Development Level

Tbio 2,328 | 11,651
Tdark 399 | 6,593
Tchem 360 | 1,388
Tclin 145 | 612

Collection

RFA-RM-18-021 43 | 328
Kinase: IDG Consortium (Target... 17 | 125
Ion Channel: IDG Consortium (T... 14 | 99
GPCR: IDG Consortium (Targets) 12 | 126
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 205 | 979
preweaning lethality, incomple... 108 | 499
abnormal behavior 64 | 298
embryonic lethality prior to t... 58 | 278
decreased total body fat amoun... 57 | 207
embryonic lethality prior to o... 47 | 239
abnormal embryo size 46 | 220
decreased body weight 42 | 161
enlarged heart 39 | 210
increased lean body mass 39 | 172
abnormal bone structure 37 | 187
decreased vertical activity 36 | 208
hyperactivity 35 | 148
increased startle reflex 33 | 112
increased circulating alkaline... 31 | 122
abnormal heart morphology 30 | 162
decreased bone mineral content 30 | 151
hypoactivity 28 | 132
decreased circulating glucose ... 26 | 126
increased bone mineral content 26 | 108
decreased body length 25 | 101
decreased grip strength 25 | 116
decreased bone mineral density 23 | 126
decreased circulating choleste... 23 | 93
decreased lean body mass 23 | 135
male infertility 23 | 123
abnormal seminal vesicle morph... 22 | 114
increased total body fat amoun... 22 | 134
cataract 21 | 92
decreased circulating serum al... 21 | 82
decreased lymphocyte cell numb... 21 | 83
decreased mean corpuscular vol... 21 | 79
decreased prepulse inhibition 21 | 82
improved glucose tolerance 20 | 79
increased mean corpuscular vol... 20 | 92
abnormal retina morphology 19 | 71
small superior vagus ganglion 18 | 74
abnormal lens morphology 17 | 81
decreased erythrocyte cell num... 17 | 62
decreased startle reflex 17 | 75
embryonic growth retardation 17 | 106
increased monocyte cell number 17 | 63
short tibia 17 | 97
abnormal behavioral response t... 16 | 66
decreased circulating insulin ... 16 | 76
increased bone mineral density 16 | 72
increased mean corpuscular hem... 16 | 96
prenatal lethality prior to he... 16 | 87
small testis 16 | 58
decreased leukocyte cell numbe... 15 | 73
increased circulating sodium l... 15 | 71
abnormal sleep behavior 14 | 70
decreased circulating HDL chol... 14 | 68
decreased circulating triglyce... 14 | 79
impaired glucose tolerance 14 | 75
increased circulating HDL chol... 14 | 80
increased or absent threshold ... 14 | 101
abnormal coat-hair pigmentatio... 13 | 64
abnormal eye morphology 13 | 68
abnormal kidney morphology 13 | 65
decreased hemoglobin content 13 | 68
decreased mean corpuscular hem... 13 | 50
female infertility 13 | 60
increased blood urea nitrogen ... 13 | 48
decreased blood urea nitrogen ... 12 | 51
decreased circulating calcium ... 12 | 36
decreased circulating total pr... 12 | 49
increased fasted circulating g... 12 | 76
limb grasping 12 | 41
abnormal bone mineralization 11 | 38
abnormal neural tube closure 11 | 46
decreased circulating alanine ... 11 | 47
enlarged lymph nodes 11 | 37
increased leukocyte cell numbe... 11 | 47
thrombocytopenia 11 | 56
abnormal gait 10 | 69
abnormal spleen morphology 10 | 55
abnormal tail morphology 10 | 25
decreased circulating aspartat... 10 | 34
decreased fasted circulating g... 10 | 65
decreased neutrophil cell numb... 10 | 42
increased heart weight 10 | 62
abnormal cranium morphology 9 | 36
abnormal skin morphology 9 | 50
abnormal testis morphology 9 | 43
abnormal tooth morphology 9 | 24
decreased caudal vertebrae num... 9 | 53
decreased circulating LDL chol... 9 | 38
decreased circulating free fat... 9 | 31
decreased circulating sodium l... 9 | 22
edema 9 | 59
increased circulating calcium ... 9 | 34
increased circulating triglyce... 9 | 42
increased hematocrit 9 | 46
increased mean corpuscular hem... 9 | 36
increased neutrophil cell numb... 9 | 46
increased vertical activity 9 | 24
abnormal epididymis morphology 8 | 42
decreased hematocrit 8 | 46
increased circulating potassiu... 8 | 29

Disease

malignant mesothelioma 3,232 | 3,232
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 3,190 | 18,159
Digestive Tract 3,176 | 17,369
Female tissues 3,175 | 17,400
Skin and soft tissues 3,168 | 17,230
Male tissues 3,166 | 17,142
Blood and immune system 3,154 | 16,909
Urinary Tract 3,153 | 16,678
Liver and Pancreas 3,146 | 16,750
Respiratory system 3,138 | 16,393
Nervous System 3,137 | 16,725
Cardiovascular System 3,027 | 15,192

Target Family

Non-IDG 1,817 | 12,091
Enzyme 728 | 4,145
Transcription Factor 243 | 1,400
Kinase 158 | 634
Transporter 86 | 473
Epigenetic 60 | 242
Ion Channel 58 | 344
GPCR 54 | 408
Nuclear Receptor 18 | 48
TF/Epigenetic 10 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
RBPJ-interacting and tubulin-associated protein 1 RITA1 Tbio Non-IDG -0.85891 6.79 61