Development Level

Tbio 5,877 | 11,651
Tdark 1,633 | 6,593
Tchem 736 | 1,388
Tclin 274 | 612

Collection

Kinase: IDG Consortium (Target... 60 | 125
Ion Channel: IDG Consortium (T... 27 | 99
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Targets) 17 | 126
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 611 | 979
preweaning lethality, incomple... 283 | 499
embryonic lethality prior to t... 187 | 278
embryonic lethality prior to o... 158 | 239
abnormal behavior 156 | 298
abnormal embryo size 138 | 220
decreased total body fat amoun... 123 | 207
enlarged heart 109 | 210
increased lean body mass 106 | 172
abnormal bone structure 103 | 187
decreased vertical activity 101 | 208
decreased body weight 92 | 161
abnormal heart morphology 86 | 162
decreased bone mineral content 84 | 151
hypoactivity 84 | 132
decreased lean body mass 74 | 135
increased total body fat amoun... 73 | 134
hyperactivity 72 | 148
decreased bone mineral density 70 | 126
decreased grip strength 70 | 116
increased circulating alkaline... 69 | 122
increased startle reflex 68 | 112
embryonic growth retardation 67 | 106
increased bone mineral content 63 | 108
abnormal seminal vesicle morph... 61 | 114
male infertility 61 | 123
short tibia 59 | 97
decreased body length 56 | 101
decreased circulating glucose ... 53 | 126
prenatal lethality prior to he... 53 | 87
increased mean corpuscular vol... 52 | 92
decreased circulating choleste... 51 | 93
increased or absent threshold ... 51 | 101
cataract 49 | 92
decreased lymphocyte cell numb... 46 | 83
increased mean corpuscular hem... 46 | 96
abnormal retina morphology 45 | 71
abnormal lens morphology 44 | 81
decreased circulating insulin ... 44 | 76
decreased circulating serum al... 44 | 82
decreased leukocyte cell numbe... 43 | 73
increased bone mineral density 43 | 72
impaired glucose tolerance 42 | 75
increased circulating HDL chol... 42 | 80
abnormal coat-hair pigmentatio... 41 | 64
decreased hemoglobin content 40 | 68
decreased mean corpuscular vol... 40 | 79
increased circulating choleste... 40 | 66
increased heart weight 40 | 62
decreased circulating triglyce... 39 | 79
decreased prepulse inhibition 39 | 82
improved glucose tolerance 39 | 79
decreased circulating HDL chol... 37 | 68
decreased startle reflex 37 | 75
small testis 37 | 58
abnormal eye morphology 36 | 68
abnormal kidney morphology 36 | 65
decreased fasted circulating g... 36 | 65
increased fasted circulating g... 35 | 76
small superior vagus ganglion 35 | 74
abnormal sleep behavior 34 | 70
decreased erythrocyte cell num... 34 | 62
edema 34 | 59
thrombocytopenia 34 | 56
abnormal behavioral response t... 33 | 66
abnormal skin morphology 33 | 50
decreased mean corpuscular hem... 33 | 50
female infertility 33 | 60
abnormal gait 31 | 69
decreased caudal vertebrae num... 31 | 53
increased monocyte cell number 31 | 63
abnormal neural tube closure 29 | 46
decreased circulating alanine ... 29 | 47
abnormal spleen morphology 28 | 55
increased circulating triglyce... 28 | 42
abnormal bone mineralization 26 | 38
decreased circulating total pr... 26 | 49
increased circulating sodium l... 26 | 71
decreased blood urea nitrogen ... 25 | 51
tremors 25 | 39
abnormal testis morphology 24 | 43
decreased circulating alkaline... 24 | 46
hydrometra 24 | 53
increased leukocyte cell numbe... 24 | 47
increased mean platelet volume 24 | 45
increased neutrophil cell numb... 24 | 46
decreased hematocrit 23 | 46
increased blood urea nitrogen ... 23 | 48
increased erythrocyte cell num... 23 | 39
abnormal embryo turning 22 | 31
enlarged spleen 22 | 41
increased hemoglobin content 22 | 45
abnormal cranium morphology 21 | 36
decreased circulating LDL chol... 21 | 38
decreased circulating creatini... 21 | 39
decreased mean corpuscular hem... 21 | 31
decreased neutrophil cell numb... 21 | 42
enlarged lymph nodes 21 | 37
increased circulating calcium ... 21 | 34
increased hematocrit 21 | 46

Disease

ovarian cancer 8,520 | 8,520
Carcinoma 11,493 | 11,493
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 8,376 | 18,159
Digestive Tract 8,309 | 17,369
Female tissues 8,306 | 17,400
Skin and soft tissues 8,293 | 17,230
Male tissues 8,273 | 17,142
Urinary Tract 8,238 | 16,678
Blood and immune system 8,237 | 16,909
Liver and Pancreas 8,230 | 16,750
Nervous System 8,229 | 16,725
Respiratory system 8,196 | 16,393
Cardiovascular System 7,975 | 15,192

Target Family

Non-IDG 4,983 | 12,091
Enzyme 2,043 | 4,145
Transcription Factor 559 | 1,400
Kinase 345 | 634
Transporter 201 | 473
Epigenetic 131 | 242
GPCR 103 | 408
Ion Channel 90 | 344
Nuclear Receptor 23 | 48
TF/Epigenetic 23 | 38
oGPCR 19 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19