Development Level

Tbio 647 | 10,625
Tdark 238 | 7,003
Tchem 142 | 1,890
Tclin 29 | 602

Collection

Eligible Ion Channel Proteins 9 | 117
Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 31 | 633
preweaning lethality, incomple... 18 | 260
decreased lean body mass 11 | 195
decreased total body fat amoun... 11 | 186
abnormal embryo size 10 | 112
decreased bone mineral content 10 | 157
increased circulating alkaline... 10 | 119
decreased bone mineral density 9 | 126
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased circulating glucose ... 8 | 121
increased lean body mass 8 | 107
abnormal bone structure 7 | 131
abnormal coat/hair pigmentatio... 7 | 54
decreased body length 7 | 108
decreased circulating triglyce... 7 | 83
increased mean corpuscular vol... 7 | 91
abnormal lens morphology 6 | 73
increased bone mineral content 6 | 92
increased rib number 6 | 41
abnormal eye morphology 5 | 38
abnormal heart morphology 5 | 51
decreased blood urea nitrogen ... 5 | 31
decreased circulating alkaline... 5 | 41
decreased circulating choleste... 5 | 85
decreased circulating free fat... 5 | 39
decreased circulating insulin ... 5 | 75
decreased hemoglobin content 5 | 53
embryonic growth retardation 5 | 28
embryonic lethality prior to t... 5 | 187
enlarged heart 5 | 111
increased blood urea nitrogen ... 5 | 44
increased exploration in new e... 5 | 56
increased mean corpuscular hem... 5 | 93
increased or absent threshold ... 5 | 128
male infertility 5 | 62
abnormal bone mineralization 4 | 55
abnormal locomotor activation 4 | 26
abnormal retina morphology 4 | 100
abnormal sleep behavior 4 | 63
abnormal tooth morphology 4 | 24
decreased circulating HDL chol... 4 | 77
decreased circulating calcium ... 4 | 33
decreased grip strength 4 | 123
decreased mean corpuscular hem... 4 | 19
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
increased circulating choleste... 4 | 53
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
increased sacral vertebrae num... 4 | 62
limb grasping 4 | 35
abnormal behavioral response t... 3 | 52
abnormal neural tube closure 3 | 37
abnormal tail morphology 3 | 17
cataract 3 | 26
decreased B cell number 3 | 30
decreased KLRG1-positive NK ce... 3 | 9
decreased circulating iron lev... 3 | 25
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased mature B cell number 3 | 25
decreased mean corpuscular hem... 3 | 34
enlarged lymph nodes 3 | 27
hydrops fetalis 3 | 22
hyperactivity 3 | 108
hypoactivity 3 | 89
impaired righting response 3 | 19
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 32
increased circulating free fat... 3 | 17
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased hematocrit 3 | 36
increased mean corpuscular hem... 3 | 25
increased neutrophil cell numb... 3 | 15
abnormal cranium morphology 2 | 32
abnormal heart left ventricle ... 2 | 20
abnormal lung morphology 2 | 15
abnormal vocalization 2 | 21
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
decreased neutrophil cell numb... 2 | 37
decreased vertical activity 2 | 22
enlarged spleen 2 | 26
impaired glucose tolerance 2 | 52
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
increased total body fat amoun... 2 | 57
short tibia 2 | 82
thrombocytopenia 2 | 46
tremors 2 | 34

Disease

nasopharyngeal carcinoma 1,056 | 1,056
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,048 | 18,473
Female tissues 1,047 | 18,647
Liver and Pancreas 1,047 | 18,136
Nervous System 1,047 | 18,561
Male tissues 1,046 | 17,969
Urinary Tract 1,045 | 18,444
Endocrine System 1,044 | 18,512
Respiratory system 1,043 | 17,484
Cardiovascular System 1,041 | 17,958
Skin and soft tissues 1,040 | 18,115
Blood and immune system 1,037 | 17,995

Target Family

Non-IDG 721 | 11,971
Enzyme 186 | 4,146
Transcription Factor 49 | 1,400
Kinase 37 | 634
Transporter 26 | 473
Ion Channel 14 | 341
GPCR 10 | 406
Epigenetic 9 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Testis-specific gene 10 protein TSGA10 Tbio Non-IDG -1.05563 13.1 82
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277