Development Level

Tbio 2,111 | 11,651
Tdark 469 | 6,593
Tchem 309 | 1,388
Tclin 100 | 612

Collection

Kinase: IDG Consortium (Target... 18 | 125
Ion Channel: IDG Consortium (T... 12 | 99
Kinase: IDG Consortium (Comple... 9 | 37
GPCR: IDG Consortium (Targets) 8 | 126
GPCR: IDG Consortium (Complete... 6 | 25

IMPC Phenotype

preweaning lethality, complete... 170 | 979
preweaning lethality, incomple... 98 | 499
abnormal behavior 54 | 298
embryonic lethality prior to t... 54 | 278
decreased total body fat amoun... 42 | 207
enlarged heart 39 | 210
abnormal bone structure 37 | 187
abnormal embryo size 36 | 220
decreased vertical activity 34 | 208
embryonic lethality prior to o... 31 | 239
decreased bone mineral density 30 | 126
decreased body weight 29 | 161
abnormal heart morphology 27 | 162
hypoactivity 27 | 132
increased circulating alkaline... 27 | 122
increased lean body mass 27 | 172
decreased bone mineral content 26 | 151
decreased grip strength 25 | 116
increased startle reflex 25 | 112
decreased circulating glucose ... 24 | 126
cataract 23 | 92
hyperactivity 23 | 148
embryonic growth retardation 22 | 106
increased bone mineral content 22 | 108
increased total body fat amoun... 22 | 134
male infertility 22 | 123
abnormal lens morphology 20 | 81
decreased circulating triglyce... 20 | 79
abnormal seminal vesicle morph... 19 | 114
decreased lean body mass 19 | 135
decreased leukocyte cell numbe... 19 | 73
decreased lymphocyte cell numb... 19 | 83
increased or absent threshold ... 19 | 101
decreased body length 18 | 101
decreased circulating choleste... 18 | 93
impaired glucose tolerance 18 | 75
decreased circulating insulin ... 17 | 76
decreased circulating serum al... 17 | 82
decreased mean corpuscular vol... 17 | 79
decreased prepulse inhibition 17 | 82
decreased startle reflex 17 | 75
increased fasted circulating g... 17 | 76
increased mean corpuscular hem... 17 | 96
improved glucose tolerance 16 | 79
increased circulating HDL chol... 16 | 80
increased mean corpuscular vol... 16 | 92
increased heart weight 15 | 62
increased bone mineral density 14 | 72
prenatal lethality prior to he... 14 | 87
short tibia 14 | 97
abnormal behavioral response t... 13 | 66
abnormal retina morphology 13 | 71
abnormal skin morphology 13 | 50
decreased circulating HDL chol... 13 | 68
decreased fasted circulating g... 13 | 65
edema 13 | 59
increased circulating triglyce... 13 | 42
abnormal coat-hair pigmentatio... 12 | 64
abnormal eye morphology 12 | 68
increased hematocrit 12 | 46
increased monocyte cell number 12 | 63
limb grasping 12 | 41
small superior vagus ganglion 12 | 74
small testis 12 | 58
abnormal gait 11 | 69
abnormal kidney morphology 11 | 65
decreased circulating alkaline... 11 | 46
decreased erythrocyte cell num... 11 | 62
decreased neutrophil cell numb... 11 | 42
decreased red blood cell distr... 11 | 41
female infertility 11 | 60
impaired righting response 11 | 26
increased circulating choleste... 11 | 66
increased leukocyte cell numbe... 11 | 47
thrombocytopenia 11 | 56
tremors 11 | 39
abnormal sleep behavior 10 | 70
abnormal spleen morphology 10 | 55
abnormal testis morphology 10 | 43
cardiovascular system phenotyp... 10 | 36
corneal opacity 10 | 32
decreased caudal vertebrae num... 10 | 53
decreased circulating calcium ... 10 | 36
decreased circulating creatini... 10 | 39
decreased mean corpuscular hem... 10 | 50
increased erythrocyte cell num... 10 | 39
increased mean platelet volume 10 | 45
abnormal cranium morphology 9 | 36
abnormal epididymis morphology 9 | 42
abnormal tail morphology 9 | 25
decreased circulating iron lev... 9 | 32
decreased hemoglobin content 9 | 68
decreased mean corpuscular hem... 9 | 31
hydrometra 9 | 53
increased blood urea nitrogen ... 9 | 48
increased circulating creatini... 9 | 38
increased circulating sodium l... 9 | 71
increased mean corpuscular hem... 9 | 36
increased neutrophil cell numb... 9 | 46
increased circulating chloride... 8 | 41

Disease

intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 2,954 | 17,369
Endocrine System 2,949 | 18,159
Skin and soft tissues 2,948 | 17,230
Female tissues 2,946 | 17,400
Liver and Pancreas 2,944 | 16,750
Urinary Tract 2,938 | 16,678
Male tissues 2,934 | 17,142
Blood and immune system 2,930 | 16,909
Respiratory system 2,916 | 16,393
Nervous System 2,909 | 16,725
Cardiovascular System 2,818 | 15,192

Target Family

Non-IDG 1,754 | 12,091
Enzyme 673 | 4,145
Transcription Factor 193 | 1,400
Kinase 135 | 634
Transporter 85 | 473
GPCR 47 | 408
Ion Channel 47 | 344
Epigenetic 32 | 242
Nuclear Receptor 14 | 48
TF/Epigenetic 9 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Calcium homeostasis modulator protein 6 CALHM6 Tdark Ion Channel -0.43644 4.12 26