Development Level

Tbio 514 | 10,625
Tdark 211 | 7,003
Tchem 81 | 1,890
Tclin 34 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 34 | 633
decreased total body fat amoun... 13 | 186
embryonic lethality prior to t... 12 | 187
embryonic lethality prior to o... 11 | 148
preweaning lethality, incomple... 10 | 260
abnormal embryo size 9 | 112
decreased body weight 9 | 174
abnormal behavior 8 | 226
enlarged heart 8 | 111
short tibia 8 | 82
abnormal bone structure 7 | 131
decreased lean body mass 7 | 195
increased circulating HDL chol... 7 | 63
increased circulating alkaline... 7 | 119
increased circulating choleste... 7 | 53
abnormal coat/hair pigmentatio... 6 | 54
decreased body length 6 | 108
decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 85
decreased circulating serum al... 6 | 79
decreased lumbar vertebrae num... 6 | 62
hyperactivity 6 | 108
increased sacral vertebrae num... 6 | 62
male infertility 6 | 62
prenatal lethality prior to he... 6 | 64
decreased circulating glucose ... 5 | 121
decreased rib number 5 | 59
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
increased total body fat amoun... 5 | 57
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
abnormal retina morphology 4 | 100
decreased circulating HDL chol... 4 | 77
decreased circulating insulin ... 4 | 75
decreased circulating triglyce... 4 | 83
decreased heart weight 4 | 44
increased mean corpuscular vol... 4 | 91
abnormal bone mineralization 3 | 55
abnormal seminal vesicle morph... 3 | 47
abnormal skin morphology 3 | 23
abnormal vocalization 3 | 21
absent startle reflex 3 | 15
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating calcium ... 3 | 33
decreased grip strength 3 | 123
decreased monocyte cell number 3 | 28
decreased startle reflex 3 | 48
enlarged lymph nodes 3 | 27
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased circulating chloride... 3 | 43
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
increased hematocrit 3 | 36
increased startle reflex 3 | 38
small adrenal glands 3 | 15
thrombocytopenia 3 | 46
abnormal coat appearance 2 | 25
abnormal coping response 2 | 12
abnormal eye morphology 2 | 38
abnormal kidney morphology 2 | 30
abnormal neural tube closure 2 | 37
abnormal retinal blood vessel ... 2 | 18
abnormal rib morphology 2 | 28
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 35
decreased CD4-positive, alpha ... 2 | 19
decreased CD8-positive, alpha-... 2 | 26
decreased Ly6C high monocyte n... 2 | 18
decreased T cell number 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
female infertility 2 | 34
hypoactivity 2 | 89
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased CD4-positive, CD25-p... 2 | 18
increased NK cell number 2 | 19
increased circulating amylase ... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating creatini... 2 | 29
increased circulating free fat... 2 | 17
increased circulating serum al... 2 | 25
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
limb grasping 2 | 35
shortened ST segment 2 | 9
small testis 2 | 37
trunk curl 2 | 15

Disease

non primary Sjogren syndrome sicca 840 | 840
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 823 | 18,473
Female tissues 823 | 18,647
Endocrine System 821 | 18,512
Liver and Pancreas 819 | 18,136
Nervous System 819 | 18,561
Urinary Tract 819 | 18,444
Male tissues 817 | 17,969
Blood and immune system 816 | 17,995
Skin and soft tissues 816 | 18,115
Cardiovascular System 815 | 17,958
Respiratory system 807 | 17,484

Target Family

Non-IDG 483 | 11,971
Enzyme 212 | 4,146
Transcription Factor 55 | 1,400
Transporter 26 | 473
Kinase 22 | 634
Ion Channel 17 | 341
GPCR 10 | 406
Epigenetic 8 | 242
oGPCR 4 | 421
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Transmembrane 6 superfamily member 1 TM6SF1 Tdark Non-IDG -0.16400 2.15 54
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Putative uncharacterized protein ST20-AS1 ST20-AS1 Tdark Non-IDG 0.00000 0