Development Level

Tbio 1,772 | 10,625
Tdark 443 | 7,003
Tchem 382 | 1,890
Tclin 116 | 602

Collection

Eligible Ion Channel Proteins 14 | 117
Eligible non-olfactory GPCR Proteins 14 | 143
Eligible Kinase Proteins 13 | 134

IMPC Term

preweaning lethality, complete... 92 | 633
preweaning lethality, incomple... 52 | 260
embryonic lethality prior to t... 33 | 187
decreased lean body mass 31 | 195
decreased total body fat amoun... 30 | 186
abnormal behavior 29 | 226
increased circulating alkaline... 28 | 119
decreased grip strength 27 | 123
decreased body weight 25 | 174
enlarged heart 23 | 111
increased mean corpuscular vol... 23 | 91
increased mean corpuscular hem... 22 | 93
decreased bone mineral density 21 | 126
decreased circulating glucose ... 21 | 121
increased lean body mass 21 | 107
embryonic lethality prior to o... 20 | 148
decreased bone mineral content 19 | 157
increased or absent threshold ... 19 | 128
abnormal embryo size 18 | 112
abnormal retina morphology 17 | 100
decreased body length 17 | 108
hyperactivity 17 | 108
abnormal sleep behavior 16 | 63
increased grip strength 16 | 83
abnormal bone structure 15 | 131
abnormal lens morphology 14 | 73
decreased circulating HDL chol... 14 | 77
decreased circulating choleste... 14 | 85
hypoactivity 14 | 89
improved glucose tolerance 14 | 56
increased bone mineral content 14 | 92
increased circulating sodium l... 14 | 71
decreased circulating insulin ... 13 | 75
increased circulating HDL chol... 13 | 63
male infertility 13 | 62
decreased lumbar vertebrae num... 12 | 62
increased total body fat amoun... 12 | 57
abnormal heart morphology 11 | 51
abnormal retinal pigmentation 11 | 61
decreased circulating serum al... 11 | 79
decreased circulating triglyce... 11 | 83
decreased eosinophil cell numb... 11 | 41
decreased leukocyte cell numbe... 11 | 54
decreased prepulse inhibition 11 | 52
decreased startle reflex 11 | 48
increased circulating calcium ... 11 | 32
increased fasted circulating g... 11 | 68
increased sacral vertebrae num... 11 | 62
abnormal neural tube closure 10 | 37
decreased circulating total pr... 10 | 41
decreased erythrocyte cell num... 10 | 43
decreased hemoglobin content 10 | 53
impaired glucose tolerance 10 | 52
short tibia 10 | 82
thrombocytopenia 10 | 46
decreased circulating alanine ... 9 | 53
decreased mean corpuscular vol... 9 | 50
female infertility 9 | 34
increased blood urea nitrogen ... 9 | 44
increased body weight 9 | 42
increased bone mineral density 9 | 52
increased startle reflex 9 | 38
abnormal hindbrain development 8 | 24
abnormal midbrain development 8 | 22
decreased circulating chloride... 8 | 32
decreased fasted circulating g... 8 | 49
decreased hematocrit 8 | 25
decreased rib number 8 | 59
enlarged lymph nodes 8 | 27
increased circulating potassiu... 8 | 31
increased circulating total pr... 8 | 20
increased circulating triglyce... 8 | 24
increased exploration in new e... 8 | 56
increased hematocrit 8 | 36
increased leukocyte cell numbe... 8 | 37
abnormal behavioral response t... 7 | 52
abnormal coat/hair pigmentatio... 7 | 54
abnormal kidney morphology 7 | 30
abnormal seminal vesicle morph... 7 | 47
cardiovascular system phenotyp... 7 | 35
decreased CD8-positive, alpha-... 7 | 26
decreased T cell number 7 | 31
decreased blood urea nitrogen ... 7 | 31
decreased caudal vertebrae num... 7 | 49
decreased circulating free fat... 7 | 39
decreased threshold for audito... 7 | 32
increased body length 7 | 20
increased circulating choleste... 7 | 53
increased heart weight 7 | 37
prenatal lethality prior to he... 7 | 64
small testis 7 | 37
abnormal bone mineralization 6 | 55
abnormal epididymis morphology 6 | 31
abnormal gait 6 | 51
decreased circulating LDL chol... 6 | 37
decreased circulating fructosa... 6 | 31
increased circulating chloride... 6 | 43
increased circulating free fat... 6 | 17
increased erythrocyte cell num... 6 | 26
increased hemoglobin content 6 | 45

Disease

lung adenocarcinoma 2,713 | 2,713
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 2,685 | 18,473
Female tissues 2,683 | 18,647
Nervous System 2,681 | 18,561
Liver and Pancreas 2,679 | 18,136
Male tissues 2,679 | 17,969
Urinary Tract 2,678 | 18,444
Endocrine System 2,676 | 18,512
Respiratory system 2,670 | 17,484
Blood and immune system 2,669 | 17,995
Cardiovascular System 2,666 | 17,958
Skin and soft tissues 2,659 | 18,115

Target Family

Non-IDG 1,655 | 11,971
Enzyme 590 | 4,146
Transcription Factor 134 | 1,400
Kinase 108 | 634
Transporter 76 | 473
GPCR 64 | 406
Ion Channel 47 | 341
Epigenetic 20 | 242
Nuclear Receptor 10 | 48
TF/Epigenetic 7 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345