Development Level

Tbio 1,276 | 10,625
Tdark 364 | 7,003
Tchem 248 | 1,890
Tclin 84 | 602

Collection

Eligible Ion Channel Proteins 13 | 117
Eligible Kinase Proteins 13 | 134
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 65 | 633
abnormal behavior 42 | 226
preweaning lethality, incomple... 39 | 260
decreased total body fat amoun... 30 | 186
enlarged heart 22 | 111
hyperactivity 22 | 108
decreased lean body mass 20 | 195
increased or absent threshold ... 20 | 128
decreased body weight 19 | 174
increased circulating alkaline... 19 | 119
decreased bone mineral content 18 | 157
decreased circulating HDL chol... 18 | 77
embryonic lethality prior to t... 18 | 187
abnormal bone structure 17 | 131
decreased circulating choleste... 17 | 85
decreased grip strength 17 | 123
increased lean body mass 17 | 107
decreased bone mineral density 16 | 126
short tibia 16 | 82
increased bone mineral content 15 | 92
abnormal embryo size 14 | 112
decreased circulating glucose ... 14 | 121
increased blood urea nitrogen ... 14 | 44
decreased body length 13 | 108
decreased circulating insulin ... 13 | 75
abnormal bone mineralization 12 | 55
hypoactivity 12 | 89
increased circulating sodium l... 12 | 71
increased mean corpuscular vol... 12 | 91
abnormal heart morphology 11 | 51
embryonic lethality prior to o... 11 | 148
increased mean corpuscular hem... 11 | 93
increased sacral vertebrae num... 11 | 62
abnormal behavioral response t... 10 | 52
abnormal lens morphology 10 | 73
abnormal retina morphology 10 | 100
decreased circulating triglyce... 10 | 83
decreased fasted circulating g... 10 | 49
decreased lumbar vertebrae num... 10 | 62
improved glucose tolerance 10 | 56
increased bone mineral density 10 | 52
decreased hemoglobin content 9 | 53
increased grip strength 9 | 83
increased rib number 9 | 41
thrombocytopenia 9 | 46
abnormal epididymis morphology 8 | 31
abnormal seminal vesicle morph... 8 | 47
decreased circulating free fat... 8 | 39
decreased circulating serum al... 8 | 79
decreased circulating total pr... 8 | 41
decreased heart weight 8 | 44
decreased prepulse inhibition 8 | 52
prenatal lethality prior to he... 8 | 64
abnormal gait 7 | 51
abnormal neural tube closure 7 | 37
abnormal sleep behavior 7 | 63
decreased circulating alanine ... 7 | 53
decreased circulating alkaline... 7 | 41
decreased leukocyte cell numbe... 7 | 54
decreased rib number 7 | 59
impaired glucose tolerance 7 | 52
increased circulating HDL chol... 7 | 63
increased circulating calcium ... 7 | 32
increased circulating chloride... 7 | 43
increased circulating choleste... 7 | 53
increased exploration in new e... 7 | 56
increased startle reflex 7 | 38
increased total body fat amoun... 7 | 57
limb grasping 7 | 35
abnormal heart left ventricle ... 6 | 20
abnormal kidney morphology 6 | 30
abnormal retinal pigmentation 6 | 61
abnormal spleen morphology 6 | 36
abnormal testis morphology 6 | 30
decreased circulating LDL chol... 6 | 37
decreased circulating amylase ... 6 | 24
decreased mean corpuscular hem... 6 | 34
decreased startle reflex 6 | 48
enlarged epididymis 6 | 27
impaired righting response 6 | 19
increased circulating creatini... 6 | 29
increased fasted circulating g... 6 | 68
increased heart weight 6 | 37
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 37
male infertility 6 | 62
small testis 6 | 37
abnormal tooth morphology 5 | 24
decreased NK T cell number 5 | 28
decreased circulating aspartat... 5 | 27
decreased circulating calcium ... 5 | 33
decreased circulating iron lev... 5 | 25
decreased mean corpuscular vol... 5 | 50
increased body weight 5 | 42
increased circulating iron lev... 5 | 25
increased heart rate 5 | 17
tremors 5 | 34
abnormal coat/hair pigmentatio... 4 | 54
cardiovascular system phenotyp... 4 | 35
decreased circulating glycerol... 4 | 19

Disease

pituitary cancer 1,972 | 1,972
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,956 | 18,561
Female tissues 1,954 | 18,647
Urinary Tract 1,954 | 18,444
Digestive Tract 1,953 | 18,473
Endocrine System 1,952 | 18,512
Liver and Pancreas 1,948 | 18,136
Cardiovascular System 1,946 | 17,958
Male tissues 1,945 | 17,969
Blood and immune system 1,943 | 17,995
Skin and soft tissues 1,934 | 18,115
Respiratory system 1,929 | 17,484

Target Family

Non-IDG 1,156 | 11,971
Enzyme 405 | 4,146
Transcription Factor 140 | 1,400
Kinase 77 | 634
Transporter 67 | 473
Ion Channel 51 | 341
GPCR 41 | 406
Epigenetic 18 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34