Development Level

Tbio 1,755 | 10,625
Tdark 535 | 7,003
Tchem 396 | 1,890
Tclin 158 | 602

Collection

Eligible Ion Channel Proteins 27 | 117
Eligible non-olfactory GPCR Proteins 19 | 143
Eligible Kinase Proteins 18 | 134

IMPC Term

preweaning lethality, complete... 68 | 633
preweaning lethality, incomple... 52 | 260
abnormal behavior 45 | 226
decreased total body fat amoun... 33 | 186
decreased lean body mass 31 | 195
decreased body weight 27 | 174
decreased bone mineral content 27 | 157
decreased grip strength 27 | 123
hyperactivity 26 | 108
enlarged heart 25 | 111
embryonic lethality prior to t... 22 | 187
increased circulating alkaline... 22 | 119
decreased body length 21 | 108
decreased bone mineral density 21 | 126
decreased circulating glucose ... 20 | 121
increased lean body mass 19 | 107
increased or absent threshold ... 19 | 128
decreased circulating HDL chol... 18 | 77
hypoactivity 18 | 89
decreased circulating choleste... 17 | 85
increased mean corpuscular hem... 17 | 93
increased bone mineral content 16 | 92
abnormal bone structure 15 | 131
decreased circulating insulin ... 15 | 75
decreased circulating serum al... 15 | 79
short tibia 15 | 82
abnormal heart morphology 14 | 51
increased fasted circulating g... 14 | 68
increased grip strength 14 | 83
abnormal sleep behavior 13 | 63
decreased blood urea nitrogen ... 13 | 31
decreased lumbar vertebrae num... 13 | 62
decreased rib number 13 | 59
increased blood urea nitrogen ... 13 | 44
increased body weight 13 | 42
increased mean corpuscular vol... 13 | 91
increased sacral vertebrae num... 13 | 62
abnormal embryo size 12 | 112
decreased circulating triglyce... 12 | 83
impaired glucose tolerance 12 | 52
improved glucose tolerance 12 | 56
abnormal gait 11 | 51
abnormal lens morphology 11 | 73
abnormal retina morphology 11 | 100
decreased fasted circulating g... 11 | 49
decreased hemoglobin content 11 | 53
increased bone mineral density 11 | 52
male infertility 11 | 62
prenatal lethality prior to he... 11 | 64
decreased circulating alanine ... 10 | 53
decreased leukocyte cell numbe... 10 | 54
decreased mean corpuscular vol... 10 | 50
decreased startle reflex 10 | 48
increased circulating calcium ... 10 | 32
increased circulating sodium l... 10 | 71
increased heart weight 10 | 37
abnormal epididymis morphology 9 | 31
abnormal retinal pigmentation 9 | 61
corneal opacity 9 | 25
decreased prepulse inhibition 9 | 52
decreased threshold for audito... 9 | 32
increased circulating chloride... 9 | 43
increased circulating potassiu... 9 | 31
small testis 9 | 37
abnormal behavioral response t... 8 | 52
abnormal coat/hair pigmentatio... 8 | 54
abnormal testis morphology 8 | 30
decreased caudal vertebrae num... 8 | 49
decreased vertical activity 8 | 22
embryonic lethality prior to o... 8 | 148
increased exploration in new e... 8 | 56
increased startle reflex 8 | 38
thrombocytopenia 8 | 46
abnormal bone mineralization 7 | 55
abnormal retinal blood vessel ... 7 | 18
abnormal rib morphology 7 | 28
abnormal tooth morphology 7 | 24
cardiovascular system phenotyp... 7 | 35
decreased CD8-positive, alpha-... 7 | 26
decreased circulating bilirubi... 7 | 14
decreased erythrocyte cell num... 7 | 43
decreased hematocrit 7 | 25
enlarged epididymis 7 | 27
increased circulating HDL chol... 7 | 63
increased circulating choleste... 7 | 53
increased rib number 7 | 41
tremors 7 | 34
abnormal locomotor activation 6 | 26
abnormal neural tube closure 6 | 37
abnormal vocalization 6 | 21
decreased NK T cell number 6 | 28
decreased T cell number 6 | 31
decreased circulating potassiu... 6 | 17
decreased eosinophil cell numb... 6 | 41
decreased heart weight 6 | 44
decreased mean corpuscular hem... 6 | 34
impaired righting response 6 | 19
increased total body fat amoun... 6 | 57
limb grasping 6 | 35
straub tail 6 | 26

Disease

lung carcinoma 2,844 | 2,844
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 2,808 | 18,473
Female tissues 2,808 | 18,647
Nervous System 2,806 | 18,561
Liver and Pancreas 2,804 | 18,136
Endocrine System 2,799 | 18,512
Urinary Tract 2,797 | 18,444
Male tissues 2,794 | 17,969
Cardiovascular System 2,787 | 17,958
Respiratory system 2,786 | 17,484
Skin and soft tissues 2,783 | 18,115
Blood and immune system 2,781 | 17,995

Target Family

Non-IDG 1,703 | 11,971
Enzyme 598 | 4,146
Transcription Factor 146 | 1,400
Kinase 114 | 634
Transporter 95 | 473
Ion Channel 80 | 341
GPCR 69 | 406
Epigenetic 18 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 6 | 38
oGPCR 6 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3