Development Level

Tbio 1,946 | 10,625
Tdark 467 | 7,003
Tchem 413 | 1,890
Tclin 124 | 602

Collection

Eligible Kinase Proteins 14 | 134
Eligible Ion Channel Proteins 9 | 117
Eligible non-olfactory GPCR Proteins 9 | 143

IMPC Term

preweaning lethality, complete... 98 | 633
preweaning lethality, incomple... 58 | 260
abnormal behavior 44 | 226
decreased total body fat amoun... 36 | 186
decreased lean body mass 31 | 195
decreased body weight 29 | 174
increased or absent threshold ... 28 | 128
increased circulating alkaline... 27 | 119
embryonic lethality prior to t... 26 | 187
abnormal bone structure 25 | 131
decreased bone mineral content 25 | 157
decreased grip strength 24 | 123
decreased bone mineral density 23 | 126
abnormal embryo size 21 | 112
abnormal retina morphology 21 | 100
increased lean body mass 21 | 107
increased mean corpuscular vol... 21 | 91
decreased circulating HDL chol... 20 | 77
enlarged heart 20 | 111
decreased circulating choleste... 19 | 85
increased total body fat amoun... 19 | 57
decreased circulating glucose ... 18 | 121
hypoactivity 18 | 89
increased mean corpuscular hem... 18 | 93
decreased circulating insulin ... 17 | 75
decreased prepulse inhibition 17 | 52
increased bone mineral content 17 | 92
increased circulating HDL chol... 17 | 63
abnormal lens morphology 16 | 73
decreased body length 16 | 108
hyperactivity 16 | 108
embryonic lethality prior to o... 15 | 148
short tibia 15 | 82
decreased circulating serum al... 14 | 79
decreased circulating triglyce... 14 | 83
decreased fasted circulating g... 13 | 49
decreased leukocyte cell numbe... 13 | 54
increased circulating choleste... 13 | 53
increased fasted circulating g... 13 | 68
increased hematocrit 13 | 36
abnormal retinal pigmentation 12 | 61
decreased heart weight 12 | 44
impaired glucose tolerance 12 | 52
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating alanine ... 11 | 53
decreased hemoglobin content 11 | 53
decreased startle reflex 11 | 48
improved glucose tolerance 11 | 56
increased grip strength 11 | 83
increased hemoglobin content 11 | 45
male infertility 11 | 62
thrombocytopenia 11 | 46
abnormal bone mineralization 10 | 55
abnormal gait 10 | 51
abnormal sleep behavior 10 | 63
decreased rib number 10 | 59
increased circulating sodium l... 10 | 71
increased sacral vertebrae num... 10 | 62
abnormal neural tube closure 9 | 37
cardiovascular system phenotyp... 9 | 35
decreased caudal vertebrae num... 9 | 49
decreased circulating alkaline... 9 | 41
increased blood urea nitrogen ... 9 | 44
increased bone mineral density 9 | 52
increased heart weight 9 | 37
abnormal eye morphology 8 | 38
abnormal spleen morphology 8 | 36
decreased CD8-positive, alpha-... 8 | 26
decreased circulating LDL chol... 8 | 37
decreased circulating creatini... 8 | 31
decreased circulating total pr... 8 | 41
decreased erythrocyte cell num... 8 | 43
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular vol... 8 | 50
decreased spleen weight 8 | 13
increased B cell number 8 | 23
increased circulating iron lev... 8 | 25
increased erythrocyte cell num... 8 | 26
increased exploration in new e... 8 | 56
increased rib number 8 | 41
abnormal behavioral response t... 7 | 52
abnormal cranium morphology 7 | 32
cataract 7 | 26
corneal opacity 7 | 25
decreased CD4-positive, CD25-p... 7 | 24
decreased T cell number 7 | 31
decreased blood urea nitrogen ... 7 | 31
decreased circulating calcium ... 7 | 33
decreased circulating free fat... 7 | 39
decreased eosinophil cell numb... 7 | 41
decreased mean corpuscular hem... 7 | 34
decreased monocyte cell number 7 | 28
decreased threshold for audito... 7 | 32
enlarged lymph nodes 7 | 27
enlarged spleen 7 | 26
increased body weight 7 | 42
increased circulating calcium ... 7 | 32
increased circulating potassiu... 7 | 31
increased circulating triglyce... 7 | 24
increased leukocyte cell numbe... 7 | 37

Disease

invasive ductal carcinoma 2,950 | 2,950
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,927 | 18,561
Digestive Tract 2,926 | 18,473
Female tissues 2,926 | 18,647
Urinary Tract 2,926 | 18,444
Liver and Pancreas 2,925 | 18,136
Endocrine System 2,921 | 18,512
Blood and immune system 2,920 | 17,995
Male tissues 2,920 | 17,969
Cardiovascular System 2,918 | 17,958
Respiratory system 2,913 | 17,484
Skin and soft tissues 2,905 | 18,115

Target Family

Non-IDG 1,745 | 11,971
Enzyme 663 | 4,146
Transcription Factor 196 | 1,400
Kinase 127 | 634
Transporter 75 | 473
GPCR 59 | 406
Ion Channel 34 | 341
Epigenetic 32 | 242
Nuclear Receptor 14 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.15987 17.5 42
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523