Development Level

Tbio 965 | 10,625
Tdark 269 | 7,003
Tchem 200 | 1,890
Tclin 77 | 602

Collection

Eligible Ion Channel Proteins 12 | 117
Eligible non-olfactory GPCR Proteins 8 | 143
Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 43 | 633
preweaning lethality, incomple... 26 | 260
decreased bone mineral content 24 | 157
decreased lean body mass 24 | 195
abnormal behavior 23 | 226
decreased total body fat amoun... 23 | 186
increased or absent threshold ... 21 | 128
decreased bone mineral density 20 | 126
abnormal bone structure 19 | 131
decreased body weight 17 | 174
increased circulating alkaline... 17 | 119
increased lean body mass 15 | 107
decreased circulating insulin ... 14 | 75
decreased grip strength 14 | 123
hyperactivity 14 | 108
abnormal sleep behavior 13 | 63
decreased body length 12 | 108
decreased circulating choleste... 12 | 85
embryonic lethality prior to t... 12 | 187
increased bone mineral content 12 | 92
embryonic lethality prior to o... 11 | 148
increased circulating chloride... 11 | 43
increased mean corpuscular vol... 11 | 91
short tibia 11 | 82
decreased circulating glucose ... 10 | 121
decreased prepulse inhibition 10 | 52
increased blood urea nitrogen ... 10 | 44
hypoactivity 9 | 89
impaired glucose tolerance 9 | 52
improved glucose tolerance 9 | 56
increased mean corpuscular hem... 9 | 93
abnormal coat/hair pigmentatio... 8 | 54
abnormal lens morphology 8 | 73
decreased circulating HDL chol... 8 | 77
enlarged heart 8 | 111
increased fasted circulating g... 8 | 68
increased grip strength 8 | 83
abnormal retina morphology 7 | 100
decreased hemoglobin content 7 | 53
increased circulating sodium l... 7 | 71
abnormal embryo size 6 | 112
abnormal locomotor activation 6 | 26
decreased caudal vertebrae num... 6 | 49
impaired righting response 6 | 19
increased circulating choleste... 6 | 53
abnormal gait 5 | 51
abnormal joint morphology 5 | 14
abnormal kidney morphology 5 | 30
abnormal seminal vesicle morph... 5 | 47
abnormal tooth morphology 5 | 24
decreased circulating LDL chol... 5 | 37
decreased circulating alkaline... 5 | 41
decreased circulating serum al... 5 | 79
decreased circulating triglyce... 5 | 83
decreased fasted circulating g... 5 | 49
decreased heart weight 5 | 44
female infertility 5 | 34
increased total body fat amoun... 5 | 57
thrombocytopenia 5 | 46
tremors 5 | 34
abnormal QRS complex 4 | 25
abnormal behavioral response t... 4 | 52
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
abnormal eye morphology 4 | 38
cardiovascular system phenotyp... 4 | 35
decreased B cell number 4 | 30
decreased CD8-positive, alpha-... 4 | 26
decreased blood urea nitrogen ... 4 | 31
decreased circulating creatini... 4 | 31
decreased circulating iron lev... 4 | 25
decreased eosinophil cell numb... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased hematocrit 4 | 25
decreased mean corpuscular hem... 4 | 19
decreased mean corpuscular vol... 4 | 50
decreased rib number 4 | 59
increased bone mineral density 4 | 52
increased circulating HDL chol... 4 | 63
increased circulating alanine ... 4 | 11
increased circulating calcium ... 4 | 32
increased circulating glucose ... 4 | 16
increased circulating iron lev... 4 | 25
increased heart weight 4 | 37
limb grasping 4 | 35
straub tail 4 | 26
abnormal cranium morphology 3 | 32
abnormal heart morphology 3 | 51
convulsive seizures 3 | 11
decreased T cell number 3 | 31
decreased circulating calcium ... 3 | 33
decreased effector memory CD8-... 3 | 24
decreased mean corpuscular hem... 3 | 34
decreased vertical activity 3 | 22
increased body weight 3 | 42
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 21
long tibia 3 | 13
prenatal lethality prior to he... 3 | 64
small testis 3 | 37

Disease

posterior fossa group A ependymoma 1,511 | 1,511
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,498 | 18,561
Digestive Tract 1,493 | 18,473
Endocrine System 1,493 | 18,512
Female tissues 1,493 | 18,647
Liver and Pancreas 1,493 | 18,136
Male tissues 1,492 | 17,969
Cardiovascular System 1,491 | 17,958
Urinary Tract 1,491 | 18,444
Blood and immune system 1,486 | 17,995
Respiratory system 1,484 | 17,484
Skin and soft tissues 1,484 | 18,115

Target Family

Non-IDG 899 | 11,971
Enzyme 319 | 4,146
Transcription Factor 94 | 1,400
Kinase 53 | 634
Ion Channel 45 | 341
Transporter 40 | 473
GPCR 35 | 406
Epigenetic 15 | 242
Nuclear Receptor 6 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345