Development Level

Tbio 2,091 | 10,625
Tdark 471 | 7,003
Tchem 467 | 1,890
Tclin 134 | 602

Collection

Kinase: IDG Consortium (Targets) 17 | 125
Ion Channel: IDG Consortium (Targets) 14 | 102
GPCR: IDG Consortium (Targets) 11 | 127
Kinase: IDG Consortium (Complete/Control) 10 | 37
GPCR: IDG Consortium (Complete/Control) 3 | 26

IMPC Phenotype

preweaning lethality, complete... 122 | 633
preweaning lethality, incomple... 51 | 260
abnormal behavior 49 | 226
decreased total body fat amoun... 49 | 186
decreased body weight 46 | 174
decreased lean body mass 42 | 195
embryonic lethality prior to t... 33 | 187
decreased bone mineral content 32 | 157
decreased body length 31 | 108
increased circulating alkaline... 31 | 119
decreased grip strength 27 | 123
abnormal bone structure 25 | 131
abnormal embryo size 25 | 112
embryonic lethality prior to o... 25 | 148
increased lean body mass 24 | 107
decreased circulating choleste... 23 | 85
decreased circulating glucose ... 23 | 121
increased mean corpuscular vol... 22 | 91
decreased bone mineral density 21 | 126
decreased circulating serum al... 21 | 79
increased grip strength 21 | 83
abnormal retina morphology 20 | 100
decreased circulating HDL chol... 20 | 77
hyperactivity 20 | 108
increased sacral vertebrae num... 20 | 62
decreased lumbar vertebrae num... 19 | 62
increased or absent threshold ... 19 | 128
decreased circulating triglyce... 17 | 83
increased mean corpuscular hem... 17 | 93
abnormal lens morphology 16 | 73
enlarged heart 16 | 111
increased bone mineral content 16 | 92
decreased circulating insulin ... 15 | 75
improved glucose tolerance 15 | 56
abnormal coat-hair pigmentatio... 14 | 54
hypoactivity 14 | 89
increased circulating sodium l... 14 | 71
short tibia 14 | 82
decreased heart weight 13 | 44
decreased hemoglobin content 13 | 53
decreased mean corpuscular vol... 13 | 50
increased fasted circulating g... 13 | 68
abnormal bone mineralization 12 | 55
decreased erythrocyte cell num... 12 | 43
decreased rib number 12 | 59
increased blood urea nitrogen ... 12 | 44
increased circulating HDL chol... 12 | 63
increased exploration in new e... 12 | 56
increased total body fat amoun... 12 | 57
prenatal lethality prior to he... 12 | 64
abnormal retinal pigmentation 11 | 61
abnormal tooth morphology 11 | 24
decreased circulating alanine ... 11 | 53
decreased circulating calcium ... 11 | 33
decreased circulating free fat... 11 | 39
decreased leukocyte cell numbe... 11 | 54
increased body weight 11 | 42
increased bone mineral density 11 | 52
thrombocytopenia 11 | 46
abnormal behavioral response t... 10 | 52
abnormal heart morphology 10 | 51
abnormal sleep behavior 10 | 63
decreased circulating total pr... 10 | 41
decreased mean corpuscular hem... 10 | 34
decreased prepulse inhibition 10 | 52
increased circulating potassiu... 10 | 31
increased leukocyte cell numbe... 10 | 37
male infertility 10 | 62
small testis 10 | 37
abnormal cranium morphology 9 | 32
abnormal neural tube closure 9 | 37
decreased circulating LDL chol... 9 | 37
decreased circulating alkaline... 9 | 41
decreased circulating chloride... 9 | 32
increased circulating phosphat... 9 | 24
increased hemoglobin content 9 | 45
increased rib number 9 | 41
limb grasping 9 | 35
vertebral fusion 9 | 23
abnormal locomotor activation 8 | 26
abnormal spleen morphology 8 | 36
abnormal tail morphology 8 | 17
abnormal testis morphology 8 | 30
decreased blood urea nitrogen ... 8 | 31
decreased caudal vertebrae num... 8 | 49
decreased circulating fructosa... 8 | 31
decreased circulating sodium l... 8 | 18
decreased eosinophil cell numb... 8 | 41
decreased startle reflex 8 | 48
impaired glucose tolerance 8 | 52
increased B cell number 8 | 23
increased circulating calcium ... 8 | 32
increased circulating choleste... 8 | 53
increased circulating triglyce... 8 | 24
abnormal rib morphology 7 | 28
cardiovascular system phenotyp... 7 | 35
corneal opacity 7 | 25
decreased circulating aspartat... 7 | 27
decreased circulating creatini... 7 | 31
increased hematocrit 7 | 36

Disease

malignant mesothelioma 3,163 | 3,163
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 3,139 | 18,560
Female tissues 3,136 | 18,646
Digestive Tract 3,133 | 18,472
Liver and Pancreas 3,131 | 18,135
Endocrine System 3,130 | 18,511
Urinary Tract 3,130 | 18,443
Male tissues 3,126 | 17,968
Cardiovascular System 3,124 | 17,957
Blood and immune system 3,122 | 17,994
Skin and soft tissues 3,108 | 18,114
Respiratory system 3,098 | 17,483

Target Family

Non-IDG 1,771 | 11,969
Enzyme 719 | 4,146
Transcription Factor 242 | 1,400
Kinase 151 | 634
Transporter 86 | 473
Epigenetic 57 | 242
Ion Channel 57 | 341
GPCR 53 | 408
Nuclear Receptor 17 | 48
TF/Epigenetic 10 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 22
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.51625 341.8 227
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
LIM domain-containing protein 2 LIMD2 Tdark Non-IDG -0.89117 2.22 53
mRNA cap guanine-N7 methyltransferase RNMT Tbio Enzyme -1.91115 79.0 301
Small cell adhesion glycoprotein SMAGP Tdark Non-IDG 0.00000 1.85 72