Development Level

Tbio 220 | 10,625
Tdark 82 | 7,003
Tchem 78 | 1,890
Tclin 33 | 602

Collection

GPCR: IDG Consortium (Targets) 3 | 127
Ion Channel: IDG Consortium (Targets) 2 | 102
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 633
preweaning lethality, incomple... 11 | 260
abnormal embryo size 4 | 112
decreased circulating glucose ... 4 | 121
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
abnormal behavior 3 | 226
abnormal lens morphology 3 | 73
abnormal retinal pigmentation 3 | 61
cataract 3 | 26
decreased blood urea nitrogen ... 3 | 31
decreased circulating serum al... 3 | 79
decreased total body fat amoun... 3 | 186
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased startle reflex 3 | 38
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal nail morphology 2 | 7
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
abnormal spine curvature 2 | 7
decreased NK T cell number 2 | 28
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating creatini... 2 | 31
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased monocyte cell number 2 | 28
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
edema 2 | 11
hydrops fetalis 2 | 22
hyperactivity 2 | 108
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64
shortened RR interval 2 | 19
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal skin appearance 1 | 8
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
cleft palate 1 | 6
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating calcium ... 1 | 33
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
increased Ly6C high monocyte n... 1 | 12
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
mydriasis 1 | 9
persistence of hyaloid vascula... 1 | 22
prolonged PR interval 1 | 4
short tibia 1 | 82
shortened ST segment 1 | 9
small adrenal glands 1 | 15
small kidney 1 | 10
small spleen 1 | 11
thrombocytopenia 1 | 46

Disease

non-small cell lung carcinoma 413 | 413
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 408 | 18,472
Female tissues 408 | 18,646
Liver and Pancreas 407 | 18,135
Respiratory system 407 | 17,483
Urinary Tract 407 | 18,443
Male tissues 406 | 17,968
Nervous System 406 | 18,560
Endocrine System 405 | 18,511
Blood and immune system 404 | 17,994
Cardiovascular System 402 | 17,957
Skin and soft tissues 399 | 18,114

Target Family

Non-IDG 243 | 11,969
Enzyme 89 | 4,146
Kinase 24 | 634
Transcription Factor 16 | 1,400
GPCR 14 | 408
Transporter 14 | 473
Ion Channel 8 | 341
Epigenetic 2 | 242
oGPCR 2 | 421
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
Ran-binding protein 3-like RANBP3L Tdark Non-IDG 0.32 0.79 58
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Guanylate-binding protein 4 GBP4 Tbio Non-IDG -1.67376 45.5 102
RNA-binding protein 7 RBM7 Tbio Non-IDG -0.67056 6.57 67
Radial spoke head protein 4 homolog A RSPH4A Tdark Non-IDG -0.74481 5.30 34
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Coiled-coil domain-containing protein 141 CCDC141 Tdark Non-IDG -0.61681 3.82 82