Development Level

Tbio 1,833 | 10,625
Tchem 431 | 1,890
Tdark 411 | 7,003
Tclin 123 | 602

Collection

Eligible Kinase Proteins 16 | 134
Eligible Ion Channel Proteins 12 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 106 | 633
preweaning lethality, incomple... 47 | 260
embryonic lethality prior to t... 37 | 187
decreased lean body mass 36 | 195
abnormal behavior 35 | 226
decreased total body fat amoun... 34 | 186
abnormal retina morphology 30 | 100
decreased bone mineral content 29 | 157
increased mean corpuscular vol... 29 | 91
decreased body weight 26 | 174
decreased circulating glucose ... 26 | 121
enlarged heart 26 | 111
increased circulating alkaline... 24 | 119
decreased grip strength 23 | 123
decreased circulating HDL chol... 22 | 77
decreased bone mineral density 21 | 126
decreased circulating choleste... 21 | 85
embryonic lethality prior to o... 21 | 148
abnormal bone structure 20 | 131
abnormal embryo size 20 | 112
hyperactivity 20 | 108
increased mean corpuscular hem... 20 | 93
abnormal lens morphology 19 | 73
increased lean body mass 19 | 107
abnormal sleep behavior 17 | 63
decreased body length 16 | 108
decreased circulating triglyce... 16 | 83
abnormal retinal pigmentation 15 | 61
increased circulating HDL chol... 15 | 63
increased fasted circulating g... 15 | 68
increased or absent threshold ... 15 | 128
increased total body fat amoun... 15 | 57
decreased circulating insulin ... 14 | 75
hypoactivity 14 | 89
thrombocytopenia 14 | 46
decreased circulating alanine ... 13 | 53
decreased heart weight 13 | 44
decreased prepulse inhibition 13 | 52
decreased startle reflex 13 | 48
improved glucose tolerance 13 | 56
increased blood urea nitrogen ... 13 | 44
increased circulating calcium ... 13 | 32
increased sacral vertebrae num... 13 | 62
abnormal heart morphology 12 | 51
decreased leukocyte cell numbe... 12 | 54
increased grip strength 12 | 83
male infertility 12 | 62
abnormal behavioral response t... 11 | 52
decreased hemoglobin content 11 | 53
decreased mean corpuscular vol... 11 | 50
increased circulating sodium l... 11 | 71
short tibia 11 | 82
decreased blood urea nitrogen ... 10 | 31
decreased circulating alkaline... 10 | 41
decreased circulating free fat... 10 | 39
decreased eosinophil cell numb... 10 | 41
decreased lumbar vertebrae num... 10 | 62
decreased mean corpuscular hem... 10 | 34
increased bone mineral content 10 | 92
increased circulating potassiu... 10 | 31
increased circulating triglyce... 10 | 24
abnormal coat appearance 9 | 25
abnormal coat/hair pigmentatio... 9 | 54
decreased circulating LDL chol... 9 | 37
increased body weight 9 | 42
increased circulating chloride... 9 | 43
increased heart weight 9 | 37
increased hemoglobin content 9 | 45
abnormal bone mineralization 8 | 55
abnormal gait 8 | 51
abnormal neural tube closure 8 | 37
cardiovascular system phenotyp... 8 | 35
decreased erythrocyte cell num... 8 | 43
decreased fasted circulating g... 8 | 49
decreased rib number 8 | 59
decreased threshold for audito... 8 | 32
female infertility 8 | 34
increased circulating choleste... 8 | 53
increased exploration in new e... 8 | 56
increased rib number 8 | 41
prenatal lethality prior to he... 8 | 64
abnormal cranium morphology 7 | 32
abnormal seminal vesicle morph... 7 | 47
abnormal skin morphology 7 | 23
corneal opacity 7 | 25
decreased CD8-positive, alpha-... 7 | 26
decreased circulating calcium ... 7 | 33
impaired glucose tolerance 7 | 52
increased circulating total pr... 7 | 20
small testis 7 | 37
abnormal epididymis morphology 6 | 31
abnormal kidney morphology 6 | 30
abnormal locomotor activation 6 | 26
abnormal spleen morphology 6 | 36
decreased caudal vertebrae num... 6 | 49
increased circulating bilirubi... 6 | 16
increased circulating iron lev... 6 | 25
increased erythrocyte cell num... 6 | 26
increased hematocrit 6 | 36
tremors 6 | 34

Disease

non-small cell lung cancer 2,798 | 2,798
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,780 | 18,561
Female tissues 2,779 | 18,647
Liver and Pancreas 2,778 | 18,136
Digestive Tract 2,777 | 18,473
Male tissues 2,776 | 17,969
Endocrine System 2,775 | 18,512
Urinary Tract 2,775 | 18,444
Blood and immune system 2,770 | 17,995
Cardiovascular System 2,768 | 17,958
Respiratory system 2,766 | 17,484
Skin and soft tissues 2,757 | 18,115

Target Family

Non-IDG 1,699 | 11,971
Enzyme 598 | 4,146
Transcription Factor 151 | 1,400
Kinase 144 | 634
Transporter 87 | 473
GPCR 48 | 406
Ion Channel 32 | 341
Epigenetic 25 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 6 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241