Development Level

Tbio 1,379 | 11,651
Tdark 308 | 6,593
Tchem 198 | 1,388
Tclin 77 | 612

Collection

RFA-RM-18-021 19 | 328
Kinase: IDG Consortium (Target... 9 | 125
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 5 | 99
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 142 | 979
preweaning lethality, incomple... 66 | 499
abnormal behavior 39 | 298
embryonic lethality prior to t... 35 | 278
embryonic lethality prior to o... 31 | 239
abnormal embryo size 30 | 220
decreased total body fat amoun... 27 | 207
enlarged heart 26 | 210
decreased lean body mass 25 | 135
increased lean body mass 23 | 172
abnormal heart morphology 20 | 162
increased startle reflex 20 | 112
decreased circulating glucose ... 19 | 126
hypoactivity 19 | 132
abnormal bone structure 18 | 187
decreased body weight 18 | 161
decreased circulating choleste... 18 | 93
increased bone mineral density 18 | 72
increased or absent threshold ... 18 | 101
increased total body fat amoun... 18 | 134
decreased vertical activity 17 | 208
decreased bone mineral density 16 | 126
abnormal seminal vesicle morph... 15 | 114
cataract 15 | 92
decreased bone mineral content 15 | 151
decreased circulating HDL chol... 15 | 68
hyperactivity 15 | 148
increased circulating alkaline... 14 | 122
abnormal coat-hair pigmentatio... 13 | 64
decreased prepulse inhibition 13 | 82
embryonic growth retardation 13 | 106
increased mean corpuscular vol... 13 | 92
prenatal lethality prior to he... 13 | 87
short tibia 13 | 97
decreased circulating serum al... 12 | 82
decreased fasted circulating g... 12 | 65
decreased leukocyte cell numbe... 12 | 73
improved glucose tolerance 12 | 79
increased bone mineral content 12 | 108
increased circulating choleste... 12 | 66
increased mean corpuscular hem... 12 | 96
abnormal lens morphology 11 | 81
decreased grip strength 11 | 116
decreased circulating total pr... 10 | 49
decreased mean corpuscular vol... 10 | 79
abnormal eye morphology 9 | 68
decreased circulating triglyce... 9 | 79
decreased lymphocyte cell numb... 9 | 83
male infertility 9 | 123
abnormal gait 8 | 69
abnormal retina morphology 8 | 71
abnormal snout morphology 8 | 23
decreased circulating insulin ... 8 | 76
edema 8 | 59
increased circulating HDL chol... 8 | 80
increased fasted circulating g... 8 | 76
increased heart weight 8 | 62
small superior vagus ganglion 8 | 74
thrombocytopenia 8 | 56
abnormal kidney morphology 7 | 65
abnormal neural tube closure 7 | 46
abnormal sleep behavior 7 | 70
abnormal testis morphology 7 | 43
cardiovascular system phenotyp... 7 | 36
decreased blood urea nitrogen ... 7 | 51
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
decreased circulating LDL chol... 7 | 38
decreased circulating alkaline... 7 | 46
decreased erythrocyte cell num... 7 | 62
persistence of hyaloid vascula... 7 | 33
prolonged QT interval 7 | 38
abnormal behavioral response t... 6 | 66
abnormal bone mineralization 6 | 38
abnormal epididymis morphology 6 | 42
abnormal retinal blood vessel ... 6 | 26
abnormal skin morphology 6 | 50
abnormal tooth morphology 6 | 24
corneal opacity 6 | 32
decreased hemoglobin content 6 | 68
decreased mean corpuscular hem... 6 | 50
increased blood urea nitrogen ... 6 | 48
increased body weight 6 | 25
increased circulating sodium l... 6 | 71
increased hematocrit 6 | 46
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
increased monocyte cell number 6 | 63
increased prepulse inhibition 6 | 32
microphthalmia 6 | 26
pallor 6 | 34
small testis 6 | 58
vertebral fusion 6 | 23
abnormal retinal vasculature m... 5 | 27
anophthalmia 5 | 33
decreased circulating creatini... 5 | 39
impaired glucose tolerance 5 | 75
increased circulating calcium ... 5 | 34
increased mean platelet volume 5 | 45
pale yolk sac 5 | 25

Disease

pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Liver and Pancreas 1,941 | 16,750
Urinary Tract 1,936 | 16,678
Endocrine System 1,934 | 18,159
Digestive Tract 1,932 | 17,369
Female tissues 1,924 | 17,400
Skin and soft tissues 1,919 | 17,230
Male tissues 1,911 | 17,142
Blood and immune system 1,904 | 16,909
Nervous System 1,897 | 16,725
Respiratory system 1,887 | 16,393
Cardiovascular System 1,836 | 15,192

Target Family

Non-IDG 1,043 | 12,091
Enzyme 619 | 4,145
Transcription Factor 87 | 1,400
Transporter 81 | 473
Kinase 65 | 634
Epigenetic 25 | 242
Ion Channel 17 | 344
GPCR 14 | 408
Nuclear Receptor 7 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
HEAT repeat-containing protein 5A HEATR5A Tdark Non-IDG 0.00000 5
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667