Development Level

Tbio 1,144 | 10,625
Tdark 349 | 7,003
Tchem 229 | 1,890
Tclin 73 | 602

Collection

Eligible Kinase Proteins 7 | 134
Eligible non-olfactory GPCR Proteins 5 | 143
Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 87 | 633
preweaning lethality, incomple... 30 | 260
embryonic lethality prior to t... 26 | 187
abnormal behavior 22 | 226
decreased lean body mass 22 | 195
decreased body weight 20 | 174
embryonic lethality prior to o... 20 | 148
abnormal embryo size 18 | 112
abnormal retina morphology 16 | 100
decreased total body fat amoun... 16 | 186
increased mean corpuscular hem... 15 | 93
increased or absent threshold ... 15 | 128
decreased circulating glucose ... 14 | 121
increased circulating alkaline... 14 | 119
increased lean body mass 14 | 107
increased mean corpuscular vol... 14 | 91
decreased bone mineral content 13 | 157
decreased bone mineral density 13 | 126
hypoactivity 13 | 89
decreased circulating HDL chol... 11 | 77
decreased circulating choleste... 11 | 85
enlarged heart 11 | 111
prenatal lethality prior to he... 11 | 64
abnormal bone structure 10 | 131
abnormal lens morphology 10 | 73
decreased circulating triglyce... 10 | 83
increased body weight 10 | 42
increased bone mineral content 9 | 92
decreased caudal vertebrae num... 8 | 49
decreased circulating insulin ... 8 | 75
decreased circulating serum al... 8 | 79
decreased leukocyte cell numbe... 8 | 54
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular hem... 8 | 34
decreased prepulse inhibition 8 | 52
hyperactivity 8 | 108
improved glucose tolerance 8 | 56
increased circulating choleste... 8 | 53
increased hemoglobin content 8 | 45
abnormal snout morphology 7 | 18
decreased CD8-positive, alpha-... 7 | 26
decreased circulating alanine ... 7 | 53
decreased grip strength 7 | 123
decreased rib number 7 | 59
increased B cell number 7 | 23
increased circulating HDL chol... 7 | 63
increased circulating sodium l... 7 | 71
increased fasted circulating g... 7 | 68
increased sacral vertebrae num... 7 | 62
increased total body fat amoun... 7 | 57
thrombocytopenia 7 | 46
abnormal coat/hair pigmentatio... 6 | 54
abnormal cranium morphology 6 | 32
abnormal heart morphology 6 | 51
abnormal retinal pigmentation 6 | 61
decreased body length 6 | 108
decreased circulating total pr... 6 | 41
decreased fasted circulating g... 6 | 49
decreased mean corpuscular vol... 6 | 50
increased bone mineral density 6 | 52
increased exploration in new e... 6 | 56
short tibia 6 | 82
abnormal behavioral response t... 5 | 52
abnormal gait 5 | 51
abnormal kidney morphology 5 | 30
abnormal neural tube closure 5 | 37
abnormal seminal vesicle morph... 5 | 47
abnormal sleep behavior 5 | 63
abnormal testis morphology 5 | 30
abnormal tooth morphology 5 | 24
cardiovascular system phenotyp... 5 | 35
corneal opacity 5 | 25
decreased Ly6C high monocyte n... 5 | 18
decreased T cell number 5 | 31
decreased circulating LDL chol... 5 | 37
decreased erythrocyte cell num... 5 | 43
decreased neutrophil cell numb... 5 | 37
impaired glucose tolerance 5 | 52
increased NK cell number 5 | 19
increased body length 5 | 20
increased circulating calcium ... 5 | 32
increased grip strength 5 | 83
increased heart weight 5 | 37
persistence of hyaloid vascula... 5 | 22
abnormal coping response 4 | 12
abnormal cornea morphology 4 | 24
abnormal locomotor activation 4 | 26
abnormal skin morphology 4 | 23
decreased blood urea nitrogen ... 4 | 31
decreased effector memory CD8-... 4 | 24
embryonic growth retardation 4 | 28
hydrops fetalis 4 | 22
increased CD4-positive, CD25-p... 4 | 18
increased circulating alanine ... 4 | 11
increased circulating total pr... 4 | 20
increased hematocrit 4 | 36
increased rib number 4 | 41
male infertility 4 | 62
small testis 4 | 37
vertebral fusion 4 | 23

Disease

pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Liver and Pancreas 1,785 | 18,136
Blood and immune system 1,783 | 17,995
Digestive Tract 1,783 | 18,473
Endocrine System 1,783 | 18,512
Nervous System 1,783 | 18,561
Female tissues 1,782 | 18,647
Urinary Tract 1,781 | 18,444
Male tissues 1,780 | 17,969
Cardiovascular System 1,778 | 17,958
Respiratory system 1,774 | 17,484
Skin and soft tissues 1,771 | 18,115

Target Family

Non-IDG 937 | 11,971
Enzyme 586 | 4,146
Transcription Factor 78 | 1,400
Transporter 76 | 473
Kinase 54 | 634
Epigenetic 25 | 242
GPCR 14 | 406
Ion Channel 14 | 341
Nuclear Receptor 7 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123