Development Level

Tbio 3,853 | 10,625
Tdark 1,413 | 7,003
Tchem 722 | 1,890
Tclin 246 | 602

Collection

Eligible Kinase Proteins 51 | 134
Eligible Ion Channel Proteins 41 | 117
Eligible non-olfactory GPCR Proteins 29 | 143

IMPC Term

preweaning lethality, complete... 222 | 633
preweaning lethality, incomple... 120 | 260
abnormal behavior 109 | 226
decreased total body fat amoun... 93 | 186
decreased lean body mass 85 | 195
decreased grip strength 70 | 123
embryonic lethality prior to t... 70 | 187
decreased body weight 68 | 174
decreased bone mineral content 63 | 157
hyperactivity 63 | 108
increased circulating alkaline... 56 | 119
abnormal bone structure 54 | 131
decreased body length 54 | 108
increased or absent threshold ... 54 | 128
increased lean body mass 53 | 107
decreased bone mineral density 50 | 126
decreased circulating choleste... 50 | 85
embryonic lethality prior to o... 48 | 148
increased bone mineral content 47 | 92
decreased circulating HDL chol... 46 | 77
abnormal retina morphology 42 | 100
decreased circulating glucose ... 42 | 121
decreased circulating triglyce... 42 | 83
enlarged heart 41 | 111
hypoactivity 41 | 89
short tibia 40 | 82
increased grip strength 39 | 83
abnormal embryo size 38 | 112
increased mean corpuscular vol... 37 | 91
increased mean corpuscular hem... 34 | 93
decreased circulating serum al... 31 | 79
abnormal lens morphology 30 | 73
abnormal sleep behavior 30 | 63
increased circulating HDL chol... 29 | 63
increased blood urea nitrogen ... 28 | 44
increased fasted circulating g... 28 | 68
male infertility 28 | 62
decreased prepulse inhibition 27 | 52
decreased leukocyte cell numbe... 26 | 54
increased circulating choleste... 26 | 53
abnormal retinal pigmentation 25 | 61
increased circulating sodium l... 25 | 71
increased sacral vertebrae num... 25 | 62
abnormal bone mineralization 24 | 55
abnormal heart morphology 24 | 51
decreased circulating insulin ... 24 | 75
decreased hemoglobin content 24 | 53
abnormal gait 23 | 51
decreased fasted circulating g... 23 | 49
decreased lumbar vertebrae num... 23 | 62
decreased caudal vertebrae num... 22 | 49
decreased rib number 22 | 59
increased bone mineral density 22 | 52
abnormal coat/hair pigmentatio... 21 | 54
decreased circulating LDL chol... 21 | 37
decreased circulating alanine ... 21 | 53
decreased eosinophil cell numb... 21 | 41
decreased startle reflex 21 | 48
improved glucose tolerance 21 | 56
impaired glucose tolerance 20 | 52
increased circulating calcium ... 20 | 32
increased startle reflex 20 | 38
decreased erythrocyte cell num... 19 | 43
decreased mean corpuscular vol... 19 | 50
increased circulating chloride... 19 | 43
prenatal lethality prior to he... 19 | 64
tremors 19 | 34
abnormal behavioral response t... 18 | 52
decreased circulating free fat... 18 | 39
increased total body fat amoun... 18 | 57
thrombocytopenia 18 | 46
abnormal seminal vesicle morph... 17 | 47
decreased circulating calcium ... 17 | 33
decreased heart weight 17 | 44
limb grasping 17 | 35
abnormal neural tube closure 16 | 37
increased heart weight 16 | 37
increased leukocyte cell numbe... 16 | 37
abnormal tooth morphology 15 | 24
cardiovascular system phenotyp... 15 | 35
decreased NK T cell number 15 | 28
decreased circulating total pr... 15 | 41
decreased mean corpuscular hem... 15 | 34
decreased vertical activity 15 | 22
vertebral fusion 15 | 23
abnormal cranium morphology 14 | 32
abnormal kidney morphology 14 | 30
decreased CD8-positive, alpha-... 14 | 26
decreased neutrophil cell numb... 14 | 37
female infertility 14 | 34
increased body weight 14 | 42
increased circulating triglyce... 14 | 24
increased mean corpuscular hem... 14 | 25
small testis 14 | 37
abnormal spleen morphology 13 | 36
decreased circulating alkaline... 13 | 41
decreased circulating fructosa... 13 | 31
increased circulating iron lev... 13 | 25
increased exploration in new e... 13 | 56
increased hemoglobin content 13 | 45

Disease

medulloblastoma, large-cell 6,234 | 6,234
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 6,168 | 18,647
Nervous System 6,165 | 18,561
Digestive Tract 6,160 | 18,473
Urinary Tract 6,151 | 18,444
Endocrine System 6,145 | 18,512
Liver and Pancreas 6,136 | 18,136
Cardiovascular System 6,118 | 17,958
Blood and immune system 6,117 | 17,995
Male tissues 6,113 | 17,969
Skin and soft tissues 6,103 | 18,115
Respiratory system 6,044 | 17,484

Target Family

Non-IDG 3,589 | 11,971
Enzyme 1,319 | 4,146
Transcription Factor 451 | 1,400
Kinase 280 | 634
Transporter 183 | 473
Ion Channel 141 | 341
GPCR 113 | 406
Epigenetic 107 | 242
Nuclear Receptor 20 | 48
oGPCR 19 | 421
TF/Epigenetic 12 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628