Development Level

Tbio 1,802 | 10,625
Tdark 565 | 7,003
Tchem 357 | 1,890
Tclin 125 | 602

Collection

Eligible Ion Channel Proteins 28 | 117
Eligible Kinase Proteins 27 | 134
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 93 | 633
abnormal behavior 71 | 226
preweaning lethality, incomple... 61 | 260
decreased total body fat amoun... 41 | 186
decreased lean body mass 40 | 195
embryonic lethality prior to t... 35 | 187
hyperactivity 34 | 108
decreased bone mineral content 32 | 157
decreased circulating choleste... 28 | 85
increased lean body mass 28 | 107
decreased bone mineral density 27 | 126
decreased grip strength 27 | 123
abnormal bone structure 26 | 131
decreased body weight 26 | 174
decreased circulating HDL chol... 26 | 77
increased circulating alkaline... 26 | 119
decreased circulating glucose ... 25 | 121
hypoactivity 25 | 89
increased or absent threshold ... 25 | 128
abnormal embryo size 23 | 112
abnormal retina morphology 21 | 100
enlarged heart 21 | 111
decreased body length 20 | 108
decreased circulating triglyce... 20 | 83
abnormal sleep behavior 18 | 63
embryonic lethality prior to o... 18 | 148
increased bone mineral content 18 | 92
abnormal gait 17 | 51
decreased circulating serum al... 17 | 79
decreased circulating insulin ... 16 | 75
increased mean corpuscular vol... 16 | 91
short tibia 16 | 82
abnormal lens morphology 15 | 73
male infertility 14 | 62
abnormal retinal pigmentation 13 | 61
increased blood urea nitrogen ... 13 | 44
decreased lumbar vertebrae num... 12 | 62
decreased prepulse inhibition 12 | 52
increased circulating HDL chol... 12 | 63
increased startle reflex 12 | 38
prenatal lethality prior to he... 12 | 64
abnormal coat/hair pigmentatio... 11 | 54
abnormal heart morphology 11 | 51
abnormal testis morphology 11 | 30
decreased circulating LDL chol... 11 | 37
decreased leukocyte cell numbe... 11 | 54
decreased startle reflex 11 | 48
increased circulating calcium ... 11 | 32
increased circulating sodium l... 11 | 71
increased mean corpuscular hem... 11 | 93
increased rib number 11 | 41
increased sacral vertebrae num... 11 | 62
tremors 11 | 34
cataract 10 | 26
decreased circulating calcium ... 10 | 33
decreased circulating total pr... 10 | 41
decreased heart weight 10 | 44
improved glucose tolerance 10 | 56
increased circulating chloride... 10 | 43
increased circulating triglyce... 10 | 24
increased hemoglobin content 10 | 45
small testis 10 | 37
abnormal bone mineralization 9 | 55
abnormal neural tube closure 9 | 37
abnormal seminal vesicle morph... 9 | 47
cardiovascular system phenotyp... 9 | 35
decreased circulating alanine ... 9 | 53
decreased fasted circulating g... 9 | 49
increased body weight 9 | 42
increased fasted circulating g... 9 | 68
increased grip strength 9 | 83
limb grasping 9 | 35
abnormal behavioral response t... 8 | 52
abnormal epididymis morphology 8 | 31
abnormal retinal blood vessel ... 8 | 18
decreased eosinophil cell numb... 8 | 41
decreased erythrocyte cell num... 8 | 43
decreased hemoglobin content 8 | 53
decreased rib number 8 | 59
enlarged spleen 8 | 26
increased circulating choleste... 8 | 53
increased circulating phosphat... 8 | 24
increased exploration in new e... 8 | 56
increased hematocrit 8 | 36
increased total body fat amoun... 8 | 57
thrombocytopenia 8 | 46
abnormal forebrain development 7 | 18
abnormal hindbrain development 7 | 24
abnormal midbrain development 7 | 22
decreased circulating alkaline... 7 | 41
decreased circulating free fat... 7 | 39
decreased vertical activity 7 | 22
enlarged epididymis 7 | 27
enlarged lymph nodes 7 | 27
impaired glucose tolerance 7 | 52
increased leukocyte cell numbe... 7 | 37
abnormal cornea morphology 6 | 24
decreased caudal vertebrae num... 6 | 49
increased erythrocyte cell num... 6 | 26
increased prepulse inhibition 6 | 21

Disease

oligodendroglioma 2,849 | 2,849
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,832 | 18,561
Digestive Tract 2,829 | 18,473
Female tissues 2,827 | 18,647
Liver and Pancreas 2,827 | 18,136
Endocrine System 2,824 | 18,512
Urinary Tract 2,822 | 18,444
Cardiovascular System 2,820 | 17,958
Male tissues 2,817 | 17,969
Blood and immune system 2,812 | 17,995
Skin and soft tissues 2,807 | 18,115
Respiratory system 2,793 | 17,484

Target Family

Non-IDG 1,680 | 11,971
Enzyme 585 | 4,146
Transcription Factor 181 | 1,400
Kinase 125 | 634
Ion Channel 91 | 341
Transporter 70 | 473
GPCR 55 | 406
Epigenetic 49 | 242
Nuclear Receptor 7 | 48
TF/Epigenetic 6 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748