Development Level

Tbio 2,109 | 10,625
Tdark 624 | 7,003
Tchem 439 | 1,890
Tclin 117 | 602

Collection

Eligible Kinase Proteins 21 | 134
Eligible Ion Channel Proteins 11 | 117
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 132 | 633
preweaning lethality, incomple... 65 | 260
embryonic lethality prior to t... 53 | 187
decreased lean body mass 49 | 195
abnormal behavior 48 | 226
decreased bone mineral content 45 | 157
decreased total body fat amoun... 44 | 186
decreased body weight 40 | 174
abnormal bone structure 31 | 131
decreased bone mineral density 30 | 126
decreased grip strength 29 | 123
embryonic lethality prior to o... 29 | 148
decreased body length 27 | 108
increased circulating alkaline... 27 | 119
increased lean body mass 27 | 107
decreased circulating glucose ... 26 | 121
hypoactivity 25 | 89
increased or absent threshold ... 25 | 128
abnormal embryo size 24 | 112
increased bone mineral content 24 | 92
hyperactivity 23 | 108
decreased circulating triglyce... 22 | 83
abnormal retina morphology 21 | 100
decreased circulating HDL chol... 21 | 77
decreased circulating insulin ... 21 | 75
enlarged heart 21 | 111
increased mean corpuscular vol... 21 | 91
abnormal lens morphology 20 | 73
decreased circulating choleste... 20 | 85
decreased circulating serum al... 19 | 79
increased mean corpuscular hem... 19 | 93
short tibia 18 | 82
increased fasted circulating g... 17 | 68
abnormal sleep behavior 15 | 63
decreased lumbar vertebrae num... 15 | 62
decreased mean corpuscular vol... 15 | 50
decreased startle reflex 15 | 48
improved glucose tolerance 15 | 56
abnormal coat/hair pigmentatio... 14 | 54
abnormal neural tube closure 14 | 37
abnormal retinal pigmentation 14 | 61
increased circulating HDL chol... 14 | 63
increased sacral vertebrae num... 14 | 62
increased startle reflex 14 | 38
abnormal bone mineralization 12 | 55
decreased leukocyte cell numbe... 12 | 54
decreased prepulse inhibition 12 | 52
female infertility 12 | 34
increased grip strength 12 | 83
prenatal lethality prior to he... 12 | 64
abnormal epididymis morphology 11 | 31
decreased heart weight 11 | 44
decreased rib number 11 | 59
impaired glucose tolerance 11 | 52
increased blood urea nitrogen ... 11 | 44
increased body weight 11 | 42
increased bone mineral density 11 | 52
abnormal cranium morphology 10 | 32
abnormal seminal vesicle morph... 10 | 47
decreased circulating alanine ... 10 | 53
decreased eosinophil cell numb... 10 | 41
decreased fasted circulating g... 10 | 49
increased circulating sodium l... 10 | 71
increased rib number 10 | 41
male infertility 10 | 62
thrombocytopenia 10 | 46
abnormal hindbrain development 9 | 24
abnormal midbrain development 9 | 22
abnormal tooth morphology 9 | 24
cardiovascular system phenotyp... 9 | 35
decreased CD8-positive, alpha-... 9 | 26
decreased circulating total pr... 9 | 41
decreased erythrocyte cell num... 9 | 43
decreased hemoglobin content 9 | 53
decreased mean corpuscular hem... 9 | 34
enlarged epididymis 9 | 27
enlarged lymph nodes 9 | 27
increased exploration in new e... 9 | 56
increased hematocrit 9 | 36
increased hemoglobin content 9 | 45
increased red blood cell distr... 9 | 21
limb grasping 9 | 35
abnormal behavioral response t... 8 | 52
abnormal forebrain development 8 | 18
abnormal heart morphology 8 | 51
abnormal testis morphology 8 | 30
decreased CD4-positive, CD25-p... 8 | 24
decreased hematocrit 8 | 25
decreased vertical activity 8 | 22
increased circulating bilirubi... 8 | 16
increased heart weight 8 | 37
increased leukocyte cell numbe... 8 | 37
increased total body fat amoun... 8 | 57
decreased NK T cell number 7 | 28
decreased circulating alkaline... 7 | 41
decreased circulating calcium ... 7 | 33
decreased circulating free fat... 7 | 39
decreased circulating iron lev... 7 | 25
increased circulating potassiu... 7 | 31
small testis 7 | 37

Disease

intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Liver and Pancreas 3,261 | 18,136
Digestive Tract 3,258 | 18,473
Female tissues 3,258 | 18,647
Nervous System 3,256 | 18,561
Male tissues 3,254 | 17,969
Blood and immune system 3,252 | 17,995
Endocrine System 3,249 | 18,512
Cardiovascular System 3,248 | 17,958
Urinary Tract 3,248 | 18,444
Respiratory system 3,242 | 17,484
Skin and soft tissues 3,233 | 18,115

Target Family

Non-IDG 1,856 | 11,971
Enzyme 816 | 4,146
Transcription Factor 212 | 1,400
Kinase 152 | 634
Transporter 96 | 473
GPCR 47 | 406
Ion Channel 46 | 341
Epigenetic 41 | 242
Nuclear Receptor 16 | 48
TF/Epigenetic 7 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290