Development Level

Tbio 2,997 | 10,625
Tchem 662 | 1,890
Tdark 606 | 7,003
Tclin 201 | 602

Collection

Eligible Kinase Proteins 24 | 134
Eligible Ion Channel Proteins 18 | 117
Eligible non-olfactory GPCR Proteins 15 | 143

IMPC Term

preweaning lethality, complete... 191 | 633
preweaning lethality, incomple... 90 | 260
decreased total body fat amoun... 63 | 186
decreased body weight 61 | 174
decreased lean body mass 57 | 195
abnormal behavior 56 | 226
embryonic lethality prior to t... 54 | 187
embryonic lethality prior to o... 43 | 148
enlarged heart 43 | 111
increased or absent threshold ... 40 | 128
abnormal embryo size 38 | 112
decreased bone mineral content 37 | 157
decreased bone mineral density 37 | 126
increased circulating alkaline... 37 | 119
abnormal bone structure 36 | 131
increased lean body mass 35 | 107
decreased body length 33 | 108
decreased grip strength 33 | 123
increased mean corpuscular hem... 33 | 93
abnormal retina morphology 32 | 100
increased bone mineral content 31 | 92
decreased circulating glucose ... 29 | 121
decreased circulating triglyce... 28 | 83
hypoactivity 27 | 89
increased mean corpuscular vol... 27 | 91
abnormal lens morphology 26 | 73
decreased circulating choleste... 26 | 85
decreased circulating serum al... 24 | 79
improved glucose tolerance 24 | 56
increased sacral vertebrae num... 24 | 62
decreased circulating HDL chol... 23 | 77
decreased lumbar vertebrae num... 23 | 62
hyperactivity 23 | 108
increased circulating sodium l... 23 | 71
decreased caudal vertebrae num... 22 | 49
increased bone mineral density 22 | 52
increased grip strength 22 | 83
decreased circulating insulin ... 20 | 75
decreased prepulse inhibition 20 | 52
abnormal sleep behavior 19 | 63
decreased mean corpuscular vol... 19 | 50
prenatal lethality prior to he... 19 | 64
thrombocytopenia 19 | 46
abnormal bone mineralization 18 | 55
abnormal retinal pigmentation 18 | 61
decreased circulating alanine ... 18 | 53
increased exploration in new e... 18 | 56
increased fasted circulating g... 18 | 68
abnormal heart morphology 17 | 51
decreased mean corpuscular hem... 17 | 34
increased rib number 17 | 41
male infertility 17 | 62
abnormal coat/hair pigmentatio... 16 | 54
abnormal neural tube closure 16 | 37
decreased erythrocyte cell num... 16 | 43
decreased hemoglobin content 16 | 53
impaired glucose tolerance 16 | 52
increased body weight 16 | 42
increased circulating chloride... 16 | 43
increased total body fat amoun... 16 | 57
short tibia 16 | 82
decreased rib number 15 | 59
abnormal gait 14 | 51
decreased fasted circulating g... 14 | 49
decreased heart weight 14 | 44
decreased startle reflex 14 | 48
abnormal behavioral response t... 13 | 52
cardiovascular system phenotyp... 13 | 35
decreased NK T cell number 13 | 28
decreased circulating creatini... 13 | 31
decreased leukocyte cell numbe... 13 | 54
enlarged lymph nodes 13 | 27
increased blood urea nitrogen ... 13 | 44
increased circulating calcium ... 13 | 32
increased hematocrit 13 | 36
increased startle reflex 13 | 38
abnormal hindbrain development 12 | 24
decreased CD8-positive, alpha-... 12 | 26
decreased circulating LDL chol... 12 | 37
decreased circulating alkaline... 12 | 41
decreased circulating total pr... 12 | 41
decreased eosinophil cell numb... 12 | 41
increased circulating HDL chol... 12 | 63
increased circulating creatini... 12 | 29
increased circulating potassiu... 12 | 31
limb grasping 12 | 35
tremors 12 | 34
abnormal cranium morphology 11 | 32
abnormal midbrain development 11 | 22
abnormal spleen morphology 11 | 36
decreased circulating aspartat... 11 | 27
enlarged spleen 11 | 26
increased circulating choleste... 11 | 53
increased circulating triglyce... 11 | 24
abnormal cornea morphology 10 | 24
abnormal seminal vesicle morph... 10 | 47
abnormal startle reflex 10 | 14
decreased circulating glycerol... 10 | 19
decreased hematocrit 10 | 25
increased hemoglobin content 10 | 45

Disease

lung cancer 4,466 | 4,466
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 4,431 | 18,561
Female tissues 4,428 | 18,647
Digestive Tract 4,427 | 18,473
Male tissues 4,422 | 17,969
Endocrine System 4,421 | 18,512
Liver and Pancreas 4,419 | 18,136
Urinary Tract 4,418 | 18,444
Blood and immune system 4,413 | 17,995
Cardiovascular System 4,412 | 17,958
Respiratory system 4,392 | 17,484
Skin and soft tissues 4,389 | 18,115

Target Family

Non-IDG 2,536 | 11,971
Enzyme 1,065 | 4,146
Transcription Factor 330 | 1,400
Kinase 194 | 634
Transporter 105 | 473
GPCR 71 | 406
Ion Channel 69 | 341
Epigenetic 65 | 242
Nuclear Receptor 17 | 48
TF/Epigenetic 14 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359