Development Level

Tbio 2,090 | 10,625
Tdark 471 | 7,003
Tchem 467 | 1,890
Tclin 134 | 602

Collection

Eligible Kinase Proteins 19 | 134
Eligible Ion Channel Proteins 16 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 122 | 633
preweaning lethality, incomple... 51 | 260
abnormal behavior 49 | 226
decreased total body fat amoun... 49 | 186
decreased body weight 46 | 174
decreased lean body mass 42 | 195
embryonic lethality prior to t... 33 | 187
decreased bone mineral content 32 | 157
decreased body length 31 | 108
increased circulating alkaline... 31 | 119
decreased grip strength 27 | 123
abnormal bone structure 25 | 131
abnormal embryo size 25 | 112
embryonic lethality prior to o... 25 | 148
increased lean body mass 24 | 107
decreased circulating choleste... 23 | 85
decreased circulating glucose ... 23 | 121
increased mean corpuscular vol... 22 | 91
decreased bone mineral density 21 | 126
decreased circulating serum al... 21 | 79
increased grip strength 21 | 83
abnormal retina morphology 20 | 100
decreased circulating HDL chol... 20 | 77
hyperactivity 20 | 108
increased sacral vertebrae num... 20 | 62
decreased lumbar vertebrae num... 19 | 62
increased or absent threshold ... 19 | 128
decreased circulating triglyce... 17 | 83
increased mean corpuscular hem... 17 | 93
abnormal lens morphology 16 | 73
enlarged heart 16 | 111
increased bone mineral content 16 | 92
decreased circulating insulin ... 15 | 75
improved glucose tolerance 15 | 56
abnormal coat/hair pigmentatio... 14 | 54
hypoactivity 14 | 89
increased circulating sodium l... 14 | 71
short tibia 14 | 82
decreased heart weight 13 | 44
decreased hemoglobin content 13 | 53
decreased mean corpuscular vol... 13 | 50
increased fasted circulating g... 13 | 68
abnormal bone mineralization 12 | 55
decreased erythrocyte cell num... 12 | 43
decreased rib number 12 | 59
increased blood urea nitrogen ... 12 | 44
increased circulating HDL chol... 12 | 63
increased exploration in new e... 12 | 56
increased total body fat amoun... 12 | 57
prenatal lethality prior to he... 12 | 64
abnormal retinal pigmentation 11 | 61
abnormal tooth morphology 11 | 24
decreased circulating alanine ... 11 | 53
decreased circulating calcium ... 11 | 33
decreased circulating free fat... 11 | 39
decreased leukocyte cell numbe... 11 | 54
increased body weight 11 | 42
increased bone mineral density 11 | 52
thrombocytopenia 11 | 46
abnormal behavioral response t... 10 | 52
abnormal heart morphology 10 | 51
abnormal sleep behavior 10 | 63
decreased circulating total pr... 10 | 41
decreased mean corpuscular hem... 10 | 34
decreased prepulse inhibition 10 | 52
increased circulating potassiu... 10 | 31
increased leukocyte cell numbe... 10 | 37
male infertility 10 | 62
small testis 10 | 37
abnormal cranium morphology 9 | 32
abnormal neural tube closure 9 | 37
decreased circulating LDL chol... 9 | 37
decreased circulating alkaline... 9 | 41
decreased circulating chloride... 9 | 32
increased circulating phosphat... 9 | 24
increased hemoglobin content 9 | 45
increased rib number 9 | 41
limb grasping 9 | 35
vertebral fusion 9 | 23
abnormal locomotor activation 8 | 26
abnormal spleen morphology 8 | 36
abnormal tail morphology 8 | 17
abnormal testis morphology 8 | 30
decreased blood urea nitrogen ... 8 | 31
decreased caudal vertebrae num... 8 | 49
decreased circulating fructosa... 8 | 31
decreased circulating sodium l... 8 | 18
decreased eosinophil cell numb... 8 | 41
decreased startle reflex 8 | 48
impaired glucose tolerance 8 | 52
increased B cell number 8 | 23
increased circulating calcium ... 8 | 32
increased circulating choleste... 8 | 53
increased circulating triglyce... 8 | 24
abnormal rib morphology 7 | 28
cardiovascular system phenotyp... 7 | 35
corneal opacity 7 | 25
decreased circulating aspartat... 7 | 27
decreased circulating creatini... 7 | 31
increased hematocrit 7 | 36

Disease

malignant mesothelioma 3,162 | 3,162
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 3,138 | 18,561
Female tissues 3,135 | 18,647
Digestive Tract 3,132 | 18,473
Liver and Pancreas 3,130 | 18,136
Endocrine System 3,129 | 18,512
Urinary Tract 3,129 | 18,444
Male tissues 3,125 | 17,969
Cardiovascular System 3,123 | 17,958
Blood and immune system 3,121 | 17,995
Skin and soft tissues 3,107 | 18,115
Respiratory system 3,097 | 17,484

Target Family

Non-IDG 1,770 | 11,971
Enzyme 719 | 4,146
Transcription Factor 242 | 1,400
Kinase 151 | 634
Transporter 86 | 473
Epigenetic 57 | 242
Ion Channel 57 | 341
GPCR 53 | 406
Nuclear Receptor 17 | 48
TF/Epigenetic 10 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788