Development Level

Tbio 1,880 | 11,445
Tdark 464 | 6,588
Tchem 338 | 1,598
Tclin 161 | 613

Collection

RFA-RM-18-021 59 | 328
Ion Channel: IDG Consortium (T... 25 | 99
GPCR: IDG Consortium (Targets) 18 | 126
Kinase: IDG Consortium (Target... 16 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 104 | 979
preweaning lethality, incomple... 94 | 499
enlarged heart 51 | 210
abnormal behavior 48 | 298
decreased vertical activity 48 | 208
decreased total body fat amoun... 40 | 207
abnormal heart morphology 37 | 162
embryonic lethality prior to t... 33 | 278
hyperactivity 32 | 148
increased lean body mass 29 | 172
abnormal embryo size 25 | 220
abnormal bone structure 24 | 187
increased bone mineral content 24 | 108
decreased grip strength 22 | 116
hypoactivity 22 | 132
decreased body weight 21 | 161
decreased lean body mass 21 | 135
increased or absent threshold ... 21 | 101
decreased bone mineral content 20 | 151
decreased lymphocyte cell numb... 20 | 83
abnormal gait 18 | 69
abnormal seminal vesicle morph... 18 | 114
cataract 18 | 92
decreased blood urea nitrogen ... 18 | 51
decreased circulating glucose ... 18 | 126
increased total body fat amoun... 18 | 134
decreased bone mineral density 17 | 126
increased circulating alkaline... 17 | 122
abnormal lens morphology 16 | 81
abnormal sleep behavior 16 | 70
decreased startle reflex 16 | 75
increased heart weight 16 | 62
impaired glucose tolerance 15 | 75
improved glucose tolerance 15 | 79
increased fasted circulating g... 15 | 76
increased mean corpuscular hem... 15 | 96
prenatal lethality prior to he... 15 | 87
abnormal behavioral response t... 14 | 66
abnormal eye morphology 14 | 68
decreased circulating choleste... 14 | 93
decreased circulating serum al... 14 | 82
decreased hemoglobin content 14 | 68
decreased mean corpuscular vol... 14 | 79
increased blood urea nitrogen ... 14 | 48
increased mean corpuscular vol... 14 | 92
male infertility 14 | 123
short tibia 14 | 97
small superior vagus ganglion 14 | 74
abnormal kidney morphology 13 | 65
decreased body length 13 | 101
decreased circulating insulin ... 13 | 76
decreased leukocyte cell numbe... 13 | 73
increased bone mineral density 13 | 72
increased circulating HDL chol... 13 | 80
increased monocyte cell number 13 | 63
increased startle reflex 13 | 112
abnormal skin morphology 12 | 50
decreased circulating triglyce... 12 | 79
decreased fasted circulating g... 12 | 65
decreased prepulse inhibition 12 | 82
increased circulating choleste... 12 | 66
increased circulating sodium l... 12 | 71
increased circulating triglyce... 12 | 42
abnormal epididymis morphology 11 | 42
abnormal testis morphology 11 | 43
decreased circulating HDL chol... 11 | 68
embryonic growth retardation 11 | 106
embryonic lethality prior to o... 11 | 239
increased neutrophil cell numb... 11 | 46
small testis 11 | 58
thrombocytopenia 11 | 56
abnormal spleen morphology 10 | 55
decreased circulating alanine ... 10 | 47
hydrometra 10 | 53
increased circulating calcium ... 10 | 34
abnormal coat-hair pigmentatio... 9 | 64
abnormal retina morphology 9 | 71
decreased erythrocyte cell num... 9 | 62
enlarged spleen 9 | 41
impaired righting response 9 | 26
increased circulating chloride... 9 | 41
increased erythrocyte cell num... 9 | 39
increased leukocyte cell numbe... 9 | 47
limb grasping 9 | 41
cardiovascular system phenotyp... 8 | 36
corneal opacity 8 | 32
decreased circulating amylase ... 8 | 28
decreased hematocrit 8 | 46
decreased neutrophil cell numb... 8 | 42
edema 8 | 59
enlarged epididymis 8 | 31
abnormal locomotor behavior 7 | 24
decreased circulating bilirubi... 7 | 19
decreased circulating calcium ... 7 | 36
decreased circulating potassiu... 7 | 20
decreased mean corpuscular hem... 7 | 50
decreased red blood cell distr... 7 | 41
increased circulating potassiu... 7 | 29
increased hematocrit 7 | 46
tremors 7 | 39

Disease

lung carcinoma 2,843 | 2,843
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,798 | 18,159
Female tissues 2,780 | 17,400
Digestive Tract 2,775 | 17,369
Male tissues 2,759 | 17,142
Skin and soft tissues 2,759 | 17,230
Respiratory system 2,749 | 16,393
Liver and Pancreas 2,736 | 16,750
Urinary Tract 2,736 | 16,678
Nervous System 2,735 | 16,725
Blood and immune system 2,727 | 16,909
Cardiovascular System 2,549 | 15,192

Target Family

Non-IDG 1,699 | 12,091
Enzyme 598 | 4,145
Transcription Factor 146 | 1,400
Kinase 115 | 634
Transporter 95 | 473
Ion Channel 82 | 344
GPCR 69 | 408
Epigenetic 18 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 6 | 38
oGPCR 6 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187