Development Level

Tbio 1,887 | 11,445
Tdark 387 | 6,588
Tchem 322 | 1,598
Tclin 120 | 613

Collection

RFA-RM-18-021 37 | 328
Ion Channel: IDG Consortium (T... 14 | 99
GPCR: IDG Consortium (Targets) 12 | 126
Kinase: IDG Consortium (Target... 11 | 125
GPCR: IDG Consortium (Complete... 7 | 25
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 144 | 979
preweaning lethality, incomple... 101 | 499
embryonic lethality prior to t... 46 | 278
decreased vertical activity 44 | 208
abnormal behavior 42 | 298
enlarged heart 40 | 210
decreased total body fat amoun... 38 | 207
abnormal embryo size 37 | 220
embryonic lethality prior to o... 33 | 239
abnormal heart morphology 32 | 162
increased lean body mass 28 | 172
decreased grip strength 24 | 116
abnormal bone structure 23 | 187
hyperactivity 23 | 148
increased circulating alkaline... 23 | 122
hypoactivity 22 | 132
increased mean corpuscular vol... 22 | 92
abnormal seminal vesicle morph... 21 | 114
increased bone mineral content 20 | 108
increased mean corpuscular hem... 20 | 96
male infertility 20 | 123
abnormal lens morphology 19 | 81
decreased lean body mass 19 | 135
embryonic growth retardation 19 | 106
abnormal eye morphology 18 | 68
cataract 18 | 92
increased circulating HDL chol... 18 | 80
decreased body weight 17 | 161
decreased circulating choleste... 17 | 93
decreased circulating glucose ... 17 | 126
improved glucose tolerance 17 | 79
increased total body fat amoun... 17 | 134
abnormal sleep behavior 16 | 70
decreased bone mineral content 15 | 151
decreased bone mineral density 15 | 126
decreased lymphocyte cell numb... 15 | 83
decreased startle reflex 15 | 75
increased bone mineral density 15 | 72
increased startle reflex 15 | 112
abnormal retina morphology 14 | 71
impaired glucose tolerance 14 | 75
increased circulating sodium l... 14 | 71
increased or absent threshold ... 14 | 101
short tibia 14 | 97
decreased hemoglobin content 13 | 68
decreased leukocyte cell numbe... 13 | 73
decreased mean corpuscular vol... 13 | 79
increased heart weight 13 | 62
abnormal kidney morphology 12 | 65
decreased body length 12 | 101
decreased circulating serum al... 12 | 82
decreased prepulse inhibition 12 | 82
edema 12 | 59
increased fasted circulating g... 12 | 76
increased monocyte cell number 12 | 63
small superior vagus ganglion 12 | 74
abnormal behavioral response t... 11 | 66
abnormal gait 11 | 69
abnormal skin morphology 11 | 50
prenatal lethality prior to he... 11 | 87
abnormal neural tube closure 10 | 46
abnormal testis morphology 10 | 43
decreased circulating HDL chol... 10 | 68
decreased circulating insulin ... 10 | 76
decreased circulating triglyce... 10 | 79
decreased erythrocyte cell num... 10 | 62
decreased hematocrit 10 | 46
decreased red blood cell distr... 10 | 41
enlarged lymph nodes 10 | 37
increased blood urea nitrogen ... 10 | 48
increased body length 10 | 32
increased circulating calcium ... 10 | 34
increased hematocrit 10 | 46
increased leukocyte cell numbe... 10 | 47
small testis 10 | 58
abnormal epididymis morphology 9 | 42
decreased circulating total pr... 9 | 49
female infertility 9 | 60
hydrometra 9 | 53
impaired righting response 9 | 26
increased circulating choleste... 9 | 66
increased circulating potassiu... 9 | 29
increased erythrocyte cell num... 9 | 39
thrombocytopenia 9 | 56
abnormal cornea morphology 8 | 31
abnormal lung morphology 8 | 26
abnormal spleen morphology 8 | 55
decreased circulating alanine ... 8 | 47
decreased circulating chloride... 8 | 30
decreased fasted circulating g... 8 | 65
limb grasping 8 | 41
abnormal coat-hair pigmentatio... 7 | 64
cardiovascular system phenotyp... 7 | 36
decreased blood urea nitrogen ... 7 | 51
decreased caudal vertebrae num... 7 | 53
decreased mean corpuscular hem... 7 | 31
enlarged epididymis 7 | 31
increased circulating total pr... 7 | 28
increased circulating triglyce... 7 | 42
increased heart rate 7 | 23

Disease

lung adenocarcinoma 2,716 | 2,716
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,669 | 18,159
Female tissues 2,667 | 17,400
Skin and soft tissues 2,658 | 17,230
Digestive Tract 2,657 | 17,369
Respiratory system 2,653 | 16,393
Male tissues 2,646 | 17,142
Urinary Tract 2,640 | 16,678
Blood and immune system 2,637 | 16,909
Liver and Pancreas 2,631 | 16,750
Nervous System 2,605 | 16,725
Cardiovascular System 2,462 | 15,192

Target Family

Non-IDG 1,656 | 12,091
Enzyme 591 | 4,145
Transcription Factor 134 | 1,400
Kinase 109 | 634
Transporter 76 | 473
GPCR 64 | 408
Ion Channel 47 | 344
Epigenetic 20 | 242
Nuclear Receptor 10 | 48
TF/Epigenetic 7 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119