Development Level

Tbio 5,396 | 10,625
Tdark 1,844 | 7,003
Tchem 981 | 1,890
Tclin 270 | 602

Collection

Kinase: IDG Consortium (Targets) 59 | 125
Ion Channel: IDG Consortium (Targets) 28 | 102
GPCR: IDG Consortium (Targets) 19 | 127
Kinase: IDG Consortium (Complete/Control) 18 | 37
GPCR: IDG Consortium (Complete/Control) 10 | 26

IMPC Phenotype

preweaning lethality, complete... 394 | 633
preweaning lethality, incomple... 144 | 260
embryonic lethality prior to t... 129 | 187
abnormal behavior 120 | 226
decreased total body fat amoun... 111 | 186
decreased lean body mass 110 | 195
decreased body weight 102 | 174
embryonic lethality prior to o... 93 | 148
decreased bone mineral content 84 | 157
decreased grip strength 76 | 123
abnormal embryo size 71 | 112
increased lean body mass 70 | 107
abnormal bone structure 69 | 131
decreased bone mineral density 65 | 126
increased or absent threshold ... 65 | 128
increased circulating alkaline... 64 | 119
decreased body length 63 | 108
abnormal retina morphology 62 | 100
increased bone mineral content 61 | 92
enlarged heart 60 | 111
hyperactivity 58 | 108
hypoactivity 55 | 89
decreased circulating glucose ... 54 | 121
increased mean corpuscular hem... 54 | 93
short tibia 48 | 82
increased mean corpuscular vol... 46 | 91
decreased circulating choleste... 45 | 85
decreased circulating HDL chol... 44 | 77
abnormal lens morphology 43 | 73
decreased circulating serum al... 43 | 79
decreased circulating insulin ... 42 | 75
increased grip strength 42 | 83
decreased circulating triglyce... 41 | 83
prenatal lethality prior to he... 40 | 64
decreased lumbar vertebrae num... 36 | 62
decreased mean corpuscular vol... 36 | 50
increased sacral vertebrae num... 36 | 62
male infertility 35 | 62
increased fasted circulating g... 34 | 68
abnormal bone mineralization 33 | 55
abnormal retinal pigmentation 33 | 61
abnormal sleep behavior 33 | 63
abnormal coat-hair pigmentatio... 32 | 54
decreased hemoglobin content 32 | 53
decreased circulating alanine ... 31 | 53
decreased leukocyte cell numbe... 30 | 54
decreased prepulse inhibition 30 | 52
improved glucose tolerance 30 | 56
increased circulating choleste... 30 | 53
increased total body fat amoun... 30 | 57
thrombocytopenia 30 | 46
abnormal heart morphology 29 | 51
impaired glucose tolerance 29 | 52
increased circulating HDL chol... 29 | 63
decreased erythrocyte cell num... 28 | 43
decreased startle reflex 28 | 48
increased bone mineral density 28 | 52
decreased mean corpuscular hem... 27 | 34
increased body weight 27 | 42
increased circulating sodium l... 27 | 71
decreased caudal vertebrae num... 26 | 49
decreased fasted circulating g... 26 | 49
decreased heart weight 26 | 44
abnormal neural tube closure 25 | 37
decreased rib number 25 | 59
abnormal behavioral response t... 24 | 52
abnormal seminal vesicle morph... 24 | 47
increased exploration in new e... 24 | 56
abnormal eye morphology 23 | 38
abnormal gait 22 | 51
decreased NK T cell number 22 | 28
decreased circulating total pr... 22 | 41
decreased eosinophil cell numb... 22 | 41
decreased circulating LDL chol... 21 | 37
decreased circulating alkaline... 21 | 41
decreased circulating free fat... 21 | 39
decreased circulating fructosa... 21 | 31
female infertility 21 | 34
increased blood urea nitrogen ... 21 | 44
increased hemoglobin content 21 | 45
increased rib number 21 | 41
increased startle reflex 21 | 38
small testis 21 | 37
abnormal cranium morphology 20 | 32
decreased T cell number 20 | 31
decreased circulating creatini... 20 | 31
tremors 20 | 34
abnormal spleen morphology 19 | 36
abnormal testis morphology 19 | 30
decreased CD8-positive, alpha-... 19 | 26
decreased neutrophil cell numb... 19 | 37
increased circulating calcium ... 19 | 32
increased circulating chloride... 18 | 43
increased circulating triglyce... 18 | 24
increased heart weight 18 | 37
increased leukocyte cell numbe... 18 | 37
abnormal tooth morphology 17 | 24
cardiovascular system phenotyp... 17 | 35
decreased circulating aspartat... 17 | 27
decreased circulating calcium ... 17 | 33

Disease

ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 8,398 | 18,646
Nervous System 8,398 | 18,560
Digestive Tract 8,396 | 18,472
Urinary Tract 8,385 | 18,443
Endocrine System 8,383 | 18,511
Liver and Pancreas 8,367 | 18,135
Blood and immune system 8,352 | 17,994
Cardiovascular System 8,350 | 17,957
Male tissues 8,347 | 17,968
Skin and soft tissues 8,329 | 18,114
Respiratory system 8,286 | 17,483

Target Family

Non-IDG 4,964 | 11,969
Enzyme 2,039 | 4,146
Transcription Factor 560 | 1,400
Kinase 339 | 634
Transporter 201 | 473
Epigenetic 131 | 242
GPCR 104 | 408
Ion Channel 88 | 341
Nuclear Receptor 23 | 48
TF/Epigenetic 23 | 38
oGPCR 19 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130