Development Level

Tbio 125 | 10,625
Tdark 39 | 7,003
Tchem 30 | 1,890
Tclin 6 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal behavior 6 | 226
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 121
hyperactivity 4 | 108
preweaning lethality, incomple... 4 | 260
abnormal heart morphology 3 | 51
abnormal sleep behavior 3 | 63
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
increased circulating triglyce... 3 | 24
limb grasping 3 | 35
abnormal behavioral response t... 2 | 52
abnormal epididymis morphology 2 | 31
abnormal lens morphology 2 | 73
decreased circulating insulin ... 2 | 75
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
enlarged epididymis 2 | 27
increased bone mineral content 2 | 92
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased red blood cell distr... 2 | 21
increased sacral vertebrae num... 2 | 62
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal limb morphology 1 | 7
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal skin appearance 1 | 8
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
cataract 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased red blood cell distr... 1 | 11
decreased thermal nociceptive ... 1 | 4
decreased threshold for audito... 1 | 32
edema 1 | 11
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
fusion of vertebral arches 1 | 7
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
long tibia 1 | 13
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened PQ interval 1 | 6
small testis 1 | 37
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

non diabetic and post-ischemic heart failure 200 | 200
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 194 | 18,473
Endocrine System 194 | 18,512
Female tissues 194 | 18,647
Nervous System 194 | 18,561
Urinary Tract 194 | 18,444
Cardiovascular System 193 | 17,958
Skin and soft tissues 193 | 18,115
Blood and immune system 192 | 17,995
Liver and Pancreas 192 | 18,136
Male tissues 192 | 17,969
Respiratory system 191 | 17,484

Target Family

Non-IDG 125 | 11,969
Enzyme 45 | 4,146
Transporter 8 | 473
GPCR 5 | 408
Transcription Factor 5 | 1,400
Kinase 4 | 634
Ion Channel 2 | 341
TF/Epigenetic 2 | 38
oGPCR 2 | 421
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Scavenger receptor cysteine-rich type 1 protein M130 CD163 Tbio Non-IDG -2.86758 701.8 663
tRNA-splicing ligase RtcB homolog RTCB Tbio Enzyme -1.71251 52.7 117
Oncostatin-M-specific receptor subunit beta OSMR Tbio Non-IDG -2.24105 170.5 217
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 ABHD5 Tbio Enzyme -1.91233 87.9 230
Zinc finger matrin-type protein 1 ZMAT1 Tdark Non-IDG 0.30 0.83 37
Transmembrane protein 140 TMEM140 Tdark Non-IDG -0.49208 3.07 8
DNA repair protein XRCC4 XRCC4 Tbio Non-IDG -2.36590 222.7 297
Lysine-specific demethylase 5D KDM5D Tbio TF/Epigenetic -2.35467 227.8 33
Hexokinase-2 HK2 Tchem Kinase -2.60415 391.1 373
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241