Development Level

Tbio 1,535 | 10,625
Tchem 361 | 1,890
Tdark 312 | 7,003
Tclin 92 | 602

Collection

Eligible Kinase Proteins 12 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 6 | 143

IMPC Term

preweaning lethality, complete... 85 | 633
preweaning lethality, incomple... 42 | 260
decreased total body fat amoun... 35 | 186
abnormal behavior 32 | 226
decreased lean body mass 32 | 195
embryonic lethality prior to t... 31 | 187
decreased body weight 23 | 174
decreased circulating HDL chol... 23 | 77
abnormal bone structure 22 | 131
decreased bone mineral content 22 | 157
decreased circulating choleste... 21 | 85
decreased grip strength 20 | 123
increased bone mineral content 20 | 92
increased lean body mass 20 | 107
abnormal embryo size 19 | 112
enlarged heart 19 | 111
improved glucose tolerance 18 | 56
short tibia 18 | 82
abnormal lens morphology 17 | 73
embryonic lethality prior to o... 17 | 148
hypoactivity 17 | 89
increased mean corpuscular hem... 17 | 93
decreased body length 16 | 108
decreased bone mineral density 16 | 126
decreased circulating insulin ... 16 | 75
decreased circulating serum al... 15 | 79
decreased circulating triglyce... 15 | 83
hyperactivity 15 | 108
increased circulating alkaline... 15 | 119
increased mean corpuscular vol... 15 | 91
increased fasted circulating g... 14 | 68
abnormal retina morphology 13 | 100
decreased circulating glucose ... 12 | 121
decreased mean corpuscular vol... 12 | 50
increased hemoglobin content 12 | 45
increased circulating HDL chol... 11 | 63
abnormal bone mineralization 10 | 55
decreased lumbar vertebrae num... 10 | 62
increased blood urea nitrogen ... 10 | 44
increased or absent threshold ... 10 | 128
increased sacral vertebrae num... 10 | 62
prenatal lethality prior to he... 10 | 64
abnormal neural tube closure 9 | 37
cataract 9 | 26
decreased prepulse inhibition 9 | 52
female infertility 9 | 34
increased grip strength 9 | 83
increased heart weight 9 | 37
abnormal coat/hair pigmentatio... 8 | 54
abnormal gait 8 | 51
abnormal seminal vesicle morph... 8 | 47
decreased circulating alanine ... 8 | 53
decreased startle reflex 8 | 48
increased bone mineral density 8 | 52
increased rib number 8 | 41
male infertility 8 | 62
thrombocytopenia 8 | 46
abnormal hindbrain development 7 | 24
abnormal midbrain development 7 | 22
abnormal sleep behavior 7 | 63
decreased NK T cell number 7 | 28
decreased circulating LDL chol... 7 | 37
decreased circulating free fat... 7 | 39
decreased fasted circulating g... 7 | 49
decreased leukocyte cell numbe... 7 | 54
impaired glucose tolerance 7 | 52
increased body weight 7 | 42
increased circulating calcium ... 7 | 32
increased circulating choleste... 7 | 53
increased total body fat amoun... 7 | 57
tremors 7 | 34
abnormal forebrain development 6 | 18
abnormal heart morphology 6 | 51
abnormal locomotor activation 6 | 26
cardiovascular system phenotyp... 6 | 35
corneal opacity 6 | 25
decreased circulating chloride... 6 | 32
decreased circulating fructosa... 6 | 31
decreased circulating total pr... 6 | 41
decreased mean corpuscular hem... 6 | 34
decreased monocyte cell number 6 | 28
increased circulating chloride... 6 | 43
increased circulating sodium l... 6 | 71
increased circulating triglyce... 6 | 24
increased exploration in new e... 6 | 56
increased hematocrit 6 | 36
abnormal eye morphology 5 | 38
abnormal skin morphology 5 | 23
abnormal spleen morphology 5 | 36
decreased circulating alkaline... 5 | 41
decreased circulating bilirubi... 5 | 14
decreased eosinophil cell numb... 5 | 41
decreased heart weight 5 | 44
decreased hemoglobin content 5 | 53
enlarged epididymis 5 | 27
enlarged lymph nodes 5 | 27
increased body length 5 | 20
increased circulating serum al... 5 | 25
increased circulating total pr... 5 | 20
increased startle reflex 5 | 38

Disease

pancreatic cancer 2,300 | 2,300
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 2,287 | 18,473
Liver and Pancreas 2,287 | 18,136
Female tissues 2,285 | 18,647
Nervous System 2,285 | 18,561
Endocrine System 2,282 | 18,512
Male tissues 2,280 | 17,969
Urinary Tract 2,280 | 18,444
Blood and immune system 2,277 | 17,995
Cardiovascular System 2,275 | 17,958
Respiratory system 2,273 | 17,484
Skin and soft tissues 2,264 | 18,115

Target Family

Non-IDG 1,362 | 11,971
Enzyme 532 | 4,146
Transcription Factor 141 | 1,400
Kinase 105 | 634
Transporter 62 | 473
GPCR 35 | 406
Ion Channel 32 | 341
Epigenetic 18 | 242
Nuclear Receptor 10 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851