Development Level

Tbio 1,390 | 11,651
Tdark 320 | 6,593
Tchem 178 | 1,388
Tclin 84 | 612

Collection

RFA-RM-18-021 35 | 328
Kinase: IDG Consortium (Target... 14 | 125
Ion Channel: IDG Consortium (T... 11 | 99
GPCR: IDG Consortium (Targets) 10 | 126
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 97 | 979
preweaning lethality, incomple... 66 | 499
abnormal behavior 51 | 298
enlarged heart 38 | 210
decreased total body fat amoun... 36 | 207
abnormal embryo size 30 | 220
increased lean body mass 30 | 172
abnormal heart morphology 28 | 162
decreased vertical activity 28 | 208
hyperactivity 26 | 148
abnormal bone structure 25 | 187
embryonic lethality prior to t... 25 | 278
increased total body fat amoun... 24 | 134
decreased bone mineral content 21 | 151
decreased body weight 20 | 161
hypoactivity 20 | 132
increased circulating alkaline... 20 | 122
abnormal seminal vesicle morph... 19 | 114
decreased bone mineral density 19 | 126
embryonic lethality prior to o... 19 | 239
increased startle reflex 19 | 112
decreased lean body mass 18 | 135
abnormal lens morphology 17 | 81
cataract 16 | 92
increased bone mineral content 16 | 108
male infertility 16 | 123
decreased body length 15 | 101
decreased circulating glucose ... 15 | 126
decreased grip strength 15 | 116
increased or absent threshold ... 15 | 101
short tibia 15 | 97
decreased circulating choleste... 13 | 93
decreased circulating insulin ... 13 | 76
abnormal kidney morphology 12 | 65
decreased lymphocyte cell numb... 12 | 83
decreased prepulse inhibition 12 | 82
increased blood urea nitrogen ... 12 | 48
increased bone mineral density 12 | 72
abnormal behavioral response t... 11 | 66
decreased fasted circulating g... 11 | 65
increased circulating sodium l... 11 | 71
increased heart weight 11 | 62
increased mean corpuscular vol... 11 | 92
abnormal neural tube closure 10 | 46
decreased circulating HDL chol... 10 | 68
edema 10 | 59
improved glucose tolerance 10 | 79
increased circulating HDL chol... 10 | 80
increased mean corpuscular hem... 10 | 96
increased monocyte cell number 10 | 63
small testis 10 | 58
abnormal epididymis morphology 9 | 42
abnormal gait 9 | 69
abnormal spleen morphology 9 | 55
abnormal testis morphology 9 | 43
decreased circulating triglyce... 9 | 79
embryonic growth retardation 9 | 106
abnormal sleep behavior 8 | 70
decreased blood urea nitrogen ... 8 | 51
decreased circulating serum al... 8 | 82
decreased circulating total pr... 8 | 49
decreased leukocyte cell numbe... 8 | 73
enlarged spleen 8 | 41
female infertility 8 | 60
increased circulating chloride... 8 | 41
increased circulating choleste... 8 | 66
increased fasted circulating g... 8 | 76
increased leukocyte cell numbe... 8 | 47
limb grasping 8 | 41
thrombocytopenia 8 | 56
abnormal eye morphology 7 | 68
abnormal skin morphology 7 | 50
decreased circulating alanine ... 7 | 47
decreased circulating alkaline... 7 | 46
decreased erythrocyte cell num... 7 | 62
decreased hemoglobin content 7 | 68
decreased mean corpuscular hem... 7 | 50
decreased mean corpuscular vol... 7 | 79
decreased startle reflex 7 | 75
enlarged epididymis 7 | 31
impaired glucose tolerance 7 | 75
increased circulating creatini... 7 | 38
increased neutrophil cell numb... 7 | 46
prenatal lethality prior to he... 7 | 87
abnormal bone mineralization 6 | 38
abnormal locomotor behavior 6 | 24
abnormal lung morphology 6 | 26
abnormal retina morphology 6 | 71
abnormal tail morphology 6 | 25
decreased circulating LDL chol... 6 | 38
decreased circulating calcium ... 6 | 36
decreased mean corpuscular hem... 6 | 31
decreased threshold for audito... 6 | 26
impaired righting response 6 | 26
increased circulating calcium ... 6 | 34
increased mean corpuscular hem... 6 | 36
increased vertical activity 6 | 24
mammalian phenotype 6 | 17
small superior vagus ganglion 6 | 74
tremors 6 | 39

Disease

pituitary cancer 1,972 | 1,972
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 1,947 | 18,159
Female tissues 1,928 | 17,400
Nervous System 1,926 | 16,725
Digestive Tract 1,922 | 17,369
Skin and soft tissues 1,915 | 17,230
Male tissues 1,911 | 17,142
Liver and Pancreas 1,895 | 16,750
Blood and immune system 1,892 | 16,909
Urinary Tract 1,887 | 16,678
Respiratory system 1,871 | 16,393
Cardiovascular System 1,762 | 15,192

Target Family

Non-IDG 1,154 | 12,091
Enzyme 406 | 4,145
Transcription Factor 140 | 1,400
Kinase 78 | 634
Transporter 67 | 473
Ion Channel 51 | 344
GPCR 41 | 408
Epigenetic 18 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112