Development Level

Tbio 2,290 | 11,651
Tdark 540 | 6,593
Tchem 343 | 1,388
Tclin 118 | 612

Collection

RFA-RM-18-021 43 | 328
Kinase: IDG Consortium (Target... 20 | 125
GPCR: IDG Consortium (Targets) 11 | 126
Ion Channel: IDG Consortium (T... 11 | 99
GPCR: IDG Consortium (Complete... 6 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 187 | 979
preweaning lethality, incomple... 115 | 499
embryonic lethality prior to t... 71 | 278
abnormal behavior 66 | 298
decreased total body fat amoun... 48 | 207
enlarged heart 48 | 210
abnormal embryo size 47 | 220
abnormal bone structure 46 | 187
embryonic lethality prior to o... 44 | 239
decreased bone mineral content 41 | 151
decreased vertical activity 41 | 208
increased lean body mass 35 | 172
decreased bone mineral density 34 | 126
abnormal seminal vesicle morph... 32 | 114
decreased body weight 32 | 161
hypoactivity 32 | 132
abnormal heart morphology 31 | 162
hyperactivity 28 | 148
increased startle reflex 27 | 112
increased total body fat amoun... 27 | 134
decreased lean body mass 26 | 135
embryonic growth retardation 26 | 106
decreased circulating glucose ... 25 | 126
decreased grip strength 24 | 116
increased bone mineral content 24 | 108
increased circulating alkaline... 24 | 122
increased or absent threshold ... 24 | 101
decreased circulating choleste... 23 | 93
decreased circulating insulin ... 23 | 76
decreased body length 21 | 101
increased bone mineral density 21 | 72
cataract 20 | 92
decreased prepulse inhibition 20 | 82
increased mean corpuscular vol... 20 | 92
prenatal lethality prior to he... 19 | 87
short tibia 19 | 97
abnormal lens morphology 18 | 81
decreased circulating HDL chol... 18 | 68
decreased startle reflex 18 | 75
increased fasted circulating g... 18 | 76
increased mean corpuscular hem... 18 | 96
abnormal coat-hair pigmentatio... 17 | 64
abnormal eye morphology 17 | 68
decreased circulating serum al... 17 | 82
decreased mean corpuscular vol... 17 | 79
impaired glucose tolerance 17 | 75
improved glucose tolerance 17 | 79
increased circulating HDL chol... 17 | 80
increased heart weight 17 | 62
abnormal epididymis morphology 16 | 42
abnormal retina morphology 16 | 71
decreased circulating triglyce... 16 | 79
decreased leukocyte cell numbe... 16 | 73
abnormal neural tube closure 15 | 46
decreased lymphocyte cell numb... 15 | 83
increased circulating triglyce... 15 | 42
male infertility 15 | 123
abnormal kidney morphology 14 | 65
abnormal skin morphology 14 | 50
abnormal sleep behavior 14 | 70
decreased fasted circulating g... 14 | 65
increased monocyte cell number 14 | 63
small superior vagus ganglion 14 | 74
small testis 14 | 58
decreased red blood cell distr... 13 | 41
enlarged epididymis 13 | 31
increased circulating choleste... 13 | 66
abnormal retinal vasculature m... 12 | 27
decreased erythrocyte cell num... 12 | 62
decreased hemoglobin content 12 | 68
decreased mean corpuscular hem... 12 | 50
thrombocytopenia 12 | 56
abnormal spleen morphology 11 | 55
abnormal testis morphology 11 | 43
decreased caudal vertebrae num... 11 | 53
decreased hematocrit 11 | 46
female infertility 11 | 60
increased hematocrit 11 | 46
increased leukocyte cell numbe... 11 | 47
limb grasping 11 | 41
abnormal behavioral response t... 10 | 66
abnormal cranium morphology 10 | 36
abnormal gait 10 | 69
cardiovascular system phenotyp... 10 | 36
corneal opacity 10 | 32
edema 10 | 59
enlarged lymph nodes 10 | 37
impaired righting response 10 | 26
increased circulating sodium l... 10 | 71
abnormal retinal blood vessel ... 9 | 26
abnormal tooth morphology 9 | 24
decreased circulating alkaline... 9 | 46
decreased neutrophil cell numb... 9 | 42
hydrometra 9 | 53
abnormal bone mineralization 8 | 38
decreased circulating creatini... 8 | 39
decreased circulating iron lev... 8 | 32
decreased circulating total pr... 8 | 49
increased circulating bilirubi... 8 | 16
increased hemoglobin content 8 | 45

Disease

intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,290
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,519
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,577
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,954
invasive ductal carcinoma 2,951 | 2,950
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,744
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,695
breast carcinoma 1,638 | 1,637
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,108
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 3,247 | 17,369
Endocrine System 3,243 | 18,159
Female tissues 3,239 | 17,400
Liver and Pancreas 3,239 | 16,750
Skin and soft tissues 3,239 | 17,230
Urinary Tract 3,233 | 16,678
Blood and immune system 3,224 | 16,909
Male tissues 3,221 | 17,142
Respiratory system 3,206 | 16,393
Nervous System 3,200 | 16,725
Cardiovascular System 3,091 | 15,192

Target Family

Non-IDG 1,857 | 12,091
Enzyme 817 | 4,145
Transcription Factor 211 | 1,400
Kinase 153 | 634
Transporter 96 | 473
GPCR 47 | 408
Ion Channel 46 | 344
Epigenetic 41 | 242
Nuclear Receptor 16 | 48
TF/Epigenetic 7 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11