Development Level

Tbio 224 | 11,651
Tdark 142 | 6,593
Tchem 34 | 1,388
Tclin 16 | 612

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 15 | 499
enlarged heart 10 | 210
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
embryonic lethality prior to t... 7 | 278
abnormal behavior 6 | 298
decreased vertical activity 6 | 208
abnormal bone structure 5 | 187
abnormal heart morphology 5 | 162
cataract 5 | 92
decreased circulating glucose ... 5 | 126
abnormal lens morphology 4 | 81
decreased bone mineral density 4 | 126
decreased circulating alanine ... 4 | 47
decreased circulating triglyce... 4 | 79
decreased mean corpuscular vol... 4 | 79
increased circulating choleste... 4 | 66
increased lean body mass 4 | 172
male infertility 4 | 123
abnormal coat-hair pigmentatio... 3 | 64
decreased body length 3 | 101
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased mean platelet volume 3 | 25
decreased prepulse inhibition 3 | 82
edema 3 | 59
embryonic lethality prior to o... 3 | 239
female infertility 3 | 60
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal optic disc morphology 2 | 10
abnormal retinal blood vessel ... 2 | 26
abnormal sleep behavior 2 | 70
corneal opacity 2 | 32
decreased basophil cell number 2 | 16
decreased cardiac muscle contr... 2 | 11
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating glycerol... 2 | 16
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased monocyte cell number 2 | 8
embryonic growth retardation 2 | 106
hemorrhage 2 | 23
hydrometra 2 | 53
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating amylase ... 2 | 25
increased circulating glycerol... 2 | 9
increased circulating iron lev... 2 | 30
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 36
increased startle reflex 2 | 112
iris synechia 2 | 3
narrow eye opening 2 | 12
small superior vagus ganglion 2 | 74
thin ventricular wall 2 | 24
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged ovary 1 | 2
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood uric acid leve... 1 | 5
increased cardiac muscle contr... 1 | 8
increased circulating magnesiu... 1 | 10
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33

Disease

posterior fossa group B ependymoma 416 | 416
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 409 | 18,159
Female tissues 407 | 17,400
Male tissues 401 | 17,142
Digestive Tract 399 | 17,369
Nervous System 399 | 16,725
Skin and soft tissues 399 | 17,230
Respiratory system 398 | 16,393
Blood and immune system 397 | 16,909
Liver and Pancreas 395 | 16,750
Urinary Tract 395 | 16,678
Cardiovascular System 368 | 15,192

Target Family

Non-IDG 255 | 12,091
Enzyme 86 | 4,145
Kinase 22 | 634
Transcription Factor 18 | 1,400
Transporter 12 | 473
Ion Channel 9 | 344
Epigenetic 6 | 242
GPCR 5 | 408
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Cilia- and flagella-associated protein 74 CFAP74 Tdark Non-IDG 0.38 0.16 21
G-protein coupled receptor 176 GPR176 Tbio GPCR -2.38327 235.4 133
Cation channel sperm-associated protein subunit epsilon CATSPERE Tdark Non-IDG 0.00000 21
Fibronectin type III domain-containing protein 10 FNDC10 Tdark Non-IDG 0.00000 0
Centrosomal protein of 83 kDa CEP83 Tdark Non-IDG -0.47180 2.89 0
RNA-binding motif, single-stranded-interacting protein 3 RBMS3 Tbio Non-IDG -0.93602 12.0 95
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Probable tubulin polyglutamylase TTLL1 TTLL1 Tdark Enzyme -0.79170 5.84 34