Development Level

Tbio 2,028 | 11,445
Tchem 370 | 1,598
Tdark 361 | 6,588
Tclin 131 | 613

Collection

Kinase: IDG Consortium (Target... 14 | 125
Ion Channel: IDG Consortium (T... 13 | 99
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 152 | 979
preweaning lethality, incomple... 98 | 499
embryonic lethality prior to t... 54 | 278
abnormal behavior 47 | 298
decreased vertical activity 46 | 208
enlarged heart 46 | 210
abnormal embryo size 42 | 220
decreased total body fat amoun... 39 | 207
abnormal heart morphology 37 | 162
embryonic lethality prior to o... 36 | 239
increased mean corpuscular vol... 28 | 92
abnormal bone structure 26 | 187
decreased bone mineral content 26 | 151
decreased circulating glucose ... 25 | 126
increased lean body mass 25 | 172
hyperactivity 24 | 148
decreased grip strength 23 | 116
abnormal seminal vesicle morph... 22 | 114
hypoactivity 22 | 132
increased total body fat amoun... 22 | 134
decreased body weight 21 | 161
decreased circulating choleste... 21 | 93
abnormal sleep behavior 20 | 70
decreased bone mineral density 20 | 126
decreased lymphocyte cell numb... 20 | 83
increased circulating alkaline... 20 | 122
abnormal lens morphology 19 | 81
cataract 19 | 92
embryonic growth retardation 19 | 106
increased mean corpuscular hem... 19 | 96
abnormal retina morphology 18 | 71
decreased circulating HDL chol... 18 | 68
decreased lean body mass 18 | 135
increased fasted circulating g... 18 | 76
male infertility 18 | 123
decreased mean corpuscular vol... 17 | 79
decreased prepulse inhibition 17 | 82
improved glucose tolerance 17 | 79
increased circulating HDL chol... 16 | 80
abnormal eye morphology 15 | 68
decreased startle reflex 15 | 75
increased bone mineral content 15 | 108
increased monocyte cell number 15 | 63
increased startle reflex 15 | 112
small superior vagus ganglion 15 | 74
abnormal kidney morphology 14 | 65
decreased circulating insulin ... 14 | 76
decreased leukocyte cell numbe... 14 | 73
increased heart weight 14 | 62
increased or absent threshold ... 14 | 101
prenatal lethality prior to he... 14 | 87
thrombocytopenia 14 | 56
decreased body length 13 | 101
decreased circulating triglyce... 13 | 79
edema 13 | 59
short tibia 13 | 97
abnormal behavioral response t... 12 | 66
abnormal gait 12 | 69
abnormal skin morphology 12 | 50
decreased circulating alanine ... 12 | 47
decreased erythrocyte cell num... 12 | 62
increased blood urea nitrogen ... 12 | 48
increased circulating calcium ... 12 | 34
decreased blood urea nitrogen ... 11 | 51
decreased hemoglobin content 11 | 68
increased bone mineral density 11 | 72
abnormal coat appearance 10 | 31
abnormal epididymis morphology 10 | 42
abnormal testis morphology 10 | 43
decreased circulating alkaline... 10 | 46
decreased circulating calcium ... 10 | 36
increased hematocrit 10 | 46
increased neutrophil cell numb... 10 | 46
small testis 10 | 58
abnormal coat-hair pigmentatio... 9 | 64
abnormal spleen morphology 9 | 55
decreased circulating serum al... 9 | 82
decreased fasted circulating g... 9 | 65
decreased hematocrit 9 | 46
enlarged spleen 9 | 41
female infertility 9 | 60
hydrometra 9 | 53
impaired glucose tolerance 9 | 75
increased circulating sodium l... 9 | 71
increased circulating triglyce... 9 | 42
abnormal neural tube closure 8 | 46
cardiovascular system phenotyp... 8 | 36
decreased circulating LDL chol... 8 | 38
decreased circulating chloride... 8 | 30
decreased circulating free fat... 8 | 31
decreased mean corpuscular hem... 8 | 50
impaired righting response 8 | 26
increased body length 8 | 32
increased circulating chloride... 8 | 41
increased circulating choleste... 8 | 66
increased erythrocyte cell num... 8 | 39
increased grip strength 8 | 41
persistence of hyaloid vascula... 8 | 33
corneal opacity 7 | 32
decreased circulating total pr... 7 | 49

Disease

non-small cell lung cancer 2,890 | 2,890
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Female tissues 2,857 | 17,400
Endocrine System 2,856 | 18,159
Digestive Tract 2,851 | 17,369
Blood and immune system 2,843 | 16,909
Skin and soft tissues 2,842 | 17,230
Male tissues 2,840 | 17,142
Urinary Tract 2,837 | 16,678
Respiratory system 2,824 | 16,393
Liver and Pancreas 2,816 | 16,750
Nervous System 2,799 | 16,725
Cardiovascular System 2,669 | 15,192

Target Family

Non-IDG 1,756 | 12,091
Enzyme 618 | 4,145
Transcription Factor 154 | 1,400
Kinase 145 | 634
Transporter 90 | 473
GPCR 53 | 408
Ion Channel 35 | 344
Epigenetic 25 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 6 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Paraneoplastic antigen Ma2 PNMA2 Tbio Non-IDG -2.92781 822.4 113
Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 Tbio Enzyme -1.87527 79.6 110
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
1-aminocyclopropane-1-carboxylate synthase-like protein 1 ACCS Tbio Enzyme -2.31602 195.2 154
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344