Development Level

Tbio 530 | 10,625
Tchem 121 | 1,890
Tdark 87 | 7,003
Tclin 51 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 19 | 633
decreased bone mineral density 10 | 126
decreased bone mineral content 9 | 157
decreased lean body mass 9 | 195
preweaning lethality, incomple... 9 | 260
abnormal behavior 8 | 226
decreased total body fat amoun... 8 | 186
abnormal retina morphology 7 | 100
decreased circulating triglyce... 7 | 83
embryonic lethality prior to t... 7 | 187
increased circulating alkaline... 7 | 119
increased mean corpuscular hem... 7 | 93
abnormal coat/hair pigmentatio... 6 | 54
decreased body weight 6 | 174
decreased circulating HDL chol... 6 | 77
decreased grip strength 6 | 123
increased bone mineral content 6 | 92
short tibia 6 | 82
abnormal bone structure 5 | 131
abnormal retinal pigmentation 5 | 61
abnormal sleep behavior 5 | 63
decreased body length 5 | 108
decreased circulating insulin ... 5 | 75
decreased circulating serum al... 5 | 79
decreased leukocyte cell numbe... 5 | 54
enlarged heart 5 | 111
hypoactivity 5 | 89
increased circulating HDL chol... 5 | 63
increased heart weight 5 | 37
increased hematocrit 5 | 36
increased hemoglobin content 5 | 45
increased lean body mass 5 | 107
increased mean corpuscular vol... 5 | 91
increased neutrophil cell numb... 5 | 15
increased or absent threshold ... 5 | 128
thrombocytopenia 5 | 46
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased CD4-positive, CD25-p... 4 | 24
decreased CD8-positive, alpha-... 4 | 26
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased lymphocyte cell numb... 4 | 9
decreased mature B cell number 4 | 25
decreased mean corpuscular hem... 4 | 19
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
increased CD4-positive, alpha ... 4 | 15
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
increased circulating potassiu... 4 | 31
increased circulating sodium l... 4 | 71
male infertility 4 | 62
abnormal bone mineralization 3 | 55
abnormal neural tube closure 3 | 37
decreased B cell number 3 | 30
decreased circulating creatini... 3 | 31
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating iron lev... 3 | 25
decreased circulating potassiu... 3 | 17
decreased effector memory CD8-... 3 | 24
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased hematocrit 3 | 25
decreased hemoglobin content 3 | 53
decreased mean corpuscular hem... 3 | 34
enlarged lymph nodes 3 | 27
hyperactivity 3 | 108
immune system phenotype 3 | 17
increased circulating calcium ... 3 | 32
increased circulating total pr... 3 | 20
increased mean corpuscular hem... 3 | 25
increased monocyte cell number 3 | 27
increased sacral vertebrae num... 3 | 62
small testis 3 | 37
abnormal behavioral response t... 2 | 52
abnormal epididymis morphology 2 | 31
abnormal neural tube morpholog... 2 | 8
abnormal vibrissa morphology 2 | 17
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased caudal vertebrae num... 2 | 49
decreased circulating glycerol... 2 | 19
decreased fasted circulating g... 2 | 49
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
decreased startle reflex 2 | 48
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased circulating fructosa... 2 | 11
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased total body fat amoun... 2 | 57
tremors 2 | 34

Disease

primary Sjogren syndrome 789 | 789
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 781 | 17,995
Digestive Tract 781 | 18,473
Female tissues 781 | 18,647
Liver and Pancreas 781 | 18,136
Nervous System 781 | 18,561
Endocrine System 779 | 18,512
Male tissues 779 | 17,969
Urinary Tract 779 | 18,444
Cardiovascular System 777 | 17,958
Respiratory system 777 | 17,484
Skin and soft tissues 773 | 18,115

Target Family

Non-IDG 450 | 11,971
Enzyme 180 | 4,146
Transcription Factor 62 | 1,400
Kinase 33 | 634
GPCR 25 | 406
Transporter 16 | 473
Ion Channel 13 | 341
Epigenetic 7 | 242
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.17754 15.9 54
Killer cell lectin-like receptor subfamily B member 1 KLRB1 Tbio Non-IDG -2.39953 313.9 488
Serine/arginine repetitive matrix protein 2 SRRM2 Tbio Non-IDG -1.90106 71.6 51
Inactive phospholipase C-like protein 2 PLCL2 Tbio Enzyme -0.27372 2.11 81