Development Level

Tbio 875 | 11,651
Tdark 157 | 6,593
Tchem 131 | 1,388
Tclin 24 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 76 | 979
preweaning lethality, incomple... 43 | 499
abnormal behavior 28 | 298
embryonic lethality prior to t... 23 | 278
decreased total body fat amoun... 20 | 207
decreased body weight 19 | 161
abnormal bone structure 16 | 187
decreased lean body mass 16 | 135
abnormal embryo size 15 | 220
hypoactivity 15 | 132
decreased bone mineral content 14 | 151
embryonic lethality prior to o... 14 | 239
enlarged heart 14 | 210
increased lean body mass 14 | 172
increased bone mineral density 13 | 72
decreased leukocyte cell numbe... 12 | 73
increased bone mineral content 12 | 108
decreased body length 11 | 101
decreased bone mineral density 11 | 126
decreased mean corpuscular vol... 11 | 79
increased heart weight 11 | 62
increased mean corpuscular hem... 11 | 36
abnormal coat-hair pigmentatio... 10 | 64
cataract 10 | 92
decreased circulating glucose ... 10 | 126
decreased vertical activity 10 | 208
decreased grip strength 9 | 116
hyperactivity 9 | 148
increased circulating HDL chol... 9 | 80
increased circulating choleste... 9 | 66
abnormal lens morphology 8 | 81
increased fasted circulating g... 8 | 76
increased mean corpuscular hem... 8 | 96
increased mean corpuscular vol... 8 | 92
increased or absent threshold ... 8 | 101
increased startle reflex 8 | 112
male infertility 8 | 123
short tibia 8 | 97
abnormal retina morphology 7 | 71
abnormal seminal vesicle morph... 7 | 114
abnormal sleep behavior 7 | 70
decreased caudal vertebrae num... 7 | 53
decreased circulating HDL chol... 7 | 68
decreased circulating serum al... 7 | 82
decreased lymphocyte cell numb... 7 | 83
improved glucose tolerance 7 | 79
increased circulating alkaline... 7 | 122
increased erythrocyte cell num... 7 | 39
increased leukocyte cell numbe... 7 | 47
increased mean platelet volume 7 | 45
increased total body fat amoun... 7 | 134
decreased circulating choleste... 6 | 93
decreased circulating insulin ... 6 | 76
decreased hemoglobin content 6 | 68
decreased mean corpuscular hem... 6 | 50
decreased mean corpuscular hem... 6 | 31
decreased neutrophil cell numb... 6 | 42
edema 6 | 59
embryonic growth retardation 6 | 106
enlarged lymph nodes 6 | 37
increased lymphocyte cell numb... 6 | 32
prenatal lethality prior to he... 6 | 87
abnormal eye morphology 5 | 68
abnormal gait 5 | 69
abnormal heart morphology 5 | 162
abnormal joint morphology 5 | 23
decreased blood urea nitrogen ... 5 | 51
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
decreased fasted circulating g... 5 | 65
decreased prepulse inhibition 5 | 82
decreased red blood cell distr... 5 | 41
enlarged spleen 5 | 41
increased blood urea nitrogen ... 5 | 48
increased circulating chloride... 5 | 41
increased circulating iron lev... 5 | 30
increased circulating sodium l... 5 | 71
increased heart rate 5 | 23
increased monocyte cell number 5 | 63
increased neutrophil cell numb... 5 | 46
small superior vagus ganglion 5 | 74
thrombocytopenia 5 | 56
tremors 5 | 39
abnormal behavioral response t... 4 | 66
abnormal cornea morphology 4 | 31
abnormal cranium morphology 4 | 36
abnormal placenta size 4 | 20
abnormal skin morphology 4 | 50
abnormal spleen morphology 4 | 55
abnormal tooth morphology 4 | 24
corneal opacity 4 | 32
decreased circulating amylase ... 4 | 28
decreased circulating fructosa... 4 | 30
decreased hematocrit 4 | 46
impaired glucose tolerance 4 | 75
increased body length 4 | 32
increased body weight 4 | 25
increased circulating triglyce... 4 | 42
small testis 4 | 58
thrombocytosis 4 | 27

Disease

juvenile dermatomyositis 1,187 | 1,187
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 1,176 | 18,159
Digestive Tract 1,173 | 17,369
Skin and soft tissues 1,173 | 17,230
Female tissues 1,170 | 17,400
Male tissues 1,170 | 17,142
Liver and Pancreas 1,168 | 16,750
Urinary Tract 1,168 | 16,678
Blood and immune system 1,167 | 16,909
Nervous System 1,163 | 16,725
Respiratory system 1,162 | 16,393
Cardiovascular System 1,157 | 15,192

Target Family

Non-IDG 733 | 12,091
Enzyme 251 | 4,145
Transcription Factor 79 | 1,400
Kinase 51 | 634
Epigenetic 26 | 242
Transporter 25 | 473
GPCR 8 | 408
TF/Epigenetic 6 | 38
Ion Channel 5 | 344
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Protein TANC1 TANC1 Tdark Non-IDG -1.18264 15.5 31
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104