Development Level

Tbio 1,956 | 10,625
Tdark 611 | 7,003
Tchem 366 | 1,890
Tclin 153 | 602

Collection

Eligible Ion Channel Proteins 35 | 117
Eligible Kinase Proteins 19 | 134
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 68 | 633
preweaning lethality, incomple... 59 | 260
abnormal behavior 54 | 226
decreased total body fat amoun... 52 | 186
decreased lean body mass 48 | 195
decreased bone mineral content 41 | 157
increased circulating alkaline... 38 | 119
abnormal bone structure 36 | 131
hyperactivity 34 | 108
decreased body weight 32 | 174
decreased grip strength 32 | 123
increased bone mineral content 30 | 92
decreased bone mineral density 29 | 126
increased lean body mass 29 | 107
decreased body length 27 | 108
embryonic lethality prior to t... 25 | 187
increased or absent threshold ... 24 | 128
hypoactivity 23 | 89
short tibia 22 | 82
abnormal sleep behavior 21 | 63
decreased circulating insulin ... 21 | 75
increased mean corpuscular hem... 21 | 93
decreased circulating choleste... 20 | 85
decreased circulating glucose ... 20 | 121
enlarged heart 19 | 111
abnormal gait 18 | 51
decreased circulating HDL chol... 18 | 77
decreased circulating serum al... 18 | 79
increased circulating HDL chol... 18 | 63
abnormal retina morphology 17 | 100
decreased circulating triglyce... 17 | 83
increased mean corpuscular vol... 17 | 91
decreased prepulse inhibition 16 | 52
increased blood urea nitrogen ... 16 | 44
abnormal embryo size 14 | 112
decreased circulating alanine ... 14 | 53
increased circulating chloride... 14 | 43
male infertility 14 | 62
abnormal lens morphology 13 | 73
decreased erythrocyte cell num... 13 | 43
decreased hemoglobin content 13 | 53
decreased leukocyte cell numbe... 13 | 54
decreased rib number 13 | 59
embryonic lethality prior to o... 13 | 148
improved glucose tolerance 13 | 56
increased body weight 13 | 42
increased circulating choleste... 13 | 53
increased circulating sodium l... 13 | 71
increased fasted circulating g... 13 | 68
thrombocytopenia 13 | 46
decreased eosinophil cell numb... 12 | 41
decreased startle reflex 12 | 48
increased circulating calcium ... 12 | 32
increased startle reflex 12 | 38
limb grasping 12 | 35
tremors 12 | 34
abnormal coat/hair pigmentatio... 11 | 54
cardiovascular system phenotyp... 11 | 35
decreased circulating calcium ... 11 | 33
decreased mean corpuscular vol... 11 | 50
increased bone mineral density 11 | 52
decreased CD8-positive, alpha-... 10 | 26
decreased circulating LDL chol... 10 | 37
decreased heart weight 10 | 44
decreased lumbar vertebrae num... 10 | 62
enlarged lymph nodes 10 | 27
increased grip strength 10 | 83
increased hemoglobin content 10 | 45
increased total body fat amoun... 10 | 57
abnormal epididymis morphology 9 | 31
abnormal heart morphology 9 | 51
decreased caudal vertebrae num... 9 | 49
decreased fasted circulating g... 9 | 49
impaired glucose tolerance 9 | 52
increased circulating potassiu... 9 | 31
increased exploration in new e... 9 | 56
increased heart weight 9 | 37
increased sacral vertebrae num... 9 | 62
abnormal bone mineralization 8 | 55
abnormal testis morphology 8 | 30
cataract 8 | 26
decreased blood urea nitrogen ... 8 | 31
decreased circulating alkaline... 8 | 41
decreased circulating aspartat... 8 | 27
decreased circulating free fat... 8 | 39
decreased circulating fructosa... 8 | 31
impaired righting response 8 | 19
increased hematocrit 8 | 36
increased vertical activity 8 | 18
prenatal lethality prior to he... 8 | 64
small testis 8 | 37
abnormal behavioral response t... 7 | 52
abnormal neural tube closure 7 | 37
corneal opacity 7 | 25
decreased NK T cell number 7 | 28
decreased T cell number 7 | 31
decreased circulating amylase ... 7 | 24
decreased circulating creatini... 7 | 31
increased circulating serum al... 7 | 25
decreased circulating glycerol... 6 | 19

Disease

pilocytic astrocytoma 3,086 | 3,086
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 3,061 | 18,561
Digestive Tract 3,059 | 18,473
Liver and Pancreas 3,055 | 18,136
Female tissues 3,054 | 18,647
Urinary Tract 3,052 | 18,444
Endocrine System 3,051 | 18,512
Cardiovascular System 3,049 | 17,958
Male tissues 3,042 | 17,969
Blood and immune system 3,040 | 17,995
Skin and soft tissues 3,033 | 18,115
Respiratory system 3,022 | 17,484

Target Family

Non-IDG 1,836 | 11,971
Enzyme 670 | 4,146
Transcription Factor 160 | 1,400
Kinase 128 | 634
Ion Channel 100 | 341
Transporter 81 | 473
GPCR 70 | 406
Epigenetic 24 | 242
TF/Epigenetic 9 | 38
Nuclear Receptor 7 | 48
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
VPS10 domain-containing receptor SorCS3 SORCS3 Tbio Non-IDG -0.54622 5.51 46
Seizure protein 6 homolog SEZ6 Tdark Non-IDG -0.87986 8.64 27