Development Level

Tbio 854 | 10,625
Tdark 480 | 7,003
Tchem 151 | 1,890
Tclin 45 | 602

Collection

Eligible Kinase Proteins 16 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 47 | 633
preweaning lethality, incomple... 28 | 260
decreased body weight 17 | 174
abnormal behavior 16 | 226
abnormal bone structure 13 | 131
abnormal embryo size 13 | 112
decreased bone mineral content 13 | 157
embryonic lethality prior to t... 13 | 187
enlarged heart 13 | 111
decreased circulating glucose ... 12 | 121
decreased lumbar vertebrae num... 12 | 62
abnormal retina morphology 11 | 100
decreased lean body mass 11 | 195
increased sacral vertebrae num... 11 | 62
male infertility 11 | 62
decreased total body fat amoun... 10 | 186
decreased circulating serum al... 9 | 79
hyperactivity 9 | 108
hypoactivity 9 | 89
increased lean body mass 9 | 107
increased or absent threshold ... 9 | 128
abnormal lens morphology 8 | 73
decreased body length 8 | 108
increased circulating alkaline... 8 | 119
abnormal retinal pigmentation 7 | 61
decreased bone mineral density 7 | 126
decreased caudal vertebrae num... 7 | 49
decreased circulating alanine ... 7 | 53
decreased circulating triglyce... 7 | 83
decreased eosinophil cell numb... 7 | 41
decreased fasted circulating g... 7 | 49
decreased grip strength 7 | 123
embryonic lethality prior to o... 7 | 148
increased bone mineral content 7 | 92
increased circulating HDL chol... 7 | 63
increased circulating sodium l... 7 | 71
abnormal sleep behavior 6 | 63
increased circulating iron lev... 6 | 25
increased rib number 6 | 41
increased startle reflex 6 | 38
short tibia 6 | 82
abnormal bone mineralization 5 | 55
abnormal coat/hair pigmentatio... 5 | 54
abnormal neural tube closure 5 | 37
abnormal spleen morphology 5 | 36
cataract 5 | 26
decreased circulating HDL chol... 5 | 77
decreased circulating aspartat... 5 | 27
decreased heart weight 5 | 44
decreased mean corpuscular vol... 5 | 50
decreased neutrophil cell numb... 5 | 37
decreased startle reflex 5 | 48
embryonic growth retardation 5 | 28
impaired glucose tolerance 5 | 52
increased body weight 5 | 42
increased bone mineral density 5 | 52
increased circulating creatini... 5 | 29
increased exploration in new e... 5 | 56
increased grip strength 5 | 83
increased mean corpuscular vol... 5 | 91
increased red blood cell distr... 5 | 21
increased total body fat amoun... 5 | 57
tremors 5 | 34
abnormal eye morphology 4 | 38
abnormal gait 4 | 51
abnormal retinal blood vessel ... 4 | 18
abnormal retinal vasculature m... 4 | 15
absent pinna reflex 4 | 21
decreased Ly6C low monocyte nu... 4 | 23
decreased blood urea nitrogen ... 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased circulating choleste... 4 | 85
decreased hemoglobin content 4 | 53
decreased monocyte cell number 4 | 28
decreased prepulse inhibition 4 | 52
decreased rib number 4 | 59
impaired pupillary reflex 4 | 14
increased circulating LDL chol... 4 | 15
increased circulating choleste... 4 | 53
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular hem... 4 | 93
increased mean corpuscular hem... 4 | 25
prenatal lethality prior to he... 4 | 64
abnormal behavioral response t... 3 | 52
abnormal coat appearance 3 | 25
abnormal cranium morphology 3 | 32
abnormal heart left ventricle ... 3 | 20
abnormal vertebrae morphology 3 | 14
decreased Ly6C high monocyte n... 3 | 18
decreased circulating glycerol... 3 | 19
decreased circulating potassiu... 3 | 17
enlarged spleen 3 | 26
increased body length 3 | 20
increased circulating fructosa... 3 | 11
increased circulating potassiu... 3 | 31
increased hematocrit 3 | 36
increased prepulse inhibition 3 | 21
small testis 3 | 37

Disease

posterior fossa group B ependymoma 1,530 | 1,530
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,515 | 18,561
Digestive Tract 1,514 | 18,473
Female tissues 1,513 | 18,647
Endocrine System 1,511 | 18,512
Urinary Tract 1,509 | 18,444
Cardiovascular System 1,508 | 17,958
Liver and Pancreas 1,505 | 18,136
Male tissues 1,505 | 17,969
Skin and soft tissues 1,503 | 18,115
Respiratory system 1,500 | 17,484
Blood and immune system 1,499 | 17,995

Target Family

Non-IDG 983 | 11,971
Enzyme 294 | 4,146
Transcription Factor 83 | 1,400
Kinase 70 | 634
Transporter 37 | 473
Ion Channel 28 | 341
GPCR 20 | 406
Epigenetic 11 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Protein FAM69C FAM69C Tdark Non-IDG 0.27 0.39 3
Testis-specific gene 10 protein TSGA10 Tbio Non-IDG -1.05563 13.1 82
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Transcription factor 24 TCF24 Tdark Non-IDG 0.30 0.09 0
Interferon lambda receptor 1 IFNLR1 Tchem Non-IDG -1.48464 33.1 128