Development Level

Tbio 718 | 11,651
Tdark 212 | 6,593
Tchem 97 | 1,388
Tclin 31 | 612

Collection

RFA-RM-18-021 14 | 328
Ion Channel: IDG Consortium (T... 8 | 99
GPCR: IDG Consortium (Targets) 3 | 126
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 42 | 979
preweaning lethality, incomple... 37 | 499
abnormal embryo size 16 | 220
decreased total body fat amoun... 13 | 207
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 12 | 278
abnormal heart morphology 11 | 162
increased lean body mass 11 | 172
increased total body fat amoun... 11 | 134
cataract 10 | 92
enlarged heart 10 | 210
abnormal behavior 9 | 298
embryonic growth retardation 9 | 106
increased bone mineral content 9 | 108
male infertility 9 | 123
abnormal bone structure 8 | 187
decreased lymphocyte cell numb... 8 | 83
decreased vertical activity 8 | 208
abnormal coat-hair pigmentatio... 7 | 64
decreased body weight 7 | 161
decreased circulating choleste... 7 | 93
decreased circulating glucose ... 7 | 126
decreased circulating triglyce... 7 | 79
decreased lean body mass 7 | 135
increased circulating alkaline... 7 | 122
increased heart weight 7 | 62
increased mean corpuscular vol... 7 | 92
abnormal lens morphology 6 | 81
decreased blood urea nitrogen ... 6 | 51
decreased bone mineral content 6 | 151
decreased bone mineral density 6 | 126
hyperactivity 6 | 148
increased circulating triglyce... 6 | 42
abnormal skin morphology 5 | 50
abnormal tail morphology 5 | 25
decreased circulating HDL chol... 5 | 68
decreased circulating free fat... 5 | 31
decreased fasted circulating g... 5 | 65
decreased hemoglobin content 5 | 68
female infertility 5 | 60
impaired glucose tolerance 5 | 75
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased fasted circulating g... 5 | 76
increased neutrophil cell numb... 5 | 46
abnormal eye morphology 4 | 68
abnormal seminal vesicle morph... 4 | 114
abnormal tooth morphology 4 | 24
decreased circulating alkaline... 4 | 46
decreased circulating serum al... 4 | 82
decreased grip strength 4 | 116
decreased mean corpuscular hem... 4 | 31
decreased mean corpuscular vol... 4 | 79
decreased neutrophil cell numb... 4 | 42
edema 4 | 59
enlarged lymph nodes 4 | 37
hypoactivity 4 | 132
impaired righting response 4 | 26
increased bone mineral density 4 | 72
increased circulating calcium ... 4 | 34
increased erythrocyte cell num... 4 | 39
increased mean corpuscular hem... 4 | 96
increased mean corpuscular hem... 4 | 36
increased monocyte cell number 4 | 63
increased or absent threshold ... 4 | 101
limb grasping 4 | 41
prenatal lethality prior to he... 4 | 87
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal coat appearance 3 | 31
abnormal craniofacial morpholo... 3 | 33
abnormal embryo turning 3 | 31
abnormal epididymis morphology 3 | 42
abnormal lung morphology 3 | 26
abnormal neural tube closure 3 | 46
abnormal rib morphology 3 | 10
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased circulating bilirubi... 3 | 19
decreased circulating calcium ... 3 | 36
decreased circulating insulin ... 3 | 76
decreased erythrocyte cell num... 3 | 62
decreased heart left ventricle... 3 | 28
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
enlarged epididymis 3 | 31
hydrometra 3 | 53
increased blood urea nitrogen ... 3 | 48
increased grip strength 3 | 41
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
pallor 3 | 34
small superior vagus ganglion 3 | 74
abnormal locomotor behavior 2 | 24
decreased circulating creatini... 2 | 39
decreased prepulse inhibition 2 | 82
short tibia 2 | 97

Disease

nasopharyngeal carcinoma 1,058 | 1,058
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Female tissues 1,047 | 17,400
Endocrine System 1,043 | 18,159
Skin and soft tissues 1,041 | 17,230
Digestive Tract 1,037 | 17,369
Blood and immune system 1,029 | 16,909
Male tissues 1,027 | 17,142
Respiratory system 1,026 | 16,393
Urinary Tract 1,026 | 16,678
Liver and Pancreas 1,011 | 16,750
Nervous System 1,000 | 16,725
Cardiovascular System 916 | 15,192

Target Family

Non-IDG 721 | 12,091
Enzyme 186 | 4,145
Transcription Factor 49 | 1,400
Kinase 39 | 634
Transporter 26 | 473
Ion Channel 15 | 344
GPCR 10 | 408
Epigenetic 9 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Teashirt homolog 2 TSHZ2 Tbio Non-IDG -0.01649 0.78 90
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366