Development Level

Tbio 5,103 | 11,445
Tdark 1,805 | 6,588
Tchem 776 | 1,598
Tclin 266 | 613

Collection

RFA-RM-18-021 114 | 328
Kinase: IDG Consortium (Target... 55 | 125
Ion Channel: IDG Consortium (T... 34 | 99
GPCR: IDG Consortium (Targets) 26 | 126
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 496 | 979
preweaning lethality, incomple... 254 | 499
embryonic lethality prior to t... 147 | 278
abnormal behavior 142 | 298
embryonic lethality prior to o... 125 | 239
decreased total body fat amoun... 121 | 207
abnormal embryo size 108 | 220
increased lean body mass 95 | 172
abnormal bone structure 91 | 187
enlarged heart 89 | 210
decreased vertical activity 88 | 208
decreased body weight 81 | 161
decreased bone mineral content 71 | 151
decreased circulating glucose ... 68 | 126
increased bone mineral content 66 | 108
abnormal heart morphology 65 | 162
decreased lean body mass 65 | 135
hyperactivity 65 | 148
hypoactivity 63 | 132
increased total body fat amoun... 63 | 134
increased circulating alkaline... 58 | 122
increased startle reflex 57 | 112
embryonic growth retardation 56 | 106
male infertility 55 | 123
decreased grip strength 54 | 116
abnormal seminal vesicle morph... 53 | 114
increased mean corpuscular vol... 53 | 92
decreased circulating choleste... 51 | 93
decreased bone mineral density 48 | 126
decreased lymphocyte cell numb... 48 | 83
increased mean corpuscular hem... 47 | 96
increased or absent threshold ... 46 | 101
prenatal lethality prior to he... 46 | 87
decreased prepulse inhibition 45 | 82
decreased body length 42 | 101
decreased circulating insulin ... 42 | 76
decreased leukocyte cell numbe... 42 | 73
increased bone mineral density 42 | 72
decreased circulating triglyce... 41 | 79
cataract 40 | 92
decreased mean corpuscular vol... 40 | 79
abnormal lens morphology 39 | 81
decreased hemoglobin content 39 | 68
decreased erythrocyte cell num... 38 | 62
abnormal coat-hair pigmentatio... 37 | 64
abnormal gait 37 | 69
abnormal retina morphology 37 | 71
decreased circulating HDL chol... 37 | 68
decreased circulating serum al... 37 | 82
impaired glucose tolerance 37 | 75
short tibia 37 | 97
abnormal sleep behavior 36 | 70
increased circulating HDL chol... 35 | 80
increased heart weight 35 | 62
decreased startle reflex 34 | 75
increased circulating choleste... 34 | 66
increased monocyte cell number 34 | 63
small superior vagus ganglion 34 | 74
improved glucose tolerance 33 | 79
increased circulating sodium l... 33 | 71
increased fasted circulating g... 33 | 76
small testis 33 | 58
edema 32 | 59
abnormal behavioral response t... 31 | 66
abnormal kidney morphology 30 | 65
decreased caudal vertebrae num... 30 | 53
decreased circulating total pr... 30 | 49
abnormal eye morphology 29 | 68
decreased mean corpuscular hem... 29 | 50
decreased circulating alanine ... 28 | 47
decreased circulating alkaline... 27 | 46
thrombocytopenia 27 | 56
decreased blood urea nitrogen ... 26 | 51
enlarged spleen 26 | 41
female infertility 26 | 60
decreased hematocrit 25 | 46
increased neutrophil cell numb... 25 | 46
decreased circulating calcium ... 24 | 36
decreased fasted circulating g... 24 | 65
increased circulating triglyce... 24 | 42
increased mean platelet volume 24 | 45
abnormal spleen morphology 23 | 55
abnormal testis morphology 23 | 43
tremors 23 | 39
abnormal bone mineralization 22 | 38
abnormal cranium morphology 22 | 36
hydrometra 22 | 53
increased hematocrit 22 | 46
increased blood urea nitrogen ... 21 | 48
abnormal epididymis morphology 20 | 42
decreased mean corpuscular hem... 20 | 31
increased circulating calcium ... 20 | 34
increased erythrocyte cell num... 20 | 39
increased red blood cell distr... 20 | 34
abnormal skin morphology 19 | 50
decreased circulating LDL chol... 19 | 38
decreased circulating creatini... 19 | 39
increased hemoglobin content 19 | 45
limb grasping 19 | 41
increased circulating chloride... 18 | 41

Disease

osteosarcoma 7,950 | 7,950
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 7,744 | 18,159
Female tissues 7,681 | 17,400
Digestive Tract 7,678 | 17,369
Skin and soft tissues 7,666 | 17,230
Blood and immune system 7,618 | 16,909
Male tissues 7,617 | 17,142
Liver and Pancreas 7,598 | 16,750
Urinary Tract 7,581 | 16,678
Nervous System 7,548 | 16,725
Respiratory system 7,539 | 16,393
Cardiovascular System 7,251 | 15,192

Target Family

Non-IDG 4,497 | 12,091
Enzyme 1,797 | 4,145
Transcription Factor 635 | 1,400
Kinase 349 | 634
Transporter 206 | 473
Epigenetic 153 | 242
GPCR 126 | 408
Ion Channel 118 | 344
Nuclear Receptor 26 | 48
TF/Epigenetic 24 | 38
oGPCR 19 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158