Development Level

Tbio 1,753 | 11,651
Tchem 280 | 1,388
Tdark 265 | 6,593
Tclin 100 | 612

Collection

Kinase: IDG Consortium (Target... 12 | 125
Ion Channel: IDG Consortium (T... 9 | 99
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 124 | 979
preweaning lethality, incomple... 75 | 499
embryonic lethality prior to t... 41 | 278
abnormal behavior 40 | 298
decreased total body fat amoun... 38 | 207
enlarged heart 35 | 210
abnormal bone structure 31 | 187
abnormal embryo size 30 | 220
decreased vertical activity 29 | 208
increased lean body mass 28 | 172
abnormal heart morphology 25 | 162
embryonic lethality prior to o... 25 | 239
decreased body weight 23 | 161
hypoactivity 23 | 132
abnormal seminal vesicle morph... 22 | 114
cataract 22 | 92
hyperactivity 22 | 148
decreased bone mineral content 21 | 151
increased bone mineral content 21 | 108
decreased lean body mass 20 | 135
abnormal lens morphology 19 | 81
improved glucose tolerance 19 | 79
increased heart weight 19 | 62
increased startle reflex 19 | 112
decreased grip strength 18 | 116
short tibia 18 | 97
decreased circulating HDL chol... 17 | 68
decreased circulating choleste... 17 | 93
increased fasted circulating g... 17 | 76
increased total body fat amoun... 16 | 134
decreased circulating insulin ... 15 | 76
decreased circulating triglyce... 15 | 79
decreased mean corpuscular vol... 15 | 79
decreased circulating serum al... 14 | 82
decreased lymphocyte cell numb... 14 | 83
decreased prepulse inhibition 14 | 82
increased circulating HDL chol... 14 | 80
increased mean corpuscular vol... 14 | 92
abnormal eye morphology 13 | 68
abnormal sleep behavior 13 | 70
embryonic growth retardation 13 | 106
increased circulating alkaline... 13 | 122
increased circulating choleste... 13 | 66
prenatal lethality prior to he... 13 | 87
abnormal coat-hair pigmentatio... 12 | 64
abnormal gait 12 | 69
increased bone mineral density 12 | 72
increased hemoglobin content 12 | 45
increased mean corpuscular hem... 12 | 96
decreased bone mineral density 11 | 126
abnormal kidney morphology 10 | 65
decreased body length 10 | 101
decreased circulating glucose ... 10 | 126
decreased circulating total pr... 10 | 49
decreased leukocyte cell numbe... 10 | 73
increased monocyte cell number 10 | 63
increased neutrophil cell numb... 10 | 46
male infertility 10 | 123
decreased startle reflex 9 | 75
increased or absent threshold ... 9 | 101
small superior vagus ganglion 9 | 74
abnormal behavioral response t... 8 | 66
abnormal skin morphology 8 | 50
abnormal spleen morphology 8 | 55
decreased circulating LDL chol... 8 | 38
decreased circulating alanine ... 8 | 47
decreased fasted circulating g... 8 | 65
decreased hemoglobin content 8 | 68
edema 8 | 59
female infertility 8 | 60
increased blood urea nitrogen ... 8 | 48
increased circulating triglyce... 8 | 42
increased hematocrit 8 | 46
increased leukocyte cell numbe... 8 | 47
abnormal coat appearance 7 | 31
abnormal retina morphology 7 | 71
cardiovascular system phenotyp... 7 | 36
corneal opacity 7 | 32
decreased circulating chloride... 7 | 30
decreased circulating free fat... 7 | 31
enlarged spleen 7 | 41
impaired glucose tolerance 7 | 75
increased body length 7 | 32
increased circulating calcium ... 7 | 34
increased heart rate 7 | 23
thrombocytopenia 7 | 56
tremors 7 | 39
abnormal bone mineralization 6 | 38
abnormal craniofacial morpholo... 6 | 33
abnormal epididymis morphology 6 | 42
abnormal limb bud morphology 6 | 17
abnormal neural tube closure 6 | 46
decreased caudal vertebrae num... 6 | 53
decreased circulating bilirubi... 6 | 19
decreased mean corpuscular hem... 6 | 50
decreased mean corpuscular hem... 6 | 31
decreased red blood cell distr... 6 | 41
increased circulating chloride... 6 | 41
increased circulating iron lev... 6 | 30
limb grasping 6 | 41

Disease

pancreatic cancer 2,398 | 2,398
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,362 | 18,159
Digestive Tract 2,356 | 17,369
Female tissues 2,355 | 17,400
Skin and soft tissues 2,351 | 17,230
Liver and Pancreas 2,344 | 16,750
Urinary Tract 2,338 | 16,678
Male tissues 2,333 | 17,142
Blood and immune system 2,331 | 16,909
Respiratory system 2,316 | 16,393
Nervous System 2,294 | 16,725
Cardiovascular System 2,210 | 15,192

Target Family

Non-IDG 1,419 | 12,091
Enzyme 543 | 4,145
Transcription Factor 149 | 1,400
Kinase 112 | 634
Transporter 66 | 473
Ion Channel 38 | 344
GPCR 36 | 408
Epigenetic 22 | 242
Nuclear Receptor 10 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Calcium homeostasis modulator protein 6 CALHM6 Tdark Ion Channel -0.43644 4.12 26