Development Level

Tbio 323 | 11,651
Tdark 78 | 6,593
Tchem 47 | 1,388
Tclin 20 | 612

Collection

RFA-RM-18-021 5 | 328
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 17 | 499
enlarged heart 11 | 210
decreased vertical activity 9 | 208
embryonic lethality prior to o... 9 | 239
abnormal behavior 7 | 298
embryonic lethality prior to t... 7 | 278
impaired glucose tolerance 7 | 75
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal heart morphology 6 | 162
abnormal lens morphology 6 | 81
decreased circulating glucose ... 6 | 126
cataract 5 | 92
decreased prepulse inhibition 5 | 82
decreased total body fat amoun... 5 | 207
hypoactivity 5 | 132
increased fasted circulating g... 5 | 76
abnormal behavioral response t... 4 | 66
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased circulating insulin ... 4 | 76
hydrometra 4 | 53
hyperactivity 4 | 148
increased circulating sodium l... 4 | 71
increased lean body mass 4 | 172
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
abnormal QT variability 3 | 10
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
abnormal testis morphology 3 | 43
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
male infertility 3 | 123
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal hindbrain development 2 | 16
abnormal liver morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal retina morphology 2 | 71
absent startle reflex 2 | 24
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased mature B cell number 2 | 7
decreased mean corpuscular hem... 2 | 50
decreased respiratory quotient 2 | 16
decreased threshold for audito... 2 | 26
enlarged spleen 2 | 41
female infertility 2 | 60
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased circulating glucose ... 2 | 24
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
prolonged PR interval 2 | 15
prolonged QT interval 2 | 38
small thymus 2 | 16
thin ventricular wall 2 | 24
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal vocalization 1 | 21
decreased circulating bilirubi... 1 | 19
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased heart weight 1 | 62
long tibia 1 | 25

Disease

posterior fossa group A ependymoma 468 | 468
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 463 | 18,159
Digestive Tract 461 | 17,369
Skin and soft tissues 460 | 17,230
Urinary Tract 459 | 16,678
Female tissues 458 | 17,400
Male tissues 458 | 17,142
Nervous System 457 | 16,725
Blood and immune system 453 | 16,909
Liver and Pancreas 453 | 16,750
Respiratory system 450 | 16,393
Cardiovascular System 424 | 15,192

Target Family

Non-IDG 284 | 12,091
Enzyme 98 | 4,145
Transcription Factor 32 | 1,400
Kinase 18 | 634
Transporter 14 | 473
GPCR 8 | 408
Ion Channel 5 | 344
Epigenetic 4 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Protein phosphatase 1 regulatory subunit 29 ELFN2 Tdark Enzyme 0.06 0.68 51
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Immunoglobulin superfamily containing leucine-rich repeat protein 2 ISLR2 Tbio Non-IDG -1.71209 49.0 64
Zinc finger protein 678 ZNF678 Tdark Transcription Factor 0.00000 70
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Transmembrane protein 251 TMEM251 Tdark Non-IDG 0.00000 4