortium (Comple... 9 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 155 | 979
preweaning lethality, incomple... 120 | 499
abnormal behavior 85 | 298
decreased total body fat amoun... 53 | 207
embryonic lethality prior to t... 50 | 278
abnormal bone structure 44 | 187
embryonic lethality prior to o... 43 | 239
abnormal embryo size 41 | 220
increased lean body mass 40 | 172
hyperactivity 39 | 148
decreased body weight 35 | 161
increased bone mineral content 35 | 108
increased circulating alkaline... 35 | 122
decreased vertical activity 33 | 208
hypoactivity 33 | 132
decreased bone mineral content 32 | 151
decreased grip strength 32 | 116
enlarged heart 31 | 210
male infertility 29 | 123
decreased bone mineral density 28 | 126
decreased circulating choleste... 26 | 93
decreased prepulse inhibition 26 | 82
decreased lean body mass 24 | 135
increased startle reflex 24 | 112
decreased circulating HDL chol... 23 | 68
increased fasted circulating g... 23 | 76
cataract 22 | 92
abnormal lens morphology 21 | 81
increased mean corpuscular vol... 21 | 92
increased total body fat amoun... 21 | 134
short tibia 21 | 97
decreased fasted circulating g... 20 | 65
decreased lymphocyte cell numb... 20 | 83
increased heart weight 20 | 62
abnormal gait 19 | 69
abnormal heart morphology 19 | 162
decreased circulating serum al... 19 | 82
decreased hemoglobin content 19 | 68
decreased startle reflex 19 | 75
embryonic growth retardation 19 | 106
increased bone mineral density 19 | 72
increased mean corpuscular hem... 19 | 96
tremors 19 | 39
abnormal eye morphology 18 | 68
abnormal seminal vesicle morph... 18 | 114
increased circulating HDL chol... 18 | 80
increased or absent threshold ... 18 | 101
abnormal retina morphology 17 | 71
decreased body length 17 | 101
decreased circulating glucose ... 16 | 126
decreased circulating insulin ... 16 | 76
decreased circulating triglyce... 16 | 79
abnormal coat-hair pigmentatio... 15 | 64
abnormal sleep behavior 15 | 70
improved glucose tolerance 15 | 79
increased circulating choleste... 15 | 66
increased monocyte cell number 15 | 63
decreased caudal vertebrae num... 14 | 53
decreased erythrocyte cell num... 14 | 62
decreased mean corpuscular vol... 14 | 79
female infertility 14 | 60
increased circulating calcium ... 14 | 34
limb grasping 14 | 41
prenatal lethality prior to he... 14 | 87
increased blood urea nitrogen ... 13 | 48
increased circulating chloride... 13 | 41
increased circulating sodium l... 13 | 71
increased circulating triglyce... 13 | 42
abnormal behavioral response t... 12 | 66
abnormal kidney morphology 12 | 65
decreased circulating LDL chol... 12 | 38
decreased circulating alanine ... 12 | 47
edema 12 | 59
corneal opacity 11 | 32
decreased circulating alkaline... 11 | 46
decreased mean corpuscular hem... 11 | 50
enlarged lymph nodes 11 | 37
increased hematocrit 11 | 46
increased mean platelet volume 11 | 45
increased red blood cell distr... 11 | 34
abnormal locomotor behavior 10 | 24
decreased circulating creatini... 10 | 39
decreased circulating total pr... 10 | 49
decreased heart left ventricle... 10 | 28
impaired glucose tolerance 10 | 75
increased hemoglobin content 10 | 45
small testis 10 | 58
abnormal bone mineralization 9 | 38
abnormal epididymis morphology 9 | 42
abnormal retinal blood vessel ... 9 | 26
abnormal spleen morphology 9 | 55
abnormal tooth morphology 9 | 24
decreased circulating calcium ... 9 | 36
decreased hematocrit 9 | 46
decreased leukocyte cell numbe... 9 | 73
increased grip strength 9 | 41
increased mean corpuscular hem... 9 | 36
increased vertical activity 9 | 24
small superior vagus ganglion 9 | 74
thrombocytopenia 9 | 56

Disease

primitive neuroectodermal tumor 3,035 | 3,035
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Nervous System 3,005 | 16,725
Endocrine System 3,004 | 18,159
Female tissues 2,974 | 17,400
Digestive Tract 2,973 | 17,369
Skin and soft tissues 2,970 | 17,230
Male tissues 2,951 | 17,142
Liver and Pancreas 2,923 | 16,750
Urinary Tract 2,917 | 16,678
Blood and immune system 2,898 | 16,909
Respiratory system 2,886 | 16,393
Cardiovascular System 2,771 | 15,192

Target Family

Non-IDG 1,703 | 12,091
Enzyme 643 | 4,145
Transcription Factor 237 | 1,400
Kinase 136 | 634
Ion Channel 87 | 344
Transporter 87 | 473
Epigenetic 63 | 242
GPCR 55 | 408
Nuclear Receptor 14 | 48
TF/Epigenetic 9 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
F-box/LRR-repeat protein 17 FBXL17 Tbio Non-IDG -0.49601 3.17 90