Development Level

Tbio 1,728 | 10,625
Tdark 530 | 7,003
Tchem 333 | 1,890
Tclin 121 | 602

Collection

Ion Channel: IDG Consortium (Targets) 18 | 102
Kinase: IDG Consortium (Targets) 18 | 125
GPCR: IDG Consortium (Targets) 8 | 127
Kinase: IDG Consortium (Complete/Control) 7 | 37
GPCR: IDG Consortium (Complete/Control) 5 | 26

IMPC Phenotype

preweaning lethality, complete... 85 | 633
preweaning lethality, incomple... 52 | 260
decreased lean body mass 49 | 195
decreased total body fat amoun... 44 | 186
abnormal behavior 41 | 226
decreased bone mineral content 36 | 157
increased circulating alkaline... 36 | 119
embryonic lethality prior to t... 31 | 187
decreased body weight 30 | 174
abnormal bone structure 29 | 131
decreased bone mineral density 27 | 126
increased lean body mass 27 | 107
decreased grip strength 26 | 123
hyperactivity 25 | 108
increased or absent threshold ... 25 | 128
decreased circulating choleste... 24 | 85
decreased circulating glucose ... 24 | 121
decreased body length 23 | 108
abnormal retina morphology 22 | 100
decreased circulating HDL chol... 22 | 77
short tibia 22 | 82
embryonic lethality prior to o... 21 | 148
increased circulating sodium l... 21 | 71
abnormal embryo size 20 | 112
hypoactivity 19 | 89
increased mean corpuscular vol... 19 | 91
increased circulating chloride... 18 | 43
decreased prepulse inhibition 17 | 52
decreased circulating triglyce... 16 | 83
increased fasted circulating g... 16 | 68
abnormal lens morphology 15 | 73
abnormal sleep behavior 15 | 63
increased bone mineral content 15 | 92
increased grip strength 15 | 83
decreased rib number 14 | 59
enlarged heart 14 | 111
increased mean corpuscular hem... 14 | 93
increased sacral vertebrae num... 13 | 62
increased total body fat amoun... 13 | 57
male infertility 13 | 62
abnormal coat-hair pigmentatio... 12 | 54
decreased circulating serum al... 12 | 79
improved glucose tolerance 12 | 56
increased blood urea nitrogen ... 12 | 44
increased circulating HDL chol... 12 | 63
increased circulating choleste... 12 | 53
abnormal gait 11 | 51
decreased circulating alanine ... 11 | 53
increased startle reflex 11 | 38
decreased circulating LDL chol... 10 | 37
decreased circulating insulin ... 10 | 75
decreased hemoglobin content 10 | 53
impaired glucose tolerance 10 | 52
cardiovascular system phenotyp... 9 | 35
decreased CD8-positive, alpha-... 9 | 26
decreased circulating creatini... 9 | 31
decreased eosinophil cell numb... 9 | 41
decreased lumbar vertebrae num... 9 | 62
decreased startle reflex 9 | 48
decreased threshold for audito... 9 | 32
increased body weight 9 | 42
increased bone mineral density 9 | 52
increased heart weight 9 | 37
increased rib number 9 | 41
abnormal bone mineralization 8 | 55
abnormal neural tube closure 8 | 37
abnormal retinal pigmentation 8 | 61
corneal opacity 8 | 25
decreased NK T cell number 8 | 28
decreased caudal vertebrae num... 8 | 49
decreased circulating alkaline... 8 | 41
decreased circulating free fat... 8 | 39
decreased leukocyte cell numbe... 8 | 54
immune system phenotype 8 | 17
increased circulating calcium ... 8 | 32
increased exploration in new e... 8 | 56
increased hematocrit 8 | 36
increased mean corpuscular hem... 8 | 25
thrombocytopenia 8 | 46
tremors 8 | 34
abnormal kidney morphology 7 | 30
abnormal rib morphology 7 | 28
decreased T cell number 7 | 31
decreased effector memory CD8-... 7 | 24
decreased fasted circulating g... 7 | 49
decreased heart weight 7 | 44
decreased mean corpuscular hem... 7 | 34
increased circulating iron lev... 7 | 25
limb grasping 7 | 35
prenatal lethality prior to he... 7 | 64
straub tail 7 | 26
abnormal behavioral response t... 6 | 52
abnormal cranium morphology 6 | 32
abnormal epididymis morphology 6 | 31
abnormal tooth morphology 6 | 24
decreased circulating calcium ... 6 | 33
decreased circulating potassiu... 6 | 17
decreased mean corpuscular vol... 6 | 50
decreased vertical activity 6 | 22
increased hemoglobin content 6 | 45

Disease

pediatric high grade glioma 2,712 | 2,712
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,692 | 18,560
Digestive Tract 2,687 | 18,472
Female tissues 2,686 | 18,646
Liver and Pancreas 2,683 | 18,135
Cardiovascular System 2,682 | 17,957
Endocrine System 2,682 | 18,511
Urinary Tract 2,679 | 18,443
Blood and immune system 2,678 | 17,994
Male tissues 2,676 | 17,968
Skin and soft tissues 2,668 | 18,114
Respiratory system 2,662 | 17,483

Target Family

Non-IDG 1,593 | 11,969
Enzyme 563 | 4,146
Transcription Factor 170 | 1,400
Kinase 122 | 634
Transporter 89 | 473
Ion Channel 75 | 341
GPCR 48 | 408
Epigenetic 37 | 242
TF/Epigenetic 8 | 38
Nuclear Receptor 7 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Sorting nexin-32 SNX32 Tdark Non-IDG 0.60 0.07 75
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 22
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.51625 341.8 227
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.13830 1.14 48