Development Level

Tbio 4,744 | 10,625
Tdark 2,028 | 7,003
Tchem 902 | 1,890
Tclin 259 | 602

Collection

Kinase: IDG Consortium (Targets) 55 | 125
Ion Channel: IDG Consortium (Targets) 35 | 102
GPCR: IDG Consortium (Targets) 26 | 127
Kinase: IDG Consortium (Complete/Control) 21 | 37
GPCR: IDG Consortium (Complete/Control) 8 | 26

IMPC Phenotype

preweaning lethality, complete... 307 | 633
preweaning lethality, incomple... 133 | 260
abnormal behavior 114 | 226
decreased total body fat amoun... 111 | 186
embryonic lethality prior to t... 99 | 187
decreased lean body mass 96 | 195
decreased body weight 87 | 174
embryonic lethality prior to o... 77 | 148
decreased bone mineral content 76 | 157
abnormal bone structure 65 | 131
decreased circulating glucose ... 65 | 121
decreased grip strength 61 | 123
decreased body length 60 | 108
decreased bone mineral density 60 | 126
abnormal retina morphology 58 | 100
increased bone mineral content 58 | 92
increased lean body mass 58 | 107
increased or absent threshold ... 57 | 128
increased circulating alkaline... 56 | 119
increased mean corpuscular vol... 55 | 91
hyperactivity 54 | 108
increased mean corpuscular hem... 50 | 93
abnormal embryo size 49 | 112
enlarged heart 45 | 111
decreased circulating choleste... 43 | 85
decreased circulating triglyce... 43 | 83
hypoactivity 43 | 89
decreased circulating insulin ... 41 | 75
increased grip strength 40 | 83
abnormal lens morphology 39 | 73
decreased circulating HDL chol... 38 | 77
increased circulating sodium l... 36 | 71
short tibia 36 | 82
prenatal lethality prior to he... 35 | 64
abnormal retinal pigmentation 34 | 61
decreased circulating serum al... 33 | 79
decreased lumbar vertebrae num... 33 | 62
decreased mean corpuscular vol... 32 | 50
decreased leukocyte cell numbe... 31 | 54
abnormal bone mineralization 30 | 55
decreased circulating alanine ... 30 | 53
decreased rib number 30 | 59
abnormal coat-hair pigmentatio... 29 | 54
abnormal sleep behavior 29 | 63
decreased hemoglobin content 29 | 53
increased bone mineral density 29 | 52
increased circulating HDL chol... 29 | 63
increased fasted circulating g... 29 | 68
increased sacral vertebrae num... 29 | 62
decreased prepulse inhibition 28 | 52
increased total body fat amoun... 28 | 57
abnormal gait 27 | 51
decreased erythrocyte cell num... 27 | 43
male infertility 27 | 62
decreased circulating total pr... 26 | 41
impaired glucose tolerance 26 | 52
increased circulating choleste... 25 | 53
abnormal behavioral response t... 24 | 52
decreased heart weight 24 | 44
decreased mean corpuscular hem... 24 | 34
decreased caudal vertebrae num... 23 | 49
improved glucose tolerance 23 | 56
thrombocytopenia 23 | 46
decreased neutrophil cell numb... 22 | 37
increased blood urea nitrogen ... 22 | 44
increased hemoglobin content 22 | 45
increased rib number 22 | 41
abnormal cranium morphology 21 | 32
decreased circulating free fat... 21 | 39
decreased fasted circulating g... 21 | 49
decreased circulating creatini... 20 | 31
decreased startle reflex 20 | 48
increased exploration in new e... 20 | 56
increased startle reflex 20 | 38
small testis 20 | 37
tremors 20 | 34
decreased circulating alkaline... 19 | 41
increased body weight 19 | 42
increased hematocrit 19 | 36
abnormal heart morphology 18 | 51
decreased blood urea nitrogen ... 18 | 31
decreased circulating LDL chol... 18 | 37
decreased circulating calcium ... 18 | 33
enlarged spleen 18 | 26
increased circulating calcium ... 18 | 32
abnormal epididymis morphology 17 | 31
abnormal testis morphology 17 | 30
cardiovascular system phenotyp... 17 | 35
decreased threshold for audito... 17 | 32
increased circulating chloride... 17 | 43
increased circulating iron lev... 17 | 25
increased heart weight 17 | 37
limb grasping 17 | 35
abnormal QRS complex 16 | 25
abnormal neural tube closure 16 | 37
abnormal spleen morphology 16 | 36
abnormal tooth morphology 16 | 24
decreased circulating aspartat... 16 | 27
decreased circulating iron lev... 16 | 25
decreased eosinophil cell numb... 16 | 41

Disease

osteosarcoma 7,933 | 7,933
ovarian cancer 8,491 | 8,491
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 7,805 | 18,560
Female tissues 7,796 | 18,646
Digestive Tract 7,794 | 18,472
Endocrine System 7,787 | 18,511
Urinary Tract 7,778 | 18,443
Liver and Pancreas 7,776 | 18,135
Blood and immune system 7,760 | 17,994
Male tissues 7,758 | 17,968
Cardiovascular System 7,750 | 17,957
Skin and soft tissues 7,729 | 18,114
Respiratory system 7,696 | 17,483

Target Family

Non-IDG 4,487 | 11,969
Enzyme 1,794 | 4,146
Transcription Factor 635 | 1,400
Kinase 348 | 634
Transporter 206 | 473
Epigenetic 152 | 242
GPCR 126 | 408
Ion Channel 116 | 341
Nuclear Receptor 26 | 48
TF/Epigenetic 24 | 38
oGPCR 19 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
T-cell surface protein tactile CD96 Tbio Non-IDG -2.03517 108.7 142
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173
Zinc finger protein 606 ZNF606 Tdark Transcription Factor 0.00000 1.48 76