Development Level

Tbio 1,289 | 11,178
Tdark 304 | 6,569
Tchem 244 | 1,885
Tclin 74 | 612

Collection

Kinase: IDG Consortium (Target... 8 | 125
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 5 | 99
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 138 | 979
preweaning lethality, incomple... 64 | 499
abnormal behavior 38 | 298
embryonic lethality prior to t... 34 | 278
embryonic lethality prior to o... 31 | 239
abnormal embryo size 29 | 220
decreased total body fat amoun... 27 | 207
enlarged heart 25 | 210
decreased lean body mass 22 | 135
increased lean body mass 22 | 172
abnormal heart morphology 20 | 162
decreased circulating glucose ... 19 | 126
hypoactivity 18 | 132
increased bone mineral density 18 | 72
increased or absent threshold ... 18 | 101
increased startle reflex 18 | 112
abnormal bone structure 17 | 187
decreased body weight 17 | 161
decreased vertical activity 17 | 208
decreased bone mineral density 16 | 126
decreased circulating choleste... 16 | 93
abnormal seminal vesicle morph... 15 | 114
cataract 15 | 92
increased total body fat amoun... 15 | 134
decreased bone mineral content 14 | 151
hyperactivity 14 | 148
decreased circulating HDL chol... 13 | 68
decreased prepulse inhibition 13 | 82
increased circulating alkaline... 13 | 122
increased mean corpuscular vol... 13 | 92
abnormal coat-hair pigmentatio... 12 | 64
decreased circulating serum al... 12 | 82
decreased fasted circulating g... 12 | 65
decreased leukocyte cell numbe... 12 | 73
embryonic growth retardation 12 | 106
improved glucose tolerance 12 | 79
increased bone mineral content 12 | 108
increased circulating choleste... 12 | 66
prenatal lethality prior to he... 12 | 87
short tibia 12 | 97
abnormal lens morphology 11 | 81
decreased grip strength 11 | 116
increased mean corpuscular hem... 11 | 96
decreased circulating total pr... 10 | 49
decreased mean corpuscular vol... 10 | 79
decreased lymphocyte cell numb... 9 | 83
male infertility 9 | 123
abnormal eye morphology 8 | 68
abnormal gait 8 | 69
abnormal retina morphology 8 | 71
decreased circulating triglyce... 8 | 79
edema 8 | 59
increased circulating HDL chol... 8 | 80
increased fasted circulating g... 8 | 76
increased heart weight 8 | 62
small superior vagus ganglion 8 | 74
abnormal kidney morphology 7 | 65
abnormal neural tube closure 7 | 46
abnormal sleep behavior 7 | 70
abnormal snout morphology 7 | 23
abnormal testis morphology 7 | 43
cardiovascular system phenotyp... 7 | 36
decreased blood urea nitrogen ... 7 | 51
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
decreased circulating LDL chol... 7 | 38
decreased circulating alkaline... 7 | 46
decreased circulating insulin ... 7 | 76
persistence of hyaloid vascula... 7 | 33
abnormal behavioral response t... 6 | 66
abnormal bone mineralization 6 | 38
abnormal tooth morphology 6 | 24
corneal opacity 6 | 32
decreased hemoglobin content 6 | 68
decreased mean corpuscular hem... 6 | 50
increased blood urea nitrogen ... 6 | 48
increased body weight 6 | 25
increased circulating sodium l... 6 | 71
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
increased monocyte cell number 6 | 63
increased prepulse inhibition 6 | 32
microphthalmia 6 | 26
prolonged QT interval 6 | 38
small testis 6 | 58
thrombocytopenia 6 | 56
vertebral fusion 6 | 23
abnormal craniofacial morpholo... 5 | 33
abnormal epididymis morphology 5 | 42
abnormal retinal vasculature m... 5 | 27
abnormal skin morphology 5 | 50
anophthalmia 5 | 33
decreased red blood cell distr... 5 | 41
impaired glucose tolerance 5 | 75
impaired pupillary reflex 5 | 26
increased body length 5 | 32
increased circulating calcium ... 5 | 34
increased hematocrit 5 | 46
increased mean platelet volume 5 | 45
pallor 5 | 34

Disease

pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Liver and Pancreas 1,891 | 16,750
Urinary Tract 1,887 | 16,678
Endocrine System 1,884 | 18,159
Digestive Tract 1,882 | 17,369
Female tissues 1,874 | 17,400
Skin and soft tissues 1,870 | 17,230
Male tissues 1,862 | 17,142
Blood and immune system 1,856 | 16,909
Nervous System 1,847 | 16,725
Respiratory system 1,841 | 16,393
Cardiovascular System 1,789 | 15,192

Target Family

Non-IDG 1,034 | 12,091
Enzyme 584 | 4,145
Transcription Factor 83 | 1,400
Transporter 79 | 473
Kinase 64 | 634
Epigenetic 25 | 242
Ion Channel 17 | 344
GPCR 14 | 408
Nuclear Receptor 7 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Cysteine and glycine-rich protein 2 CSRP2 Tbio Non-IDG -0.96898 10.3 178
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159
Pantothenate kinase 1 PANK1 Tbio Kinase -1.80926 56.9 188
AP2-associated protein kinase 1 AAK1 Tchem Kinase -1.28486 18.8 271
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256