Targets

This is where graphics are reside..

	Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count	Knowledge Availability
	Proto-oncogene c-Fos	FOS	Tchem	Transcription Factor	-4.11560	13094.7	961
	Apolipoprotein E	APOE	Tbio	Non-IDG	-4.17470	15380.4	788

	Tbio	514 \| 10,625
	Tdark	211 \| 7,003
	Tchem	81 \| 1,890
	Tclin	34 \| 602

	Eligible Ion Channel Proteins	4 \| 117
	Eligible Kinase Proteins	2 \| 134
	Eligible non-olfactory GPCR Proteins	2 \| 143

	preweaning lethality, complete...	34 \| 633
	decreased total body fat amoun...	13 \| 186
	embryonic lethality prior to t...	12 \| 187
	embryonic lethality prior to o...	11 \| 148
	preweaning lethality, incomple...	10 \| 260
	abnormal embryo size	9 \| 112
	decreased body weight	9 \| 174
	abnormal behavior	8 \| 226
	enlarged heart	8 \| 111
	short tibia	8 \| 82
	abnormal bone structure	7 \| 131
	decreased lean body mass	7 \| 195
	increased circulating HDL chol...	7 \| 63
	increased circulating alkaline...	7 \| 119
	increased circulating choleste...	7 \| 53
	abnormal coat/hair pigmentatio...	6 \| 54
	decreased body length	6 \| 108
	decreased bone mineral content	6 \| 157
	decreased bone mineral density	6 \| 126
	decreased circulating choleste...	6 \| 85
	decreased circulating serum al...	6 \| 79
	decreased lumbar vertebrae num...	6 \| 62
	hyperactivity	6 \| 108
	increased sacral vertebrae num...	6 \| 62
	male infertility	6 \| 62
	prenatal lethality prior to he...	6 \| 64
	decreased circulating glucose ...	5 \| 121
	decreased rib number	5 \| 59
	increased lean body mass	5 \| 107
	increased or absent threshold ...	5 \| 128
	increased total body fat amoun...	5 \| 57
	abnormal gait	4 \| 51
	abnormal heart morphology	4 \| 51
	abnormal lens morphology	4 \| 73
	abnormal retina morphology	4 \| 100
	decreased circulating HDL chol...	4 \| 77
	decreased circulating insulin ...	4 \| 75
	decreased circulating triglyce...	4 \| 83
	decreased heart weight	4 \| 44
	increased mean corpuscular vol...	4 \| 91
	abnormal bone mineralization	3 \| 55
	abnormal seminal vesicle morph...	3 \| 47
	abnormal skin morphology	3 \| 23
	abnormal vocalization	3 \| 21
	absent startle reflex	3 \| 15
	decreased caudal vertebrae num...	3 \| 49
	decreased circulating LDL chol...	3 \| 37
	decreased circulating alanine ...	3 \| 53
	decreased circulating calcium ...	3 \| 33
	decreased grip strength	3 \| 123
	decreased monocyte cell number	3 \| 28
	decreased startle reflex	3 \| 48
	enlarged lymph nodes	3 \| 27
	impaired glucose tolerance	3 \| 52
	increased blood urea nitrogen ...	3 \| 44
	increased bone mineral content	3 \| 92
	increased circulating chloride...	3 \| 43
	increased circulating sodium l...	3 \| 71
	increased grip strength	3 \| 83
	increased hematocrit	3 \| 36
	increased startle reflex	3 \| 38
	small adrenal glands	3 \| 15
	thrombocytopenia	3 \| 46
	abnormal coat appearance	2 \| 25
	abnormal coping response	2 \| 12
	abnormal eye morphology	2 \| 38
	abnormal kidney morphology	2 \| 30
	abnormal neural tube closure	2 \| 37
	abnormal retinal blood vessel ...	2 \| 18
	abnormal rib morphology	2 \| 28
	abnormal sleep behavior	2 \| 63
	abnormal testis morphology	2 \| 30
	abnormal tooth morphology	2 \| 24
	cardiovascular system phenotyp...	2 \| 35
	decreased CD4-positive, alpha ...	2 \| 19
	decreased CD8-positive, alpha-...	2 \| 26
	decreased Ly6C high monocyte n...	2 \| 18
	decreased T cell number	2 \| 31
	decreased circulating chloride...	2 \| 32
	decreased circulating free fat...	2 \| 39
	decreased mean corpuscular vol...	2 \| 50
	decreased prepulse inhibition	2 \| 52
	female infertility	2 \| 34
	hypoactivity	2 \| 89
	impaired righting response	2 \| 19
	improved glucose tolerance	2 \| 56
	increased CD4-positive, CD25-p...	2 \| 18
	increased NK cell number	2 \| 19
	increased circulating amylase ...	2 \| 13
	increased circulating bilirubi...	2 \| 16
	increased circulating calcium ...	2 \| 32
	increased circulating creatini...	2 \| 29
	increased circulating free fat...	2 \| 17
	increased circulating serum al...	2 \| 25
	increased hemoglobin content	2 \| 45
	increased mean corpuscular hem...	2 \| 93
	limb grasping	2 \| 35
	shortened ST segment	2 \| 9
	small testis	2 \| 37
	trunk curl	2 \| 15

	non primary Sjogren syndrome sicca	840 \| 840
	ovarian cancer	8,484 \| 8,484
	osteosarcoma	7,933 \| 7,933
	psoriasis	6,685 \| 6,685
	medulloblastoma, large-cell	6,234 \| 6,234
	glioblastoma	5,572 \| 5,572
	lung cancer	4,466 \| 4,466
	atypical teratoid / rhabdoid tumor	4,369 \| 4,369
	intraductal papillary-mucinous neoplasm (IPMN)	3,289 \| 3,289
	malignant mesothelioma	3,162 \| 3,162
	Breast cancer	3,094 \| 3,094
	pilocytic astrocytoma	3,086 \| 3,086
	primitive neuroectodermal tumor	3,031 \| 3,031
	intraductal papillary-mucinous carcinoma (IPMC)	2,988 \| 2,988
	intraductal papillary-mucinous adenoma (IPMA)	2,956 \| 2,956
	invasive ductal carcinoma	2,950 \| 2,950
	oligodendroglioma	2,849 \| 2,849
	lung carcinoma	2,844 \| 2,844
	non-small cell lung cancer	2,798 \| 2,798
	lung adenocarcinoma	2,713 \| 2,713
	pediatric high grade glioma	2,712 \| 2,712
	ependymoma	2,514 \| 2,514
	Cancer	2,346 \| 2,346
	pancreatic cancer	2,300 \| 2,300
	interstitial cystitis	2,299 \| 2,299
	subependymal giant cell astrocytoma	2,287 \| 2,287
	group 3 medulloblastoma	2,254 \| 2,254
	astrocytic glioma	2,241 \| 2,241
	adult high grade glioma	2,148 \| 2,148
	Carcinoma	2,147 \| 2,147
	ulcerative colitis	2,087 \| 2,087
	pituitary cancer	1,972 \| 1,972
	Pick disease	1,893 \| 1,893
	group 4 medulloblastoma	1,875 \| 1,875
	pancreatic ductal adenocarcinoma liver metastasis	1,795 \| 1,795
	ductal carcinoma in situ	1,745 \| 1,745
	cystic fibrosis	1,665 \| 1,665
	diabetes mellitus	1,663 \| 1,663
	breast carcinoma	1,614 \| 1,614
	tuberculosis	1,557 \| 1,557
	posterior fossa group B ependymoma	1,530 \| 1,530
	medulloblastoma	1,524 \| 1,524
	posterior fossa group A ependymoma	1,511 \| 1,511
	astrocytoma	1,493 \| 1,493
	sonic hedgehog group medulloblastoma	1,482 \| 1,482
	colon cancer	1,475 \| 1,475
	adrenocortical carcinoma	1,427 \| 1,427
	Multiple myeloma	1,327 \| 1,327
	primary pancreatic ductal adenocarcinoma	1,271 \| 1,271
	juvenile dermatomyositis	1,189 \| 1,189
	Rheumatoid Arthritis	1,160 \| 1,160
	acute quadriplegic myopathy	1,157 \| 1,157
	atypical teratoid/rhabdoid tumor	1,095 \| 1,095
	spina bifida	1,064 \| 1,064
	cutaneous lupus erythematosus	1,056 \| 1,056
	nasopharyngeal carcinoma	1,056 \| 1,056
	Atopic dermatitis	944 \| 944
	dermatomyositis	933 \| 933
	active Crohn's disease	918 \| 918
	gastric carcinoma	832 \| 832
	primary Sjogren syndrome	789 \| 789
	acute myeloid leukemia	780 \| 780
	Waldenstrons macroglobulinemia	765 \| 765
	esophageal adenocarcinoma	737 \| 737
	tuberculosis and treatment for 6 months	686 \| 686
	progressive supranuclear palsy	674 \| 674
	aldosterone-producing adenoma	664 \| 664
	Alzheimer's disease	644 \| 644
	Obesity	616 \| 616
	Duchenne muscular dystrophy	602 \| 602
	Intellectual disability	573 \| 573
	pancreatic carcinoma	567 \| 567
	fibroadenoma	557 \| 557
	Down syndrome	548 \| 548
	Endometriosis	535 \| 535
	hepatocellular carcinoma	532 \| 532
	chronic rhinosinusitis	512 \| 512
	Schizophrenia	501 \| 501
	autosomal dominant Emery-Dreifuss muscular dystrophy	499 \| 499
	Multiple Sclerosis	498 \| 498
	mucosa-associated lymphoid tissue lymphoma	480 \| 480
	active ulcerative colitis	477 \| 477
	Prostatic Neoplasms	471 \| 471
	IGA Glomerulonephritis	454 \| 454
	Amyotrophic Lateral Sclerosis	431 \| 431
	gastric cancer	430 \| 430
	non-small cell lung carcinoma	413 \| 413
	Mammary Neoplasms	410 \| 410
	inflammatory breast cancer	404 \| 404
	Kidney disease	396 \| 396
	Neurodegenerative disease	383 \| 383
	Parkinson's disease	364 \| 364
	sarcoidosis	358 \| 358
	Asthma	349 \| 349
	glioblastoma multiforme	347 \| 347
	Epilepsy	346 \| 346
	Polycystic Ovary Syndrome	332 \| 332
	nephrosclerosis	329 \| 329
	tuberculosis and treatment for 3 months	327 \| 327
	Autistic Disorder	320 \| 320

	Digestive Tract	823 \| 18,473
	Female tissues	823 \| 18,647
	Endocrine System	821 \| 18,512
	Liver and Pancreas	819 \| 18,136
	Nervous System	819 \| 18,561
	Urinary Tract	819 \| 18,444
	Male tissues	817 \| 17,969
	Blood and immune system	816 \| 17,995
	Skin and soft tissues	816 \| 18,115
	Cardiovascular System	815 \| 17,958
	Respiratory system	807 \| 17,484

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Non-IDG	483 \| 11,971
	Enzyme	212 \| 4,146
	Transcription Factor	55 \| 1,400
	Transporter	26 \| 473
	Kinase	22 \| 634
	Ion Channel	17 \| 341
	GPCR	10 \| 406
	Epigenetic	8 \| 242
	oGPCR	4 \| 421
	Nuclear Receptor	2 \| 48
	TF/Epigenetic	1 \| 38