Development Level

Tbio 931 | 10,625
Tdark 342 | 7,003
Tchem 179 | 1,890
Tclin 72 | 602

Collection

Kinase: IDG Consortium (Targets) 15 | 125
Ion Channel: IDG Consortium (Targets) 14 | 102
Kinase: IDG Consortium (Complete/Control) 10 | 37
GPCR: IDG Consortium (Targets) 8 | 127
GPCR: IDG Consortium (Complete/Control) 2 | 26

IMPC Phenotype

preweaning lethality, complete... 50 | 633
abnormal behavior 31 | 226
preweaning lethality, incomple... 30 | 260
decreased lean body mass 25 | 195
decreased bone mineral content 22 | 157
decreased total body fat amoun... 20 | 186
embryonic lethality prior to t... 19 | 187
decreased body weight 18 | 174
abnormal bone structure 17 | 131
decreased grip strength 17 | 123
hyperactivity 17 | 108
increased lean body mass 17 | 107
increased bone mineral content 15 | 92
decreased bone mineral density 14 | 126
embryonic lethality prior to o... 14 | 148
hypoactivity 14 | 89
increased circulating alkaline... 14 | 119
decreased body length 12 | 108
decreased circulating HDL chol... 12 | 77
decreased circulating serum al... 12 | 79
abnormal retina morphology 11 | 100
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 11 | 121
decreased circulating triglyce... 11 | 83
increased circulating HDL chol... 11 | 63
short tibia 10 | 82
increased sacral vertebrae num... 9 | 62
abnormal embryo size 8 | 112
decreased fasted circulating g... 8 | 49
decreased lumbar vertebrae num... 8 | 62
enlarged heart 8 | 111
increased circulating choleste... 8 | 53
increased mean corpuscular vol... 8 | 91
increased or absent threshold ... 8 | 128
abnormal bone mineralization 7 | 55
abnormal gait 7 | 51
decreased caudal vertebrae num... 7 | 49
decreased circulating LDL chol... 7 | 37
decreased circulating alanine ... 7 | 53
decreased circulating insulin ... 7 | 75
decreased hemoglobin content 7 | 53
decreased leukocyte cell numbe... 7 | 54
increased circulating calcium ... 7 | 32
abnormal neural tube closure 6 | 37
abnormal sleep behavior 6 | 63
decreased heart weight 6 | 44
increased body weight 6 | 42
increased circulating chloride... 6 | 43
increased circulating serum al... 6 | 25
increased fasted circulating g... 6 | 68
increased mean corpuscular hem... 6 | 93
increased startle reflex 6 | 38
male infertility 6 | 62
tremors 6 | 34
abnormal coat-hair pigmentatio... 5 | 54
abnormal hindbrain development 5 | 24
abnormal lens morphology 5 | 73
abnormal midbrain development 5 | 22
decreased circulating alkaline... 5 | 41
decreased circulating aspartat... 5 | 27
decreased circulating total pr... 5 | 41
decreased eosinophil cell numb... 5 | 41
decreased neutrophil cell numb... 5 | 37
decreased prepulse inhibition 5 | 52
decreased rib number 5 | 59
increased CD4-positive, CD25-p... 5 | 18
increased bone mineral density 5 | 52
increased circulating creatini... 5 | 29
increased circulating iron lev... 5 | 25
increased circulating phosphat... 5 | 24
increased exploration in new e... 5 | 56
increased grip strength 5 | 83
increased heart weight 5 | 37
increased hemoglobin content 5 | 45
increased mean corpuscular hem... 5 | 25
increased rib number 5 | 41
prenatal lethality prior to he... 5 | 64
thrombocytosis 5 | 23
vertebral fusion 5 | 23
abnormal eye morphology 4 | 38
abnormal forebrain development 4 | 18
abnormal retinal pigmentation 4 | 61
abnormal spleen morphology 4 | 36
cardiovascular system phenotyp... 4 | 35
decreased cervical vertebrae n... 4 | 12
decreased circulating creatini... 4 | 31
decreased circulating free fat... 4 | 39
decreased circulating fructosa... 4 | 31
decreased erythrocyte cell num... 4 | 43
decreased lactate dehydrogenas... 4 | 14
decreased mean corpuscular hem... 4 | 34
enlarged epididymis 4 | 27
increased blood urea nitrogen ... 4 | 44
increased circulating free fat... 4 | 17
increased circulating total pr... 4 | 20
thrombocytopenia 4 | 46
decreased NK T cell number 3 | 28
decreased circulating glycerol... 3 | 19
decreased startle reflex 3 | 48
impaired glucose tolerance 3 | 52

Disease

medulloblastoma 1,524 | 1,524
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,510 | 18,560
Digestive Tract 1,507 | 18,472
Female tissues 1,507 | 18,646
Urinary Tract 1,507 | 18,443
Endocrine System 1,506 | 18,511
Liver and Pancreas 1,506 | 18,135
Cardiovascular System 1,505 | 17,957
Skin and soft tissues 1,503 | 18,114
Male tissues 1,500 | 17,968
Blood and immune system 1,495 | 17,994
Respiratory system 1,491 | 17,483

Target Family

Non-IDG 831 | 11,969
Enzyme 339 | 4,146
Transcription Factor 105 | 1,400
Kinase 83 | 634
Ion Channel 51 | 341
Epigenetic 38 | 242
Transporter 35 | 473
GPCR 33 | 408
TF/Epigenetic 5 | 38
Nuclear Receptor 4 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Zinc finger protein 606 ZNF606 Tdark Transcription Factor 0.00000 1.48 76
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 22
Protein N-lysine methyltransferase METTL21A METTL21A Tchem Enzyme 0.02 1.05 62
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.13830 1.14 48
BTB/POZ domain-containing protein 9 BTBD9 Tbio Non-IDG -1.30579 21.1 87
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336